Evolutionary relationships among diverse bacteriophages and prophages: All the world’s a phage

Proceedings of the National Academy of Sciences of the United States of America - Tập 96 Số 5 - Trang 2192-2197 - 1999
Roger W. Hendrix1, Margaret C. M. Smith1, Robin Burns1, Michael E. Ford1, Graham F. Hatfull1
1Pittsburgh Bacteriophage Institute, Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260; and Department of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom

Tóm tắt

We report DNA and predicted protein sequence similarities, implying homology, among genes of double-stranded DNA (dsDNA) bacteriophages and prophages spanning a broad phylogenetic range of host bacteria. The sequence matches reported here establish genetic connections, not always direct, among the lambdoid phages of Escherichia coli , phage φC31 of Streptomyces , phages of Mycobacterium , a previously unrecognized cryptic prophage, φflu, in the Haemophilus influenzae genome, and two small prophage-like elements, φRv1 and φRv2, in the genome of Mycobacterium tuberculosis . The results imply that these phage genes, and very possibly all of the dsDNA tailed phages, share common ancestry. We propose a model for the genetic structure and dynamics of the global phage population in which all dsDNA phage genomes are mosaics with access, by horizontal exchange, to a large common genetic pool but in which access to the gene pool is not uniform for all phage.

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Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 96 Số 5

2192-2197

Thông tin tác giả