Immune Signaling by RIG-I-like Receptors

Immunity - Tập 34 - Trang 680-692 - 2011
Yueh-Ming Loo1, Michael Gale1
1Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195-7650, USA

Tài liệu tham khảo

Ablasser, 2009, RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate, Nat. Immunol., 10, 1065, 10.1038/ni.1779 Anz, 2010, Immunostimulatory RNA blocks suppression by regulatory T cells, J. Immunol., 184, 939, 10.4049/jimmunol.0901245 Arimoto, 2007, Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125, Proc. Natl. Acad. Sci. USA, 104, 7500, 10.1073/pnas.0611551104 Arimoto, 2008, UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I, Mol. Immunol., 45, 1078, 10.1016/j.molimm.2007.07.021 Bamming, 2009, Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2, J. Biol. Chem., 284, 9700, 10.1074/jbc.M807365200 Baum, 2010, Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing, Proc. Natl. Acad. Sci. USA, 107, 16303, 10.1073/pnas.1005077107 Betteridge, 2009, Pathogenic mechanisms of disease in myositis: autoantigens as clues, Curr. Opin. Rheumatol., 21, 604, 10.1097/BOR.0b013e328331638a Bhoj, 2008, MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus, Proc. Natl. Acad. Sci. USA, 105, 14046, 10.1073/pnas.0804717105 Biron, 1999, Natural killer cells in antiviral defense: function and regulation by innate cytokines, Annu. Rev. Immunol., 17, 189, 10.1146/annurev.immunol.17.1.189 Castanier, 2010, Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway, EMBO Rep., 11, 133, 10.1038/embor.2009.258 Chen, 2010, Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cells, Cell Cycle, 9, 3552, 10.4161/cc.9.17.12792 Chiu, 2009, RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway, Cell, 138, 576, 10.1016/j.cell.2009.06.015 Choudhary, 2009, Lysine acetylation targets protein complexes and co-regulates major cellular functions, Science, 325, 834, 10.1126/science.1175371 Colli, 2010, MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA, Hum. Mol. Genet., 19, 135, 10.1093/hmg/ddp474 Concannon, 2008, A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3, Diabetes, 57, 2858, 10.2337/db08-0753 Cui, 2008, The C-terminal regulatory domain is the RNA 5′-triphosphate sensor of RIG-I, Mol. Cell, 29, 169, 10.1016/j.molcel.2007.10.032 Cui, 2010, NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways, Cell, 141, 483, 10.1016/j.cell.2010.03.040 Daffis, 2008, Toll-like receptor 3 has a protective role against West Nile virus infection, J. Virol., 82, 10349, 10.1128/JVI.00935-08 Daffis, 2009, Induction of IFN-beta and the innate antiviral response in myeloid cells occurs through an IPS-1-dependent signal that does not require IRF-3 and IRF-7, PLoS Pathog., 5, e1000607, 10.1371/journal.ppat.1000607 Diao, 2007, Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase, Proc. Natl. Acad. Sci. USA, 104, 11706, 10.1073/pnas.0700544104 Dixit, 2010, Peroxisomes are signaling platforms for antiviral innate immunity, Cell, 141, 668, 10.1016/j.cell.2010.04.018 Donnelly, 2010, Interferon-lambda: a new addition to an old family, J. Interferon Cytokine Res., 30, 555, 10.1089/jir.2010.0078 Downes, 2010, Reduced expression of IFIH1 is protective for type 1 diabetes, PLoS ONE, 5, 10.1371/journal.pone.0012646 Fredericksen, 2006, West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and -independent pathways without antagonizing host defense signaling, J. Virol., 80, 2913, 10.1128/JVI.80.6.2913-2923.2006 Fredericksen, 2008, Establishment and maintenance of the innate antiviral response to West Nile Virus involves both RIG-I and MDA5 signaling through IPS-1, J. Virol., 82, 609, 10.1128/JVI.01305-07 Friedman, 2008, The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response, EMBO Rep., 9, 930, 10.1038/embor.2008.136 Funke, 2011, Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in crohn's disease, Inflamm. Bowel Dis., 10.1002/ibd.21572 Gack, 2007, TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity, Nature, 446, 916, 10.1038/nature05732 Gack, 2008, Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction, Proc. Natl. Acad. Sci. USA, 105, 16743, 10.1073/pnas.0804947105 Gao, 2009, REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I, PLoS ONE, 4, e5760, 10.1371/journal.pone.0005760 Gitlin, 2006, Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus, Proc. Natl. Acad. Sci. USA, 103, 8459, 10.1073/pnas.0603082103 Gondai, 2008, Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon, Nucleic Acids Res., 36, e18, 10.1093/nar/gkm1043 Gono, 2010, Clinical manifestation and prognostic factor in anti-melanoma differentiation-associated gene 5 antibody-associated interstitial lung disease as a complication of dermatomyositis, Rheumatology (Oxford), 49, 1713, 10.1093/rheumatology/keq149 Habjan, 2008, Processing of genome 5′ termini as a strategy of negative-strand RNA viruses to avoid RIG-I-dependent interferon induction, PLoS ONE, 3, e2032, 10.1371/journal.pone.0002032 Häcker, 2006, Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6, Nature, 439, 204, 10.1038/nature04369 Hall, 2010, Type I interferons: crucial participants in disease amplification in autoimmunity, Nat Rev Rheumatol, 6, 40, 10.1038/nrrheum.2009.237 Hiscott, 2006, Recruitment of an interferon molecular signaling complex to the mitochondrial membrane: disruption by hepatitis C virus NS3-4A protease, Biochem. Pharmacol., 72, 1477, 10.1016/j.bcp.2006.06.030 Hornung, 2006, 5′-Triphosphate RNA is the ligand for RIG-I, Science, 314, 994, 10.1126/science.1132505 Hu, 2010, A common polymorphism in the caspase recruitment domain of RIG-I modifies the innate immune response of human dendritic cells, J. Immunol., 185, 424, 10.4049/jimmunol.0903291 Huang, 2005, SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways, EMBO J., 24, 4018, 10.1038/sj.emboj.7600863 Ishikawa, 2008, STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling, Nature, 455, 674, 10.1038/nature07317 Jaïdane, 2010, Enteroviruses and type 1 diabetes: towards a better understanding of the relationship, Rev. Med. Virol., 20, 265, 10.1002/rmv.647 Jego, 2003, Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6, Immunity, 19, 225, 10.1016/S1074-7613(03)00208-5 Jia, 2009, Negative regulation of MAVS-mediated innate immune response by PSMA7, J. Immunol., 183, 4241, 10.4049/jimmunol.0901646 Johnsen, 2009, The tyrosine kinase c-Src enhances RIG-I (retinoic acid-inducible gene I)-elicited antiviral signaling, J. Biol. Chem., 284, 19122, 10.1074/jbc.M808233200 Jounai, 2007, The Atg5 Atg12 conjugate associates with innate antiviral immune responses, Proc. Natl. Acad. Sci. USA, 104, 14050, 10.1073/pnas.0704014104 Kang, 2004, Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene, Oncogene, 23, 1789, 10.1038/sj.onc.1207300 Kato, 2005, Cell type-specific involvement of RIG-I in antiviral response, Immunity, 23, 19, 10.1016/j.immuni.2005.04.010 Kato, 2006, Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses, Nature, 441, 101, 10.1038/nature04734 Kato, 2008, Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5, J. Exp. Med., 205, 1601, 10.1084/jem.20080091 Kawai, 2009, The roles of TLRs, RLRs and NLRs in pathogen recognition, Int. Immunol., 21, 317, 10.1093/intimm/dxp017 Kayagaki, 2007, DUBA: a deubiquitinase that regulates type I interferon production, Science, 318, 1628, 10.1126/science.1145918 Kim, 2008, Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation, J. Virol., 82, 1474, 10.1128/JVI.01650-07 Kong, 2008, Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly, J. Virol., 82, 7613, 10.1128/JVI.00618-08 Koop, 2011, Novel splice variants of human IKKɛ negatively regulate IKKɛ-induced IRF3 and NF-kB activation, Eur. J. Immunol., 41, 224, 10.1002/eji.201040814 Koshiba, 2011, Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling, Sci. Signal., 4, ra7, 10.1126/scisignal.2001147 Koyama, 2007, Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination, J. Immunol., 179, 4711, 10.4049/jimmunol.179.7.4711 Kubota, 2008, Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression, J. Biol. Chem., 283, 25660, 10.1074/jbc.M804479200 Kumar, 2006, Essential role of IPS-1 in innate immune responses against RNA viruses, J. Exp. Med., 203, 1795, 10.1084/jem.20060792 Le Bon, 2001, Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo, Immunity, 14, 461, 10.1016/S1074-7613(01)00126-1 Li, 2009, Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5, Arch. Biochem. Biophys., 488, 23, 10.1016/j.abb.2009.06.008 Li, 2009, The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA, J. Biol. Chem., 284, 13881, 10.1074/jbc.M900818200 Li, 2010, Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6, J. Biol. Chem., 285, 4291, 10.1074/jbc.M109.074971 Lin, 2006, Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage, J. Virol., 80, 6072, 10.1128/JVI.02495-05 Lin, 2006, Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20, J. Biol. Chem., 281, 2095, 10.1074/jbc.M510326200 Liu, 2009, IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells, Hum. Mol. Genet., 18, 358, 10.1093/hmg/ddn342 Liu, 2010, Tom70 mediates activation of interferon regulatory factor 3 on mitochondria, Cell Res., 20, 994, 10.1038/cr.2010.103 Loo, 2008, Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity, J. Virol., 82, 335, 10.1128/JVI.01080-07 Lu, 2010, The structural basis of 5′ triphosphate double-stranded RNA recognition by RIG-I C-terminal domain, Structure, 18, 1032, 10.1016/j.str.2010.05.007 Luke, 2011, Coexpressed RIG-I agonist enhances humoral immune response to influenza virus DNA vaccine, J. Virol., 85, 1370, 10.1128/JVI.01250-10 Luthra, 2011, Activation of IFN-β; expression by a viral mRNA through RNase L and MDA5, Proc. Natl. Acad. Sci. USA, 108, 2118, 10.1073/pnas.1012409108 Malathi, 2007, Small self-RNA generated by RNase L amplifies antiviral innate immunity, Nature, 448, 816, 10.1038/nature06042 Malathi, 2010, RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP, RNA, 16, 2108, 10.1261/rna.2244210 Marié, 1998, Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7, EMBO J., 17, 6660, 10.1093/emboj/17.22.6660 Marques, 2006, A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells, Nat. Biotechnol., 24, 559, 10.1038/nbt1205 Mashima, 2005, FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling, J. Biol. Chem., 280, 41289, 10.1074/jbc.M508221200 Mattei, 2010, Regulation of immune cell homeostasis by type I interferons, Cytokine Growth Factor Rev., 21, 227, 10.1016/j.cytogfr.2010.05.002 McCartney, 2008, MDA-5 recognition of a murine norovirus, PLoS Pathog., 4, e1000108, 10.1371/journal.ppat.1000108 McCartney, 2011, RNA sensor-induced type I IFN prevents diabetes caused by a β cell-tropic virus in mice, J. Clin. Invest., 121, 1497, 10.1172/JCI44005 Michallet, 2008, TRADD protein is an essential component of the RIG-like helicase antiviral pathway, Immunity, 28, 651, 10.1016/j.immuni.2008.03.013 Monroe, 2009, Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila, PLoS Pathog., 5, e1000665, 10.1371/journal.ppat.1000665 Moore, 2008, NLRX1 is a regulator of mitochondrial antiviral immunity, Nature, 451, 573, 10.1038/nature06501 Murali, 2008, Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response, J. Biol. Chem., 283, 15825, 10.1074/jbc.M800542200 Nakashima, 2010, The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody, Rheumatology (Oxford), 49, 433, 10.1093/rheumatology/kep375 Nakhaei, 2009, The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation, PLoS Pathog., 5, e1000650, 10.1371/journal.ppat.1000650 Nejentsev, 2009, Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes, Science, 324, 387, 10.1126/science.1167728 Nistal-Villán, 2010, Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production, J. Biol. Chem., 285, 20252, 10.1074/jbc.M109.089912 Oganesyan, 2006, Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response, Nature, 439, 208, 10.1038/nature04374 Ohman, 2009, Actin and RIG-I/MAVS signaling components translocate to mitochondria upon influenza A virus infection of human primary macrophages, J. Immunol., 182, 5682, 10.4049/jimmunol.0803093 Okabe, 2009, Regulation of the innate immune response by threonine-phosphatase of Eyes absent, Nature, 460, 520, 10.1038/nature08138 Onoguchi, 2007, Viral infections activate types I and III interferon genes through a common mechanism, J. Biol. Chem., 282, 7576, 10.1074/jbc.M608618200 Onoguchi, 2010, Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1, PLoS Pathog., 6, e1001012, 10.1371/journal.ppat.1001012 Oshiumi, 2009, Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection, J. Biol. Chem., 284, 807, 10.1074/jbc.M804259200 Oshiumi, 2010, The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection, Cell Host Microbe, 8, 496, 10.1016/j.chom.2010.11.008 Osterlund, 2005, Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells, J. Virol., 79, 9608, 10.1128/JVI.79.15.9608-9617.2005 Ovsyannikova, 2010, Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination, J. Infect. Dis., 201, 207, 10.1086/649588 Panne, 2008, The enhanceosome, Curr. Opin. Struct. Biol., 18, 236, 10.1016/j.sbi.2007.12.002 Paz, 2006, Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway, Cell. Mol. Biol. (Noisy-le-grand), 52, 17 Paz, 2009, Ubiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter, Mol. Cell. Biol., 29, 3401, 10.1128/MCB.00880-08 Paz, 2011, A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response, Cell Res., 10.1038/cr.2011.2 Pichlmair, 2006, RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates, Science, 314, 997, 10.1126/science.1132998 Pichlmair, 2009, Activation of MDA5 requires higher-order RNA structures generated during virus infection, J. Virol., 83, 10761, 10.1128/JVI.00770-09 Pippig, 2009, The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA, Nucleic Acids Res., 37, 2014, 10.1093/nar/gkp059 Plumet, 2007, Cytosolic 5′-triphosphate ended viral leader transcript of measles virus as activator of the RIG I-mediated interferon response, PLoS ONE, 2, e279, 10.1371/journal.pone.0000279 Poeck, 2010, Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production, Nat. Immunol., 11, 63, 10.1038/ni.1824 Pothlichet, 2009, Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response, PLoS ONE, 4, e7582, 10.1371/journal.pone.0007582 Pothlichet, 2011, A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients, EMBO Mol. Med., 3, 142, 10.1002/emmm.201000120 Ranjith-Kumar, 2009, Agonist and antagonist recognition by RIG-I, a cytoplasmic innate immunity receptor, J. Biol. Chem., 284, 1155, 10.1074/jbc.M806219200 Roth-Cross, 2008, Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia, J. Virol., 82, 9829, 10.1128/JVI.01199-08 Ryzhakov, 2007, SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK, EMBO J., 26, 3180, 10.1038/sj.emboj.7601743 Saito, 2007, Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2, Proc. Natl. Acad. Sci. USA, 104, 582, 10.1073/pnas.0606699104 Saito, 2008, Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA, Nature, 454, 523, 10.1038/nature07106 Samanta, 2006, EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN, EMBO J., 25, 4207, 10.1038/sj.emboj.7601314 Sanada, 2008, FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway, J. Biol. Chem., 283, 33858, 10.1074/jbc.M806923200 Sasai, 2006, NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction, J. Immunol., 177, 8676, 10.4049/jimmunol.177.12.8676 Sato, 1998, Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7, FEBS Lett., 441, 106, 10.1016/S0014-5793(98)01514-2 Sato, 2005, Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis, Arthritis Rheum., 52, 1571, 10.1002/art.21023 Sato, 2009, RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease, Arthritis Rheum., 60, 2193, 10.1002/art.24621 Satoh, 2010, LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses, Proc. Natl. Acad. Sci. USA, 107, 1512, 10.1073/pnas.0912986107 Schlee, 2010, The chase for the RIG-I ligand—recent advances, Mol. Ther., 18, 1254, 10.1038/mt.2010.90 Schlee, 2009, Recognition of 5′ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus, Immunity, 31, 25, 10.1016/j.immuni.2009.05.008 Scott, 2010, The role of mitochondria in the mammalian antiviral defense system, Mitochondrion, 10, 316, 10.1016/j.mito.2010.02.005 Shigemoto, 2009, Identification of loss of function mutations in human genes encoding RIG-I and MDA5: implications for resistance to type I diabetes, J. Biol. Chem., 284, 13348, 10.1074/jbc.M809449200 Smyth, 2006, A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region, Nat. Genet., 38, 617, 10.1038/ng1800 Song, 2010, c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response, FEBS Lett., 584, 33, 10.1016/j.febslet.2009.11.025 Stark, 1998, How cells respond to interferons, Annu. Rev. Biochem., 67, 227, 10.1146/annurev.biochem.67.1.227 Sumpter, 2005, Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I, J. Virol., 79, 2689, 10.1128/JVI.79.5.2689-2699.2005 Sun, 2011, Phosphorylation of RIG-I by casein kinase II inhibits its antiviral response, J. Virol., 85, 1036, 10.1128/JVI.01734-10 Suthar, 2010, IPS-1 is essential for the control of West Nile virus infection and immunity, PLoS Pathog., 6, e1000757, 10.1371/journal.ppat.1000757 Szretter, 2009, The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis, J. Virol., 83, 9329, 10.1128/JVI.00836-09 Szretter, 2010, The innate immune adaptor molecule MyD88 restricts West Nile virus replication and spread in neurons of the central nervous system, J. Virol., 84, 12125, 10.1128/JVI.01026-10 Takahasi, 2009, Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors, J. Biol. Chem., 284, 17465, 10.1074/jbc.M109.007179 Takeshita, 2008, The non-canonical role of Atg family members as suppressors of innate antiviral immune signaling, Autophagy, 4, 67, 10.4161/auto.5055 Town, 2009, Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing, Immunity, 30, 242, 10.1016/j.immuni.2008.11.012 Uzri, 2009, Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities, J. Virol., 83, 4174, 10.1128/JVI.02449-08 Venkataraman, 2007, Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses, J. Immunol., 178, 6444, 10.4049/jimmunol.178.10.6444 Vitour, 2009, Polo-like kinase 1 (PLK1) regulates interferon (IFN) induction by MAVS, J. Biol. Chem., 284, 21797, 10.1074/jbc.M109.018275 Wang, 2004, Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis, Nat. Med., 10, 1366, 10.1038/nm1140 Wang, 2007, Rig-I-/- mice develop colitis associated with downregulation of G alpha i2, Cell Res., 17, 858, 10.1038/cr.2007.81 Wang, 2008, RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages, PLoS Pathog., 4, e1000099, 10.1371/journal.ppat.1000099 Wang, 2010, Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I, Nat. Immunol., 11, 912, 10.1038/ni.1933 Welte, 2009, Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection, J. Gen. Virol., 90, 2660, 10.1099/vir.0.011783-0 Yasukawa, 2009, Mitofusin 2 inhibits mitochondrial antiviral signaling, Sci. Signal., 2, ra47, 10.1126/scisignal.2000287 Yoneyama, 2004, The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses, Nat. Immunol., 5, 730, 10.1038/ni1087 Yoneyama, 2005, Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity, J. Immunol., 175, 2851, 10.4049/jimmunol.175.5.2851 Yount, 2007, Cytokine-independent upregulation of MDA5 in viral infection, J. Virol., 81, 7316, 10.1128/JVI.00545-07 Zeng, 2010, Reconstitution of the RIG-I pathway reveals a signaling role of unanchored polyubiquitin chains in innate immunity, Cell, 141, 315, 10.1016/j.cell.2010.03.029 Zhang, 2008, Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD, J. Biol. Chem., 283, 18621, 10.1074/jbc.M801451200 Zhong, 2008, The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation, Immunity, 29, 538, 10.1016/j.immuni.2008.09.003 Zhou, 2010, Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus, J. Virol., 84, 9452, 10.1128/JVI.00155-10