Intranasal delivery of formulations containing virucidal lipids for treatment of respiratory syncytial virus (RSV) infection in rats

Journal of Drug Delivery Science and Technology - Tập 23 - Trang 455-457 - 2013
H. Hilmarsson1, T. Kristmundsdóttir2, E. Gunnarsson3, H. Thormar1
1Faculty of Life and Environmental Sciences, University of Iceland, Askja, Sturlugata 7, 101 Reykjavik, Iceland
2Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland
3Institute for Experimental Pathology at Keldur, University of Iceland, Reykjavik, Iceland

Tài liệu tham khảo

Simoes, 2002, Immunoprophylaxis of respiratory syncytial virus: global experience, Respir. Res., 3, S26, 10.1186/rr187 Wyde, 2003, Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection, Antiviral Res., 60, 221, 10.1016/j.antiviral.2003.07.002 Bergsson, 2011, Antibacterial, antiviral and antifungal activities of lipids, 47 Hilmarsson, 2007, Virucidal activities of medium- and long-chain fatty alcohols, fatty acids and monoglycerides against respiratory syncytial virus and parainfluenza virus type 2: comparison at different pH levels, Arch. Virol., 152, 2225, 10.1007/s00705-007-1063-5 Hilmarsson, 2008, Microbicidal activity of lipids, their effect on mucosal infections in animals and their potential as disinfecting agents Thormar, 1999, Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro, Sex. Transm. Infect., 75, 181, 10.1136/sti.75.3.181 Neyts, 2000, Hydrogels containing monocaprin prevent intravaginal and intracutaneous infections with HSV-2 in mice: impact on the search for vaginal microbicides, Med. Virol., 61, 107, 10.1002/(SICI)1096-9071(200005)61:1<107::AID-JMV17>3.0.CO;2-W Reed, 1938, A simple method of estimating 50 per cent end points, Am. J. Hyg., 27, 493 Thormar, 2007, The role of microbicidal lipids in host defense against pathogens and their potential as therapeutic agents, Chem. Phys. Lip., 150, 1, 10.1016/j.chemphyslip.2007.06.220 Thormar, 2011, Antimicrobial lipids and innate immunity, 123 Conrood, 1983, Détection and partial characterization of antibacterial factor(s) in alveolar lining material of rats, J. Clin. Invest., 71, 129, 10.1172/JCI110741 Conrood, 1984, Characterization of the extracellular bactericidal factors of rat alveolar lining material, J. Clin. Invest., 74, 1269, 10.1172/JCI111537 Hall, 1981, Infectivity of respiratory syncytial virus by various routes of inoculation, Infect. Immun, 33, 779, 10.1128/IAI.33.3.779-783.1981