The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells

Gynecologic Oncology - Tập 112 - Trang 623-630 - 2009
Karen McLean1, Natalie A. VanDeVen1, Dorothy R. Sorenson2, Sayeema Daudi1, J. Rebecca Liu1
1Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI (USA)
2Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

Tài liệu tham khảo

American Cancer Society Statistics for 2006 www.cancer.org. Herzog, 2006, The current treatment of recurrent ovarian cancer, Curr. Oncol. Rep., 8, 448, 10.1007/s11912-006-0074-9 Fraser, 2003, Chemoresistance in human ovarian cancer: the role of apoptotic regulators, Reprod. Biol. Endocrinol., 1, 66, 10.1186/1477-7827-1-66 Kaufmann, 2003, Alterations in the apoptotic machinery and their potential role in anticancer drug resistance, Oncogene, 22, 7414, 10.1038/sj.onc.1206945 Monini, 2004, Antitumour effects of antiretroviral therapy, Nat. Rev., Cancer, 4, 861, 10.1038/nrc1479 Gupta, 2005, HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo, Cancer Res., 65, 8256, 10.1158/0008-5472.CAN-05-1220 Gills, 2007, Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo, Clin. Cancer Res., 13, 5183, 10.1158/1078-0432.CCR-07-0161 Srirangam, 2006, Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer, Clin. Cancer Res., 12, 1883, 10.1158/1078-0432.CCR-05-1167 Sgadari, 2002, HIV protease inhibitors are potent anti-angiogenic molecules and promote regression of Kaposi sarcoma, Nat. Med., 8, 225, 10.1038/nm0302-225 Esposito, 2006, Evaluation of antitumoral properties of the protease inhibitor indinavir in a murine model of hepatocarcinoma, Clin. Cancer Res., 12, 2634, 10.1158/1078-0432.CCR-05-2188 Pore, 2006, Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy, Cancer Res., 66, 9252, 10.1158/0008-5472.CAN-06-1239 Pyrko, 2007, HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress, Cancer Res., 67, 10920, 10.1158/0008-5472.CAN-07-0796 Skehan, 1990, New colorimetric cytotoxicity assay for anticancer-drug screening, J. Natl. Cancer Inst., 82, 1107, 10.1093/jnci/82.13.1107 Yaginuma, 1992, Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines, Cancer Res., 52, 4196 Raff, 1998, Cell suicide for beginners, Nature, 396, 119, 10.1038/24055 Garcia-Calvo, 1999, Purification and catalytic properties of human caspase family members, Cell Death Differ., 6, 362, 10.1038/sj.cdd.4400497 Lorenzo, 2007, Therapeutic potential of AIF-mediated caspase-independent programmed cell death, Drug Resist. Updat., 10, 235, 10.1016/j.drup.2007.11.001 Schonthal, 2008, Endoplasmic reticulum stress and autophagy as targets for cancer therapy, Cancer Lett. Moenner, 2007, Integrated endoplasmic reticulum stress responses in cancer, Cancer Res., 67, 10631, 10.1158/0008-5472.CAN-07-1705 Kabeya, 2000, LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing, Embo J., 19, 5720, 10.1093/emboj/19.21.5720 Ha, 1999, Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion, Proc. Natl. Acad. Sci. U. S. A., 96, 13978, 10.1073/pnas.96.24.13978 Moubarak, 2007, Sequential activation of poly(ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis, Mol. Cell. Biol., 27, 4844, 10.1128/MCB.02141-06 Hajra, 2008, Defective apoptosis underlies chemoresistance in ovarian cancer, Adv. Exp. Med. Biol., 622, 197, 10.1007/978-0-387-68969-2_16 Yang, 2006, NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines, Br. J. Cancer, 95, 1653, 10.1038/sj.bjc.6603435 Jiang, 2007, HIV protease inhibitor nelfinavir inhibits growth of human melanoma cells by induction of cell cycle arrest, Cancer Res., 67, 1221, 10.1158/0008-5472.CAN-06-3377 Yang, 2005, HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling, Cancer Sci., 96, 425, 10.1111/j.1349-7006.2005.00063.x Ikezoe, 2004, HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2, Mol. Cancer Ther., 3, 473, 10.1158/1535-7163.473.3.4 Manning, 2007, AKT/PKB signaling: navigating downstream, Cell, 129, 1261, 10.1016/j.cell.2007.06.009 Kim, 2002, Akt: versatile mediator of cell survival and beyond, J. Biochem. Mol. Biol., 35, 106 Murata, 2000, The mechanism of insulin resistance caused by HIV protease inhibitor therapy, J. Biol. Chem., 275, 20251, 10.1074/jbc.C000228200 Kraus, 2008, Ritonavir induces endoplasmic reticulum stress and sensitizes sarcoma cells toward bortezomib-induced apoptosis, Mol. Cancer Ther., 7, 1940, 10.1158/1535-7163.MCT-07-2375 Kondo, 2005, The role of autophagy in cancer development and response to therapy, Nat. Rev., Cancer, 5, 726, 10.1038/nrc1692 Brunner, 2008, Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer, J. Clin. Oncol., 26, 2699, 10.1200/JCO.2007.15.2355