Potential risks of glucagon stimulation test in elderly people

Cook, 2009, American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth-hormone deficient adults and transition patients—2009 update, Endocr. Pract., 15, 1, 10.4158/EP.15.S2.1 Ho, 2007, Eur. J. Endocrinol., 157, 695, 10.1530/EJE-07-0631 Molitch, 2011, Evaluation and treatment of adult growth hormone deficiency: an endocrine society clinical practice guideline, J. Clin. Endocrinol. Metab., 96, 1587, 10.1210/jc.2011-0179 Yuen, 2009, Is slack of recombinant growth hormone (GH)-releasing hormone in the United States a setback or time to consider glucagon testing for adult GH deficiency?, J. Clin. Endocrinol. Metab., 94, 2702, 10.1210/jc.2009-0299 Gómez, 2002, Growth hormone release after glucagon as a reliable test of growth hormone assessment in adults, Clin. Endocrinol., 56, 320, 10.1046/j.1365-2265.2002.01472.x Yuen, 2013, Clinical characteristics, timing of peak responses and safety aspects of two regimens of the glucagon stimulation test in evaluating growth hormone and cortisol secretion in adults, Pituitary, 220, 10.1007/s11102-012-0407-7 Micmacher, 2009, Growth hormone secretion in response to glucagon stimulation test in healthy middle-aged men, Arq. Bras. Endocrinol. Metab., 53, 853, 10.1590/S0004-27302009000700009 Leong, 2011, An audit of 500 subcutaneous glucagon stimulation tests to assess growth hormone and ACTH secretion in patients with hypothalamic–pituitary disease, Clin. Endocrinol., 54, 463, 10.1046/j.1365-2265.2001.01169.x Rao, 1987, Intramuscular glucagon as a provocative stimulus for the assessment of pituitary function: growth hormone and cortisol responses, Metabolism, 36, 658, 10.1016/0026-0495(87)90150-8 Conceição, 2003, Glucagon stimulation test for the diagnosis of GH deficiency in adults, J. Endocrinol. Invest., 26, 1065, 10.1007/BF03345251 Arvat, 2000, Interaction between glucagon and human corticotropin- releasing hormone or vasopressin on ACTH and cortisol secretion in humans, Eur. J. Endocrinol., 143, 99, 10.1530/eje.0.1430099 Goodwin, 1976, The metabolic and hormonal response to glucagon, J. Neurol. Sci., 27, 373, 10.1016/0022-510X(76)90009-5 Iranmanesh, 1991, Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men, J. Clin. Endocrinol. Metab., 73, 1081, 10.1210/jcem-73-5-1081