Cardiac involvement in small and medium-sized vessel vasculitides

Lupus - Tập 14 Số 9 - Trang 718-722 - 2005
Christian Lavigne1, Loı̈c Guillevin1
1Department of Internal Medicine, Hôpital Cochin, Université Paris, Paris, France,

Tóm tắt

The heart can be involved in vasculitides but the frequency of its involvement and the manifestations vary according to the vasculitis. Cardiovascular manifestations include cardiomyopathy (specific or resulting from myocardial infarctions), coronary arteritis (with risk of aneurysms, stenoses and thrombosis formation or rupture), pericarditis, valvulitis, conduction-tissue involvement (with heart blocks), arrhythmias (mainly supraventricular) and/or dissection of the aorta (and/or its proximal branches). As many of these manifestations are clinically silent, at least during their early stages, heart function should be systematically assessed in vasculitis patients, with at least ECG and echocardiography, and more invasive exploratory procedures when the former reveal abnormalities or symptoms become manifest. Specific cardiomyopathy has been identified as a factor of poor outcome in small and medium-sized vessel vasculitides (five-factor score). Therefore, in addition to symptomatic treatments, prescription of corticosteroids and immunosuppressants (mainly cyclophosphamide) is considered mandatory. This regimen has dramatically improved the overall prognosis of affected patients.

Từ khóa


Tài liệu tham khảo

10.1002/art.1780370206

Chumbley LC, 1977, Mayo Clin Proc, 52, 477

10.1161/01.CIR.25.4.610

10.1016/0049-0172(80)90005-0

10.1136/pgmj.61.714.341

10.1016/0002-9343(67)90144-1

10.1016/0002-8703(85)90365-5

10.1002/1529-0131(199809)41:9<1538::AID-ART3>3.0.CO;2-M

10.1016/0002-8703(90)90227-O

10.1378/chest.88.5.745

Blétry O, 1980, Arch Mal Coeur Vaiss, 73, 1027

Marette P, 1989, Ann Cardiol Angéiol (Paris), 38, 305

Kussmaul A, 1866, Dtsch Arch Klin Med, 1, 484

10.1136/bmj.2.5091.265

10.1136/hrt.73.2.110

10.1007/s002960000059

Churg J, 1951, Am J Pathol, 27, 277

10.1007/BF01747501

10.1136/hrt.77.6.576

10.1136/hrt.62.6.462

10.1136/hrt.70.6.553

10.1002/1529-0131(199904)42:3<421::AID-ANR5>3.0.CO;2-6

Ferri C, 1991, Clin Exp Rheumatol, 9, 621

10.1093/rheumatology/41.3.290

Smedema JP, 2004, Clin Exp Rheumatol, 22, S75

10.1097/00005792-199601000-00003

10.1002/art.10922

10.1080/17402520400001744

10.1016/j.berh.2004.11.004

10.1056/NEJMoa041884

Thông tin
Thông tin xuất bản

Lupus

Tập 14 Số 9

718-722

Thông tin tác giả