Tumor associated macrophages and angiogenesis dual-recognizable nanoparticles for enhanced cancer chemotherapy

Chen, 2016, Tumor-triggered drug release with tumor-targeted accumulation and elevated drug retention to overcome multidrug resistance, Chem Mater, 28, 6742, 10.1021/acs.chemmater.6b03236 Chen, 2015, MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery, Chem Commun, 51, 465, 10.1039/C4CC07563C Chen, 2016, Programmed nanococktail for intracellular cascade reaction regulating self-synergistic tumor targeting therapy, Small, 12, 733, 10.1002/smll.201503280 Joyce, 2005, Therapeutic targeting of the tumor microenvironment, Cancer Cell, 7, 513, 10.1016/j.ccr.2005.05.024 Lin, 2013, Selective ablation of tumor-associated macrophages suppresses metastasis and angiogenesis, Cancer Sci, 104, 1217, 10.1111/cas.12202 Zamarron, 2011, Dual roles of immune cells and their factors in cancer development and progression, Int J Biol Sci, 7, 651, 10.7150/ijbs.7.651 Franklin, 2014, The cellular and molecular origin of tumor-associated macrophages, Science, 344, 921, 10.1126/science.1252510 Mukhtar, 2011, Tumor-associated macrophages in breast cancer as potential biomarkers for new treatments and diagnostics, Expert Rev Mol Diagn, 11, 91, 10.1586/erm.10.97 Jinushi, 2011, Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells, Proc Natl Acad Sci U S A, 108, 12425, 10.1073/pnas.1106645108 Mantovani, 2015, The interaction of anticancer therapies with tumor-associated macrophages, J Exp Med, 212, 435, 10.1084/jem.20150295 Nakasone, 2012, Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance, Cancer Cell, 21, 488, 10.1016/j.ccr.2012.02.017 Carmeliet, 2003, Angiogenesis in health and disease, Nat Med, 9, 653, 10.1038/nm0603-653 Shweiki, 1992, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis, Nature, 359, 843, 10.1038/359843a0 Fukumura, 1998, Tumor induction of VEGF promoter activity in stromal cells, Cell, 94, 715, 10.1016/S0092-8674(00)81731-6 Shojaei, 2012, Anti-angiogenesis therapy in cancer: current challenges and future perspectives, Cancer Lett, 320, 130, 10.1016/j.canlet.2012.03.008 Bai, 2013, Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer, Biomaterials, 34, 6163, 10.1016/j.biomaterials.2013.04.062 Ebos, 2009, Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis, Cancer Cell, 15, 232, 10.1016/j.ccr.2009.01.021 Yan, 2014, Development of Y-shaped peptide for constructing nanoparticle systems targeting tumor-associated macrophages in vitro and in vivo, Mater Res Express, 1, 10.1088/2053-1591/1/2/025007 Liu, 2003, Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy, Cancer Res, 63, 2957 Li, 2013, Effects of legumain as a potential prognostic factor on gastric cancers, Med Oncol, 30, 621, 10.1007/s12032-013-0621-9 Reisfeld, 2013, The tumor microenvironment: a target for combination therapy of breast cancer, Crit Rev Oncog, 18, 115, 10.1615/CritRevOncog.v18.i1-2.70 Miller, 2011, Asparagine endopeptidase is required for normal kidney physiology and homeostasis, FASEB J, 25, 1606, 10.1096/fj.10-172312 Hatakeyama, 2011, Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide, Proc Natl Acad Sci U S A, 108, 19587, 10.1073/pnas.1105057108 Oh, 2004, Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy, Nature, 429, 629, 10.1038/nature02580 Gerke, 2005, Annexins: linking Ca2þ signalling to membrane dynamics, Nat Rev Mol Cell Biol, 6, 449, 10.1038/nrm1661 Rescher, 2004, Annexins-unique membrane binding proteins with diverse functions, J Cell Sci, 117, 2631, 10.1242/jcs.01245 Perretti, 1996, Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration, Nat Med, 2, 1259, 10.1038/nm1196-1259 Matsuo, 2011, A new phage-display tumor-homing peptide fused to antiangiogenic peptide generates a novel bioactive molecule with antimelanoma activity, Mol Cancer Res, 9, 1471, 10.1158/1541-7786.MCR-10-0501 Gao, 2014, Angiopep-2 and activatable cell-penetrating peptide dual-functionalized nanoparticles for systemic glioma-targeting delivery, Mol Pharm, 11, 2755, 10.1021/mp500113p Ernsting, 2013, Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles, J Control Release, 172, 782, 10.1016/j.jconrel.2013.09.013