Acute lupus myocarditis: Clinical features and outcome

Lupus - Tập 20 Số 9 - Trang 981-988 - 2011
Simone Appenzeller1,2, CA Pineau3, AE Clarke1
1Divisions of Clinical Immunology/Allergy and Clinical Epidemiology, McGill University Health Centre, Canada
2Faculty of Medical Science-State University of Campinas (UNICAMP)
3Division of Rheumatology, McGill University Health Centre, Canada

Tóm tắt

Background: Cardiomyopathy in systemic lupus erythematosus (SLE) may be secondary to myocardial inflammation (i.e. myocarditis) or to systemic complications such as hypertension. Symptomatic left ventricular dysfunction is the most common clinical presentation of cardiomyopathy and is potentially life threatening. Identifying the cause is critical as it dictates therapy. Methods: We present three cases of left ventricular failure suggestive of myocarditis in SLE patients followed in the Lupus Clinic of the Montreal General Hospital over a 5-year period. Results: The most frequent presentation is acute onset of a marked reduction of the left ventricular ejection fraction (LVEF). All patients were treated with cardiac support, prednisone, and additional immunosuppressive medications. Improvement of symptoms and LVEF was observed in two of three patients. Conclusion: Myocarditis is a rare, but life-threatening, manifestation of SLE. With immunosuppressive medications and cardiovascular support, the long-term outcome is usually favorable.

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Lupus

Tập 20 Số 9

981-988

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