Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis

Angela A. Wendel1, Tal M. Lewin1, Rosalind A. Coleman1
1Department of Nutrition, CB# 7461, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

Tài liệu tham khảo

Kennedy, 1961, Biosynthesis of complex lipids, Fed. Proc., 20, 934 Weiss, 1956, The enzymatic synthesis of triglycerides, J. Am. Chem. Soc., 78, 3550, 10.1021/ja01595a088 Monroy, 1973, Partial purification and properties of an acyl coenzyme A:sn-glycerol 3-phosphate acyltransferase from rat liver mitochondria, J. Biol. Chem., 248, 2845, 10.1016/S0021-9258(19)44084-2 Coleman, 2004, Enzymes of triacylglycerol synthesis and their regulation, Prog. Lipid Res., 43, 134, 10.1016/S0163-7827(03)00051-1 Yet, 1993, Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase, Biochemistry, 32, 9486, 10.1021/bi00087a029 Bhat, 1999, Rat hepatic sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein, Biochim. Biophys. Acta, 1439, 415, 10.1016/S1388-1981(99)00103-1 Wang, 2007, Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2), Arch. Biochem. Biophys., 465, 347, 10.1016/j.abb.2007.06.033 Harada, 2007, Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1), Mol. Cell. Biochem., 297, 41, 10.1007/s11010-006-9321-5 Cao, 2006, Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis, Proc. Natl. Acad. Sci. U. S. A., 103, 19695, 10.1073/pnas.0609140103 Nagle, 2008, Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice, J. Lipid Res., 49, 823, 10.1194/jlr.M700592-JLR200 Chen, 2008, AGPAT6 Is a novel microsomal glycerol-3-phosphate acyltransferase (GPAT), J. Biol. Chem., 283, 10048, 10.1074/jbc.M708151200 Lewin, 2004, Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria, J. Biol. Chem., 279, 13488, 10.1074/jbc.M314032200 Neuwald, 1997, Barth syndrome may be due to an acyltransferase deficiency, Curr. Biol., 7, R465, 10.1016/S0960-9822(06)00237-5 Heath, 1999, A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant, J. Bacteriol., 181, 1944, 10.1128/JB.181.6.1944-1946.1999 Lewin, 1999, Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction, Biochemistry, 38, 5764, 10.1021/bi982805d Dircks, 1999, A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity: significance of arginine 318 in catalysis, J. Biol. Chem., 274, 34728, 10.1074/jbc.274.49.34728 Ofman, 1998, Acyl-CoA:dihydroxyacetonephosphate acyltransferse: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2, Hum. Mol. Genet., 7, 847, 10.1093/hmg/7.5.847 Heath, 1998, A conserved histidine is essential for glycerolipid acyltransferase catalysis, J. Bacteriol., 180, 1425, 10.1128/JB.180.6.1425-1430.1998 Soupene, 2008, Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes, Proc. Natl. Acad. Sci. U. S. A., 105, 88, 10.1073/pnas.0709737104 Zhao, 2008, Identification and characterization of a major liver lysophosphatidylcholine acyltransferase, J. Biol. Chem., 283, 8258, 10.1074/jbc.M710422200 Cao, 2000, Intracellular unesterified arachidonic acid signals apoptosis, Proc. Natl. Acad. Sci., 97, 11280, 10.1073/pnas.200367597 Cao, 2004, A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated Acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse, J. Biol. Chem., 279, 31727, 10.1074/jbc.M402930200 Lu, 2004, Cloning and characterization of murine 1-acyl-sn-glycerol-3-phosphate acyltransferases and their regulation by PPARalpha in murine heart, Biochem. J., 385, 469, 10.1042/BJ20041348 Nakanishi, 2006, Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production., J. Biol. Chem., 281, 20140, 10.1074/jbc.M600225200 Yang, 2004, Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase, J. Biol. Chem., 279, 55866, 10.1074/jbc.M406710200 Xu, 2003, Remodeling of cardiolipin by phospholipid transacylation, J. Biol. Chem., 278, 51380, 10.1074/jbc.M307382200 Xu, 2006, The enzymatic function of tafazzin, J. Biol. Chem., 281, 39217, 10.1074/jbc.M606100200 Testet, 2005, Ypr140wp, ‘the yeast tafazzin’, displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis, Biochem. J., 387, 617, 10.1042/BJ20041491 Agarwal, 2002, AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34, Nat. Genet., 31, 21, 10.1038/ng880 Johnston, 1997, Mutation characterization and genotype–phenotype correlation in Barth syndrome, Am. J. Hum. Genet., 61, 1053, 10.1086/301604 Dircks, 1997, Mammalian mitochondrial glycerol-3-phosphate acyltransferase, Biochim. Biophys. Acta, 1348, 17, 10.1016/S0005-2760(97)00106-9 Lewin, 2001, Regulation of mitochondrial sn-glycerol-3-phophate acyltransferase activity: response to feeding status is unique in various rat tissues and is discordant with protein expression, Arch. Biochem. Biophys., 396, 119, 10.1006/abbi.2001.2604 Bell, 1983, 87, 10.1016/S1874-6047(08)60301-7 Shin, 1991, Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase, J. Biol. Chem., 266, 23834, 10.1016/S0021-9258(18)54359-3 Horton, 2002, Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis, Biochem. Soc. Trans., 30, 1091, 10.1042/bst0301091 Eberle, 2004, SREBP transcription factors: master regulators of lipid homeostasis, Biochimie, 86, 839, 10.1016/j.biochi.2004.09.018 Jerkins, 1995, Characterization of the murine mitochondrial glycerol-3-phosphate acyltransferase promoter, J. Biol. Chem., 270, 1416, 10.1074/jbc.270.3.1416 Ericsson, 1997, Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene, J. Biol. Chem., 272, 7298, 10.1074/jbc.272.11.7298 Shimano, 1999, Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes, J. Biol. Chem., 274, 35832, 10.1074/jbc.274.50.35832 Yoshikawa, 2001, Identification of liver X receptor–retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter, Mol. Cell. Biol., 21, 2991, 10.1128/MCB.21.9.2991-3000.2001 Cha, 2007, The liver X receptor (LXR) and hepatic lipogenesis: the carbohydrate-response element binding protein is a target gene of LXR, J. Biol. Chem., 282, 743, 10.1074/jbc.M605023200 Park, 2002, Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise, J. Biol. Chem., 277, 32571, 10.1074/jbc.M201692200 Darnley, 1988, Changes in activities of some enzymes of glycerolipid synthesis in brown adipose tissue of cold-acclimated rats, Biochem. J., 253, 351, 10.1042/bj2530351 Igal, 2001, Mitochondrial glycerol phosphate acyltransferase directs incorporation of exogenous fatty acids into triacylglycerol, J. Biol. Chem., 276, 42205, 10.1074/jbc.M103386200 Lewin, 2005, Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes, Am. J. Physiol. Endocrinol. Metab., 288, E835, 10.1152/ajpendo.00300.2004 Nagle, 2007, Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance, J. Biol. Chem., 282, 14807, 10.1074/jbc.M611550200 Hammond, 2002, Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition, Mol. Cell. Biol., 22, 8204, 10.1128/MCB.22.23.8204-8214.2002 Hammond, 2005, Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs, J. Biol. Chem., 280, 25629, 10.1074/jbc.M503181200 Neschen, 2005, Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knock out mice, Cell Metab., 2, 55, 10.1016/j.cmet.2005.06.006 Xu, 2006, Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile, Biochem. Biophys. Res. Commun., 349, 439, 10.1016/j.bbrc.2006.08.071 Winder, 2007, Cellular energy sensing and signaling by AMP-activated protein kinase, Cell Biochem. Biophys., 47, 332, 10.1007/s12013-007-0008-7 Muoio, 1999, Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice, Am. J. Physiol., 276, E913 Onorato, 2005, Phosphorylation of rat liver mitochondrial glycerol-3-phosphate acyltransferase by casein kinase 2, J. Biol. Chem., 280, 19527, 10.1074/jbc.M410422200 Collison, 2005, Aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes, Biochim. Biophys. Acta, 1687, 164, 10.1016/j.bbalip.2004.11.013 Kerner, 2004, Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme, J. Biol. Chem., 279, 41104, 10.1074/jbc.M406570200 Coleman, 2000, Physiological and nutritional regulation of enzymes of triacylglycerol synthesis, Ann. Rev. Nutr., 20, 77, 10.1146/annurev.nutr.20.1.77 Coleman, 1983, Selective changes in microsomal enzymes of triacylglycerol and phosphatidylcholine synthesis in fetal and postnatal rat liver: induction of microsomal sn-glycerol 3-P and dihydroxyacetone-P acyltransferase activities, J. Biol. Chem., 258, 450, 10.1016/S0021-9258(18)33277-0 Coleman, 1980, Selective changes in enzymes of the sn-glycerol-3-phosphate and dihydroxyacetone-phosphate pathways of triacylglycerol biosynthesis during differentiation of 3T3-L1 pre-adipocytes, J. Biol. Chem., 255, 7681, 10.1016/S0021-9258(19)43883-0 Muoio, 1999, AMP-activated kinase (AMPK) reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target, Biochem. J., 338, 783, 10.1042/bj3380783 Bates, 1977, Acute effects of insulin on glycerolphosphate acyltransferase activity, ketogenesis and serum free fatty acid concentration in perfused rat liver, FEBS Lett., 84, 225, 10.1016/0014-5793(77)80693-5 Bates, 1979, A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment, Biochem. J., 182, 751, 10.1042/bj1820751 Farese, 1994, Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats, Proc. Natl. Acad. Sci. U. S. A., 91, 11040, 10.1073/pnas.91.23.11040 Vila, 1991, Insulin rapidly increases glycerol-3-phosphate acyltransferase activity in rat adipocytes, Arch. Biochem. Biophys., 284, 366, 10.1016/0003-9861(91)90309-7 Vila, 1990, Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Giα and activation of phospholipase C, Biochemistry, 29, 8735, 10.1021/bi00489a033 Yamada, 1994, Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes, Arch. Biochem. Biophys., 312, 167, 10.1006/abbi.1994.1295 Tang, 2006, Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway, J. Biochem. Mol. Biol., 39, 626 Beigneux, 2006, Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium, J. Lipid Res., 47, 734, 10.1194/jlr.M500556-JLR200 Vergnes, 2006, Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity, J. Lipid Res., 47, 745, 10.1194/jlr.M500553-JLR200 Li, 2003, Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family, J. Hum. Genet., 48, 438, 10.1007/s10038-003-0045-z Gale, 2006, A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation, J. Biol. Chem., 281, 11082, 10.1074/jbc.M509612200 Cao, 2003, Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2, J. Biol. Chem., 278, 25657, 10.1074/jbc.M302835200 Tauchi-Sato, 2002, The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition, J. Biol. Chem., 277, 44507, 10.1074/jbc.M207712200 Gonzalez-Baró, 2001, Mitochondrial glycerol phosphate acyltransferase contains two transmembrane domains with the active site in the N-terminus, facing the cytosol, J. Biol. Chem., 276, 43182, 10.1074/jbc.M107885200 Lewin, 2008, Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation and altered phospholipid fatty acid composition, Biochim. Biophys. Acta, 1781, 352, 10.1016/j.bbalip.2008.05.001