Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation
Tóm tắt
Chitosan cross-linked pentasodium tripolyphosphate particles were produced by ionotropic gelation. The aim of this study was to evaluate the influence of the molar mass and deacetylation degree of chitosan and of the concentration of pentasodium tripolyphosphate in the production of chitosan micro/nanoparticles. The obtained charge ratio (R±), mean particle size, surface electrical charge, polydispersity index, and tendency of particle aggregation were selected as dependent variables. Results demonstrated that stable particles exhibited a high zeta potential value, between +62 and +68 mV. Particles were produced in different size ranges controlling the R± between the positively charged chitosan and negatively charged pentasodium tripolyphosphate. Chitosan micro/nanoparticles were successfully prepared via the ionic gelation method controlling R±, therefore the association of an active ingredient to a micro/nanoparticle allows the molecule to intimately interact with specific structures, to overcome barriers and to prolong its residence time in the target. Chitosan cross-linked pentasodium tripolyphosphate particles are expected to be a good approach for active ingredients formulation in the agrofood sector and related industries.
Tài liệu tham khảo
Akbuga, J., and G. Durmaz. 1994. Preparation and evaluation of cross-linked chitosan microspheres containing furosemide. International Journal of Pharmaceutics 111: 217–222.
Bhumkar, D.R., and V.B. Pokharkar. 2006. Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note. AAPS PharmSciTech 7: E50.
Bokharaei, M., A. Margaritis, A. Xenocostas, and D.J. Freeman. 2011. Erythropoietin encapsulation in chitosan nanoparticles and kinetics of drug release. Current Drug Delivery 8: 164–171.
Csaba, N., M. Koping-Hoggard, and M.J. Alonso. 2009. Ionically crosslinked chitosan/tripolyphosphate nanoparticles for oligonucleotide and plasmid DNA delivery. International Journal of Pharmaceutics 382: 205–214.
da Silva, C.F., P. Severino, F. Martins, and M.H.A. Santana. 2011. Didanosine-loaded chitosan microespheres: Optimization of fabrication process. Latin America Journal of Pharmacy 30: 1037–1040.
Elzatahry, A.A., M.S.M. Eldin, E.A. Soliman, and E.A. Hassan. 2009. Evaluation of alginate–chitosan bioadhesive beads as a drug delivery system for the controlled release of theophylline. Journal of Applied Polymer Science 111: 2452–2459.
Gan, Q., T. Wang, C. Cochrane, and P. McCarron. 2005. Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery. Colloids and Surfaces B 44: 65–73.
Grant, J., J. Cho, and C. Allen. 2007. Self-assembly and physicochemical and rheological properties of a polysaccharide-surfactant system formed from the cationic biopolymer chitosan and nonionic sorbitan esters (vol 22, pg 4327, 2006). Langmuir 23: 4688.
Hu, B., C. Pan, Y. Sun, Z. Hou, H. Ye, and X. Zeng. 2008. Optimization of fabrication parameters to produce chitosan-tripolyphosphate nanoparticles for delivery of tea catechins. Journal of Agriculture and Food Chemistry 56: 7451–7458.
Hudson, D., and A. Margaritis. 2014. Biopolymer nanoparticle production for controlled release of biopharmaceuticals. Critical Reviews in Biotechnology 34: 161–179.
Inta, O., R. Yoksan, and J. Limtrakul. 2014. Hydrophobically modified chitosan: A bio-based material for antimicrobial active film. Materials Science and Engineering C 42: 569–577.
Kaloti, M., and H.B. Bohidar. 2010. Kinetics of coacervation transition versus nanoparticle formation in chitosan-sodium tripolyphosphate solutions. Colloids and Surfaces B 81: 165–173.
Khan, N., D.J. Bharali, V.M. Adhami, I.A. Siddiqui, H. Cui, S.M. Shabana, S.A. Mousa, and H. Mukhtar. 2014. Oral administration of naturally occurring chitosan-based nanoformulated green tea polyphenol EGCG effectively inhibits prostate cancer cell growth in a xenograft model. Carcinogenesis 35: 415–423.
Kumar, K., N. Dhawan, H. Sharma, S. Vaidya, and B. Vaidya. 2014. Bioadhesive polymers: Novel tool for drug delivery. Artificial Cells, Nanomedicine, and Biotechnology 42: 274–283.
Li, F.Q., R.R. Ji, X. Chen, B.M. You, Y.H. Pan, and J.C. Su. 2010. Cetirizine dihydrochloride loaded microparticles design using ionotropic cross-linked chitosan nanoparticles by spray-drying method. Archives of Pharmacal Research 33: 1967–1973.
Luo, Y., and Q. Wang. 2014. Recent development of chitosan-based polyelectrolyte complexes with natural polysaccharides for drug delivery. International Journal of Biological Macromolecules 64: 353–367.
Nagda, C., N. Chotai, S. Patel, D. Nagda, U. Patel, and T. Soni. 2010. Chitosan microspheres of aceclofenac: In vitro and in vivo evaluation. Pharmaceutical Development and Technology 15: 442–451.
Nagpal, K., S.K. Singh, and D.N. Mishra. 2010. Chitosan nanoparticles: A promising system in novel drug delivery. Chemical and Pharmaceutical Bulletin 58: 1423–1430.
Nazar, H., D.G. Fatouros, S.M. van der Merwe, N. Bouropoulos, G. Avgouropoulos, J. Tsibouklis, and M. Roldo. 2011. Thermosensitive hydrogels for nasal drug delivery: The formulation and characterisation of systems based on N-trimethyl chitosan chloride. European Journal of Pharmaceutics and Biopharmaceutics 77: 225–232.
Oyarzun-Ampuero, F.A., J. Brea, M.I. Loza, D. Torres, and M.J. Alonso. 2009. Chitosan-hyaluronic acid nanoparticles loaded with heparin for the treatment of asthma. International Journal of Pharmaceutics 381: 122–129.
Patil, S.B., and K.K. Sawant. 2011. Chitosan microspheres as a delivery system for nasal insufflation. Colloids and Surfaces B 84: 384–389.
Radler, J.O., I. Koltover, A. Jamieson, T. Salditt, and C.R. Safinya. 1998. Structure and interfacial aspects of self-assembled cationic lipid-DNA gene carrier complexes. Langmuir 14: 4272–4283.
Rampino, A., M. Borgogna, P. Blasi, B. Bellich, and A. Cesaro. 2013. Chitosan nanoparticles: Preparation, size evolution and stability. International Journal of Pharmaceutics 455: 219–228.
Saremi, S., F. Atyabi, S.P. Akhlaghi, S.N. Ostad, and R. Dinarvand. 2011. Thiolated chitosan nanoparticles for enhancing oral absorption of docetaxel: Preparation, in vitro and ex vivo evaluation. International Journal of Nanomedicine 6: 119–128.
Shu, X.Z., and K.J. Zhu. 2002. The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release. European Journal of Pharmaceutics and Biopharmaceutics 54: 235–243.
Souto, E.B., P. Severino, R. Basso, and M.H. Santana. 2013. Encapsulation of antioxidants in gastrointestinal-resistant nanoparticulate carriers. Methods in Molecular Biology 1028: 37–46.
Sun, P., P. Li, Y.M. Li, Q. Wei, and L.H. Tian. 2011. A pH-sensitive chitosan-tripolyphosphate hydrogel beads for controlled glipizide delivery. Journal of Biomedical Materials Research. Part B: Applied Biomaterials 97: 175–183.
Sun, Y., L. Gu, Y. Gao, and F. Gao. 2010. Preparation and characterization of 5-Fluorouracil loaded chitosan microspheres by a two-step solidification method. Chemical and Pharmaceutical Bulletin 58: 891–895.
Watts, P., L. Barrow, K.P. Steed, C.G. Wilson, R.C. Spiller, C.D. Melia, and M.C. Davies. 1992. The transit rate of different-sized model dosage forms through the human colon and the effects of a lactulose-induced catharsis. International Journal of Pharmaceutics 87: 215–221.