Intestinal IFN-γ–producing type 1 regulatory T cells coexpress CCR5 and programmed cell death protein 1 and downregulate IL-10 in the inflamed guts of patients with inflammatory bowel disease

Journal of Allergy and Clinical Immunology - Tập 142 - Trang 1537-1547.e8 - 2018
Johanna Sophie Alfen1, Paola Larghi1,2, Federica Facciotti1, Nicola Gagliani3,4, Roberto Bosotti1, Moira Paroni1, Stefano Maglie1, Paola Gruarin1, Chiara Maria Vasco1, Valeria Ranzani1, Cristina Frusteri5, Andrea Iseppon4, Monica Moro1, Maria Cristina Crosti1, Stefano Gatti6, Massimiliano Pagani1,7, Flavio Caprioli2,5, Sergio Abrignani1,8, Richard A. Flavell4,9, Jens Geginat1
1INGM–National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi” Milan, Milan, Italy
2Department of Pathophysiology and Transplantation (DEPT), University of Milan, Milan, Italy
3Department of Medicine & Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg–Eppendorf, Hamburg, Germany
4Department of Immunobiology, School of Medicine, Yale University, New Haven, Conn
5Unità Operativa di Gastroenterologia ed Endoscopia, Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
6Centro Ricerche Precliniche, Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
7Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
8Department of Clinical Science and Community Health (DISCCO), University of Milan, Milan, Italy
9Howard Hughes Medical Institute, School of Medicine, Yale University, New Haven, Conn

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