A randomized clinical trial evaluating the immunomodulatory effect of convalescent plasma on COVID-19-related cytokine storm

Internal and Emergency Medicine - Tập 16 - Trang 2181-2191 - 2021
Mandana Pouladzadeh1, Mehdi Safdarian2, Peyman Eshghi3,4, Hassan Abolghasemi5, Alireza Ghorbani bavani6, Behnam Sheibani7, Parastoo Moradi Choghakabodi8, Abdolaziz Feghhi9, Mehri Ghafourian Boroujerdnia10, Arash Forouzan11, Mohammad Ali Jalali Far8, Gholam Abbas Kaydani12, Elham Rajaei13, Mansour Amin14,15, Mehdi Torabizadeh16, Farid Yousefi15, Reza Hadaddezfuli17
1Emergency Medicine Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
5Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
6Radiology Department, Abadan University of Medical Sciences, Abadan, Iran
7Infectious Diseases Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
8Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
9Blood Transfusion Organization, Ahvaz, Iran
10Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
11Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
12Department of Laboratory Sciences, Allied Health Sciences School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
13Department of internal medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
14Department of Microbiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
15Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz, Iran
16Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
17Ahvaz, Jundishapur University of Medical Sciences, Ahvaz, Iran

Tóm tắt

Evaluating the effect of convalescent plasma (CP) on some cytokine storm indices in severe COVID-19 patients. Totally, 62 patients were randomly assigned into two groups for this clinical trial. Patients in the intervention group received one unit (500 mL) plasma on the admission day plus standard drugs while the controls merely received standard treatments. Eventually, primary and secondary outcomes were evaluated. In the CP group, compared with controls, the mean levels of lymphocytes and IL-10 significantly increased while the levels of IL-6, TNF-α, and IFN-γ decreased (p < 0.05). The length of in-hospital stay, and mortality rate did not significantly reduce in the CP group compared with controls (p > 0.05) while WHO severity scores remarkably improved (p = 0.01), despite the higher frequency of underlying diseases among the CP group (66.7%) vs. controls (33.3%). Although CP has a remarkable immunomodulatory and antiviral potential to improve the cytokine storm and disease severity in COVID-19 patients, it did not considerably affect the mortality rate.

Tài liệu tham khảo

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