Genetic link between rheumatoid arthritis and autoimmune liver diseases: A two-sample Mendelian randomization study

Ellinghaus, 2022, How genetic risk contributes to autoimmune liver disease, Semin Immunopathol, 44, 397, 10.1007/s00281-022-00950-8 Tanaka, 2019, The genetics of primary biliary cholangitis, Curr Opin Gastroenterol, 35, 93, 10.1097/MOG.0000000000000507 Karlsen, 2017, Primary sclerosing cholangitis - a comprehensive review, J Hepatol, 67, 1298, 10.1016/j.jhep.2017.07.022 Pape, 2019, Clinical management of autoimmune hepatitis, United European Gastroenterol J, 7, 1156, 10.1177/2050640619872408 Wang, 2022, Autoimmune liver diseases in systemic rheumatic diseases, World J Gastroenterol, 28, 2527, 10.3748/wjg.v28.i23.2527 Liu, 2020, Animal Models of Autoimmune Liver Diseases: a Comprehensive Review, Clin Rev Allergy Immunol, 58, 252, 10.1007/s12016-020-08778-6 Wang, 2021, Gut microbiome, liver immunology, and liver diseases, Cell Mol Immunol, 18, 4, 10.1038/s41423-020-00592-6 Archer, 2022, EASL clinical practice guidelines: non-invasive liver tests for evaluation of liver disease severity and prognosis, Frontline Gastroenterol, 13, 436, 10.1136/flgastro-2021-102064 KD, 2021, Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: an Emerging Paradigm Shift, Arthritis Rheumatol, 73, 181, 10.1002/art.41417 Radovanović-Dinić, 2018, Clinical connection between rheumatoid arthritis and liver damage, Rheumatol Int, 38, 715, 10.1007/s00296-018-4021-5 Selmi, 2018, Rheumatic manifestations in autoimmune liver disease, Rheum Dis Clin North Am, 44, 65, 10.1016/j.rdc.2017.09.008 Emdin, 2017, JAMA, 318, 1925, 10.1001/jama.2017.17219 Skrivankova, 2021, Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement, JAMA, 326, 1614, 10.1001/jama.2021.18236 de Boer, 2014, Genome-wide association study identifies variants associated with autoimmune hepatitis type 1, Gastroenterology, 147, 443, 10.1053/j.gastro.2014.04.022 Cordell, 2021, An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs, J Hepatol, 75, 572, 10.1016/j.jhep.2021.04.055 Liu, 2013, Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis, Nat Genet, 45, 670, 10.1038/ng.2616 Qiu, 2021, Rheumatoid arthritis and cardio-cerebrovascular disease: a Mendelian randomization study, Front Genet, 12, 10.3389/fgene.2021.745224 Boef, 2015, Mendelian randomization studies: a review of the approaches used and the quality of reporting, Int J Epidemiol, 44, 496, 10.1093/ije/dyv071 Bowden, 2018, Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the Radial plot and Radial regression, Int J Epidemiol, 47, 1264, 10.1093/ije/dyy101 Burgess, 2020, Guidelines for performing Mendelian randomization investigations, Wellcome Open Res, 4, 186, 10.12688/wellcomeopenres.15555.2 Selmi, 2011, Liver involvement in subjects with rheumatic disease, Arthritis Res Ther, 13, 226, 10.1186/ar3319 Gebreselassie, 2019, Rheumatologic Diseases and the Liver, Clin Liver Dis, 23, 247, 10.1016/j.cld.2018.12.007 Matsumoto, 2000, The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteritis, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver, Liver, 20, 366, 10.1034/j.1600-0676.2000.020005366.x Takahashi, 2010, Clinical features of liver dysfunction in collagen diseases, Hepatol Res, 40, 1092, 10.1111/j.1872-034X.2010.00707.x Marasini, 2001, Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients, Ann Rheum Dis, 60, 1046, 10.1136/ard.60.11.1046 Watt, 2004, Patterns of autoimmunity in primary biliary cirrhosis patients and their families: a population-based cohort study, QJM, 97, 397, 10.1093/qjmed/hch078 Gershwin, 2005, Risk factors and comorbidities in primary biliary cirrhosis: a controlled interview-based study of 1032 patients, Hepatology, 42, 1194, 10.1002/hep.20907 Wang, 2013, Connective tissue diseases in primary biliary cirrhosis: a population-based cohort study, World J Gastroenterol, 19, 5131, 10.3748/wjg.v19.i31.5131 Floreani, 2015, Extrahepatic autoimmune conditions associated with primary biliary cirrhosis, Clin Rev Allergy Immunol, 48, 192, 10.1007/s12016-014-8427-x Efe, 2021, Extrahepatic autoimmune diseases in primary biliary cholangitis: prevalence and significance for clinical presentation and disease outcome, J Gastroenterol Hepatol, 36, 936, 10.1111/jgh.15214 Leuschner, 2003, Primary biliary cirrhosis–presentation and diagnosis, Clin Liver Dis, 7, 741, 10.1016/S1089-3261(03)00101-6 Smyk, 2012, Rheumatoid arthritis and primary biliary cirrhosis: cause, consequence, or coincidence?, Arthritis, 2012, 10.1155/2012/391567 Saarinen, 2000, Increased frequency of autoimmune diseases in patients with primary sclerosing cholangitis, Am J Gastroenterol, 95, 3195, 10.1111/j.1572-0241.2000.03292.x Lamberts, 2011, Immune-mediated diseases in primary sclerosing cholangitis, Dig Liver Dis, 43, 802, 10.1016/j.dld.2011.05.009 Gow, 2001, Primary sclerosing cholangitis associated with rheumatoid arthritis and HLA DR4: is the association a marker of patients with progressive liver disease?, J Hepatol, 34, 631, 10.1016/S0168-8278(00)00060-X Teufel, 2010, Concurrent autoimmune diseases in patients with autoimmune hepatitis, J Clin Gastroenterol, 44, 208, 10.1097/MCG.0b013e3181c74e0d Abe, 2011, Present status of autoimmune hepatitis in Japan: a nationwide survey, J Gastroenterol, 46, 1136, 10.1007/s00535-011-0421-y Wong, 2017, Concurrent extrahepatic autoimmunity in autoimmune hepatitis: implications for diagnosis, clinical course and long-term outcomes, Liver Int, 37, 449, 10.1111/liv.13236 Efe, 2012, Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome and associated extrahepatic autoimmune diseases, Eur J Gastroenterol Hepatol, 24, 531, 10.1097/MEG.0b013e328350f95b Webb, 2016, Using GWAS to identify genetic predisposition in hepatic autoimmunity, J Autoimmun, 66, 25, 10.1016/j.jaut.2015.08.016 Eyre, 2017, The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping, Nat Rev Rheumatol, 13, 421, 10.1038/nrrheum.2017.80 Dedmon, 2020, The genetics of rheumatoid arthritis, Rheumatology (Oxford), 59, 2661, 10.1093/rheumatology/keaa232