Haematological changes associated with intranasal and parenteral routes of vaccination against Peste des petits ruminants in West African dwarf goats
Tóm tắt
The haematological indices of West African dwarf goats vaccinated against Peste des petits ruminants virus via the parenteral and the mucosal (intranasal) routes were studied and compared with an unvaccinated control. The post vaccination packed cell volume (PCV) and haemoglobin (Hb) concentrations of the vaccinated groups did not show any statistically significant difference (p > 0.05) from the unvaccinated control. However, a statistically significant difference was observed in the total white blood cell (WBC) counts between the vaccinated groups and the unvaccinated control, as well as between those vaccinated via the mucosal route and those vaccinated via the parenteral routes, though all within the normal reference values for West African dwarf goats. Differential WBC counts showed the significant difference to be due to increase in lymphocyte population, suggesting that PPR vaccine administered via the different routes was able to stimulate a cellular immune response which is mostly lymphoproliferative. Thus, it can be suggested that intranasal vaccination against Peste des petits ruminants as well as vaccination via the conventional route is safe.
Tài liệu tham khảo
Aikhuomobhogbe PU, Orheruata AM (2006) Haematological and blood biochemical indices of West African dwarf goats vaccinated against Peste des petits ruminants (PPR). Afr J Biotechnol Vol 5(9):743–748
Ajala OO, Daneji AL, Kumshe HA, Oyeyemi MO (1997) Treatment of Peste des petits ruminants (PPR) in pre-weaned West African Dwarf Goat Kids. Trop Vet 1(15):39–42
Banyard AC, Parida S, Batten C, Oura C, Kwiatek O & Libeau G (2010) Global distribution of Peste des petits ruminants virus and prospects for improved diagnosis and control. JGV Papers in Press. Published September 15, 2010.
Daramola JO, Adeloye AA, Fatoba TA, Soladoye AO (2005) Haematological and biochemical parameters of West African Dwarf goats. Livest Res Rural Dev 17(8)
Diallo A (2006) Control of Peste des petits ruminants and poverty alleviation. J Veteinary Med B 53:11–13
Effendy AW, Zamri-Saad M, Puspa R and Rosiah S (1998) Efficacy of intranasal administration of formalin-killed Pasteurella haemolytica A2 against intratracheal challenge in goats. Vet Rec.18;142(16):428–31.
Emikpe BO, Ezeasor CK, Sabri MY, Anosa VO (2013) Clinicopathological evaluation of intranasal, subcutaneous and intramuscular routes of vaccination against intratracheal challenge of Peste des petits ruminants virus in goats. Small Rumin Res. doi:10.1016/j.smallrumres.2013.03.007
Emikpe BO, Sabri MY, Akpavie SO, Zamri-Saad M (2010) Experimental infection of Peste des petits ruminant virus and Mannheimia haemolytica A2 in goats: Immunolocalization of Mannheimia haemolytica antigens. Vet Res Commun. doi:10.1007/s 11259-010-9425-y
Ezeasor CK, Emikpe BO, Sabri MY, Afusat J, Anosa VO (2013) Cellular responses in the respiratory tract following intranasal administration of Peste des petits ruminant vaccine in goats. Int J Morphol 31(2):687–692
Intizar M, Ahmad MD, Anjum AA, Hanif A (2009) Comparative efficacy of Peste des petits ruminants vaccines available in Pakistan in sheep and goats. Pakistan Vet J 29(4):202–205
Nanda YP, Chatterjee A, Purohit AK et al (1996) The isolation of Peste des petits ruminants virus from Northern India. Vet Microbiol 51:207–216
Rashid A, Hussain A, Asim M (2010) Evaluation of Peste des petits ruminants cell culture vaccine in sheep and goats in Pakistan. Vet Ital 46(3):315–318
Sabri MY, Shahrom-Salisi M, Emikpe BO (2013) Comparison prior and post vaccination of inactivated recombinant vaccine against Mannheimiosis in Boer Goats Farm in Sabah. J Vaccines Vaccin 4:173. doi:10.4172/2157- 7560.1000173
Schalm OW, Jain NC, Carol EJ (1975) Veterinary Haematology 3rd Ed. Lea and Febiger, Philadelphia, p 807
Shaila MS, Shamaki D, Forsyth MA, Diallo A, Goatley L, Kitching RP, Barrett T (1996) Geographic distribution and epidemiology of Peste des petits ruminants virus. Virus Res 43:149–153
Streatfield SJ (2005) Plant based vaccines for animal health. Rev sci tech Off Int Epi 24(1):189–199