Stability of S-HBsAg in long-term stored lyophilised plant tissue

Pniewski, 2012, Is an oral plant-based vaccine against hepatitis B virus possible?, Curr Pharm Biotechnol, 13, 2692, 10.2174/138920112804724837 Passot, 2007, Effect of product temperature during primary drying on the long-term stability of lyophilized proteins, Pharm Dev Technol, 12, 543, 10.1080/10837450701563459 Carpenter, 1997, Rational design of stable lyophilized protein formulations: some practical advice, Pharm Res, 14, 969, 10.1023/A:1012180707283 Czyz, 2014, Freeze-drying of plant tissue containing HBV surface antigen for the oral vaccine against hepatitis B, BioMed Res Int, 2014, 485689, 10.1155/2014/485689 Wang, 2000, Lyophilization and development of solid protein pharmaceuticals, Int J Pharm, 203, 1, 10.1016/S0378-5173(00)00423-3 Byrn, 2001, Chemical reactivity in solid-state pharmaceuticals: formulation implications, Adv Drug Deliv Rev, 48, 115, 10.1016/S0169-409X(01)00102-8 Chang, 2009, Mechanisms of protein stabilization in the solid state, J Pharm Sci, 98, 2886, 10.1002/jps.21825 Lai, 1999, Solid-state chemical stability of proteins and peptides, J Pharm Sci, 88, 489, 10.1021/js980374e Carpenter, 2002, Rational design of stable lyophilized protein formulations: theory and practice, Pharm Biotechnol, 13, 109, 10.1007/978-1-4615-0557-0_5 Varshney, 2007, Glycine crystallization in frozen and freeze-dried systems: effect of pH and buffer concentration, Pharm Res, 24, 593, 10.1007/s11095-006-9178-z Maa, 2004, Influenza vaccine powder formulation development: spray-freeze-drying and stability evaluation, J Pharm Sci, 93, 1912, 10.1002/jps.20104 Maa, 2007, Hepatitis-B surface antigen (HBsAg) powder formulation: process and stability assessment, Curr Drug Deliv, 4, 57, 10.2174/156720107779314758 Krishnamurthy, 2002, The stability factor: importance in formulation development, Curr Pharm Biotechnol, 3, 361, 10.2174/1389201023378229 Carpenter, 1986, Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection in the presence of divalent cations, Arch Biochem Biophys, 250, 505, 10.1016/0003-9861(86)90755-1 Carpenter, 1987, Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations, Biochim Biophys Acta, 923, 109, 10.1016/0304-4165(87)90133-4 Pniewski, 2011, Low-dose oral immunization with lyophilized tissue of herbicide-resistant lettuce expressing hepatitis B surface antigen for prototype plant-derived vaccine tablet formulation, J Appl Genet, 52, 125, 10.1007/s13353-010-0001-5 May, 1989, The gravimetric method for the determination of residual moisture in freeze-dried biological products, Cryobiology, 26, 277, 10.1016/0011-2240(89)90023-0 Diminsky, 1999, Physical, chemical and immunological stability of CHO-derived hepatitis B surface antigen (HBsAg) particles, Vaccine, 18, 3, 10.1016/S0264-410X(99)00149-8 Kwon, 2013, Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells, Plant Biotechnol J, 11, 77, 10.1111/pbi.12008 Lakshmi, 2013, Low cost tuberculosis vaccine antigens in capsules: expression in chloroplasts, bio-encapsulation, stability and functional evaluation in vitro, PloS One, 8, e54708, 10.1371/journal.pone.0054708