Direct inhibitory effect of curcumin on Src and focal adhesion kinase activity

Govindarajan, 1980, Turmeric-chemistry, technology, and quality, Crit. Rev. Food Sci. Nutr., 12, 199, 10.1080/10408398009527278 Leu, 2002, The molecular mechanisms for the antitumorigenic effect of curcumin, Curr. Med. Chem-Anti-Cancer Agent, 2, 357, 10.2174/1568011024606370 Robinson, 2000, The protein tyrosine kinase family of the human genome, Oncogene, 19, 5548, 10.1038/sj.onc.1203957 Biscardi, 1999, c-Src, receptor tyrosine kinases, and human cancer, Adv. Cancer Res., 76, 61, 10.1016/S0065-230X(08)60774-5 Leu, 2003, Functional implication of the interaction between EGF receptor and c-Src, Front Biosci., 8, s28, 10.2741/980 Kanner, 1990, Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases, Proc. Natl. Acad. Sci. U.S.A., 7, 3328, 10.1073/pnas.87.9.3328 Wu, 1991, Identification and characterization of a novel cytoskeleton-associated pp60src substrate, Mol. Cell Biol., 11, 5113, 10.1128/MCB.11.10.5113 Maa, 1992, Identification and characterization of a cytoskeleton-associated, epidermal growth factor sensitive pp60c-src substrate, Oncogene, 7, 2429 McGlade, 1992, Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein tyrosine kinases, Proc. Natl. Acad. Sci. U.S.A., 89, 8869, 10.1073/pnas.89.19.8869 Salcini, 1994, Formation of Shc–Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins, Oncogene, 9, 2827 Wary, 1998, A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth, Cell, 94, 625, 10.1016/S0092-8674(00)81604-9 Parsons, 2000, Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movement, Oncogene, 19, 5606, 10.1038/sj.onc.1203877 Cobb, 1994, Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK, Mol. Cell Biol., 14, 147, 10.1128/MCB.14.1.147 Schaller, 1994, Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src, Mol. Cell Biol., 14, 1680, 10.1128/MCB.14.3.1680 Calalb, 1995, Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases, Mol. Cell Biol., 15, 954, 10.1128/MCB.15.2.954 Maa, 1998, Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576/577 phosphorylation, Biochem. Biophys. Res. Commun., 251, 344, 10.1006/bbrc.1998.9464 Leu, 2002, Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397, Oncogene, 21, 6992, 10.1038/sj.onc.1205904 Schlaepfer, 1994, Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase, Nature, 372, 786, 10.1038/372786a0 Korutla, 1995, Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin, Carcinogenesis, 16, 1741, 10.1093/carcin/16.8.1741 Hong, 1999, Curcumin inhibits tyrosine kinase activity of p185neu and also depletes p185neu, Clin. Cancer Res., 5, 1884 Luttrell, 1988, Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src, Mol. Cell Biol., 8, 497, 10.1128/MCB.8.1.497 Maa, 1999, Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src, Biochim. Biophys. Acta, 1450, 341, 10.1016/S0167-4889(99)00069-5 Wang, 1999, Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis, J. Biol. Chem., 274, 35343, 10.1074/jbc.274.50.35343 Sturgill, 1988, Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II, Nature, 334, 715, 10.1038/334715a0 Payne, 1991, Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase), EMBO J., 10, 885, 10.1002/j.1460-2075.1991.tb08021.x Huang, 1995, Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion, Carcinogenesis, 16, 2493, 10.1093/carcin/16.10.2493 Dinkova-Kostova, 1999, Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes, Carcinogenesis, 20, 911, 10.1093/carcin/20.5.911 Venkatesan, 2000, Structure–activity relationships for the inhibition of lipid peroxidation and the scavenging of free radicals by synthetic symmetrical curcumin analogues, J. Pharm. Pharmacol., 52, 1123, 10.1211/0022357001774886 Marshall, 1995, Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation, Cell, 80, 179, 10.1016/0092-8674(95)90401-8 Huang, 1998, The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells, J. Biol. Chem., 270, 25570 Santibanez, 2000, Genistein and curcumin block TGF-beta 1-induced u-PA expression and migratory and invasive phenotype in mouse epidermal keratinocytes, Nutr. Cancer, 37, 49, 10.1207/S15327914NC3701_6 Mirnics, 2001, Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse, Trends Neurosci., 24, 479, 10.1016/S0166-2236(00)01862-2 Mariadason, 2000, Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer, Cancer Res., 60, 4561 Soni, 1992, Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers, J. Physiol. Pharmacol., 36, 273 Rao, 1995, Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate, Cancer Res., 55, 4311 Owens, 1995, Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors, Cancer Res., 55, 2752 Agochiya, 1999, Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells, Oncogene, 18, 5646, 10.1038/sj.onc.1202957