Forecasting carbapenem resistance from antimicrobial consumption surveillance: Lessons learnt from an OXA-48-producing Klebsiella pneumoniae outbreak in a West London renal unit

Watkins, 2013, Increasing prevalence of carbapenem-resistant Enterobacteriaceae and strategies to avert a looming crisis, Expert Rev Anti Infect Ther, 11, 543, 10.1586/eri.13.46 Jacobson, 1995, The relationship between antecedent antibiotic use and resistance to extended-spectrum cephalosporins in group I β-lactamase-producing organisms, Clin Infect Dis, 21, 1107, 10.1093/clinids/21.5.1107 World Health Organization, 2012 Davies, 2013 European Centre for Disease Prevention and Control (ECDC), 2014 Freeman, 2013, Evaluation of a national microbiological surveillance system to inform automated outbreak detection, J Infect, 67, 378, 10.1016/j.jinf.2013.07.021 Davies, 2013 US Centres for Disease Control and Prevention, 2013 Willetts, 2013 Baquero, 1998, Antibiotic-selective environments, Clin Infect Dis, 27, S5, 10.1086/514916 Thacker, 1989, The science of public health surveillance, J Public Health Policy, 10, 187, 10.2307/3342679 Thomas, 2013, Early (2008–2010) hospital outbreak of Klebsiella pneumoniae producing OXA-48 carbapenemase in the UK, Int J Antimicrob Agents, 42, 531, 10.1016/j.ijantimicag.2013.08.020 World Health Organization, 2012 Moore, 2014, Homogeneity of antimicrobial policy, yet heterogeneity of antimicrobial resistance: antimicrobial non-susceptibility among 108,717 clinical isolates from primary, secondary and tertiary care patients in London, J Antimicrob Chemother, 69, 3409, 10.1093/jac/dku307 Helfenstein, 1991, The use of transfer function models, intervention analysis and related time series methods in epidemiology, Int J Epidemiol, 20, 808, 10.1093/ije/20.3.808 Box, 1976 Wagner, 2002, Segmented regression analysis of interrupted time series studies in medication use research, J Clin Pharm Ther, 27, 299, 10.1046/j.1365-2710.2002.00430.x Davey, 2013, Interventions to improve antibiotic prescribing practices for hospital inpatients, Cochrane Database Syst Rev, 4, CD003543 Stone, 2007, The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection, Lancet Infect Dis, 7, 282, 10.1016/S1473-3099(07)70082-8 Ramsey, 2003, Interrupted time series designs in health technology assessment: lessons from two systematic reviews of behaviour change strategies, Int J Technol Assess Health Care, 19, 613, 10.1017/S0266462303000576 Seyler, 2011, Recommended β-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy, Crit Care, 15, R137, 10.1186/cc10257 Bauer, 2012, Pharmacokinetics and pharmacodynamics of piperacillin–tazobactam in 42 patients treated with concomitant CRRT, Clin J Am Soc Nephrol, 7, 452, 10.2215/CJN.10741011 Golledge, 1992, Ciprofloxacin and Clostridium difficile-associated diarrhoea, J Antimicrob Chemother, 30, 141, 10.1093/jac/30.2.141 Dancer, 2013, Approaching zero: temporal effects of a restrictive antibiotic policy on hospital-acquired Clostridium difficile, extended-spectrum β-lactamase-producing coliforms and meticillin-resistant Staphylococcus aureus, Int J Antimicrob Agents, 41, 137, 10.1016/j.ijantimicag.2012.10.013 Woodford, 2011, Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance, FEMS Microbiol Rev, 35, 736, 10.1111/j.1574-6976.2011.00268.x Gravatt, 2013, Challenges in measuring antibiotic consumption, Curr Infect Dis Rep, 15, 559, 10.1007/s11908-013-0374-9 Fridkin, 2014, Implementing a strategy for monitoring inpatient antimicrobial use among hospitals in the United States, Clin Infect Dis, 58, 401, 10.1093/cid/cit710 López-Lozano, 2000, Modelling and forecasting antimicrobial resistance and its dynamic relationship to antimicrobial use: a time series analysis, Int J Antimicrob Agents, 14, 21, 10.1016/S0924-8579(99)00135-1 US Centers for Disease Control and Prevention, 2012 Public Health England, 2013