The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells
Tài liệu tham khảo
American Cancer Society Statistics for 2006 www.cancer.org.
Herzog, 2006, The current treatment of recurrent ovarian cancer, Curr. Oncol. Rep., 8, 448, 10.1007/s11912-006-0074-9
Fraser, 2003, Chemoresistance in human ovarian cancer: the role of apoptotic regulators, Reprod. Biol. Endocrinol., 1, 66, 10.1186/1477-7827-1-66
Kaufmann, 2003, Alterations in the apoptotic machinery and their potential role in anticancer drug resistance, Oncogene, 22, 7414, 10.1038/sj.onc.1206945
Monini, 2004, Antitumour effects of antiretroviral therapy, Nat. Rev., Cancer, 4, 861, 10.1038/nrc1479
Gupta, 2005, HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo, Cancer Res., 65, 8256, 10.1158/0008-5472.CAN-05-1220
Gills, 2007, Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo, Clin. Cancer Res., 13, 5183, 10.1158/1078-0432.CCR-07-0161
Srirangam, 2006, Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer, Clin. Cancer Res., 12, 1883, 10.1158/1078-0432.CCR-05-1167
Sgadari, 2002, HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma, Nat. Med., 8, 225, 10.1038/nm0302-225
Esposito, 2006, Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma, Clin. Cancer Res., 12, 2634, 10.1158/1078-0432.CCR-05-2188
Pore, 2006, Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy, Cancer Res., 66, 9252, 10.1158/0008-5472.CAN-06-1239
Pyrko, 2007, HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress, Cancer Res., 67, 10920, 10.1158/0008-5472.CAN-07-0796
Skehan, 1990, New colorimetric cytotoxicity assay for anticancer-drug screening, J. Natl. Cancer Inst., 82, 1107, 10.1093/jnci/82.13.1107
Yaginuma, 1992, Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines, Cancer Res., 52, 4196
Raff, 1998, Cell suicide for beginners, Nature, 396, 119, 10.1038/24055
Garcia-Calvo, 1999, Purification and catalytic properties of human caspase family members, Cell Death Differ., 6, 362, 10.1038/sj.cdd.4400497
Lorenzo, 2007, Therapeutic potential of AIF-mediated caspase-independent programmed cell death, Drug Resist. Updat., 10, 235, 10.1016/j.drup.2007.11.001
Schonthal, 2008, Endoplasmic reticulum stress and autophagy as targets for cancer therapy, Cancer Lett.
Moenner, 2007, Integrated endoplasmic reticulum stress responses in cancer, Cancer Res., 67, 10631, 10.1158/0008-5472.CAN-07-1705
Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, Embo J., 19, 5720, 10.1093/emboj/19.21.5720
Ha, 1999, Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion, Proc. Natl. Acad. Sci. U. S. A., 96, 13978, 10.1073/pnas.96.24.13978
Moubarak, 2007, Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis, Mol. Cell. Biol., 27, 4844, 10.1128/MCB.02141-06
Hajra, 2008, Defective apoptosis underlies chemoresistance in ovarian cancer, Adv. Exp. Med. Biol., 622, 197, 10.1007/978-0-387-68969-2_16
Yang, 2006, NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines, Br. J. Cancer, 95, 1653, 10.1038/sj.bjc.6603435
Jiang, 2007, HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest, Cancer Res., 67, 1221, 10.1158/0008-5472.CAN-06-3377
Yang, 2005, HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling, Cancer Sci., 96, 425, 10.1111/j.1349-7006.2005.00063.x
Ikezoe, 2004, HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2, Mol. Cancer Ther., 3, 473, 10.1158/1535-7163.473.3.4
Manning, 2007, AKT/PKB signaling: navigating downstream, Cell, 129, 1261, 10.1016/j.cell.2007.06.009
Kim, 2002, Akt: versatile mediator of cell survival and beyond, J. Biochem. Mol. Biol., 35, 106
Murata, 2000, The mechanism of insulin resistance caused by HIV protease inhibitor therapy, J. Biol. Chem., 275, 20251, 10.1074/jbc.C000228200
Kraus, 2008, Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis, Mol. Cancer Ther., 7, 1940, 10.1158/1535-7163.MCT-07-2375
Kondo, 2005, The role of autophagy in cancer development and response to therapy, Nat. Rev., Cancer, 5, 726, 10.1038/nrc1692
Brunner, 2008, Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer, J. Clin. Oncol., 26, 2699, 10.1200/JCO.2007.15.2355