High-Density Lipoprotein Function Measurement in Human Studies: Focus on Cholesterol Efflux Capacity

Stone, 2013, 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, Circulation Kathiresan, 2006, Increased small low-density lipoprotein particle number: a prominent feature of the metabolic syndrome in the Framingham Heart Study, Circulation, 113, 20, 10.1161/CIRCULATIONAHA.105.567107 Waterworth, 2010, Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease, Arterioscler Thromb Vasc Biol, 30, 2264, 10.1161/ATVBAHA.109.201020 Edmondson, 2009, Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans, J Clin Invest, 119, 1042 2014, Effects of Extended-Release Niacin with Laropiprant in High-Risk Patients, N Engl J Med, 371, 203, 10.1056/NEJMoa1300955 Barter, 2007, HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events, N Engl J Med, 357, 1301, 10.1056/NEJMoa064278 Boden, 2011, Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy, N Engl J Med, 365, 2255, 10.1056/NEJMoa1107579 Schwartz, 2012, Effects of dalcetrapib in patients with a recent acute coronary syndrome, N Engl J Med, 367, 2089, 10.1056/NEJMoa1206797 Rader, 2009, The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis, J Lipid Res, S189, 10.1194/jlr.R800088-JLR200 Mineo, 2013, Regulation of signal transduction by HDL, J Lipid Res, 54, 2315, 10.1194/jlr.R039479 Rader, 2014, HDL and cardiovascular disease, Lancet, 384, 618, 10.1016/S0140-6736(14)61217-4 Rothblat, 2002, Cellular cholesterol flux studies: methodological considerations, Atherosclerosis, 163, 1, 10.1016/S0021-9150(01)00713-4 Li, 2013, Paradoxical association of enhanced cholesterol efflux with increased incident cardiovascular risks, Arterioscler Thromb Vasc Biol, 33, 1696, 10.1161/ATVBAHA.113.301373 Fielding, 1981, Evidence for a lipoprotein carrier in human plasma catalyzing sterol efflux from cultured fibroblasts and its relationship to lecithin:cholesterol acyltransferase, Proc Natl Acad Sci U S A, 78, 3911, 10.1073/pnas.78.6.3911 Low, 2012, Advanced glycation end-products (AGEs) and functionality of reverse cholesterol transport in patients with type 2 diabetes and in mouse models, Diabetologia, 55, 2513, 10.1007/s00125-012-2570-9 Syvänne, 1996, Cholesterol efflux from Fu5AH hepatoma cells induced by plasma of subjects with or without coronary artery disease and non-insulin-dependent diabetes: importance of LpA-I:A-II particles and phospholipid transfer protein, Atherosclerosis, 127, 245, 10.1016/S0021-9150(96)05962-X Linsel-Nitschke, 2009, Macrophage cholesterol efflux correlates with lipoprotein subclass distribution and risk of obstructive coronary artery disease in patients undergoing coronary angiography, Lipids Health Dis, 8, 10.1186/1476-511X-8-14 Khera, 2011, Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis, N Engl J Med, 364, 127, 10.1056/NEJMoa1001689 2011, Cholesterol Efflux Capacity and Atherosclerosis, N Engl J Med, 364, 1472, 10.1056/NEJMc1101853 Khera, 2013, Cholesterol efflux capacity: full steam ahead or a bump in the road?, Arterioscler Thromb Vasc Biol, 33, 1449, 10.1161/ATVBAHA.113.301519 Rohatgi, 2014, HDL cholesterol efflux capacity and incident cardiovascular events, N Engl J Med, 371, 2383, 10.1056/NEJMoa1409065 Saleheen D, Scott R, Javad S, et al. Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study. Lancet Diabetes Endocrinol. 2015 May 26. pii: S2213-8587(15)00126-6.doi: 10.1016/S2213-8587(15)00126-6. [Epub ahead of print] Yamamoto, 2012, Dysfunctional high-density lipoprotein in patients on chronic hemodialysis, J Am Coll Cardiol, 60, 2372, 10.1016/j.jacc.2012.09.013 Kaseda, 2015, Dysfunctional high-density lipoproteins in children with chronic kidney disease, Metabolism, 64, 263, 10.1016/j.metabol.2014.10.020 Shroff, 2014, HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype, J Am Soc Nephrol, 25, 2658, 10.1681/ASN.2013111212 Dullaart, 2008, Fibroblast cholesterol efflux to plasma from metabolic syndrome subjects is not defective despite low high-density lipoprotein cholesterol, Eur J Endocrinol, 158, 53, 10.1530/EJE-07-0451 Dullaart, 2012, Pancreatic β-cell function relates positively to HDL functionality in well-controlled Type 2 diabetes mellitus, Atherosclerosis, 222, 567, 10.1016/j.atherosclerosis.2012.03.037 de Vries, 2008, Increased cholesterol efflux from cultured fibroblasts to plasma from hypertriglyceridemic type 2 diabetic patients: roles of pre beta-HDL, phospholipid transfer protein and cholesterol esterification, Atherosclerosis, 196, 733, 10.1016/j.atherosclerosis.2006.12.027 Yassine, 2014, Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes, Metab Clin Exp, 63, 727, 10.1016/j.metabol.2014.03.001 Nestel, 2012, Cholesterol efflux from macrophages is influenced differentially by plasmas from overweight insulin-sensitive and -resistant subjects, Int J Obes, 36, 407, 10.1038/ijo.2011.170 Zhou, 2008, Cellular cholesterol efflux to serum is impaired in diabetic nephropathy, Diabetes Metab Res Rev, 24, 617, 10.1002/dmrr.895 Kubota, 2014, Relationship between Serum Cholesterol Efflux Capacity and Glucose Intolerance in Japanese-Americans, J Atheroscler Thromb, 21, 1087, 10.5551/jat.24315 Mehta, 2012, Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis, Atherosclerosis, 224, 218, 10.1016/j.atherosclerosis.2012.06.068 Holzer, 2012, Psoriasis alters HDL composition and cholesterol efflux capacity, J Lipid Res, 53, 1618, 10.1194/jlr.M027367 Charles-Schoeman, 2012, Cholesterol efflux by high density lipoproteins is impaired in patients with active rheumatoid arthritis, Ann Rheum Dis, 71, 1157, 10.1136/annrheumdis-2011-200493 Ronda, 2014, Impaired serum cholesterol efflux capacity in rheumatoid arthritis and systemic lupus erythematosus, Ann Rheum Dis, 73, 609, 10.1136/annrheumdis-2012-202914 Hernáez, 2014, Olive Oil Polyphenols Enhance High-Density Lipoprotein Function in Humans A Randomized Controlled Trial, Arterioscler Thromb Vasc Biol, 10.1161/ATVBAHA.114.303374 Beulens, 2004, Moderate alcohol consumption increases cholesterol efflux mediated by ABCA1, J Lipid Res, 45, 1716, 10.1194/jlr.M400109-JLR200 Buonacorso, 2007, Macrophage cholesterol efflux elicited by human total plasma and by HDL subfractions is not affected by different types of dietary fatty acids, Am J Clin Nutr, 86, 1270, 10.1093/ajcn/86.5.1270 Kralova Lesna, 2008, Replacement of dietary saturated FAs by PUFAs in diet and reverse cholesterol transport, J Lipid Res, 49, 2414, 10.1194/jlr.M800271-JLR200 Ribeiro, 2008, HDL Atheroprotection by Aerobic Exercise Training in Type 2 Diabetes Mellitus, Med Sci Sports Exerc, 40, 779, 10.1249/MSS.0b013e3181632d2d Blazek, 2013, Exercise-mediated changes in high-density lipoprotein: Impact on form and function, Am Heart J, 166, 392, 10.1016/j.ahj.2013.05.021 Aicher, 2012, Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function, Obesity (Silver Spring), 20, 2057, 10.1038/oby.2012.56 Roe, 2014, Decreased cholesterol efflux capacity and atherogenic lipid profile in young women with PCOS, J Clin Endocrinol Metab, 99, E841, 10.1210/jc.2013-3918 Cavallero, 1995, Abnormal reverse cholesterol transport in controlled type II diabetic patients. Studies on fasting and postprandial LpA-I particles, Arterioscler Thromb Vasc Biol, 15, 2130, 10.1161/01.ATV.15.12.2130 Brites, 1999, Abnormal capacity to induce cholesterol efflux and a new LpA-I pre-beta particle in type 2 diabetic patients, Clin Chim Acta, 279, 1, 10.1016/S0009-8981(98)00155-7 Zhou, 2009, Impaired serum capacity to induce cholesterol efflux is associated with endothelial dysfunction in type 2 diabetes mellitus, Diab Vasc Dis Res, 6, 238, 10.1177/1479164109344934 Králová Lesná, 2010, May Alcohol-Induced Increase of HDL Be Considered as Atheroprotective?, Physiol Res, 59, 407, 10.33549/physiolres.931769