Photochemical Damage of the Retina

1992, —: Risk factors for neovascular age-related macular degeneration. The Eye Disease Case-Control Study Group, Arch Ophthalmol, 110, 1701, 10.1001/archopht.1992.01080240041025 Abler, 1996, Photic injury triggers apoptosis of photoreceptor cells, Res Commun Mol Pathol Pharmacol, 92, 177 Ahmed, 1993, Oxygen distribution in the macaque retina, Invest Ophthalmol Vis Sci, 34, 516 Alder, 1990, PO2 profiles and oxygen consumption in cat retina with an occluded retinal circulation, Invest Ophthalmol Vis Sci, 31, 1029 Alder, 1990, Vitreal and retinal oxygenation, Graefes Arch Clin Exp Ophthalmol, 228, 151, 10.1007/BF00935725 Alder, 1983, The retinal oxygen profile in cats, Invest Ophthalmol Vis Sci, 24, 30 Anderson, 1978, Mammalian cones: disc shedding, phagocytosis, and renewal, Invest Ophthalmol Vis Sci, 17, 117 Anderson, 1972, Lipids of ocular tissues. 8. The effects of essential fatty acid deficiency on the phospholipids of the photoreceptor membranes of rat retina, Arch Biochem Biophys, 151, 270, 10.1016/0003-9861(72)90497-3 Avalle, 2004, Observation of A2E oxidation products in human retinal lipofuscin, Exp Eye Res, 78, 895, 10.1016/j.exer.2003.10.023 Battelle, 1978, Rhodopsin content and rod outer segment length in albino rat eyes: modification by dark adaptation, Exp Eye Res, 26, 487, 10.1016/0014-4835(78)90134-3 Bazan, 1989, The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology, Prog Clin Biol Res, 312, 95 Beatty, 1999, Macular pigment and age related macular degeneration, Br J Ophthalmol, 83, 867, 10.1136/bjo.83.7.867 Beatty, 2000, The role of oxidative stress in the pathogenesis of age-related macular degeneration, Surv Ophthalmol, 45, 115, 10.1016/S0039-6257(00)00140-5 Bell, 1981, Hemoproteins, 42 Ben-Shabat, 2002, Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin, J Biol Chem, 277, 7183, 10.1074/jbc.M108981200 Berson, 2002, Phototransduction by retinal ganglion cells that set the circadian clock, Science, 295, 1070, 10.1126/science.1067262 Bill, 1983, Physiology of the choroidal vascular bed, Int Ophthalmol, 6, 101, 10.1007/BF00127638 Bill, 1990, Control of retinal and choroidal blood flow, Eye, 4, 319, 10.1038/eye.1990.43 Bill, 1980, Permeability of the intraocular blood vessels, Trans Ophthalmol Soc U K, 100, 332 Birch, 1984, Diurnal rhythm in the human rod ERG, Invest Ophthalmol Vis Sci, 25, 236 Blanks, 1992, Ascorbate treatment prevents accumulation of phagosomes in RPE in light damage, Invest Ophthalmol Vis Sci, 33, 2814 Blumenkranz, 1986, Risk factors in age-related maculopathy complicated by choroidal neovascularization, Ophthalmology, 93, 552, 10.1016/S0161-6420(86)33702-3 Boettner, 1962, Transmission of the ocular media, Invest. Ophthalmol, 1, 776 Bok, 1993, The retinal pigment epithelium: a versatile partner in vision, J Cell Sci Suppl, 17, 189, 10.1242/jcs.1993.Supplement_17.27 Bok, 1990, Processing and transport of retinoids by the retinal pigment epithelium, Eye, 4, 326, 10.1038/eye.1990.44 Bonnett, 1980, Triplet states of porphyrin esters, J Chem Soc, 76, 852 Borges, 1990, A comparative study of photic injury in four inbred strains of albino rats, Curr Eye Res, 9, 799, 10.3109/02713689008999576 Boulton, 1993, Lipofuscin is a photoinducible free radical generator, J Photochem Photobiol B, 19, 201, 10.1016/1011-1344(93)87085-2 Braun, 1995, Retinal oxygen tension and the electroretinogram during arterial occlusion in the cat, Invest Ophthalmol Vis Sci, 36, 523 Brinkmann, 2000, Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen, Lasers Surg Med, 27, 451, 10.1002/1096-9101(2000)27:5<451::AID-LSM1006>3.0.CO;2-1 Busch, 1999, The effects of two stereoisomers of N-acetylcysteine on photochemical damage by UVA and blue light in rat retina, Photochem Photobiol, 70, 353 Bush, 1994, Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina, Invest Ophthalmol Vis Sci, 35, 91 Bush, 1991, Light damage in the rat retina: the effect of dietary deprivation of N-3 fatty acids on acute structural alterations, Exp Eye Res, 53, 741, 10.1016/0014-4835(91)90109-R Bynoe, 1998, Photosensitization of retinal pigment epithelium by protoporphyrin IX, Graefes Arch Clin Exp Ophthalmol, 236, 230, 10.1007/s004170050069 Byrnes, 1992, Photic maculopathy after extracapsular cataract surgery. A prospective study, Ophthalmology, 99, 731, 10.1016/S0161-6420(92)31903-7 Cahill, 1995, Circadian rhythmicity in vertebrate retinas: regulation by a photoreceptor oscillator, Prog Retinal Eye Res, 14, 267, 10.1016/1350-9462(94)00001-Y Chen, 1999, Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase, Proc Natl Acad Sci U S A, 96, 3718, 10.1073/pnas.96.7.3718 Chen, 1993, Inhibition of cytochrome oxidase and blue-light damage in rat retina, Graefes Arch Clin Exp Ophthalmol, 231, 416, 10.1007/BF00919652 Chen, 1996, bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations, Proc Natl Acad Sci U S A, 93, 7042, 10.1073/pnas.93.14.7042 Chen, 1999, Increased susceptibility to light damage in an arrestin knockout mouse model of Oguchi disease (stationary night blindness), Invest Ophthalmol Vis Sci, 40, 2978 Cicerone, 1976, Cones survive rods in the light-damaged eye of the albino rat, Science, 194, 1183, 10.1126/science.996550 Clarke, 1969, An equilibrium thermal model for retinal injury from optical sources, Appl Opt, 8, 1951, 10.1364/AO.8.001051 Cleary, 1969, Laser-induced acoustic transients in the mammalian eye, J Acoust Soc Am, 46, 1037, 10.1121/1.1911797 Conn, 1991, The singlet oxygen and carotenoid interaction, J Photochem Photobiol B, 11, 41, 10.1016/1011-1344(91)80266-K Crabb, 2002, Drusen proteome analysis: an approach to the etiology of age-related macular degeneration, Proc Natl Acad Sci U S A, 99, 14682, 10.1073/pnas.222551899 Cringle, 1996, Light-induced changes in retinal oxygen consumption, Invest Ophthalmol Vis Sci, 37, 473 Cruickshanks, 2001, Sunlight and the 5-year incidence of early age-related maculopathy: the beaver dam eye study, Arch Ophthalmol, 119, 246 Cruickshanks, 1993, Sunlight and age-related macular degeneration. The Beaver Dam Eye Study, Arch Ophthalmol, 111, 514, 10.1001/archopht.1993.01090040106042 Cubeddu, 1999, Photophysical studies of A2-E, putative precursor of lipofuscin, in human retinal pigment epithelial cells, Photochem Photobiol, 70, 172, 10.1111/j.1751-1097.1999.tb07986.x Curcio, 1996, Photoreceptor loss in age-related macular degeneration, Invest Ophthalmol Vis Sci, 37, 1236 Curcio, 1993, Aging of the human photoreceptor mosaic: evidence for selective vulnerability of rods in central retina, Invest Ophthalmol Vis Sci, 34, 3278 Daemen, 1973, Vertebrate rod outer segment membranes, Biochim Biophys Acta, 300, 255, 10.1016/0304-4157(73)90006-3 Danciger, 2000, A QTL on distal chromosome 3 that influences the severity of light-induced damage to mouse photoreceptors, Mamm Genome, 11, 422, 10.1007/s003350010081 Davidson, 1993, Potential retinal phototoxicity, Am J Ophthalmol, 116, 497, 10.1016/S0002-9394(14)71411-4 Davies, 2001, Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells, Free Radic Biol Med, 31, 256, 10.1016/S0891-5849(01)00582-2 Delmelle, 1978, Retinal sensitized photodynamic damage to liposomes, Photochem Photobiol, 28, 357, 10.1111/j.1751-1097.1978.tb07718.x Delori, 2000, Autofluorescence distribution associated with drusen in age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, 496 Delori, 2001, Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects, Invest Ophthalmol Vis Sci, 42, 1855 Demontis, 2002, Molecular steps involved in light-induced oxidative damage to retinal rods, Invest Ophthalmol Vis Sci, 43, 2421 Devlin, 1999, Cryptochromes–bringing the blues to circadian rhythms, Trends Cell Biol, 9, 295, 10.1016/S0962-8924(99)01611-6 Donovan, 2001, Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent, J Biol Chem, 276, 23000, 10.1074/jbc.M005359200 Dorey, 1989, Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration, Invest Ophthalmol Vis Sci, 30, 1691 Dowling, 1962, Inherited retinal dystrophy in the rat, J Cell Biol, 14, 73, 10.1083/jcb.14.1.73 Dunaief, 2002, The role of apoptosis in age-related macular degeneration, Arch Ophthalmol, 120, 1435, 10.1001/archopht.120.11.1435 Duncan, 1985, The diurnal susceptibility of rat retinal photoreceptors to light-induced damage, Exp Eye Res, 41, 497, 10.1016/S0014-4835(85)80007-5 Eldred, 1998, Lipofuscin and other lysosomal storage deposits in the retinal pigment epithelium Fain, 2001, Adaptation in vertebrate photoreceptors, Physiol Rev, 81, 117, 10.1152/physrev.2001.81.1.117 Faktorovich, 1992, Basic fibroblast growth factor and local injury protect photoreceptors from light damage in the rat, J Neurosci, 12, 3554, 10.1523/JNEUROSCI.12-09-03554.1992 Farkas, 1971, The ultrastructure of drusen, Am J Ophthalmol, 71, 1196, 10.1016/0002-9394(71)90963-9 Feeney-Burns, 1980, Lipofuscin of human retinal pigment epithelium, Am J Ophthalmol, 90, 783, 10.1016/S0002-9394(14)75193-1 Feeney-Burns, 1984, Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells, Invest Ophthalmol Vis Sci, 25, 195 Finnemann, 2002, The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium, Proc Natl Acad Sci U S A, 99, 3842, 10.1073/pnas.052025899 Foote, 1968, Mechanisms of photosensitized oxidation. There are several different types of photosensitized oxidation which may be important in biological systems, Science, 162, 963, 10.1126/science.162.3857.963 Freedman, 1999, Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors, Science, 284, 502, 10.1126/science.284.5413.502 Gaillard, 1995, Photophysical studies on human retinal lipofuscin, Photochem Photobiol, 61, 448, 10.1111/j.1751-1097.1995.tb02343.x Gallemore, 1997, Retinal pigment epithelial transport mechanisms and their contributions to the electroretinogram, Prog Retinal Eye Res, 16, 509, 10.1016/S1350-9462(96)00037-7 Garcia, 1997, Flavin-sensitized photooxidation of amino acids present in a parenteral nutrition infusate: Protection by ascorbic acid, J. Nutr. J Nutr Biochem, 8, 341, 10.1016/S0955-2863(97)00024-7 Gass, 1972, Drusen and disciform macular detachment and degeneration, Trans Am Ophthalmol Soc, 70, 409 Geeraets, 1968, Ocular spectral characteristics as related to hazards from lasers and other light sources, Am J Ophthalmol, 66, 15, 10.1016/0002-9394(68)91780-7 Gerschenson, 2001, Virchow and apoptosis, Am J Pathol, 158, 1543, 10.1016/S0002-9440(10)64105-3 Gerster, 1991, Review: antioxidant protection of the ageing macula, Age Ageing, 20, 60, 10.1093/ageing/20.1.60 Geske, 2001, The biology of apoptosis, Hum Pathol, 32, 1029, 10.1053/hupa.2001.28250 Girotti, 2001, Photosensitized oxidation of membrane lipids: reaction pathways, cytotoxic effects, and cytoprotective mechanisms, J Photochem Photobiol B, 63, 103, 10.1016/S1011-1344(01)00207-X Goldman, 1977, Ocular damage thresholds and mechanisms for ultrashort pulses of both visible and infrared laser radiation in the rhesus monkey, Exp Eye Res, 24, 45, 10.1016/0014-4835(77)90283-4 Gorgels, 1998, Two spectral types of retinal light damage occur in albino as well as in pigmented rat: no essential role for melanin, Exp Eye Res, 66, 155, 10.1006/exer.1997.0416 Gorgels, 1995, Ultraviolet and green light cause different types of damage in rat retina, Invest Ophthalmol Vis Sci, 36, 851 Gorn, 1967, Retinal damage by visible light. A physiologic study, Arch Ophthalmol, 77, 115, 10.1001/archopht.1967.00980020117025 Griess, 1981, Additivity and repair of actinic retinal lesions, Invest Ophthalmol Vis Sci, 20, 803 Grimm, 2000, Blue light's effects on rhodopsin: photoreversal of bleaching in living rat eyes, Invest Ophthalmol Vis Sci, 41, 3984 Grimm, 2000, Gene expression in the mouse retina: the effect of damaging light, Mol Vis, 6, 252 Grimm, 2000, Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration, Nat Genet, 25, 63, 10.1038/75614 Grimm, 2001, Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching, Invest Ophthalmol Vis Sci, 42, 497 Hafezi, 1997, Light-induced apoptosis: differential timing in the retina and pigment epithelium, Exp Eye Res, 64, 963, 10.1006/exer.1997.0288 Halliwell, 1986, Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts, Arch Biochem Biophys, 246, 501, 10.1016/0003-9861(86)90305-X Ham, 1974, Ocular hazard from picosecond pulses of Nd: YAG laser radiation, Science, 185, 362, 10.1126/science.185.4148.362 Ham, 1979, Sensitivity of the retina to radiation damage as a function of wavelength, Photochem Photobiol, 29, 735, 10.1111/j.1751-1097.1979.tb07759.x Ham, 1976, Retinal sensitivity to damage from short wavelength light, Nature, 260, 153, 10.1038/260153a0 Ham, 1978, Histologic analysis of photochemical lesions produced in rhesus retina by short-wave-length light, Invest Ophthalmol Vis Sci, 17, 1029 Hammond, 1996, Iris color and macular pigment optical density, Exp Eye Res, 62, 293, 10.1006/exer.1996.0035 Handelman, 1986, The role of antoxidants in the retina and retinal pigment epithelium and the nature of prooxidant induced damage, Vol 2, 1 Hao, 2002, Evidence for two apoptotic pathways in light-induced retinal degeneration, Nat Genet, 32, 254, 10.1038/ng984 Hattar, 2002, Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity, Science, 295, 1065, 10.1126/science.1069609 Hattar, 2003, Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice, Nature, 424, 76, 10.1038/nature01761 Hillenkamp, 1989, Laser radiation tissue interaction, Health Phys, 56, 613, 10.1097/00004032-198905000-00002 Hogan, 1972, Role of the retinal pigment epithelium in macular disease, Trans Am Acad Ophthalmol Otolaryngol, 76, 64 Holz, 1999, Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin, Invest Ophthalmol Vis Sci, 40, 737 Hyman, 1983, Senile macular degeneration: a case-control study, Am J Epidemiol, 118, 213, 10.1093/oxfordjournals.aje.a113629 Irvine, 1984, Retinal damage from the illumination of the operating microscope. An experimental study in pseudophakic monkeys, Arch Ophthalmol, 102, 1358, 10.1001/archopht.1984.01040031100034 Iseli, 2002, Light damage susceptibility and RPE65 in rats, Exp Eye Res, 75, 407, 10.1016/S0014-4835(02)92032-4 Ishibashi, 1986, Formation of drusen in the human eye, Am J Ophthalmol, 101, 342, 10.1016/0002-9394(86)90830-5 Ishibashi, 1986, Pathogenesis of drusen in the primate, Invest Ophthalmol Vis Sci, 27, 184 Jacques, 1992, Laser-tissue interactions. Photochemical, photothermal, and photomechanical, Surg Clin North Am, 72, 531, 10.1016/S0039-6109(16)45731-2 Johnson, 2002, The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration, Proc Natl Acad Sci U S A, 99, 11830, 10.1073/pnas.192203399 Kano, 2002, Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene, Invest Ophthalmol Vis Sci, 43, 3744 Katz, 1994, Iron-induced fluorescence in the retina: dependence on vitamin A, Invest Ophthalmol Vis Sci, 35, 3613 Katz, 1995, Vitamin A incorporation into lipofuscin-like inclusions in the retinal pigment epithelium, Mech Ageing Dev, 84, 29, 10.1016/0047-6374(95)01633-B Katz, 1996, Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes, Mech Ageing Dev, 92, 159, 10.1016/S0047-6374(96)01817-9 Keller, 2001, Protective effect of halothane anesthesia on retinal light damage: inhibition of metabolic rhodopsin regeneration, Invest Ophthalmol Vis Sci, 42, 476 Kennedy, 1995, Lipofuscin of the retinal pigment epithelium: a review, Eye, 9, 763, 10.1038/eye.1995.192 Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, 26, 239, 10.1038/bjc.1972.33 Khachik, 1997, Identification of lutein and zeaxanthin oxidation products in human and monkey retinas, Invest Ophthalmol Vis Sci, 38, 1802 Klein, 1992, Prevalence of age-related maculopathy. The Beaver Dam Eye Study, Ophthalmology, 99, 933, 10.1016/S0161-6420(92)31871-8 Klein, 1994, Is age-related maculopathy associated with cataracts?, Arch Ophthalmol, 112, 191, 10.1001/archopht.1994.01090140067025 Klein, 2004, The epidemiology of age-related macular degeneration, Am J Ophthalmol, 137, 486, 10.1016/j.ajo.2003.11.069 Kremers, 1989, Retinal damage in macaque after white light exposures lasting ten minutes to twelve hours, Invest Ophthalmol Vis Sci, 30, 1032 Kremers, 1988, Two classes of photochemical damage of the retina, Lasers Light Ophthalmol, 2, 41 Kuhn, 1991, Photic retinal injury from endoillumination during vitrectomy, Am J Ophthalmol, 111, 42, 10.1016/S0002-9394(14)76894-1 Kutty, 1995, Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea, Proc Natl Acad Sci U S A, 92, 1177, 10.1073/pnas.92.4.1177 Kuwabara, 1970, Retinal recovery from exposure to light, Am J Ophthalmol, 70, 187, 10.1016/0002-9394(70)90001-2 Kuwabara, 1968, Retinal damage by visible light. An electron microscopic study, Arch Ophthalmol, 79, 69, 10.1001/archopht.1968.03850040071019 Lam, 1990, Amelioration of retinal photic injury in albino rats by dimethylthiourea, Arch Ophthalmol, 108, 1751, 10.1001/archopht.1990.01070140105039 Lambooij, 2000, Apoptosis is present in the primate macula at all ages, Graefes Arch Clin Exp Ophthalmol, 238, 508, 10.1007/PL00007892 Lau, 2003, Viral-mediated FGF-2 treatment of the constant light damage model of photoreceptor degeneration, Doc Ophthalmol, 106, 89, 10.1023/A:1022481306146 LaVail, 1983, Outer segment disc shedding and phagocytosis in the outer retina, Trans Ophthalmol Soc U K, 103, 397 LaVail, 1989 LaVail, 1991, Basic fibroblast growth factor protects photoreceptors from light-induced degeneration in albino rats, Ann N Y Acad Sci, 638, 341, 10.1111/j.1749-6632.1991.tb49044.x LaVail, 1987, Strain differences in sensitivity to light-induced photoreceptor degeneration in albino mice, Curr Eye Res, 6, 825, 10.3109/02713688709034850 LaVail, 1987, Genetic regulation of light damage to photoreceptors, Invest Ophthalmol Vis Sci, 28, 1043 LaVail, 1987, Light-induced retinal degeneration in albino mice and rats: strain and species differences, Prog Clin Biol Res, 247, 439 LaVail, 1992, Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light, Proc Natl Acad Sci U S A, 89, 11249, 10.1073/pnas.89.23.11249 Lawwill, 1982, Three major pathologic processes caused by light in the primate retina: a search for mechanisms, Trans Am Ophthalmol Soc, 80, 517 Lawwill, 1973, Effects of prolonged exposure of rabbit retina to low-intensity light, Invest Ophthalmol, 12, 45 Lawwill, 1977, Retinal damage secondary to chronic light exposure, thresholds and mechanisms, Doc Ophthalmol, 44, 379, 10.1007/BF00230089 Leino, 1984, Effects of melatonin and 6-methoxy-tetrahydro-beta-carboline in light induced retinal damage: a computerized morphometric method, Life Sci, 35, 1997, 10.1016/0024-3205(84)90555-1 Li, 1991, Desferrioxamine ameliorates retinal photic injury in albino rats, Curr Eye Res, 10, 133, 10.3109/02713689109001741 Li, 1985, Amelioration of photic injury in rat retina by ascorbic acid: a histopathologic study, Invest Ophthalmol Vis Sci, 26, 1589 Lim, 1992, Antioxidant activity of xanthophylls on peroxyl radical-mediated phospholipid peroxidation, Biochim Biophys Acta, 1126, 178, 10.1016/0005-2760(92)90288-7 Linsenmeier, 1986, Effects of light and darkness on oxygen distribution and consumption in the cat retina, J Gen Physiol, 88, 521, 10.1085/jgp.88.4.521 Linsenmeier, 1998, Retinal hypoxia in long-term diabetic cats, Invest Ophthalmol Vis Sci, 39, 1647 Liu, 1998, Preconditioning with bright light evokes a protective response against light damage in the rat retina, J Neurosci, 18, 1337, 10.1523/JNEUROSCI.18-04-01337.1998 Liu, 2000, The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane, J Biol Chem, 275, 29354, 10.1074/jbc.M910191199 Lucas, 2001, Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice, Behav Brain Res, 125, 97, 10.1016/S0166-4328(01)00274-1 Lucas, 1999, Regulation of the mammalian pineal by non-rod, non-cone, ocular photoreceptors, Science, 284, 505, 10.1126/science.284.5413.505 Lucas, 2003, Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice, Science, 299, 245, 10.1126/science.1077293 Lund, 1979, Ocular hazard of short pulse argon laser irradiation, Health Phys, 36, 7, 10.1097/00004032-197901000-00002 Mainster, 1987, Light and macular degeneration: a biophysical and clinical perspective, Eye, 1, 304, 10.1038/eye.1987.49 Mainster, 1983, Potential retinal hazards. Instrument and environmental light sources, Ophthalmology, 90, 927, 10.1016/S0161-6420(83)80019-0 Mainster, 1970, Retinal-temperature increases produced by intense light sources, J Opt Soc Am, 60, 264, 10.1364/JOSA.60.000264 Malek, 2003, Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy, Am J Pathol, 162, 413, 10.1016/S0002-9440(10)63836-9 Malinow, 1980, Diet-related macular anomalies in monkeys, Invest Ophthalmol Vis Sci, 19, 857 Margrain, 2004, Do blue light filters confer protection against age-related macular degeneration?, Prog Retinal Eye Res, 23, 523, 10.1016/j.preteyeres.2004.05.001 Marshall, 1985, Radiation and the ageing eye, Ophthalmic Physiol Opt, 5, 241, 10.1111/j.1475-1313.1985.tb00666.x Marshall, 1970, Thermal and mechanical mechanisms in laser damage to the retina, Invest Ophthalmol, 9, 97 Marshall, 1970, Laser irradiation of retinal tissue, Br Med Bull, 26, 156, 10.1093/oxfordjournals.bmb.a070768 Marshall, 1972, Damage to pigeon retinae by moderate illumination from fluorescent lamps, Exp Eye Res, 14, 164, 10.1016/0014-4835(72)90063-2 Mata, 2000, Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration, Proc Natl Acad Sci U S A, 97, 7154, 10.1073/pnas.130110497 McDonald, 1983, Light-induced maculopathy from the operating microscope in extracapsular cataract extraction and intraocular lens implantation, Ophthalmology, 90, 945, 10.1016/S0161-6420(83)80022-0 Mellerio, 2002, A portable instrument for measuring macular pigment with central fixation, Curr Eye Res, 25, 37, 10.1076/ceyr.25.1.37.9961 Menon, 1989, A study on the sequence of phototoxic effects of rose bengal using retinal pigment epithelial cells in vitro, Exp Eye Res, 49, 67, 10.1016/0014-4835(89)90076-6 Meyer-Arendt, 1968, Transfer functions in optical and visual testing. 1. Contrast transfer, Am J Optom Arch Am Acad Optom, 45, 507, 10.1097/00006324-196808000-00002 Michels, 1990, Operating microscope-induced retinal phototoxicity: pathophysiology, clinical manifestations and prevention, Surv Ophthalmol, 34, 237, 10.1016/0039-6257(90)90025-Q Mitchell, 1995, Prevalence of age-related maculopathy in Australia. The Blue Mountains Eye Study, Ophthalmology, 102, 1450, 10.1016/S0161-6420(95)30846-9 Mitchell, 2002, Five-year incidence of age-related maculopathy lesions: the Blue Mountains Eye Study, Ophthalmology, 109, 1092, 10.1016/S0161-6420(02)01055-2 Mittag, 1999, Light-induced retinal damage in mice carrying a mutated SOD I gene, Exp Eye Res, 69, 677, 10.1006/exer.1999.0748 Miyamoto, 1998, Vitamin B2-based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals, Proc Natl Acad Sci U S A, 95, 6097, 10.1073/pnas.95.11.6097 Moriya, 1986, Progression and reversibility of early light-induced alterations in rat retinal rods, Cell Tissue Res, 246, 607, 10.1007/BF00215203 Mullins, 2000, Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease, FASEB J, 14, 835, 10.1096/fasebj.14.7.835 Naash, 1996, Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin, Invest Ophthalmol Vis Sci, 37, 775 Noell, 1979, Effects of environmental lighting and dietary vitamin A on the vulnerability of the retina to light damage, Photochem Photobiol, 29, 717, 10.1111/j.1751-1097.1979.tb07756.x Noell, 1971, Irreversible effects on visible light on the retina: role of vitamin A, Science, 172, 76, 10.1126/science.172.3978.76 Noell, 1965, Aspects of experimental and hereditary degeneration, 51 Noell, 1987, Ascorbate and dietary protective mechanisms in retinal light damage of rats: electrophysiological, histological and DNA measurements, Prog Clin Biol Res, 247, 469 Noell, 1966, Retinal damage by light in rats, Invest Ophthalmol, 5, 450 Organisciak, 1992, The effects of L-and D-ascorbic acid administration on retinal tissue levels and light damage in rats, Curr Eye Res, 11, 231, 10.3109/02713689209001774 Organisciak, 2003, Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations, Invest Ophthalmol Vis Sci, 44, 486, 10.1167/iovs.02-0708 Organisciak, 2000, Circadian-dependent retinal light damage in rats, Invest Ophthalmol Vis Sci, 41, 3694 Organisciak, 1992, Protection by dimethylthiourea against retinal light damage in rats, Invest Ophthalmol Vis Sci, 33, 1599 Organisciak, 1990, The protective effect of ascorbic acid in retinal light damage of rats exposed to intermittent light, Invest Ophthalmol Vis Sci, 31, 1195 Organisciak, 1989, Retinal light damage in rats exposed to intermittent light. Comparison with continuous light exposure, Invest Ophthalmol Vis Sci, 30, 795 Organisciak, 1977, The rod outer segment phospholipid/opsin ratio of rats maintained in darkness or cyclic light, Invest Ophthalmol Vis Sci, 16, 188 Organisciak, 1985, The protective effect of ascorbate in retinal light damage of rats, Invest Ophthalmol Vis Sci, 26, 1580 Organisciak, 1987, Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid, Prog Clin Biol Res, 247, 455 O'Steen, 1970, Retinal and optic nerve serotonin and retinal degeneration as influenced by photoperiod, Exp Neurol, 27, 194, 10.1016/0014-4886(70)90213-X O'Steen, 1972, Photoreceptor degeneration after exposure of rats to incandescent illumination, Z Zellforsch Mikrosk Anat, 127, 306, 10.1007/BF00306875 O'Steen, 1974, Photoreceptor degeneration in albino rats: dependency on age, Invest Ophthalmol, 13, 334 O'Steen, 1982, Chronologic analysis of variations in retinal damage in two strains of rats after short-term illumination, Invest Ophthalmol Vis Sci, 22, 252 O'Steen, 1971, Early cellular disruption and phagocytosis in photically-induced retinal degeneration, Am J Anat, 130, 227, 10.1002/aja.1001300208 O'Steen, 1972, Retinal damage after prolonged exposure to visible light. A light and electron microscopic study, Am J Anat, 134, 5, 10.1002/aja.1001340103 Owsley, 2000, Psychophysical evidence for rod vulnerability in age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, 267 Panda, 2002, Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting, Science, 298, 2213, 10.1126/science.1076848 Parish, 1998, Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium, Proc Natl Acad Sci U S A, 95, 14609, 10.1073/pnas.95.25.14609 Pautler, 1990, Hemoprotein(s) mediate blue light damage in the retinal pigment epithelium, Photochem Photobiol, 51, 599, 10.1111/j.1751-1097.1990.tb01972.x Pease, 1987, Optical density of human macular pigment, Vision Res, 27, 705, 10.1016/0042-6989(87)90067-8 Penn, 1987, Effect of light history on rod outer-segment membrane composition in the rat, Exp Eye Res, 44, 767, 10.1016/S0014-4835(87)80040-4 Penn, 1987, Effect of light history on retinal antioxidants and light damage susceptibility in the rat, Exp Eye Res, 44, 779, 10.1016/S0014-4835(87)80041-6 Penn, 1986, Photostasis: regulation of daily photon-catch by rat retinas in response to various cyclic illuminances, Exp Eye Res, 43, 915, 10.1016/0014-4835(86)90070-9 Pepe, 1999, Rhodopsin and phototransduction, J Photochem Photobiol B, 48, 1, 10.1016/S1011-1344(99)00200-6 Postel, 1998, Long-term follow-up of iatrogenic phototoxicity, Arch Ophthalmol, 116, 753, 10.1001/archopht.116.6.753 Pryor, 1976, Autoxidation of polyunsaturated fatty acids: II. A suggested mechanism for the formation of TBA-reactive materials from prostaglandin-like endoperoxides, Lipids, 11, 370, 10.1007/BF02532843 Putting, 1994, Blue-light-induced dysfunction of the blood-retinal barrier at the pigment epithelium in albino versus pigmented rabbits, Exp Eye Res, 58, 31, 10.1006/exer.1994.1192 Ranchon, 2001, Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage, Invest Ophthalmol Vis Sci, 42, 1375 Rapp, 1992, Evidence against melanin as the mediator of retinal phototoxicity by short-wavelength light, Exp Eye Res, 54, 55, 10.1016/0014-4835(92)90069-5 Rapp, 1980, The role of ocular pigmentation in protecting against retinal light damage, Vision Res, 20, 1127, 10.1016/0042-6989(80)90050-4 Reading, 1974, Macular pigment and chromatic aberration, J Opt Soc Am, 64, 231, 10.1364/JOSA.64.000231 Remé, 1991, Light damage in the rat retina: effect of a radioprotective agent (WR-77913) on acute rod outer segment disk disruptions, Photochem Photobiol, 54, 137, 10.1111/j.1751-1097.1991.tb01997.x Roberts, 1996, Ocular phototoxicity Rózanowska, 1995, Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species, J Biol Chem, 270, 18825, 10.1074/jbc.270.32.18825 Rózanowska, 1998, Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media, Free Radic Biol Med, 24, 1107, 10.1016/S0891-5849(97)00395-X Ruby, 2002, Role of melanopsin in circadian responses to light, Science, 298, 2211, 10.1126/science.1076701 Saari, 1994, Control of substrate flow at a branch in the visual cycle, Biochemistry, 33, 3106, 10.1021/bi00176a045 Sarna, 1992, Properties and function of the ocular melanin–a photobiophysical view, J Photochem Photobiol B, 12, 215, 10.1016/1011-1344(92)85027-R Schultze, 1866, Zur anatomie und physiologie der retina, Arch Mickrosk Anat, 2, 165 Schutt, 2002, Proteome analysis of lipofuscin in human retinal pigment epithelial cells, FEBS Lett, 528, 217, 10.1016/S0014-5793(02)03312-4 Schütt, 2002, Isolation of intact lysosomes from human RPE cells and effects of A2-E on the integrity of the lysosomal and other cellular membranes, Graefes Arch Clin Exp Ophthalmol, 240, 983, 10.1007/s00417-002-0558-8 Selby, 2000, Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice, Proc Natl Acad Sci U S A, 97, 14697, 10.1073/pnas.260498597 Shamsi, 2001, Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin, Invest Ophthalmol Vis Sci, 42, 3041 Shen, 2000, Photodynamic cross-linking of proteins, nature of the tyrosine-tyrosine bonds formed in the FMN-sensitized intermolecular cross-linking of N-acetyl-L-tyrosine, J Photochem Photobiol A: Chem, 133, 115, 10.1016/S1010-6030(00)00228-8 Sieving, 2001, Inhibition of the visual cycle in vivo by 13-cis retinoic acid protects from light damage and provides a mechanism for night blindness in isotretinoin therapy, Proc Natl Acad Sci U S A, 98, 1835, 10.1073/pnas.041606498 Silva, 1998, Visible light induced lipoperoxidation of a parenteral nutrition fat emulsion sensitized by flavins, J Nutr Biochem, 9, 149, 10.1016/S0955-2863(97)00177-0 Sliney, 2001, Photoprotection of the eye - UV radiation and sunglasses, J Photochem Photobiol B, 64, 166, 10.1016/S1011-1344(01)00229-9 Sliney, 1984, Quantifying retinal irradiance levels in light damage experiments, Curr Eye Res, 3, 175, 10.3109/02713688408997199 1980 Sparrow, 2001, Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2, Invest Ophthalmol Vis Sci, 42, 1356 Sparrow, 2004, Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro, J Cataract Refract Surg, 30, 873, 10.1016/j.jcrs.2004.01.031 Sparrow, 2000, The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells, Invest Ophthalmol Vis Sci, 41, 1981 Sparrow, 1999, A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture, Invest Ophthalmol Vis Sci, 40, 2988 Sparrow, 2003, A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation, J Biol Chem, 278, 18207, 10.1074/jbc.M300457200 Sparrow, 2002, Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE, Invest Ophthalmol Vis Sci, 43, 1222 Sperduto, 1981, Lens opacities and senile maculopathy, Arch Ophthalmol, 99, 1004, 10.1001/archopht.1981.03930011004003 Sperling, 1971, Red-green cone interactions in the increment-threshold spectral sensitivity of primates, Science, 172, 180, 10.1126/science.172.3979.180 Sperling, 1980, Differential spectral photic damage to primate cones, Vision Res, 20, 1117, 10.1016/0042-6989(80)90049-8 Spikes, 1972, Photodynamic effects on molecules of biological importance: amino acids, peptides and proteins, Res Prog Org Biol Med Chem, 3 Pt 1, 124 Steinberg, 1994, Survival factors in retinal degenerations, Curr Opin Neurobiol, 4, 515, 10.1016/0959-4388(94)90052-3 Steller, 1995, Mechanisms and genes of cellular suicide, Science, 267, 1445, 10.1126/science.7878463 Stone, 1979, A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments, Exp Eye Res, 28, 387, 10.1016/0014-4835(79)90114-3 Strahlman, 1983, The second eye of patients with senile macular degeneration, Arch Ophthalmol, 101, 1191, 10.1001/archopht.1983.01040020193003 Sun, 2001, ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro. Implications for retinal disease, J Biol Chem, 276, 11766, 10.1074/jbc.M010152200 Suter, 2000, Age-related macular degeneration. The lipofusion component N-retinyl-N-retinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells, J Biol Chem, 275, 39625, 10.1074/jbc.M007049200 Sykes, 1981, Damage to the monkey retina by broad-spectrum fluorescent light, Invest Ophthalmol Vis Sci, 20, 425 Tanito, 2002, Cytoprotective effect of thioredoxin against retinal photic injury in mice, Invest Ophthalmol Vis Sci, 43, 1162 Tanito, 2002, Attenuation of retinal photooxidative damage in thioredoxin transgenic mice, Neurosci Lett, 326, 142, 10.1016/S0304-3940(02)00314-2 Tate, 1995, Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells, Invest Ophthalmol Vis Sci, 36, 1271 Taylor, 1990, Visible light and risk of age-related macular degeneration, Trans Am Ophthalmol Soc, 88, 163 Thomson, 2002, Long term dietary supplementation with zeaxanthin reduces photoreceptor death in light-damaged Japanese quail, Exp Eye Res, 75, 529, 10.1006/exer.2002.2050 Thresher, 1998, Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses, Science, 282, 1490, 10.1126/science.282.5393.1490 Tomany, 2004, Sunlight and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study, Arch Ophthalmol, 122, 750, 10.1001/archopht.122.5.750 Tso, 1989, Experiments on visual cells by nature and man: in search of treatment for photoreceptor degeneration. Friedenwald lecture, Invest Ophthalmol Vis Sci, 30, 2430 Tso, 1973, Photic maculopathy in rhesus monkey. A light and electron microscopic study, Invest Ophthalmol, 12, 17 Tso, 1972, Photic maculopathy produced by the indirect ophthalmoscope. 1. Clinical and histopathologic study, Am J Ophthalmol, 73, 686, 10.1016/0002-9394(72)90386-8 Tso, 1975, The human fovea after sungazing, Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol, 79, OP788 Tso, 1972, Recovery of the rod and cone cells after photic injury, Trans Am Acad Ophthalmol Otolaryngol, 76, 1247 Tso, 1983, Effect of photic injury on the retinal tissues, Ophthalmology, 90, 952, 10.1016/S0161-6420(83)80023-2 Van Gelder, 2003, Reduced pupillary light responses in mice lacking cryptochromes, Science, 299, 222, 10.1126/science.1079536 van Norren, 1990, Blue light hazard in rat, Vision Res, 30, 1517, 10.1016/0042-6989(90)90032-G VanNewkirk, 2000, The prevalence of age-related maculopathy: the visual impairment project, Ophthalmology, 107, 1593, 10.1016/S0161-6420(00)00175-5 von Rückmann, 1997, Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope, Invest Ophthalmol Vis Sci, 38, 478 Wang, 2003, Cataract surgery and the 5-year incidence of late-stage age-related maculopathy: pooled findings from the Beaver Dam and Blue Mountains eye studies, Ophthalmology, 110, 1960, 10.1016/S0161-6420(03)00816-9 Wang, 1999, Cataract and age-related maculopathy: the Blue Mountains Eye Study, Ophthalmic Epidemiol, 6, 317, 10.1076/opep.6.4.317.4182 Wang, 1997, Expression of a mutant opsin gene increases the susceptibility of the retina to light damage, Vis Neurosci, 14, 55, 10.1017/S0952523800008750 Wassell, 1997, A role for vitamin A in the formation of ocular lipofuscin, Br J Ophthalmol, 81, 911, 10.1136/bjo.81.10.911 Wassell, 1999, The photoreactivity of the retinal age pigment lipofuscin, J Biol Chem, 274, 23828, 10.1074/jbc.274.34.23828 Weale, 1989, Do years or quanta age the retina?, Photochem Photobiol, 50, 429, 10.1111/j.1751-1097.1989.tb04181.x Weisse, 1974, Age- and light-dependent changes in the rat eye, Virchows Arch A Pathol Anat Histol, 362, 145, 10.1007/BF00432392 Weiter, 1986, Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes, Invest Ophthalmol Vis Sci, 27, 145 Weiter, 1985, Relationship of senile macular degeneration to ocular pigmentation, Am J Ophthalmol, 99, 185, 10.1016/0002-9394(85)90230-2 Wen, 1996, Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage, J Neurosci, 16, 5986, 10.1523/JNEUROSCI.16-19-05986.1996 Wen, 1995, Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina, J Neurosci, 15, 7377, 10.1523/JNEUROSCI.15-11-07377.1995 Weng, 1999, Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice, Cell, 98, 13, 10.1016/S0092-8674(00)80602-9 Wenzel, 2001, The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration, J Neurosci, 21, 53, 10.1523/JNEUROSCI.21-01-00053.2001 Werner, 1989, Loss of human photoreceptor sensitivity associated with chronic exposure to ultraviolet radiation, Ophthalmology, 96, 1552, 10.1016/S0161-6420(89)32693-5 West, 1989, Exposure to sunlight and other risk factors for age-related macular degeneration, Arch Ophthalmol, 107, 875, 10.1001/archopht.1989.01070010897038 White, 1989, Effects of exogenous melatonin on circadian disc shedding in the albino rat retina, Vision Res, 29, 167, 10.1016/0042-6989(89)90122-3 White, 1987, Degree of light damage to the retina varies with time of day of bright light exposure, Physiol Behav, 39, 607, 10.1016/0031-9384(87)90160-0 Wiechmann, 1992, Melatonin increases photoreceptor susceptibility to light-induced damage, Invest Ophthalmol Vis Sci, 33, 1894 Wiegand, 1983, Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina, Invest Ophthalmol Vis Sci, 24, 1433 Wihlmark, 1997, Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation, Free Radic Biol Med, 22, 1229, 10.1016/S0891-5849(96)00555-2 Williams, 1985, Retinal damage in pigmented and albino rats exposed to low levels of cyclic light following a single mydriatic treatment, Curr Eye Res, 4, 97, 10.3109/02713688508999974 Williams, 1983, Action spectrum of retinal light-damage in albino rats, Invest Ophthalmol Vis Sci, 24, 285 Wing, 1978, The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium, Invest Ophthalmol Vis Sci, 17, 601 Winkler B, A quantitative assessment of glucose metablism in the isolated rat retina, in Christen Y, Doly MDroy-Lefaix MT (eds): Les Seminaires Ophthalmologues, Vol. 6. Vision et Adaptation. Paris, Elsevier, 1995, pp 78–96 Witting, 1965, Lipid peroxidation in vivo, J Am Oil Chem Soc, 42, 908, 10.1007/BF02632443 Wolbarsht, 1987, Retinal oxygenation from the choroid in hyperoxia, Exp Biol, 47, 49 Wu, 1999, Failure of ascorbate to protect against broadband blue light-induced retinal damage in rat, Graefes Arch Clin Exp Ophthalmol, 237, 855, 10.1007/s004170050323 Wu, 2002, Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure, Invest Ophthalmol Vis Sci, 43, 3349 Wu, 1999, Blue light induced apoptosis in rat retina, Eye, 13, 577, 10.1038/eye.1999.142 Wyllie, 1980, Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation, Nature, 284, 555, 10.1038/284555a0 Xu, 1997, Prolonged photoresponses in transgenic mouse rods lacking arrestin, Nature, 389, 505, 10.1038/39068 Young, 1988, Solar radiation and age-related macular degeneration, Surv Ophthalmol, 32, 252, 10.1016/0039-6257(88)90174-9 Young, 1976, Visual cells and the concept of renewal, Invest Ophthalmol Vis Sci, 15, 700 Young, 1971, Shedding of discs from rod outer segments in the rhesus monkey, J Ultrastruct Res, 34, 190, 10.1016/S0022-5320(71)90014-1 Zwick, 1978, Long-term changes in spectral sensitivity after low-level laser (514 nm) exposure, Mod Probl Ophthalmol, 19, 319