Adventitial VEGF165 gene transfer prevents lumen loss through induction of positive arterial remodeling after PTCA in porcine coronary arteries

Mintz, 1996, Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study, Circulation, 94, 35, 10.1161/01.CIR.94.1.35 Andersen, 1996, Remodeling rather than neointimal formation explains luminal narrowing after deep vessel wall injury: insights from a porcine coronary (re)stenosis model, Circulation, 93, 1716, 10.1161/01.CIR.93.9.1716 Nunes, 1995, Combination of vitamins C and E alters the response to coronary balloon injury in the pig, Arterioscler Thromb Vasc Biol, 15, 156, 10.1161/01.ATV.15.1.156 Colombo, 2000, Biodegradable stents: “fulfilling the mission and stepping away”, Circulation, 102, 371, 10.1161/01.CIR.102.4.371 Heublein, 2003, Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?, Heart, 89, 651, 10.1136/heart.89.6.651 Geary, 1998, Wound healing: a paradigm for lumen narrowing after arterial reconstruction, J Vasc Surg, 27, 96, 10.1016/S0741-5214(98)70296-4 Strauss, 1994, Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis, Circ Res, 75, 650, 10.1161/01.RES.75.4.650 Lafont, 1999, Endothelial dysfunction and collagen accumulation: two independent factors for restenosis and constrictive remodeling after experimental angioplasty, Circulation, 100, 1109, 10.1161/01.CIR.100.10.1109 Shi, 1997, Origin of extracellular matrix synthesis during coronary repair, Circulation, 95, 997, 10.1161/01.CIR.95.4.997 Pels, 1999, Adventitial angiogenesis early after coronary angioplasty: correlation with arterial remodeling, Arterioscler Thromb Vasc Biol, 19, 229, 10.1161/01.ATV.19.2.229 Alon, 1995, Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity, Nat Med, 1, 1024, 10.1038/nm1095-1024 Van Belle, 1997, Passivation of metallic stents after arterial gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening, J Am Coll Cardiol, 29, 1371, 10.1016/S0735-1097(97)00049-1 Gonschior, 1995, A new catheter for prolonged local drug application, Coron Artery Dis, 6, 329, 10.1097/00019501-199504000-00010 Gonschior, 1995, Comparison of local intravascular drug-delivery catheter systems, Am Heart J, 130, 1174, 10.1016/0002-8703(95)90139-6 Huehns, 1999, Neointimal growth can be influenced by local adventitial gene manipulation via a needle injection catheter, Atherosclerosis, 144, 135, 10.1016/S0021-9150(99)00048-9 Ferrara, 1991, Purification and cloning of vascular endothelial growth factor secreted by pituitary folliculostellate cells, Methods Enzymol, 198, 391, 10.1016/0076-6879(91)98040-D Kalnins, 1983, Sequence of the lacZ gene of Escherichia coli, EMBO J, 2, 593, 10.1002/j.1460-2075.1983.tb01468.x Labinaz, 1999, Time course and importance of neoadventitial formation in arterial remodeling following balloon angioplasty of porcine coronary arteries, Cardiovasc Res, 41, 255, 10.1016/S0008-6363(98)00203-X Rosenthal, 2001, An iron-binding exochelin prevents restenosis due to coronary artery balloon injury in a porcine model, Circulation, 104, 2222, 10.1161/hc4301.097194 Noutsias, 2001, Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections, Circulation, 104, 275, 10.1161/01.CIR.104.3.275 Noutsias, 2002, Digital image analysis system for the quantification of infiltrates and cell adhesion molecules in inflammatory cardiomyopathy, Med Sci Monit, 8, MT59 Christen, 2001, Mechanisms of neointima formation and remodeling in the porcine coronary artery, Circulation, 103, 882, 10.1161/01.CIR.103.6.882 Barker, 1993, Arterial intimal hyperplasia after occlusion of the adventitial vasa vasorum in the pig, Arterioscler Thromb, 13, 70, 10.1161/01.ATV.13.1.70 Rudic, 1998, Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling, J Clin Invest, 101, 731, 10.1172/JCI1699 Stefanadis, 1995, Effect of vasa vasorum flow on structure and function of the aorta in experimental animals, Circulation, 91, 2669, 10.1161/01.CIR.91.10.2669 Kwon, 1999, Ultrastructural changes of the external elastic lamina in experimental hypercholesterolemic porcine coronary arteries, Yonsei Med J, 40, 273, 10.3349/ymj.1999.40.3.273 Kingston, 2003, Adenovirus-mediated gene transfer of transforming growth factor-{beta}3, but not transforming growth factor-{beta}1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty, Circulation, 108, 2819, 10.1161/01.CIR.0000097068.49080.A0 Ward, 2001, Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries, Circulation, 104, 467, 10.1161/hc3001.091458 Zalewski, 1997, Vascular myofibroblasts. Lessons from coronary repair and remodelling, Arterioscler Thromb Vasc Biol, 17, 417, 10.1161/01.ATV.17.3.417 Scott, 1996, Identification of a potential role for the adventitia in vascular lesion formation after balloon overstretch injury of porcine coronary arteries, Circulation, 93, 2178, 10.1161/01.CIR.93.12.2178 Wilcox, 2001, Perivascular responses after angioplasty which may contribute to postangioplasty restenosis: a role for circulating myofibroblast precursors?, Ann N Y Acad Sci, 947, 68, 10.1111/j.1749-6632.2001.tb03931.x Singer, 1999, Cutaneous wound healing, N Engl J Med, 341, 738, 10.1056/NEJM199909023411006 Paik, 2004, Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm, Exp Mol Med, 36, 524, 10.1038/emm.2004.67 Moulton, 1999, Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice, Circulation, 99, 1726, 10.1161/01.CIR.99.13.1726 Pels, 2003, Effect of adventitial VEGF165 gene transfer on vascular thickening after coronary artery balloon injury, Cardiovasc Res, 60, 664, 10.1016/j.cardiores.2003.09.003 Hedman, 2003, Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT), Circulation, 107, 2677, 10.1161/01.CIR.0000070540.80780.92