Glycerol-3-phosphate acyltransferases: Rate limiting enzymes of triacylglycerol biosynthesis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Tập 1791 - Trang 501-506 - 2009
Tài liệu tham khảo
Kennedy, 1961, Biosynthesis of complex lipids, Fed. Proc., 20, 934
Weiss, 1956, The enzymatic synthesis of triglycerides, J. Am. Chem. Soc., 78, 3550, 10.1021/ja01595a088
Monroy, 1973, Partial purification and properties of an acyl coenzyme A:sn-glycerol 3-phosphate acyltransferase from rat liver mitochondria, J. Biol. Chem., 248, 2845, 10.1016/S0021-9258(19)44084-2
Coleman, 2004, Enzymes of triacylglycerol synthesis and their regulation, Prog. Lipid Res., 43, 134, 10.1016/S0163-7827(03)00051-1
Yet, 1993, Expression and identification of p90 as the murine mitochondrial glycerol-3-phosphate acyltransferase, Biochemistry, 32, 9486, 10.1021/bi00087a029
Bhat, 1999, Rat hepatic sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein, Biochim. Biophys. Acta, 1439, 415, 10.1016/S1388-1981(99)00103-1
Wang, 2007, Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2), Arch. Biochem. Biophys., 465, 347, 10.1016/j.abb.2007.06.033
Harada, 2007, Molecular cloning of a murine glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1), Mol. Cell. Biochem., 297, 41, 10.1007/s11010-006-9321-5
Cao, 2006, Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis, Proc. Natl. Acad. Sci. U. S. A., 103, 19695, 10.1073/pnas.0609140103
Nagle, 2008, Identification of a novel sn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient in Agpat6-/- mice, J. Lipid Res., 49, 823, 10.1194/jlr.M700592-JLR200
Chen, 2008, AGPAT6 Is a novel microsomal glycerol-3-phosphate acyltransferase (GPAT), J. Biol. Chem., 283, 10048, 10.1074/jbc.M708151200
Lewin, 2004, Identification of a new glycerol-3-phosphate acyltransferase isoenzyme, mtGPAT2, in mitochondria, J. Biol. Chem., 279, 13488, 10.1074/jbc.M314032200
Neuwald, 1997, Barth syndrome may be due to an acyltransferase deficiency, Curr. Biol., 7, R465, 10.1016/S0960-9822(06)00237-5
Heath, 1999, A missense mutation accounts for the defect in the glycerol-3-phosphate acyltransferase expressed in the plsB26 mutant, J. Bacteriol., 181, 1944, 10.1128/JB.181.6.1944-1946.1999
Lewin, 1999, Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction, Biochemistry, 38, 5764, 10.1021/bi982805d
Dircks, 1999, A conserved seven amino acid stretch important for murine mitochondrial glycerol-3-phosphate acyltransferase activity: significance of arginine 318 in catalysis, J. Biol. Chem., 274, 34728, 10.1074/jbc.274.49.34728
Ofman, 1998, Acyl-CoA:dihydroxyacetonephosphate acyltransferse: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2, Hum. Mol. Genet., 7, 847, 10.1093/hmg/7.5.847
Heath, 1998, A conserved histidine is essential for glycerolipid acyltransferase catalysis, J. Bacteriol., 180, 1425, 10.1128/JB.180.6.1425-1430.1998
Soupene, 2008, Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes, Proc. Natl. Acad. Sci. U. S. A., 105, 88, 10.1073/pnas.0709737104
Zhao, 2008, Identification and characterization of a major liver lysophosphatidylcholine acyltransferase, J. Biol. Chem., 283, 8258, 10.1074/jbc.M710422200
Cao, 2000, Intracellular unesterified arachidonic acid signals apoptosis, Proc. Natl. Acad. Sci., 97, 11280, 10.1073/pnas.200367597
Cao, 2004, A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated Acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse, J. Biol. Chem., 279, 31727, 10.1074/jbc.M402930200
Lu, 2004, Cloning and characterization of murine 1-acyl-sn-glycerol-3-phosphate acyltransferases and their regulation by PPARalpha in murine heart, Biochem. J., 385, 469, 10.1042/BJ20041348
Nakanishi, 2006, Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production., J. Biol. Chem., 281, 20140, 10.1074/jbc.M600225200
Yang, 2004, Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase, J. Biol. Chem., 279, 55866, 10.1074/jbc.M406710200
Xu, 2003, Remodeling of cardiolipin by phospholipid transacylation, J. Biol. Chem., 278, 51380, 10.1074/jbc.M307382200
Xu, 2006, The enzymatic function of tafazzin, J. Biol. Chem., 281, 39217, 10.1074/jbc.M606100200
Testet, 2005, Ypr140wp, ‘the yeast tafazzin’, displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis, Biochem. J., 387, 617, 10.1042/BJ20041491
Agarwal, 2002, AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34, Nat. Genet., 31, 21, 10.1038/ng880
Johnston, 1997, Mutation characterization and genotype–phenotype correlation in Barth syndrome, Am. J. Hum. Genet., 61, 1053, 10.1086/301604
Dircks, 1997, Mammalian mitochondrial glycerol-3-phosphate acyltransferase, Biochim. Biophys. Acta, 1348, 17, 10.1016/S0005-2760(97)00106-9
Lewin, 2001, Regulation of mitochondrial sn-glycerol-3-phophate acyltransferase activity: response to feeding status is unique in various rat tissues and is discordant with protein expression, Arch. Biochem. Biophys., 396, 119, 10.1006/abbi.2001.2604
Bell, 1983, 87, 10.1016/S1874-6047(08)60301-7
Shin, 1991, Transcriptional regulation of p90 with sequence homology to Escherichia coli glycerol-3-phosphate acyltransferase, J. Biol. Chem., 266, 23834, 10.1016/S0021-9258(18)54359-3
Horton, 2002, Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis, Biochem. Soc. Trans., 30, 1091, 10.1042/bst0301091
Eberle, 2004, SREBP transcription factors: master regulators of lipid homeostasis, Biochimie, 86, 839, 10.1016/j.biochi.2004.09.018
Jerkins, 1995, Characterization of the murine mitochondrial glycerol-3-phosphate acyltransferase promoter, J. Biol. Chem., 270, 1416, 10.1074/jbc.270.3.1416
Ericsson, 1997, Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene, J. Biol. Chem., 272, 7298, 10.1074/jbc.272.11.7298
Shimano, 1999, Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes, J. Biol. Chem., 274, 35832, 10.1074/jbc.274.50.35832
Yoshikawa, 2001, Identification of liver X receptor–retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter, Mol. Cell. Biol., 21, 2991, 10.1128/MCB.21.9.2991-3000.2001
Cha, 2007, The liver X receptor (LXR) and hepatic lipogenesis: the carbohydrate-response element binding protein is a target gene of LXR, J. Biol. Chem., 282, 743, 10.1074/jbc.M605023200
Park, 2002, Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise, J. Biol. Chem., 277, 32571, 10.1074/jbc.M201692200
Darnley, 1988, Changes in activities of some enzymes of glycerolipid synthesis in brown adipose tissue of cold-acclimated rats, Biochem. J., 253, 351, 10.1042/bj2530351
Igal, 2001, Mitochondrial glycerol phosphate acyltransferase directs incorporation of exogenous fatty acids into triacylglycerol, J. Biol. Chem., 276, 42205, 10.1074/jbc.M103386200
Lewin, 2005, Mitochondrial glycerol-3-phosphate acyltransferase-1 directs the metabolic fate of exogenous fatty acids in hepatocytes, Am. J. Physiol. Endocrinol. Metab., 288, E835, 10.1152/ajpendo.00300.2004
Nagle, 2007, Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance, J. Biol. Chem., 282, 14807, 10.1074/jbc.M611550200
Hammond, 2002, Mitochondrial glycerol-3-phosphate acyltransferase-deficient mice have reduced weight and liver triacylglycerol content and altered glycerolipid fatty acid composition, Mol. Cell. Biol., 22, 8204, 10.1128/MCB.22.23.8204-8214.2002
Hammond, 2005, Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs, J. Biol. Chem., 280, 25629, 10.1074/jbc.M503181200
Neschen, 2005, Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knock out mice, Cell Metab., 2, 55, 10.1016/j.cmet.2005.06.006
Xu, 2006, Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile, Biochem. Biophys. Res. Commun., 349, 439, 10.1016/j.bbrc.2006.08.071
Winder, 2007, Cellular energy sensing and signaling by AMP-activated protein kinase, Cell Biochem. Biophys., 47, 332, 10.1007/s12013-007-0008-7
Muoio, 1999, Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice, Am. J. Physiol., 276, E913
Onorato, 2005, Phosphorylation of rat liver mitochondrial glycerol-3-phosphate acyltransferase by casein kinase 2, J. Biol. Chem., 280, 19527, 10.1074/jbc.M410422200
Collison, 2005, Aging reduces glycerol-3-phosphate acyltransferase activity in activated rat splenic T-lymphocytes, Biochim. Biophys. Acta, 1687, 164, 10.1016/j.bbalip.2004.11.013
Kerner, 2004, Phosphorylation of rat liver mitochondrial carnitine palmitoyltransferase-I: effect on the kinetic properties of the enzyme, J. Biol. Chem., 279, 41104, 10.1074/jbc.M406570200
Coleman, 2000, Physiological and nutritional regulation of enzymes of triacylglycerol synthesis, Ann. Rev. Nutr., 20, 77, 10.1146/annurev.nutr.20.1.77
Coleman, 1983, Selective changes in microsomal enzymes of triacylglycerol and phosphatidylcholine synthesis in fetal and postnatal rat liver: induction of microsomal sn-glycerol 3-P and dihydroxyacetone-P acyltransferase activities, J. Biol. Chem., 258, 450, 10.1016/S0021-9258(18)33277-0
Coleman, 1980, Selective changes in enzymes of the sn-glycerol-3-phosphate and dihydroxyacetone-phosphate pathways of triacylglycerol biosynthesis during differentiation of 3T3-L1 pre-adipocytes, J. Biol. Chem., 255, 7681, 10.1016/S0021-9258(19)43883-0
Muoio, 1999, AMP-activated kinase (AMPK) reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target, Biochem. J., 338, 783, 10.1042/bj3380783
Bates, 1977, Acute effects of insulin on glycerolphosphate acyltransferase activity, ketogenesis and serum free fatty acid concentration in perfused rat liver, FEBS Lett., 84, 225, 10.1016/0014-5793(77)80693-5
Bates, 1979, A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment, Biochem. J., 182, 751, 10.1042/bj1820751
Farese, 1994, Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats, Proc. Natl. Acad. Sci. U. S. A., 91, 11040, 10.1073/pnas.91.23.11040
Vila, 1991, Insulin rapidly increases glycerol-3-phosphate acyltransferase activity in rat adipocytes, Arch. Biochem. Biophys., 284, 366, 10.1016/0003-9861(91)90309-7
Vila, 1990, Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Giα and activation of phospholipase C, Biochemistry, 29, 8735, 10.1021/bi00489a033
Yamada, 1994, Insulin-like effects of sodium orthovanadate on diacylglycerol-protein kinase C signaling in BC3H-1 myocytes, Arch. Biochem. Biophys., 312, 167, 10.1006/abbi.1994.1295
Tang, 2006, Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway, J. Biochem. Mol. Biol., 39, 626
Beigneux, 2006, Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epithelium, J. Lipid Res., 47, 734, 10.1194/jlr.M500556-JLR200
Vergnes, 2006, Agpat6 deficiency causes subdermal lipodystrophy and resistance to obesity, J. Lipid Res., 47, 745, 10.1194/jlr.M500553-JLR200
Li, 2003, Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family, J. Hum. Genet., 48, 438, 10.1007/s10038-003-0045-z
Gale, 2006, A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation, J. Biol. Chem., 281, 11082, 10.1074/jbc.M509612200
Cao, 2003, Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2, J. Biol. Chem., 278, 25657, 10.1074/jbc.M302835200
Tauchi-Sato, 2002, The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition, J. Biol. Chem., 277, 44507, 10.1074/jbc.M207712200
Gonzalez-Baró, 2001, Mitochondrial glycerol phosphate acyltransferase contains two transmembrane domains with the active site in the N-terminus, facing the cytosol, J. Biol. Chem., 276, 43182, 10.1074/jbc.M107885200
Lewin, 2008, Mice deficient in mitochondrial glycerol-3-phosphate acyltransferase-1 have diminished myocardial triacylglycerol accumulation and altered phospholipid fatty acid composition, Biochim. Biophys. Acta, 1781, 352, 10.1016/j.bbalip.2008.05.001