Triamine-type complexes of platinum(II) and their antitumor properties
Tóm tắt
Triamines of platinum(II) (Pt(NH3)2LCl]Cl with a cis-structure (L represents cytosine, cytidine, isocytosine, theobromine, theophylline) and cis- and trans-isomers with theophylline and inosine were synthesized. The coordination formulas were demonstrated by methods of conductometry and long-wave spectroscopy. The coordination of pyrimidines through the N(3) atoms and purines through the N(7) atoms was established by PMR methods. An intensification of the acidic properties of the NH group of the ligands upon coordination with platinum was demonstrated. Cis-triamines have an antitumor effect on solid tumors and leukemias, which permits them to be assigned to a new class of water-soluble cationic monofunctional antitumor complexes of platinum(II).
Tài liệu tham khảo
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