Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

Ristow, 2011, Extending life span by increasing oxidative stress, Free Radical Biology and Medicine, 51, 327, 10.1016/j.freeradbiomed.2011.05.010 Lin, 2002, Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration, Nature, 418, 344, 10.1038/nature00829 Schulz, 2007, Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress, Cell Metabolism, 6, 280, 10.1016/j.cmet.2007.08.011 Bishop, 2007, Two neurons mediate diet-restriction-induced longevity in C. elegans, Nature, 447, 545, 10.1038/nature05904 Lin, 2000, Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae, Science, 289, 2126, 10.1126/science.289.5487.2126 Hardie, 2011, Sensing of energy and nutrients by AMP-activated protein kinase, American Journal of Clinical Nutrition, 93, 891S, 10.3945/ajcn.110.001925 Doonan, 2008, Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans, Genes and Development, 22, 3236, 10.1101/gad.504808 Ristow, 2009, Antioxidants prevent health-promoting effects of physical exercise in humans, Proceedings of the National Academy of Sciences of the United States of America, 106, 8665, 10.1073/pnas.0903485106 Van Raamsdonk, 2009, Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans, PLoS Genetics, 5, e1000361, 10.1371/journal.pgen.1000361 Mesquita, 2010, Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity, Proceedings of the National Academy of Sciences of the United States of America, 107, 15123, 10.1073/pnas.1004432107 Pan, 2011, Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling, Cell Metabolism, 13, 668, 10.1016/j.cmet.2011.03.018 Zarse, 2012, Impaired insulin/IGF1-signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal, Cell Metabolism, 15, 451, 10.1016/j.cmet.2012.02.013 Dillin, 2002, Rates of behavior and aging specified by mitochondrial function during development, Science, 298, 2398, 10.1126/science.1077780 Rea, 2007, Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in caenorhabditis elegans, Plos Biology, 5, e259, 10.1371/journal.pbio.0050259 Yang, 2010, Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans, Aging Cell, 9, 433, 10.1111/j.1474-9726.2010.00571.x Gutman, 1970, Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XVII. Reaction sites of piericidin A and rotenone, Journal of Biological Chemistry, 245, 1992, 10.1016/S0021-9258(18)63196-5 Yang, 2010, A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans, PLoS Biology, 8, e1000556, 10.1371/journal.pbio.1000556 An, 2003, SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response, Genes and Development, 17, 1882, 10.1101/gad.1107803 Schmeisser, 2011, Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species, Hormone and Metabolic Research, 43, 687, 10.1055/s-0031-1286308 Gruber, 2009, Deceptively simple but simply deceptive-Caenorhabditis elegans lifespan studies: considerations for aging and antioxidant effects, FEBS Letters, 583, 3377, 10.1016/j.febslet.2009.09.051 Wood, 2004, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Nature, 430, 686, 10.1038/nature02789 Park, 2010, Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans, Faseb Journal, 24, 383, 10.1096/fj.09-142984 Kumsta, 2011, Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans, Antioxidants and Redox Signaling, 14, 1023, 10.1089/ars.2010.3203 Trapnell, 2009, TopHat: discovering splice junctions with RNA-Seq, Bioinformatics, 25, 1105, 10.1093/bioinformatics/btp120 R Development Core Team. R: a language and environment for statistical computing. Vienna; 2008. Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616 Benjamini, 1995, Controlling the false discovery rate: a practical and powerful approach to multiple testing, Journal of the Royal Statistical Society B, 57, 289 Priebe, 2011, FungiFun: a web-based application for functional categorization of fungal genes and proteins, Fungal Genetics and Biology, 48, 353, 10.1016/j.fgb.2010.11.001 Hope, 1999 Tullet, 2008, Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans, Cell, 132, 1025, 10.1016/j.cell.2008.01.030 Degli Esposti, 1998, Inhibitors of NADH-ubiquinone reductase: an overview, Biochimica et Biophysica Acta, 1364, 222, 10.1016/S0005-2728(98)00029-2 Schapira, 2010, Complex I: inhibitors, inhibition and neurodegeneration, Experimental Neurology, 224, 331, 10.1016/j.expneurol.2010.03.028 Hosono, 1980, Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans, Experimental Gerontology, 15, 285, 10.1016/0531-5565(80)90032-7 Johnson, 1988, Long-lived lines of Caenorhabditis elegans can be used to establish predictive biomarkers of aging, Experimental Gerontology, 23, 281, 10.1016/0531-5565(88)90031-9 Warburton, 2006, Health benefits of physical activity: the evidence, Canadian Medical Association Journal (CMAJ), 174, 801, 10.1503/cmaj.051351 Lakowski, 1998, The genetics of caloric restriction in Caenorhabditis elegans, Proceedings of the National Academy of Sciences of the United States of America, 95, 13091, 10.1073/pnas.95.22.13091 Ingram, 2006, Calorie restriction mimetics: an emerging research field, Aging Cell, 5, 97, 10.1111/j.1474-9726.2006.00202.x Houthoofd, 2005, DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism, Neurobiology of Aging, 26, 689, 10.1016/j.neurobiolaging.2004.06.011 Wang, 2006, Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO, Mechanisms of Ageing and Development, 127, 48, 10.1016/j.mad.2005.09.005 Greer, 2007, An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans, Current Biology, 17, 1646, 10.1016/j.cub.2007.08.047 Emerling, 2005, Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling, Molecular Cell Biology, 25, 4853, 10.1128/MCB.25.12.4853-4862.2005 Kondo, 2005, The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei, Mechanisms of Ageing and Development, 126, 642, 10.1016/j.mad.2004.11.012 Inoue, 2005, The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response, Genes and Development, 19, 2278, 10.1101/gad.1324805 Berman, 2001, Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans, Molecular Cell Biology Research Communications, 4, 337, 10.1006/mcbr.2001.0300 Henderson, 2001, daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans, Current Biology, 11, 1975, 10.1016/S0960-9822(01)00594-2 Yanase, 2002, Adaptive responses to oxidative damage in three mutants of Caenorhabditis elegans (age-1, mev-1 and daf-16) that affect life span, Mechanisms of Ageing and Development, 123, 1579, 10.1016/S0047-6374(02)00093-3 Greer, 2009, AMP-activated protein kinase and FoxO transcription factors in dietary restriction-induced longevity, Annals of the New York Academy of Sciences, 1170, 688, 10.1111/j.1749-6632.2009.04019.x Blackwell, 1994, Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements, Science, 266, 621, 10.1126/science.7939715 Paek, 2012, Mitochondrial SKN-1/Nrf mediates a conserved starvation response, Cell Metabolism, 16, 526, 10.1016/j.cmet.2012.09.007 Ventura, 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress, Aging Cell, 8, 380, 10.1111/j.1474-9726.2009.00482.x Zini, 1999, Effects of resveratrol on the rat brain respiratory chain, Drugs Experimental Clinical Research, 25, 87 Singh, 2005, Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species, Journal of Biological Chemistry, 280, 19911, 10.1074/jbc.M412443200 Fukushima, 2005, Niacin metabolism and Parkinson's disease, Environmental Health and Preventive Medicine, 10, 3, 10.1265/ehpm.10.3 Turner, 2008, Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action, Diabetes, 57, 1414, 10.2337/db07-1552 El-Mir, 2000, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I, Journal of Biological Chemistry, 275, 223, 10.1074/jbc.275.1.223 Brunmair, 2004, Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?, Diabetes, 53, 1052, 10.2337/diabetes.53.4.1052 Nadanaciva, 2007, Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration, Toxicology and Applied Pharmacology, 223, 277, 10.1016/j.taap.2007.06.003 Brunmair, 2004, Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I, Journal of Pharmacology and Experimental Therapeutics, 311, 109, 10.1124/jpet.104.068312 Calabrese, 2003, Toxicology rethinks its central belief, Nature, 421, 691, 10.1038/421691a Gems, 2008, Stress-response hormesis and aging: that which does not kill us makes us stronger, Cell Metabolism, 7, 200, 10.1016/j.cmet.2008.01.001