Lawsone derivatives target the Wnt/β-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells

Biochemical Pharmacology - Tập 146 - Trang 63-73 - 2017
Sami Hamdoun1, Edmond Fleischer2, Anette Klinger2, Thomas Efferth1
1Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg-University, Mainz, Germany
2MicroCombiChem GmbH, Wiesbaden, Germany

Tài liệu tham khảo

Pui, 2004, Acute lymphoblastic leukemia, N. Engl. J. Med., 350, 1535, 10.1056/NEJMra023001 S. Fulda, Evasion of apoptosis as a cellular stress response in cancer. Callaghan, 2014, Inhibition of the multidrug resistance P-glycoprotein: time for a change of strategy?, Drug Metab. Dispos., 42, 623, 10.1124/dmd.113.056176 Kadioglu, 2016, Genomic and transcriptomic profiling of resistant CEM/ADR-5000 and sensitive CCRF-CEM leukaemia cells for unravelling the full complexity of multi-factorial multidrug resistance, Scientific Rep., 6, 36754, 10.1038/srep36754 Righetti, 2005, Proteomic approaches for studying chemoresistance in cancer, Expert Rev. Proteomics, 2, 215, 10.1586/14789450.2.2.215 Gottesman, 2006, The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research, FEBS Lett., 580, 998, 10.1016/j.febslet.2005.12.060 Gillet, 2007, Chemotherapy-induced resistance by ATP-binding cassette transporter genes, Biochim. Biophys. Acta, 1775, 237 Efferth, 2017, Multiple resistance to carcinogens and xenobiotics: P-glycoproteins as universal detoxifiers, Arch. Toxicol., 10.1007/s00204-017-1938-5 Marie, 1999, MDR1/P-GP expression as a prognostic factor in acute leukemias, Adv. Exp. Med. Biol., 457, 1, 10.1007/978-1-4615-4811-9_1 Volm, 2015, Role of P-glycoprotein for resistance of tumors to anticancer drugs: from bench to bedside, 1, 10.1007/978-3-319-09801-2_1 Binkhathlan, 2013, P-glycoprotein inhibition as a therapeutic approach for overcoming multidrug resistance in cancer: current status and future perspectives, Curr. Cancer Drug Targets, 13, 326, 10.2174/15680096113139990076 Long, 2016, Marine natural products as models to circumvent multidrug resistance, Molecules (Basel, Switzerland), 21 Teng, 2016, beta-carotene reverses multidrug resistant cancer cells by selectively modulating human P-glycoprotein function, Phytomedicine, 23, 316, 10.1016/j.phymed.2016.01.008 Pluchino, 2012, Collateral sensitivity as a strategy against cancer multidrug resistance, Drug Resistance Updates, 15, 98, 10.1016/j.drup.2012.03.002 Saeed, 2013, Collateral sensitivity in drug-resistant tumor cells, 187 Wu, 2015, Miltirone induces G2/M cell cycle arrest and apoptosis in CCRF-CEM acute lymphoblastic leukemia cells, J. Natural Prod., 78, 1339, 10.1021/acs.jnatprod.5b00158 Ooko, 2016, Modulation of P-glycoprotein activity by novel synthetic curcumin derivatives in sensitive and multidrug-resistant T-cell acute lymphoblastic leukemia cell lines, Toxicol. Appl. Pharmacol., 305, 216, 10.1016/j.taap.2016.06.002 Hall, 2009, Is resistance useless? Multidrug resistance and collateral sensitivity, Trends Pharmacol. Sci., 30, 546, 10.1016/j.tips.2009.07.003 Szakacs, 2006, Targeting multidrug resistance in cancer, Nat. Rev. Drug Discov., 5, 219, 10.1038/nrd1984 Komiya, 2008, Wnt signal transduction pathways, Organogenesis, 4, 68, 10.4161/org.4.2.5851 Barker, 2006, Mining the Wnt pathway for cancer therapeutics, Nat. Rev. Drug Discov., 5, 997, 10.1038/nrd2154 Blagodatski, 2014, Targeting the Wnt pathways for therapies, Mol. Cell. Therapies, 2, 28, 10.1186/2052-8426-2-28 Polakis, 2012, Wnt signaling in cancer, Cold Spring Harbor Perspect. Biol., 4, 10.1101/cshperspect.a008052 Kimmig, 1990, Susceptibility of multidrug-resistant human leukemia cell lines to human interleukin 2-activated killer cells, Cancer Res., 50, 6793 Efferth, 2003, Molecular modes of action of artesunate in tumor cell lines, Mol. Pharmacol., 64, 382, 10.1124/mol.64.2.382 O'Brien, 2000, Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity, Eur. J. Biochem., 267, 5421, 10.1046/j.1432-1327.2000.01606.x Ooko, 2015, Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells, Phytomedicine, 22, 1045, 10.1016/j.phymed.2015.08.002 Zeino, 2015, Cytotoxicity of cardiotonic steroids in sensitive and multidrug-resistant leukemia cells and the link with Na(+)/K(+)-ATPase, J. Steroid Biochem. Mol. Biol., 150, 97, 10.1016/j.jsbmb.2015.03.008 Kuete, 2016, Cytotoxicity of seven naturally occurring phenolic compounds towards multi-factorial drug-resistant cancer cells, Phytomedicine, 23, 856, 10.1016/j.phymed.2016.04.007 Veeman, 2003, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling, Dev. Cell, 5, 367, 10.1016/S1534-5807(03)00266-1 Janda, 2012, Structural basis of Wnt recognition by Frizzled, Science (New York, NY), 337, 59, 10.1126/science.1222879 van den Berg, 2000, Acute lymphoblastic leukaemia in puberty and adolescence, Ann. Oncol., 11, 1375, 10.1023/A:1026538713236 Cooper, 2015, Treatment of pediatric acute lymphoblastic leukemia, Pediatric Clin. North America, 62, 61, 10.1016/j.pcl.2014.09.006 Holleman, 2004, Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment, N. Engl. J. Med., 351, 533, 10.1056/NEJMoa033513 Goasguen, 1993, Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications, Blood, 81, 2394, 10.1182/blood.V81.9.2394.2394 Savignano, 1993, The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia, Haematologica, 78, 261 den Boer, 1998, Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia, Blood, 91, 2092, 10.1182/blood.V91.6.2092.2092_2092_2098 Dhooge, 1999, P-glycoprotein is an independent prognostic factor predicting relapse in childhood acute lymphoblastic leukaemia: results of a 6-year prospective study, Br. J. Haematol., 105, 676, 10.1046/j.1365-2141.1999.01378.x Brozek, 2009, P-glycoprotein activity predicts outcome in childhood acute lymphoblastic leukemia, J. Pediatric Hematol./Oncol., 31, 493, 10.1097/MPH.0b013e3181a974b3 Neidle, 2005, Chemical approaches to the discovery and development of cancer therapies, Nat. Rev. Cancer, 5, 285, 10.1038/nrc1587 Chong, 2015, Wnt pathway activation and ABCB1 expression account for attenuation of proteasome inhibitor-mediated apoptosis in multidrug-resistant cancer cells, Cancer Biol. Therapy, 16, 149, 10.4161/15384047.2014.987093 Shen, 2013, Inhibition of Wnt/beta-catenin signaling downregulates P-glycoprotein and reverses multi-drug resistance of cholangiocarcinoma, Cancer Sci., 104, 1303, 10.1111/cas.12223 Y.Y. Liu, V. Gupta, G.A. Fau – Patwardhan, G.A. Patwardhan, K. Fau – Bhinge, K. Bhinge, Y. Fau – Zhao, Y. Zhao, J. Fau – Bao, J. Bao, H. Fau – Mehendale, et al., Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Gala, 2015, Molecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment, Clin. Cancer Res., 21, 1543, 10.1158/1078-0432.CCR-14-0877 MacDonald, 2009, Wnt/beta-catenin signaling: components, mechanisms, and diseases, Dev. Cell, 17, 9, 10.1016/j.devcel.2009.06.016 Herbst, 2014, Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling, BMC Genomics, 15, 74, 10.1186/1471-2164-15-74 Hoffman, 2008, Apoptotic signaling by c-MYC, Oncogene, 27, 6462, 10.1038/onc.2008.312 Barnes, 1998, Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family, Trends Pharmacol. Sci., 19, 399, 10.1016/S0165-6147(98)01246-2 Niehrs, 2012, The complex world of WNT receptor signalling, Nat. Rev. Mol. Cell Biol., 13, 767, 10.1038/nrm3470 Povelones, 2005, The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling, EMBO J., 24, 3493, 10.1038/sj.emboj.7600817 Hsieh, 1999, A new secreted protein that binds to Wnt proteins and inhibits their activities, Nature, 398, 431, 10.1038/18899 Nile, 2017, Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding, Proc. Natl. Acad. Sci. U.S.A., 114, 4147, 10.1073/pnas.1618293114 Mook, 2013, Small molecule modulators of Wnt/β-catenin signaling, Bioorg. Med. Chem. Lett., 23, 2187, 10.1016/j.bmcl.2013.01.101 Correa, 2012, Wnt/beta-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia, BMC Cancer, 12, 303, 10.1186/1471-2407-12-303 Trachootham, 2009, Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?, Nat. Rev. Drug Discov., 8, 579, 10.1038/nrd2803 Laberge, 2009, P-glycoprotein (ABCB1) modulates collateral sensitivity of a multidrug resistant cell line to verapamil, Arch. Biochem. Biophys., 491, 53, 10.1016/j.abb.2009.09.012 Abdelfatah, 2015, Cytotoxicity of the indole alkaloid reserpine from Rauwolfia serpentina against drug-resistant tumor cells, Phytomedicine, 22, 308, 10.1016/j.phymed.2015.01.002 Seo, 2015, Cytotoxicity of natural products and derivatives toward MCF-7 cell monolayers and cancer stem-like mammospheres, Phytomedicine, 22, 438, 10.1016/j.phymed.2015.01.012