Pharmacologic Treatment of Pediatric Insomnia

Judith A. Owens1, Sricharan Moturi2
1Department of Pediatrics, Alpert Medical School at Brown University, Ambulatory Pediatrics Potter 200, 593 Eddy Street, Providence, RI 02903, USA
2Department of Child & Adolescent Psychiatry, Children's Memorial Hospital, Northwestern University, 2300 Children's Plaza, #10, Chicago, IL 60614, USA

Tài liệu tham khảo

2005 Sadeh, 2000, Sleep patterns and sleep disruptions in school-age children, Dev Psychol, 36, 291, 10.1037/0012-1649.36.3.291 Johnson, 2006, Epidemiology of DSM-IV insomnia in adolescence: lifetime prevalence, chronicity, and an emergent gender difference, Pediatrics, 117, e247, 10.1542/peds.2004-2629 Quine, 2001, Sleep problems in primary school children: comparison between mainstream and special school children, Child Care Health Dev, 27, 201, 10.1046/j.1365-2214.2001.00213.x Stores, 2001, Sleep-wake function in children with neurodevelopmental and psychiatric disorders, Semin Pediatr Neurol, 8, 188, 10.1053/spen.2001.29042 Roberts, 2008, Chronic insomnia and its negative consequences for health and functioning of adolescents: a 12-month prospective study, J Adolesc Health, 42, 294, 10.1016/j.jadohealth.2007.09.016 Cortese, 2006, Sleep and alertness in children with attention-deficit/hyperactivity disorder: a systematic review of literature, Sleep, 29, 504 Cortese, 2005, Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature, Sleep, 28, 1007, 10.1093/sleep/28.8.1007 Wiggs, 2001, Behavioural treatment for sleep problems in children with severe intellectual disabilities and daytime challenging behaviour: effect on mothers and fathers, Br J Health Psychol, 6, 257, 10.1348/135910701169197 Mindell, 2006, Behavioral treatment of bedtime problems and night wakings in infants and young children, Sleep, 29, 1263 Mindell, 2006, Pharmacologic management of insomnia in children and adolescents: consensus statement, Pediatrics, 117, e1223, 10.1542/peds.2005-1693 Owens, 2005, The use of pharmacotherapy in the treatment of pediatric insomnia in primary care: rational approaches. A consensus meeting summary, J Clin Sleep Med, 1, 49, 10.5664/jcsm.26297 Zito, 2003, Psychotropic practice patterns for youth: a 10-year perspective, Arch Pediatr Adolesc Med, 157, 17, 10.1001/archpedi.157.1.17 Owens, 2003, Medication use in the treatment of pediatric insomnia: results of a survey of community-based pediatricians, Pediatrics, 111, e628, 10.1542/peds.111.5.e628 Meltzer, 2007, Use of sleep medications in hospitalized pediatric patients, Pediatrics, 119, 1047, 10.1542/peds.2006-2773 Stojanovski, 2007, Trends in medication prescribing for pediatric sleep difficulties in US outpatient settings, Sleep, 30, 1013, 10.1093/sleep/30.8.1013 Owens, 2005, Use of the ‘BEARS’ sleep screening tool in a pediatric residents' continuity clinic: a pilot study, Sleep Med, 6, 63, 10.1016/j.sleep.2004.07.015 Mindell, 1999, Empirically supported treatments in pediatric psychology: bedtime refusal and night wakings in young children, J Pediatr Psychol, 24, 465, 10.1093/jpepsy/24.6.465 Kuhn, 2003, Treatment efficacy in behavioral pediatric sleep medicine, J Psychosom Res, 54, 587, 10.1016/S0022-3999(03)00061-8 Pelayo, 2008, Pediatric sleep pharmacology, Semin Pediatr Neurol, 15, 79, 10.1016/j.spen.2008.03.004 Sadeh, 1998, Sleep and pulmonary function in children with well-controlled, stable asthma, Sleep, 21, 379, 10.1093/sleep/21.4.379 Dahl, 1995, Sleep disturbances in children with atopic dermatitis, Arch Pediatr Adolesc Med, 149, 856, 10.1001/archpedi.1995.02170210030005 Amin, 2005, The relationship between sleep disturbance and pulmonary function in stable pediatric cystic fibrosis patients, Chest, 128, 1357, 10.1378/chest.128.3.1357 Lewin, 1999, Importance of sleep in the management of pediatric pain, J Dev Behav Pediatr, 20, 244, 10.1097/00004703-199908000-00007 Bloom, 2002, Sleep and its relationship to pain, dysfunction, and disease activity in juvenile rheumatoid arthritis, J Rheumatol, 29, 169 Hysing, 2009, Sleep in children with chronic illness, and the relation to emotional and behavioral problems: a population-based study, J Pediatr Psychol, 34, 665, 10.1093/jpepsy/jsn095 Ivanenko, 2006, Sleep complaints and psychiatric symptoms in children evaluated at a pediatric mental health clinic, J Clin Sleep Med, 2, 42, 10.5664/jcsm.26434 Kallepalli, 1997, Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders, J Child Adolesc Psychopharmacol, 7, 97, 10.1089/cap.1997.7.97 Richdale, 1999, Sleep problems in autism: prevalence, cause, and intervention, Dev Med Child Neurol, 41, 60, 10.1017/S0012162299000122 Schnoes, 2006, Pediatric prescribing practices for clonidine and other pharmacologic agents for children with sleep disturbance, Clin Pediatr (Phila), 45, 229, 10.1177/000992280604500304 Prince, 1996, Clonidine for sleep disturbances associated with attention-deficit hyperactivity disorder: a systematic chart review of 62 cases, J Am Acad Child Adolesc Psychiatry, 35, 599, 10.1097/00004583-199605000-00014 Palumbo, 2008, Clonidine for attention-deficit/hyperactivity disorder. I. Efficacy and tolerability outcomes, J Am Acad Child Adolesc Psychiatry, 47, 180, 10.1097/chi.0b013e31815d9af7 Daviss, 2008, Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis, J Am Acad Child Adolesc Psychiatry, 47, 189, 10.1097/chi.0b013e31815d9ae4 Ingrassia, 2005, The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders: a case series, Eur Child Adolesc Psychiatry, 14, 34, 10.1007/s00787-005-0424-4 Arnsten, 2007, Alpha2-adrenergic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: emerging concepts from new data, J Child Adolesc Psychopharmacol, 17, 393, 10.1089/cap.2006.0098 Szot, 2004, The anticonvulsant and proconvulsant effects of alpha2-adrenoreceptor agonists are mediated by distinct populations of alpha2A-adrenoreceptors, Neuroscience, 126, 795, 10.1016/j.neuroscience.2004.04.030 Biederman, 2008, A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder, Pediatrics, 121, e73, 10.1542/peds.2006-3695 Pandi-Perumal, 2007, Role of the melatonin system in the control of sleep: therapeutic implications, CNS Drugs, 21, 995, 10.2165/00023210-200721120-00004 Zhdanova, 1995, Sleep-inducing effects of low doses of melatonin ingested in the evening, Clin Pharmacol Ther, 57, 552, 10.1016/0009-9236(95)90040-3 Cavallo, 1996, Pharmacokinetics of melatonin in human sexual maturation, J Clin Endocrinol Metab, 81, 1882, 10.1210/jc.81.5.1882 O'Callaghan, 1999, Use of melatonin to treat sleep disorders in tuberous sclerosis, Dev Med Child Neurol, 41, 123, 10.1017/S0012162299000237 De Leersnyder, 2003, Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome, J Med Genet, 40, 74, 10.1136/jmg.40.1.74 McArthur, 1998, Sleep dysfunction in Rett syndrome: a trial of exogenous melatonin treatment, Dev Med Child Neurol, 40, 186, 10.1111/j.1469-8749.1998.tb15445.x Braam, 2008, Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial, J Child Neurol, 23, 649, 10.1177/0883073808314153 Sack, 2000, Entrainment of free-running circadian rhythms by melatonin in blind people, N Engl J Med, 343, 1070, 10.1056/NEJM200010123431503 Ivanenko, 2003, Melatonin in children and adolescents with insomnia: a retrospective study, Clin Pediatr (Phila), 42, 51, 10.1177/000992280304200108 Van der Heijden, 2007, Effect of melatonin on sleep, behavior, and cognition in ADHD and chronic sleep-onset insomnia, J Am Acad Child Adolesc Psychiatry, 46, 233, 10.1097/01.chi.0000246055.76167.0d Weiss, 2006, Sleep hygiene and melatonin treatment for children and adolescents with ADHD and initial insomnia, J Am Acad Child Adolesc Psychiatry, 45, 512, 10.1097/01 chi.0000205706.78818.ef Giannotti, 2006, An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism, J Autism Dev Disord, 36, 741, 10.1007/s10803-006-0116-z Andersen, 2008, Melatonin for insomnia in children with autism spectrum disorders, J Child Neurol, 23, 482, 10.1177/0883073807309783 Paavonen, 2003, Effectiveness of melatonin in the treatment of sleep disturbances in children with Asperger disorder, J Child Adolesc Psychopharmacol, 13, 83, 10.1089/104454603321666225 Buscemi, 2006, Efficacy and safety of exogenous melatonin for secondary sleep disorders and sleep disorders accompanying sleep restriction: meta-analysis, BMJ, 332, 385, 10.1136/bmj.38731.532766.F6 Sajith, 2007, Melatonin and sleep disorders associated with intellectual disability: a clinical review, J Intellect Disabil Res, 51, 2, 10.1111/j.1365-2788.2006.00893.x Luboshitzky, 1995, Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty, J Clin Endocrinol Metab, 80, 2144, 10.1210/jc.80.7.2144 Sheldon, 1998, Pro-convulsant effects of oral melatonin in neurologically disabled children, Lancet, 351, 1254, 10.1016/S0140-6736(05)79321-1 Jan, 1994, The treatment of sleep disorders with melatonin, Dev Med Child Neurol, 36, 97, 10.1111/j.1469-8749.1994.tb11818.x Sutherland, 2002, Immunomodulatory effects of melatonin in asthma, Am J Respir Crit Care Med, 166, 1055, 10.1164/rccm.200204-356OC Szeinberg, 2006, Melatonin treatment in adolescents with delayed sleep phase syndrome, Clin Pediatr (Phila), 45, 809, 10.1177/0009922806294218 Stigler, 2006, Ramelteon for insomnia in two youths with autistic disorder, J Child Adolesc Psychopharmacol, 16, 631, 10.1089/cap.2006.16.631 Merenstein, 2006, The trial of infant response to diphenhydramine: the TIRED study–a randomized, controlled, patient-oriented trial, Arch Pediatr Adolesc Med, 160, 707, 10.1001/archpedi.160.7.707 Richardson, 2002, Tolerance to daytime sedative effects of H1 antihistamines, J Clin Psychopharmacol, 22, 511, 10.1097/00004714-200210000-00012 Bender, 2001, Children's school performance is not impaired by short-term administration of diphenhydramine or loratadine, J Pediatr, 138, 656, 10.1067/mpd.2001.112647 Baker, 2003, Fatal diphenhydramine intoxication in infants, J Forensic Sci, 48, 425, 10.1520/JFS2002121 Pershad, 1999, Chloral hydrate: the good and the bad, Pediatr Emerg Care, 15, 432, 10.1097/00006565-199912000-00018 Möhler, 2002, A new benzodiazepine pharmacology, J Pharmacol Exp Ther, 300, 2, 10.1124/jpet.300.1.2 Zammit, 2006, Sleep and residual sedation after administration of zaleplon, zolpidem, and placebo during experimental middle-of-the-night awakening, J Clin Sleep Med, 2, 417, 10.5664/jcsm.26657 Walsh, 2007, Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations, Sleep, 30, 959, 10.1093/sleep/30.8.959 Liskow, 2004, Zaleplon overdose associated with sleepwalking and complex behavior, J Am Acad Child Adolesc Psychiatry, 43, 927, 10.1097/01.chi.0000129219.66563.aa Sein Anand, 2007, Przegl Lek, 64, 310 Kurta, 1997, Zolpidem (Ambien): a pediatric case series, J Toxicol Clin Toxicol, 35, 453, 10.3109/15563659709001227 Hajak, 2001, Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study, J Clin Psychiatry, 62, 453, 10.4088/JCP.v62n0609 Riemann, 2002, Trimipramine in primary insomnia: results of a polysomnographic double-blind controlled study, Pharmacopsychiatry, 35, 165, 10.1055/s-2002-34119 Walsh, 1998, Subjective hypnotic efficacy of trazodone and zolpidem in DSMIII-R primary insomnia, Hum Psychopharmacol, 13, 191, 10.1002/(SICI)1099-1077(199804)13:3<191::AID-HUP972>3.0.CO;2-X Wiegand, 2004, Nefazodone in primary insomnia: an open pilot study, Prog Neuropsychopharmacol Biol Psychiatry, 28, 1071, 10.1016/j.pnpbp.2004.05.042 Nowell, 1999, Paroxetine in the treatment of primary insomnia: preliminary clinical and electroencephalogram sleep data, J Clin Psychiatry, 60, 89, 10.4088/JCP.v60n0204 Sharpley, 2003, Risperidone augmentation decreases rapid eye movement sleep and decreases wake in treatment-resistant depressed patients, J Clin Psychiatry, 64, 192, 10.4088/JCP.v64n0212 Keshavan, 2007, Sleep quality and architecture in quetiapine, risperidone, or never-treated schizophrenia patients, J Clin Psychopharmacol, 27, 703, 10.1097/jcp.0b013e31815a884d Bourgeois, 1996, The relationship between sleep and epilepsy in children, Semin Pediatr Neurol, 3, 29, 10.1016/S1071-9091(96)80026-X Kotagal, 2007, Sleep in children at risk, Sleep Med Clin, 2, 477, 10.1016/j.jsmc.2007.05.007 Capone, 2008, Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: a naturalistic study, J Dev Behav Pediatr, 29, 106, 10.1097/DBP.0b013e318165c100 Ziegler, 2002, Efficacy and tolerability of valerian extract LI 156 compared with oxazepam in the treatment of non-organic insomnia: a randomized, double-blind, comparative clinical study, Eur J Med Res, 7, 480 Meolie, 2005, Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence, J Clin Sleep Med, 1, 173, 10.5664/jcsm.26314 Gardiner, 2002, Insomnia: herbal and dietary alternatives to counting sheep, Contemp Pediatr, 19, 69