Allosteric mechanisms in normal and pathological nicotinic acetylcholine receptors

Current Opinion in Neurobiology - Tập 11 - Trang 369-377 - 2001
Jean-Pierre Changeux1, Stuart J Edelstein2
1Laboratoire de Neurobiologie Moléculaire, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
2Département de Biochimie, Université de Genève, 30 quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland

Tài liệu tham khảo

Changeux, 1998, Allosteric receptors after 30 years, Neuron, 21, 959, 10.1016/S0896-6273(00)80616-9 Bargmann, 1998, Neurobiology of the Caenorhabditis elegans genome, Science, 282, 2028, 10.1126/science.282.5396.2028 Le Novere, 1999, The ligand gated ion channel database, Nucleic Acids Res, 27, 340, 10.1093/nar/27.1.340 Agnati, 1995, Intercellular communication in the brain: wiring versus volume transmission, Neuroscience, 69, 711, 10.1016/0306-4522(95)00308-6 Cordero-Erausquin, 2001, Tonic nicotinic modulation of serotoninergic transmission in the spinal cord, Proc Natl Acad Sci USA, 98, 2803, 10.1073/pnas.041600698 Groot-Kormelink, 1998, A reporter mutation approach shows incorporation of the ‘orphan’ subunit β3 into a functional nicotinic receptor, J Biol Chem, 273, 15317, 10.1074/jbc.273.25.15317 Nelson, 1999, Single channel properties of human α3 AChRs: impact of β2, β4 and α5 subunits, J Physiol (Lond), 516, 657, 10.1111/j.1469-7793.1999.0657u.x Vailati, 1999, Functional α6-containing nicotinic receptors are present in chick retina, Mol Pharmacol, 56, 11, 10.1124/mol.56.1.11 Kuryatov, 2000, Human α6 AChR subtypes: subunit composition, assembly, and pharmacological responses, Neuropharmacology, 39, 2570, 10.1016/S0028-3908(00)00144-1 Palma, 1999, Nicotinic acetylcholine receptors assembled from the α7 and β3 subunits, J Biol Chem, 274, 18335, 10.1074/jbc.274.26.18335 Lena, 1999, Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons, Proc Natl Acad Sci USA, 96, 12126, 10.1073/pnas.96.21.12126 Klink, 2001, Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei, J Neurosci, 21, 1452, 10.1523/JNEUROSCI.21-05-01452.2001 Sanes, 1999, Development of the vertebrate neuromuscular junction, Annu Rev Neurosci, 22, 389, 10.1146/annurev.neuro.22.1.389 Schwarz, 2000, Different functions of fetal and adult AChR subtypes for the formation and maintenance of neuromuscular synapses revealed in ε-subunit-deficient mice, Eur J Neurosci, 12, 3107, 10.1046/j.1460-9568.2000.00195.x Williams, 1998, The long internal loop of the α3 subunit targets nAChRs to subdomains within individual synapses on neurons in vivo, Nat Neurosci, 1, 557, 10.1038/2792 Shoop, 1999, Neuronal acetylcholine receptors with α7 subunits are concentrated on somatic spines for synaptic signaling in embryonic chick ciliary ganglia, J Neurosci, 19, 692, 10.1523/JNEUROSCI.19-02-00692.1999 Tsen, 2000, Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal, Nat Neurosci, 3, 126, 10.1038/72066 Sorenson, 1998, Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat, Neuroscience, 87, 659, 10.1016/S0306-4522(98)00064-5 Arroyo-Jimenez, 1999, Ultrastructural localization of the α4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra, J Neurosci, 19, 6475, 10.1523/JNEUROSCI.19-15-06475.1999 Kneussel, 2000, Clustering of inhibitory neurotransmitter receptors at developing postsynaptic sites: the membrane activation model, Trends Neurosci, 23, 429, 10.1016/S0166-2236(00)01627-1 Meier, 2000, Formation of glycine receptor clusters and their accumulation at synapses, J Cell Sci, 113, 2783, 10.1242/jcs.113.15.2783 El-Husseini, 2000, PSD-95 involvement in maturation of excitatory synapses, Science, 290, 1364, 10.1126/science.290.5495.1364 MacDermott, 1999, Presynaptic ionotropic receptors and the control of transmitter release, Annu Rev Neurosci, 22, 443, 10.1146/annurev.neuro.22.1.443 Lena, 1997, Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus, J Neurosci, 17, 576, 10.1523/JNEUROSCI.17-02-00576.1997 Dehaene, 1987, Neural networks that learn temporal sequences by selection, Proc Natl Acad Sci USA, 84, 2727, 10.1073/pnas.84.9.2727 Ji, 2000, Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons, J Neurophysiol, 83, 2682, 10.1152/jn.2000.83.5.2682 Fisher, 2000, Nicotinic receptors on hippocampal cultures can increase synaptic glutamate currents while decreasing the NMDA-receptor component, Neuropharmacology, 39, 2756, 10.1016/S0028-3908(00)00102-7 Armstrong, 1998, Structure of a glutamate-receptor ligand-binding core in complex with kainate, Nature, 395, 913, 10.1038/27692 Armstrong, 2000, Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core, Neuron, 28, 165, 10.1016/S0896-6273(00)00094-5 Paas, 2000, How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors, Trends Pharmacol Sci, 21, 87, 10.1016/S0165-6147(99)01443-1 Le Novère, 1999, Improved secondary structure predictions for a nicotinic receptor subunit: incorporation of solvent accessibility and experimental data into a two-dimensional representation, Biophys J, 76, 2329, 10.1016/S0006-3495(99)77390-X Corringer, 2000, Nicotinic receptors at the amino acid level, Annu Rev Pharmacol Toxicol, 40, 431, 10.1146/annurev.pharmtox.40.1.431 Zhong, 1998, From ab initio quantum mechanics to molecular neurobiology: a cation-π binding site in the nicotinic receptor, Proc Natl Acad Sci USA, 95, 12088, 10.1073/pnas.95.21.12088 Sullivan, 2000, Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist, J Biol Chem, 275, 12651, 10.1074/jbc.275.17.12651 Martinez, 2000, Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy, Biochemistry, 39, 6979, 10.1021/bi992811p Corringer, 1998, Critical elements determining diversity in agonist binding and desensitization of neuronal nicotinic acetylcholine receptors, J Neurosci, 18, 648, 10.1523/JNEUROSCI.18-02-00648.1998 Bohler, 2001, Desensitization of neuronal nicotinic acetylcholine receptors conferred by N-terminal segments of the β2 subunit, Biochemistry, 40, 2066, 10.1021/bi0020022 Corringer, 1999, Mutational analysis of the charge selectivity filter of the α7 nicotinic acetylcholine receptor, Neuron, 22, 831, 10.1016/S0896-6273(00)80741-2 Wilson, 1998, The location of the gate in the acetylcholine receptor channel, Neuron, 20, 1269, 10.1016/S0896-6273(00)80506-1 Keramidas, 2000, M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective, Biophys J, 79, 247, 10.1016/S0006-3495(00)76287-4 Doyle, 1998, The structure of the potassium channel: molecular basis of K+ conduction and selectivity, Science, 280, 69, 10.1126/science.280.5360.69 England, 1999, Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating, Cell, 96, 89, 10.1016/S0092-8674(00)80962-9 Miyazawa, 1999, Nicotinic acetylcholine receptor at 4.6Å resolution: transverse tunnels in the channel wall, J Mol Biol, 288, 765, 10.1006/jmbi.1999.2721 Akk, 2000, Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision, J Physiol (Lond), 527, 405, 10.1111/j.1469-7793.2000.t01-2-00405.x Quiram, 1999, Mutation causing congenital myasthenia reveals acetylcholine receptor β/Δ subunit interaction essential for assembly, J Clin Invest, 104, 1403, 10.1172/JCI8179 Hucho, 1996, The emerging three-dimensional structure of a receptor. The nicotinic acetylcholine receptor, Eur J Biochem, 239, 539, 10.1111/j.1432-1033.1996.0539u.x Jayaraman, 1999, Inhibition of nicotinic acetylcholine receptor by philanthotoxin-343: kinetic investigations in the microsecond time region using a laser-pulse photolysis technique, Biochemistry, 38, 11406, 10.1021/bi991219x Wang, 2000, Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome, J Gen Physiol, 116, 449, 10.1085/jgp.116.3.449 Herz, 1989, Distance between the agonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor, J Biol Chem, 264, 12439, 10.1016/S0021-9258(18)63878-5 Edelstein, 1997, Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model, C R Acad Sci Paris, 320, 953, 10.1016/S0764-4469(97)82468-7 Ohno, 1995, Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the ε subunit, Proc Natl Acad Sci USA, 92, 758, 10.1073/pnas.92.3.758 Bertrand, 1997, Paradoxical allosteric effects of competitive inhibitors on neuronal α7 nicotinic receptor mutants, Neuroreport, 8, 3591, 10.1097/00001756-199711100-00034 Grosman, 2000, Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12′ mutants, J Gen Physiol, 115, 621, 10.1085/jgp.115.5.621 Revah, 1991, Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor, Nature, 353, 846, 10.1038/353846a0 Rajendra, 1995, Mutation of an arginine residue transforms β-alanine and taurine from agonists into competitive antagonists, Neuron, 14, 169, 10.1016/0896-6273(95)90251-1 Taverna, 2000, The Lurcher mutation of an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunit enhances potency of glutamate and converts an antagonist to an agonist, J Biol Chem, 275, 8475, 10.1074/jbc.275.12.8475 Xie, 2001, Contributions of Torpedo nicotinic acetylcholine receptor γTrp-55 and δTrp-57 to agonist and competitive antagonist function, J Biol Chem, 276, 2417, 10.1074/jbc.M009085200 Edelstein, 1997, Single bindings versus single channel recordings: a new approach to ionotropic receptors, Biochemistry, 36, 13755, 10.1021/bi9718301 Prince, 1999, Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models, J Biol Chem, 274, 19623, 10.1074/jbc.274.28.19623 Krauss, 2000, Binding properties of agonists and antagonists to distinct allosteric states of the nicotinic acetylcholine receptor are incompatible with a concerted model, J Biol Chem, 275, 30196, 10.1074/jbc.M001782200 Kunishima, 2000, Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor, Nature, 407, 971, 10.1038/35039564 Schlessinger, 2000, Cell signaling by receptor tyrosine kinases, Cell, 103, 211, 10.1016/S0092-8674(00)00114-8 Changeux, 1967, On the cooperativity of biological membranes, Proc Natl Acad Sci USA, 57, 335, 10.1073/pnas.57.2.335 Schindler, 1984, Different channel properties of Torpedo acetylcholine receptor monomers and dimers reconstituted in planar membranes, Proc Natl Acad Sci USA, 81, 6222, 10.1073/pnas.81.19.6222 Yeramian, 1986, Acetylcholine receptors are not functionally independent, Biophys J, 50, 253, 10.1016/S0006-3495(86)83459-2 Schmidt, 1998, Incorporation of the acetylcholine receptor dimer from Torpedo californica in a peptide supported lipid membrane investigated by surface plasmon and fluorescence spectroscopy, Biosens Bioelectron, 13, 585, 10.1016/S0956-5663(98)00013-X Duke, 1999, Heightened sensitivity of a lattice of membrane receptors, Proc Natl Acad Sci USA, 96, 10104, 10.1073/pnas.96.18.10104 Qian, 1997, T cell antigen receptor signal transduction, Curr Opin Cell Biol, 9, 205, 10.1016/S0955-0674(97)80064-6 Sharma, 1998, Cryoelectron microscopy and image analysis of the cardiac ryanodine receptor, J Biol Chem, 273, 18429, 10.1074/jbc.273.29.18429 Oghalai, 1998, Fluorescence-imaged microdeformation of the outer hair cell lateral wall, J Neurosci, 18, 48, 10.1523/JNEUROSCI.18-01-00048.1998 Khakh, 2000, State-dependent cross-inhibition between transmitter-gated cation channels, Nature, 406, 405, 10.1038/35019066 Engel, 1999, Congenital myasthenic syndromes: recent advances, Arch Neurol, 56, 163, 10.1001/archneur.56.2.163 Milone, 1998, Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor ε subunit, Neuron, 20, 575, 10.1016/S0896-6273(00)80996-4 Wang, 1999, Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating, Nat Neurosci, 2, 226, 10.1038/6326 Steinlein, 2000, Neuronal nicotinic receptors in human epilepsy, Eur J Pharmacol, 393, 243, 10.1016/S0014-2999(00)00065-0 Fusco, 2000, The nicotinic receptor β2 subunit is mutant in nocturnal frontal lobe epilepsy, Nat Genet, 26, 275, 10.1038/81566 Sekhon, 1999, Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys, J Clin Invest, 103, 637, 10.1172/JCI5232 Sweatt, 2000, α7 is upregulated in the TG2576 mouse model of Alzheimer's disease, Soc Neurosci Abstr, 25, 419 Wang, 2000, β-Amyloid(1-42) binds to β7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology, J Biol Chem, 275, 5626, 10.1074/jbc.275.8.5626 Freedman, 2000, Inhibitory neurophysiological deficit as a phenotype for genetic investigation of schizophrenia, Am J Med Genet, 97, 58, 10.1002/(SICI)1096-8628(200021)97:1<58::AID-AJMG8>3.0.CO;2-Y Silverman, 2000, Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor β2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence, Am J Med Genet, 96, 646, 10.1002/1096-8628(20001009)96:5<646::AID-AJMG10>3.0.CO;2-W Cordero-Erausquin, 2000, Nicotinic receptor function: new perspectives from knockout mice, Trends Pharmacol Sci, 21, 211, 10.1016/S0165-6147(00)01489-9 Marubio, 1999, Reduced antinociception in mice lacking neuronal nicotinic receptor subunits, Nature, 398, 805, 10.1038/19756 Ross, 2000, Phenotypic characterization of an α4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse, J Neurosci, 20, 6431, 10.1523/JNEUROSCI.20-17-06431.2000 Picciotto, 1998, Acetylcholine receptors containing the β2 subunit are involved in the reinforcing properties of nicotine, Nature, 391, 173, 10.1038/34413 Zoli, 1999, Increased neurodegeneration during ageing in mice lacking high-affinity nicotine receptors, EMBO J, 18, 1235, 10.1093/emboj/18.5.1235 Xu, 1999, Megacystis, mydriasis, and ion channel defect in mice lacking the α3 neuronal nicotinic acetylcholine receptor, Proc Natl Acad Sci USA, 96, 5746, 10.1073/pnas.96.10.5746 Xu, 1999, Multiorgan autonomic dysfunction in mice lacking the β2 and the β4 subunits of neuronal nicotinic acetylcholine receptors, J Neurosci, 19, 9298, 10.1523/JNEUROSCI.19-21-09298.1999 Ragozzino, 2000, Emotional memory impairment in transgenic mice with a mutant form of the nicotinic receptor α7 subunits, Soc Neurosci Abstr, 25, 526 Labarca, 2000, Knockin mice with hypersensitive neuronal nicotinic receptors, Soc Neurosci Abstr, 25, 526 Paterson, 2000, Neuronal nicotinic receptors in the human brain, Prog Neurobiol, 61, 75, 10.1016/S0301-0082(99)00045-3 Gopalakrishnan, 1996, Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine α4β2 receptor, J Pharmacol Exp Ther, 276, 289 Peng, 1997, Chronic nicotine treatment up-regulates α3 and α7 acetylcholine receptor subtypes expressed by the human neuroblastoma cell line SH- SY5Y, Mol Pharmacol, 51, 776, 10.1124/mol.51.5.776 Wang, 1998, Chronic nicotine treatment up-regulates human α3β2 but not α3β4 acetylcholine receptors stably transfected in human embryonic kidney cells, J Biol Chem, 273, 28721, 10.1074/jbc.273.44.28721 Fenster, 1999, Upregulation of surface α4β2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine, J Neurosci, 19, 4804, 10.1523/JNEUROSCI.19-12-04804.1999 Whiteaker, 1998, Agonist-induced up-regulation of α4β2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition, Mol Pharmacol, 53, 950 Reitstetter, 1999, Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure, J Pharmacol Exp Ther, 289, 656 Green, 1999, Ion channel assembly: creating structures that function, J Gen Physiol, 113, 163, 10.1085/jgp.113.2.163 Keller, 1999, Determinants responsible for assembly of the nicotinic acetylcholine receptor, J Gen Physiol, 113, 171, 10.1085/jgp.113.2.171 Bertrand, 1999, Nicotinic receptor: a prototype of allosteric ligand-gated ion channels and its possible implications in epilepsy, Adv Neurol, 79, 171 Marubio, 2000, Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function, Eur J Pharmacol, 393, 113, 10.1016/S0014-2999(00)00007-8 Dehaene, 1998, A neuronal model of a global workspace in effortful cognitive tasks, Proc Natl Acad Sci USA, 95, 14529, 10.1073/pnas.95.24.14529 Changeux, 1965, Sur les propritétés allostériques de la L-thréonine et de la L-leucine sur la L-thréonine désaminase. VI. Discussion générale, Bull Soc Chim Biol, 47, 281 Wilson, 2001, Acetylcholine receptor channel structure in the resting, open, and desensitized states probed with the substituted-cysteine-accessibility method, Proc Natl Acad Sci USA, 98, 1241, 10.1073/pnas.031567798 Labarca, 2001, Point mutant mice with hypersensitive α4 nicotinic receptors show dopaminergic deficits and increased anxiety, Proc Natl Acad Sci USA, 98, 2786, 10.1073/pnas.041582598 Liu QS, Kawai H, Berg DK: β-Amyloid peptide blocks the response of α7-containing nicotinic receptors on hippocampal neurons. Proc Natl Acad Sci USA 2001, in press. Pettit, 2001, β-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice, J Neurosci, 21, RC210, 10.1523/JNEUROSCI.21-01-j0003.2001 Buisson, 2001, Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function, J Neurosci, 21, 1819, 10.1523/JNEUROSCI.21-06-01819.2001 Perry, 1999, Acetylcholine in mind: a neurotransmitter correlate of consciousness?, Trends Neurosci, 22, 273, 10.1016/S0166-2236(98)01361-7 Brejc, 2001, Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors, Nature, 411, 269, 10.1038/35077011 Smit, 2001, A glia-derived acetylcholine-binding protein that modulates synaptic transmission, Nature, 411, 261, 10.1038/35077000