The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

Cell Metabolism - Tập 23 - Trang 610-621 - 2016
Baokun He1, Kazunari Nohara1, Noheon Park2, Yong-Sung Park1, Bobby Guillory3, Zhaoyang Zhao1, Jose M. Garcia3, Nobuya Koike4, Cheng Chi Lee1, Joseph S. Takahashi2,5, Seung-Hee Yoo1, Zheng Chen1
1Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA
2Department of Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
3Division of Endocrinology, Diabetes and Metabolism, MCL, Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey Veterans Affairs Medical Center, and Department of Medicine, and Molecular and Cell Biology, Dan L. Duncan Cancer Center, Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
4Department of Physiology and Systems Bioscience, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
5Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas TX 75390, USA

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