Resolvin D3 multi-level proresolving actions are host protective during infection

Serhan, 2014, Pro-resolving lipid mediators are leads for resolution physiology, Nature, 510, 92, 10.1038/nature13479 Tabas, 2013, Anti-inflammatory therapy in chronic disease: challenges and opportunities, Science, 339, 166, 10.1126/science.1230720 Serhan, 2005, Resolution of inflammation: the beginning programs the end, Nat. Immunol., 6, 1191, 10.1038/ni1276 Dennis, 2015, Eicosanoid storm in infection and inflammation, Nat. Rev. Immunol., 15, 511, 10.1038/nri3859 Oh, 2011, Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation, J. Clin. Investig., 121, 569, 10.1172/JCI42545 Chiang, 2012, Infection regulates pro-resolving mediators that lower antibiotic requirements, Nature, 484, 524, 10.1038/nature11042 Winkler, 2013, Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17 R-epimer, Org. Lett., 15, 1424, 10.1021/ol400484u Dalli, 2013, Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents, Chem. Biol., 20, 188, 10.1016/j.chembiol.2012.11.010 Haeggström, 2013, Resolving resolvins, Chem. Biol., 20, 138, 10.1016/j.chembiol.2013.02.003 Bannenberg, 2005, Molecular circuits of resolution: formation and actions of resolvins and protectins, J. Immunol., 174, 4345, 10.4049/jimmunol.174.7.4345 Colas, 2014, Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue, Am. J., 307, C39 Serhan, 2002, Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals, J. Exp. Med., 196, 1025, 10.1084/jem.20020760 Nicolaou, 1989, Stereocontrolled total synthesis of (5Z,8Z,10E,12R,14Z)-12-hydroxy-5,8,10,14-eicosatetraenoic acid [(12R)-HETE], Synthesis, 898, 10.1055/s-1989-27425 Rodriguez, 2001, Total synthesis of 12(R)-HETE, 12(S)-HETE, 2H2-12(R)-HETE and LTB4 from racemic glycidol via hydrolytic kinetic resolution, Tetrahedron, 57, 25, 10.1016/S0040-4020(00)00983-2 Takai, 1986, Simple and selective method for aldehydes (RCHO)→(E)-haloalkenes (RCH:CHX) conversion by means of a haloform-chromous chloride system, J. Am. Chem. Soc., 108, 7408, 10.1021/ja00283a046 Rodriguez, 2003, First total synthesis of the E type I phytoprostanes, Tetrahedron Lett., 44, 7411, 10.1016/j.tetlet.2003.08.042 Duffield, 2006, Resolvin D series and protectin D1 mitigate acute kidney injury, J. Immunol., 177, 5902, 10.4049/jimmunol.177.9.5902 Spite, 2009, Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis, Nature, 461, 1287, 10.1038/nature08541