Modulation of peripheral blood immune cells by early use of steroids and its association with clinical outcomes in patients with metastatic non-small cell lung cancer treated with immune checkpoint inhibitors

ESMO Open - Tập 4 - Trang e000457 - 2019
Giovanni Fucà1, Giulia Galli1, Marta Poggi1, Giuseppe Lo Russo1, Claudia Proto1, Martina Imbimbo1, Roberto Ferrara1, Nicoletta Zilembo1, Monica Ganzinelli1, Antonio Sica2,3, Valter Torri4, Mario Paolo Colombo5, Claudio Vernieri1,6, Andrea Balsari7, Filippo de Braud1,8, Marina Chiara Garassino1, Diego Signorelli1
1Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
2Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale 'Amedeo Avogadro', Novara, Italy
3Department of Oncology and Hematology, Humanitas Clinical and Research Center, Rozzano, Italy
4Laboratory of Methodology for Biomedical Research, IRCCS Mario Negri Institute for Pharmacological Research, Milan, Italy
5Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
6Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy
7Dipartimento di Scienze Biomediche per la Salute, University of Milan, Milan, Italy
8Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy

Tài liệu tham khảo

Siegel, 2018, Cancer statistics, 2018, CA Cancer J Clin, 68, 7, 10.3322/caac.21442 Fucà, 2018, Immunotherapy-based combinations: an update, Curr Opin Oncol, 30, 345, 10.1097/CCO.0000000000000466 Brahmer, 2015, Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer, N Engl J Med, 373, 123, 10.1056/NEJMoa1504627 Borghaei, 2015, Nivolumab versus docetaxel in advanced Nonsquamous non-small-cell lung cancer, N Engl J Med, 373, 1627, 10.1056/NEJMoa1507643 Herbst, 2016, Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial, Lancet, 387, 1540, 10.1016/S0140-6736(15)01281-7 Reck, 2016, Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer, N Engl J Med, 375, 1823, 10.1056/NEJMoa1606774 Aguiar, 2017, PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data, Immunotherapy, 9, 499, 10.2217/imt-2016-0150 Rizvi, 2015, Cancer immunology. mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer, Science, 48, 124, 10.1126/science.aaa1348 Putzu, 2018, Blood cell count indexes as predictors of outcomes in advanced non-small-cell lung cancer patients treated with nivolumab, Cancer Immunol Immunother, 67, 1349, 10.1007/s00262-018-2182-4 Zer, 2018, Correlation of neutrophil to lymphocyte ratio and absolute neutrophil count with outcomes with PD-1 axis inhibitors in patients with advanced non-small-cell lung cancer, Clin Lung Cancer, 19, 426, 10.1016/j.cllc.2018.04.008 Park, 2018, Developing a predictive model for clinical outcomes of advanced non-small cell lung cancer patients treated with nivolumab, Clin Lung Cancer, 19, 280, 10.1016/j.cllc.2017.12.007 Diem, 2017, Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as prognostic markers in patients with non-small cell lung cancer (NSCLC) treated with nivolumab, Lung Cancer, 111, 176, 10.1016/j.lungcan.2017.07.024 Suh, 2018, Post-treatment neutrophil-to-lymphocyte ratio at week 6 is prognostic in patients with advanced non-small cell lung cancers treated with anti-PD-1 antibody, Cancer Immunol Immunother, 67, 459, 10.1007/s00262-017-2092-x Bagley, 2017, Pretreatment neutrophil-to-lymphocyte ratio as a marker of outcomes in nivolumab-treated patients with advanced non-small-cell lung cancer, Lung Cancer, 106, 1, 10.1016/j.lungcan.2017.01.013 Shi, 2018, Cancer immunotherapy: a focus on the regulation of immune checkpoints, IJMS, 19, 1389, 10.3390/ijms19051389 Fucà, 2018, Low baseline serum sodium concentration is associated with poor clinical outcomes in metastatic non-small cell lung cancer patients treated with immunotherapy, Target Oncol, 13, 795, 10.1007/s11523-018-0599-5 Remon, 2018, Immune checkpoint inhibitors in non-small cell lung cancer (NSCLC): approaches on special subgroups and unresolved burning questions, Cancer Treat Rev, 64, 21, 10.1016/j.ctrv.2018.02.002 Leonardi, 2018, Safety of programmed Death–1 pathway inhibitors among patients with Non–Small-Cell lung cancer and preexisting autoimmune disorders, JCO, 36, 1905, 10.1200/JCO.2017.77.0305 Martinez-Bernal, 2017, Baseline corticosteroids (CS) could be associated with absence of benefit to immune checkpoint inhibitors (ICI) in advanced non-small cell lung cancer (NSCLC) patients, Ann Oncol, 28:1323P Arbour, 2018, Impact of baseline steroids on efficacy of programmed cell death-1 and programmed Death-Ligand 1 blockade in patients with Non–Small-Cell lung cancer, JCO, 36, 2872, 10.1200/JCO.2018.79.0006 Leighl, 2015, Pembrolizumab for NSCLC: immune-mediated adverse events and corticosteroid use, J Thorac Oncol, 10, S66 Coutinho, 2011, The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights, Mol Cell Endocrinol, 335, 2, 10.1016/j.mce.2010.04.005 Eisenhauer, 2009, New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1), European Journal of Cancer, 45, 228, 10.1016/j.ejca.2008.10.026 Mezquita, 2018, Association of the lung immune prognostic index with immune checkpoint inhibitor outcomes in patients with advanced non-small cell lung cancer, JAMA Oncol, 4, 351, 10.1001/jamaoncol.2017.4771 Heppt, 2017, Prognostic factors and outcomes in metastatic uveal melanoma treated with programmed cell death-1 or combined PD-1/cytotoxic T-lymphocyte antigen-4 inhibition, Eur J Cancer, 82, 56, 10.1016/j.ejca.2017.05.038 Weide, 2016, Baseline biomarkers for outcome of melanoma patients treated with pembrolizumab, Clin Cancer Res, 22, 5487, 10.1158/1078-0432.CCR-16-0127 Russo, 2018, Baseline neutrophilia, derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), and outcome in non small cell lung cancer (NSCLC) treated with nivolumab or docetaxel, J Cell Physiol, 233, 6337, 10.1002/jcp.26609 Schemper, 1996, A note on quantifying follow-up in studies of failure time, Control Clin Trials, 17, 343, 10.1016/0197-2456(96)00075-X SCScott, NAPennell. Brief report: early use of systemic corticosteroids in patients with advanced NSCLC treated with nivolumab. J Thorac Oncol. Dumenil, 2018, Clinical factors associated with early progression and grade 3-4 toxicity in patients with advanced non-small-cell lung cancers treated with nivolumab, PLoS One, 13, 10.1371/journal.pone.0195945 Herold, 2006, Glucocorticoids in T cell apoptosis and function, Cell. Mol. Life Sci., 63, 60, 10.1007/s00018-005-5390-y Colotta, 1993, Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4, Science, 261, 472, 10.1126/science.8332913 Tetel, 2018, Steroids, stress and the gut microbiome-brain axis, J Neuroendocrinol, 30, e12548, 10.1111/jne.12548 Libert, 2014, How steroids steer T cells, Cell Rep, 7, 938, 10.1016/j.celrep.2014.04.041 Franchimont, 1998, Effects of dexamethasone on the profile of cytokine secretion in human whole blood cell cultures, Regul Pept, 73, 59, 10.1016/S0167-0115(97)01063-X Edward, 2017, Selective expansion of human regulatory T cells in nasal polyps, and not adjacent tissue microenvironments, in individual patients exposed to steroids, Clin Immunol, 179, 66, 10.1016/j.clim.2017.02.002 Sica, 2012, Macrophage plasticity and polarization: in vivo veritas, J. Clin. Invest., 122, 787, 10.1172/JCI59643 Sharma, 2017, Primary, adaptive, and acquired resistance to cancer immunotherapy, Cell, 168, 707, 10.1016/j.cell.2017.01.017 Shore, 2015, Advances in the understanding of cancer immunotherapy, BJU Int, 116, 321, 10.1111/bju.12692 Chen, 2016, Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade, Cancer Discov, 6, 827, 10.1158/2159-8290.CD-15-1545 Lanza, 1996, Prednisone increases apoptosis in in vitro activated human peripheral blood T lymphocytes, Clin Exp Immunol, 103, 482, 10.1111/j.1365-2249.1996.tb08306.x Haratani, 2018, Association of immune-related adverse events with nivolumab efficacy in non-small-cell lung cancer, JAMA Oncol, 4, 374, 10.1001/jamaoncol.2017.2925 Fujii, 2018, Incidence of immune-related adverse events and its association with treatment outcomes: the MD anderson cancer center experience, Invest New Drugs, 36, 638, 10.1007/s10637-017-0534-0 Mehra, 2017, Neutrophil to lymphocyte ratio in castration-resistant prostate cancer patients treated with daily oral corticosteroids, Clin Genitourin Cancer, 15, 678, 10.1016/j.clgc.2017.05.012 Hajkova, 2017, Mesenchymal stem cells attenuate the adverse effects of immunosuppressive drugs on distinct T cell Subopulations, Stem Cell Rev and Rep, 13, 104, 10.1007/s12015-016-9703-3 Akbay, 2017, Interleukin-17A promotes lung tumor progression through neutrophil attraction to tumor sites and mediating resistance to PD-1 blockade, J Thorac Oncol, 12, 1268, 10.1016/j.jtho.2017.04.017 Meagher, 1996, Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes, J Immunol, 156, 4422, 10.4049/jimmunol.156.11.4422