Evidence that the endometrial microbiota has an effect on implantation success or failure

American Journal of Obstetrics and Gynecology - Tập 215 - Trang 684-703 - 2016
Inmaculada Moreno1,2, Francisco M. Codoñer3, Felipe Vilella4,5,2, Diana Valbuena1, Juan F. Martinez-Blanch3, Jorge Jimenez-Almazán6, Roberto Alonso6, Pilar Alamá7, Jose Remohí7,8, Antonio Pellicer8,9, Daniel Ramon3,10, Carlos Simon11,4,5,8,2
1Department of Research and Development, Igenomix SL, Valencia, Spain
2Department of Obstetrics and Gynecology, School of Medicine, Stanford University, Stanford, CA
3Lifesequencing SL, Valencia, Spain
4Fundación Instituto Valenciano de Infertilidad (IVI), Valencia, Spain
5Instituto de Investigación Sanitaria INCLIVA, Valencia, Spain
6Department of Bioinformatics, Igenomix SL, Valencia, Spain
7IVI Valencia, Valencia, Spain
8Department of Pediatrics, Obstetrics, and Gynecology, Universidad de Valencia, Instituto Universitario IVI, Valencia, Spain
9IVI Rome, Rome, Italy
10Biopolis SL, Valencia, Spain
11Scientific director, Igenomix SL, Valencia, Spain

Tài liệu tham khảo

Sirota, 2014, Potential influence of the microbiome on infertility and assisted reproductive technology, Semin Reprod Med, 32, 35, 10.1055/s-0033-1361821 González, 2014, SnapShot: the human microbiome, Cell, 158, 690, 10.1016/j.cell.2014.07.019 Burton, 2002, Evaluation of the bacterial vaginal flora of 20 postmenopausal women by direct (Nugent score) and molecular (polymerase chain reaction and denaturing gradient gel electrophoresis) techniques, J Infect Dis, 186, 1770, 10.1086/345761 Pavlova, 2002, Genetic diversity of vaginal lactobacilli from women in different countries based on 16S rRNA gene sequences, J Appl Microbiol, 92, 451, 10.1046/j.1365-2672.2002.01547.x Gajer, 2012, Temporal dynamics of the human vaginal microbiota, Sci Transl Med, 4, 10.1126/scitranslmed.3003605 Onderdonk, 2016, The human microbiome during bacterial vaginosis, Clin Microbiol Rev, 29, 223, 10.1128/CMR.00075-15 Romero, 2014, The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women, Microbiome, 2, 4, 10.1186/2049-2618-2-4 Ravel, 2011, Vaginal microbiome of reproductive-age women, Proc Natl Acad Sci U S A, 108, 4680, 10.1073/pnas.1002611107 Romero, 2014, The vaginal microbiota of pregnant women who subsequently have spontaneous preterm labor and delivery and those with a normal delivery at term, Microbiome, 2, 18, 10.1186/2049-2618-2-18 Ralph, 1999, Influence of bacterial vaginosis on conception and miscarriage in the first trimester: cohort study, BMJ, 319, 220, 10.1136/bmj.319.7204.220 Hay, 1994, Abnormal bacterial colonization of the genital tract and subsequent preterm delivery and late miscarriage, BMJ, 308, 295, 10.1136/bmj.308.6924.295 Romero, 2004, Bacterial vaginosis, the inflammatory response and the risk of preterm birth: a role for genetic epidemiology in the prevention of preterm birth, Am J Obstet Gynecol, 190, 1509, 10.1016/j.ajog.2004.01.002 Fanchin, 1998, Microbial flora of the cervix assessed at the time of embryo transfer adversely affects in vitro fertilization outcome, Fertil Steril, 70, 866, 10.1016/S0015-0282(98)00277-5 Egbase, 1996, Incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer, Hum Reprod, 11, 1687, 10.1093/oxfordjournals.humrep.a019470 Moore, 2000, Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization, Fertil Steril, 74, 1118, 10.1016/S0015-0282(00)01624-1 Salim, 2002, Bacterial colonization of the uterine cervix and success rate in assisted reproduction: results of a prospective survey, Hum Reprod, 17, 337, 10.1093/humrep/17.2.337 Selman, 2007, Examination of bacterial contamination at the time of embryo transfer, and its impact on the IVF/pregnancy outcome, J Assist Reprod Genet, 24, 395, 10.1007/s10815-007-9146-5 Romero, 2004, Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?, Fertil Steril, 82, 799, 10.1016/j.fertnstert.2004.05.076 Møller, 1995, Sterility of the uterine cavity, Acta Obstet Gynecol Scand, 74, 216, 10.3109/00016349509008942 Mitchell, 2015, Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women, Am J Obstet Gynecol, 212, 611.e1, 10.1016/j.ajog.2014.11.043 Racicot, 2013, Viral infection of the pregnant cervix predisposes to ascending bacterial infection, J Immunol, 191, 934, 10.4049/jimmunol.1300661 Cho, 2012, The human microbiome: at the interface of health and disease, Nat Rev Genet, 13, 260, 10.1038/nrg3182 Vilella, 2013, PGE2 and PGF2 concentrations in human endometrial fluid as biomarkers for embryonic implantation, J Clin Endocrinol Metab, 98, 4123, 10.1210/jc.2013-2205 Ruiz-Alonso, 2013, The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure, Fertil Steril, 100, 818, 10.1016/j.fertnstert.2013.05.004 Sim, 2012, Improved detection of bifidobacteria with optimized 16S rRNA-gene based pyrosequencing, PLoS One, 7, e32543, 10.1371/journal.pone.0032543 Caporaso, 2010, QIIME allows analysis of high-throughput community sequencing data, Nat Methods, 7, 335, 10.1038/nmeth.f.303 Edgar, 2010, Search and clustering orders of magnitude faster than BLAST, Bioinformatics, 26, 2460, 10.1093/bioinformatics/btq461 Cole, 2009, The ribosomal database project: improved alignments and new tools for rRNA analysis, Nucleic Acids Res, 37, D141, 10.1093/nar/gkn879 Shannon CE. The mathematical theory of communication. University of Illinois Press. Illinis book edition, 1963. Simpson EH. Measurement of diversity. Nature 1949;163:688-8. DiGiulio, 2015, Temporal and spatial variation of the human microbiota during pregnancy, Proc Natl Acad Sci U S A, 112, 11060, 10.1073/pnas.1502875112 Spurbeck, 2008, Inhibition of Neisseria gonorrhoeae epithelial cell interactions by vaginal Lactobacillus species, Infect Immun, 76, 3124, 10.1128/IAI.00101-08 Hyman, 2012, The dynamics of the vaginal microbiome during infertility therapy with in vitro fertilization-embryo transfer, J Assist Reprod Genet, 29, 105, 10.1007/s10815-011-9694-6 Liversedge, 1999, The influence of bacterial vaginosis on in-vitro fertilization and embryo implantation during assisted reproduction treatment, Hum Reprod, 14, 2411, 10.1093/humrep/14.9.2411 van Oostrum, 2013, Risks associated with bacterial vaginosis in infertility patients: a systematic review and meta-analysis, Hum Reprod, 28, 1809, 10.1093/humrep/det096 Egbase, 1999, Prophylactic antibiotics and endocervical microbial inoculation of the endometrium at embryo transfer, Lancet, 354, 651, 10.1016/S0140-6736(99)02415-0 Franasiak, 2016, Endometrial microbiome at the time of embryo transfer: next-generation sequencing of the 16S ribosomal subunit, J Assist Reprod Genet, 33, 129, 10.1007/s10815-015-0614-z Skarin, 1986, Vaginal lactobacilli inhibiting growth of Gardnerella vaginalis, Mobiluncus and other bacterial species cultured from vaginal content of women with bacterial vaginosis, Acta Pathol Microbiol Immunol Scand B, 94, 399 Yamamoto, 2009, Bacterial populations in the vaginas of healthy adolescent women, J Pediatr Adolesc Gynecol, 22, 11, 10.1016/j.jpag.2008.01.073 Dominguez, 2010, Embryologic outcome and secretome profile of implanted blastocysts obtained after coculture in human endometrial epithelial cells versus the sequential system, Fertil Steril, 93, 774, 10.1016/j.fertnstert.2008.10.019 Cha J, Vilella F, Dey SK, Simón C. Molecular interplay in successful implantation. Science. S. Sanders. Washington; Nov. 12, 2013; Ten critical topics in reproductive medicine: 44-8. van der Gaast, 2003, Endometrial secretion aspiration prior to embryo transfer does not reduce implantation rates, Reprod Biomed Online, 7, 105, 10.1016/S1472-6483(10)61737-3 Díaz-Gimeno, 2011, A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature, Fertil Steril, 95, 50, 10.1016/j.fertnstert.2010.04.063 Díaz-Gimeno, 2013, The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity, Fertil Steril, 99, 508, 10.1016/j.fertnstert.2012.09.046 Pearson, 1997, Comparison of DNA sequences with protein sequences, Genomics, 46, 24, 10.1006/geno.1997.4995 Martin, 2011, Cutadapt removes adapter sequences from high-throughput sequencing reads, EMBnet J, 17, 10, 10.14806/ej.17.1.200 Edgar, 2011, UCHIME improves sensitivity and speed of chimera detection, Bioinformatics, 27, 2194, 10.1093/bioinformatics/btr381 Fawcett, 2006, An introduction to ROC analysis, ROC Analysis in Pattern Recognition, 27, 861, 10.1016/j.patrec.2005.10.010