Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis

The Lancet - Tập 377 - Trang 228-241 - 2011
Benedetta Allegranzi1, Sepideh Bagheri Nejad1, Christophe Combescure2, Wilco Graafmans1, Homa Attar1, Liam Donaldson1,3, Didier Pittet1,4
1First Global Patient Safety Challenge, WHO Patient Safety, Geneva, Switzerland
2Division of Clinical Epidemiology, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland
3National Patient Safety Agency, London, UK
4Infection Control Programme, and WHO Collaborating Centre on Patient Safety (Infection Control and Improving Practices), University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland

Tài liệu tham khảo

Burke, 2003, Infection control: a problem for patient safety, N Engl J Med, 348, 651, 10.1056/NEJMhpr020557 Bates, 2009, Global priorities for patient safety research, BMJ, 338, b1775, 10.1136/bmj.b1775 Pittet, 2005, Clean Care is Safer Care: a worldwide priority, Lancet, 366, 1246, 10.1016/S0140-6736(05)67506-X Allegranzi, 2008, Preventing infections acquired during health-care delivery, Lancet, 372, 1719, 10.1016/S0140-6736(08)61715-8 Rosenthal, 2008, The International Nosocomial Infection Control Consortium (INICC): goals and objectives, description of surveillance methods, and operational activities, Am J Infect Control, 36, e1, 10.1016/j.ajic.2008.06.003 Zaidi, 2005, Hospital-acquired neonatal infections in developing countries, Lancet, 365, 1175, 10.1016/S0140-6736(05)71881-X Arabi, 2008, Ventilator-associated pneumonia in adults in developing countries: a systematic review, Int J Infect Dis, 12, 505, 10.1016/j.ijid.2008.02.010 Horan, 2008, CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting, Am J Infect Control, 36, 309, 10.1016/j.ajic.2008.03.002 Thompson, 2002, How should meta-regression analyses be undertaken and interpreted?, Stat Med, 21, 1559, 10.1002/sim.1187 Danchaivijitrmd, 2005, Prevalence and impacts of nosocomial infection in Thailand 2001, J Med Assoc Thai, 88, S1 Danchaivijitr, 1996, Efficacy of hospital infection control in Thailand 1988–1992, J Hosp Infect, 32, 147, 10.1016/S0195-6701(96)90056-0 Danchaivijitr, 1995, The Second Thai National Prevalence Study on Nosocomial Infections 1992, J Med Assoc Thai, 78, S67 Danchaivijitr, 2007, Prevalence of nosocomial infection in Thailand 2006, J Med Assoc Thai, 90, 1524 Danchaivijitr, 1995, A national study on surgical wound infections 1992, J Med Assoc Thai, 78, S73 Izquierdo-Cubas, 2008, National prevalence of nosocomial infections: Cuba 2004, J Hosp Infect, 68, 234, 10.1016/j.jhin.2007.12.006 Leblebicioglu, 2003, Hospital-acquired urinary tract infections in Turkey: a nationwide multicenter point prevalence study, J Hosp Infect, 53, 207, 10.1053/jhin.2002.1362 Danchaivijitr, 2005, Development of quality indicators of nosocomial infection control, J Med Assoc Thai, 88, S75 Avila-Figueroa, 1999, Prevalence of nosocomial infections in children: survey of 21 hospitals in Mexico, Salud Publica Mex, 41, S18 Starling, 1997, Applying the Centers for Disease Control and Prevention and National Nosocomial Surveillance system methods in Brazilian hospitals, Am J Infect Control, 25, 303, 10.1016/S0196-6553(97)90022-5 Rezende, 1998, Prevalence of nosocomial infections in general hospitals in Belo Horizonte, Infect Control Hosp Epidemiol, 19, 872, 10.2307/30141571 Lahsaeizadeh, 2008, Healthcare-associated infection in Shiraz, Iran 2004–2005, J Hosp Infect, 69, 283, 10.1016/j.jhin.2008.05.006 Azzam, 2001, A one-day prevalence survey of hospital-acquired infections in Lebanon, J Hosp Infect, 49, 74, 10.1053/jhin.2001.1043 Dumpis, 2003, Prevalence of nosocomial infections in two Latvian hospitals, Euro Surveill, 8, 73, 10.2807/esm.08.03.00405-en Kasatpibal, 2006, Risk of surgical site infection and efficacy of antibiotic prophylaxis: a cohort study of appendectomy patients in Thailand, BMC Infect Dis, 6, 111, 10.1186/1471-2334-6-111 Kasatpibal, 2005, Standardized incidence rates of surgical site infection: a multicenter study in Thailand, Am J Infect Control, 33, 587, 10.1016/j.ajic.2004.11.012 Kasatpibal, 2006, Impact of surgeon-specific feedback on surgical site infection rates in Thailand, J Hosp Infect, 63, 148, 10.1016/j.jhin.2006.01.023 de Oliveira, 2006, Surgical site infection in patients submitted to digestive surgery: risk prediction and the NNIS risk index, Am J Infect Control, 34, 201, 10.1016/j.ajic.2005.12.011 Arabshahi, 2006, Investigation of risk factors for surgical wound infection among teaching hospitals in Tehran, Int Wound J, 3, 59, 10.1111/j.1742-4801.2006.00176.x Pishori, 2003, Surgical wound infection surveillance in general surgery procedures at a teaching hospital in Pakistan, Am J Infect Control, 31, 296, 10.1067/mic.2003.7 Brown, 2007, Prevalence and predictors of surgical site infection in Tbilisi, Republic of Georgia, J Hosp Infect, 66, 160, 10.1016/j.jhin.2007.03.007 Brown, 2007, Prospective surveillance for surgical site infection in St. Petersburg, Russian Federation, Infect Control Hosp Epidemiol, 28, 319, 10.1086/509849 Yalcin, 1995, Postoperative wound infections, J Hosp Infect, 29, 305, 10.1016/0195-6701(95)90278-3 Tran, 1998, Postoperative hospital-acquired infection in Hungvuong Obstetric and Gynaecological Hospital, Vietnam, J Hosp Infect, 40, 141, 10.1016/S0195-6701(98)90093-7 Ellidokuz, 2003, Hospital-acquired infections in elderly patients: results of a West Anatolian University Hospital surveillance, Arch Gerontol Geriatr, 37, 259, 10.1016/S0167-4943(03)00062-1 Durmaz, 2000, Nosocomial infections in a new medical center, Turkey, Infect Control Hosp Epidemiol, 21, 534, 10.1086/501803 Dridi, 2006, Investigation of the prevalence of nosocomial infection in a Tunisian regional hospital, Sante Publique, 18, 187, 10.3917/spub.062.0187 Kallel, 2005, Prevalence of hospital-acquired infection in a Tunisian hospital, J Hosp Infect, 59, 343, 10.1016/j.jhin.2004.09.015 Pitaksiripan, 1995, Nosocomial infections in Lampang Hospital, J Med Assoc Thai, 78, S53 Dia, 2008, Prevalence of nosocomial infections in a university hospital (Dakar, Senegal), Med Mal Infect, 38, 270, 10.1016/j.medmal.2007.11.001 Jroundi, 2007, Prevalence of hospital-acquired infection in a Moroccan university hospital, Am J Infect Control, 35, 412, 10.1016/j.ajic.2006.06.010 Hughes, 2005, Prevalence of nosocomial infection and antibiotic use at a university medical center in Malaysia, Infect Control Hosp Epidemiol, 26, 100, 10.1086/502494 Faria, 2007, The first prevalence survey of nosocomial infections in the University Hospital Centre ‘Mother Teresa’ of Tirana, Albania, J Hosp Infect, 65, 244, 10.1016/j.jhin.2006.11.007 de Lourdes Garcia-Garcia, 2001, Nosocomial infections in a community hospital in Mexico, Infect Control Hosp Epidemiol, 22, 386, 10.1017/S0195941700075949 Bôas, 2004, Occurrence of hospital infection among interned elderly in a university hospital, Rev Saude Publica, 38, 372 El Rhazi, 2007, Prevalence and risk factors for nosocomial infections in Hassan II University Hospital, Fes, Morocco, East Mediterr Health J, 13, 56 Duerink, 2006, Surveillance of healthcare-associated infections in Indonesian hospitals, J Hosp Infect, 62, 219, 10.1016/j.jhin.2005.08.004 Valinteliene, 1996, Prevalence of hospital-acquired infection in a Lithuanian hospital, J Hosp Infect, 34, 321, 10.1016/S0195-6701(96)90112-7 Metintas, 2004, Prevalence and characteristics of nosocomial infections in a Turkish university hospital, Am J Infect Control, 32, 409, 10.1016/j.ajic.2004.05.001 Ribas, 2003, Comparing hospital infections in the elderly versus younger adults: an experience in a Brazilian University Hospital, Braz J Infect Dis, 7, 210, 10.1590/S1413-86702003000300006 Gosling, 2003, Prevalence of hospital-acquired infections in a tertiary referral hospital in northern Tanzania, Ann Trop Med Parasitol, 97, 69, 10.1179/000349803125002724 Raka, 2006, Prevalence of nosocomial infections in high-risk units in the university clinical center of Kosova, Infect Control Hosp Epidemiol, 27, 421, 10.1086/503387 Wagner, 1997, Hospital-acquired infections among surgical patients in a Brazilian hospital, J Hosp Infect, 35, 277, 10.1016/S0195-6701(97)90221-8 Tinoco, 1997, Epidemiology of nosocomial infections in a second level hospital, Salud Publica Mex, 39, 25, 10.1590/S0036-36341997000100005 Valenzuela-Flores, 2004, Nosocomial infection surveillance: experience at a cardiology hospital in Mexico, Cir Cir, 72, 41 Yalcin, 2003, Nosocomial infections in a Turkish university hospital: a 2-year survey, Infect Control Hosp Epidemiol, 24, 235, 10.1086/503477 Erdinc, 2006, Five-year surveillance of nosocomial infections in Ankara Training and Research Hospital, J Hosp Infect, 64, 391, 10.1016/j.jhin.2006.06.020 Rosenthal, 2004, Effect of education and performance feedback on rates of catheter-associated urinary tract infection in intensive care units in Argentina, Infect Control Hosp Epidemiol, 25, 47, 10.1086/502291 Rosenthal, 2004, Device-associated nosocomial infection rates in intensive care units of Argentina, Infect Control Hosp Epidemiol, 25, 251, 10.1086/502386 Rosenthal, 2003, Nosocomial infections in medical-surgical intensive care units in Argentina: attributable mortality and length of stay, Am J Infect Control, 31, 291, 10.1067/mic.2003.1 Rosenthal, 2006, Impact of an infection control program on rates of ventilator-associated pneumonia in intensive care units in 2 Argentinean hospitals, Am J Infect Control, 34, 58, 10.1016/j.ajic.2005.11.002 Lde, 2008, Ventilator-associated pneumonia in an adult clinical-surgical intensive care unit of a Brazilian university hospital: incidence, risk factors, etiology, and antibiotic resistance, Braz J Infect Dis, 12, 80, 10.1590/S1413-86702008000100017 Salomao, 2008, Device-associated infection rates in intensive care units of Brazilian hospitals: findings of the International Nosocomial Infection Control Consortium, Rev Panam Salud Publica, 24, 195, 10.1590/S1020-49892008000900006 Moreno, 2006, Device-associated infection rate and mortality in intensive care units of 9 Colombian hospitals: findings of the International Nosocomial Infection Control Consortium, Infect Control Hosp Epidemiol, 27, 349, 10.1086/503341 Jaimes, 2007, Incidence and risk factors for ventilator-associated pneumonia in a developing country: where is the difference?, Respir Med, 101, 762, 10.1016/j.rmed.2006.08.008 Mehta, 2007, Device-associated nosocomial infection rates in intensive care units of seven Indian cities: findings of the International Nosocomial Infection Control Consortium (INICC), J Hosp Infect, 67, 168, 10.1016/j.jhin.2007.07.008 Habibi, 2008, Epidemiology of nosocomial infections in medicine intensive care unit at a tertiary care hospital in northern India, Trop Doct, 38, 233, 10.1258/td.2008.070395 Pawar, 2004, Central venous catheter-related blood stream infections: incidence, risk factors, outcome, and associated pathogens, J Cardiothorac Vasc Anesth, 18, 304, 10.1053/j.jvca.2004.03.009 Rakshit, 2005, Incidence, clinical outcome, and risk stratification of ventilator-associated pneumonia: a prospective cohort study, Indian J Crit Care Med, 9, 211, 10.4103/0972-5229.19761 Rosenthal, 2006, Device-associated nosocomial infections in 55 intensive care units of 8 developing countries, Ann Intern Med, 145, 582, 10.7326/0003-4819-145-8-200610170-00007 Rosenthal, 2008, International Nosocomial Infection Control Consortium report, data summary for 2002–2007, issued January 2008, Am J Infect Control, 36, 627, 10.1016/j.ajic.2008.03.003 Askarian, 2006, Nosocomial infection rates following cardiothoracic surgery in Iran, Int J Infect Dis, 10, 185, 10.1016/j.ijid.2005.04.004 Khuri-Bulos, 1999, Nosocomial infections in the intensive care units at a university hospital in a developing country: comparison with National Nosocomial Infections Surveillance intensive care unit rates, Am J Infect Control, 27, 547, 10.1016/S0196-6553(99)70035-0 Kanafani, 2003, Ventilator-associated pneumonia at a tertiary-care center in a developing country: incidence, microbiology, and susceptibility patterns of isolated microorganisms, Infect Control Hosp Epidemiol, 24, 864, 10.1086/502151 Rozaidi, 2001, The incidence of nosocomial infection in the Intensive Care Unit, Hospital Universiti Kebangsaan Malaysia: ICU-acquired nosocomial infection surveillance program 1998–1999, Med J Malaysia, 56, 207 Barba, 2006, Device-associated nosocomial infection rates in intensive care units in four Mexican public hospitals, Am J Infect Control, 34, 244, 10.1016/j.ajic.2005.05.024 Salahuddin, 2004, Reducing ventilator-associated pneumonia rates through a staff education programme, J Hosp Infect, 57, 223, 10.1016/j.jhin.2004.03.002 Noor, 2005, Risk factors associated with development of ventilator associated pneumonia, J Coll Physicians Surg Pak, 15, 92 Cuellar, 2008, Device-associated infection rates and mortality in intensive care units of Peruvian hospitals: findings of the International Nosocomial Infection Control Consortium, Rev Panam Salud Publica, 24, 16, 10.1590/S1020-49892008000700002 Wojkowska-Mach, 2006, Hospital-acquired pneumonia in the intensive care units of Polish hospitals, Infect Control Hosp Epidemiol, 27, 784, 10.1086/504447 Thongpiyapoom, 2004, Device-associated infections and patterns of antimicrobial resistance in a medical-surgical intensive care unit in a university hospital in Thailand, J Med Assoc Thai, 87, 819 Elatrous, 1996, Incidence and risk factors of ventilator-associated pneumonia: a one-year prospective survey, Clin Intensive Care, 7, 276, 10.3109/tcic.7.6.276.281 Inan, 2006, Device-associated nosocomial infection rates in Turkish medical-surgical intensive care units, Infect Control Hosp Epidemiol, 27, 343, 10.1086/503344 Leblebicioglu, 2007, Device-associated hospital-acquired infection rates in Turkish intensive care units: findings of the International Nosocomial Infection Control Consortium (INICC), J Hosp Infect, 65, 251, 10.1016/j.jhin.2006.10.012 Simsek, 2001, Ventilator-associated pneumonias in a cardiothoracic surgery centre postoperative intensive care unit, J Hosp Infect, 47, 321, 10.1053/jhin.2000.0932 Ertugrul, 2006, Ventilator-associated pneumonia in surgical emergency intensive care unit, Saudi Med J, 27, 52 Erdem, 2008, Incidence, etiology, and antibiotic resistance patterns of gram-negative microorganisms isolated from patients with ventilator-associated pneumonia in a medical-surgical intensive care unit of a teaching hospital in istanbul, Turkey (2004–2006), Jpn J Infect Dis, 61, 339 Turgut, 2008, Evaluation of device associated infection rates in intensive care units of Pamukkale University Hospital, Infection, 36, 262, 10.1007/s15010-008-6346-6 Rosenthal, 2005, Reduction in nosocomial infection with improved hand hygiene in intensive care units of a tertiary care hospital in Argentina, Am J Infect Control, 33, 392, 10.1016/j.ajic.2004.08.009 Velasco, 1997, Nosocomial infections in an oncology intensive care unit, Am J Infect Control, 25, 458, 10.1016/S0196-6553(97)90067-5 Agarwal, 2006, Epidemiology, risk factors and outcome of nosocomial infections in a respiratory intensive care unit in North India, J Infect, 53, 98, 10.1016/j.jinf.2005.10.021 Askarian, 2004, Incidence and outcome of nosocomial infections in female burn patients in Shiraz, Iran, Am J Infect Control, 32, 23, 10.1016/j.ajic.2003.03.004 Meric, 2005, Intensive care unit-acquired infections: incidence, risk factors and associated mortality in a Turkish university hospital, Jpn J Infect Dis, 58, 297 Erbay, 2003, Nosocomial infections in intensive care unit in a Turkish university hospital: a 2-year survey, Intensive Care Med, 29, 1482, 10.1007/s00134-003-1788-x Cevik, 2005, Relationship between nosocomial infection and mortality in a neurology intensive care unit in Turkey, J Hosp Infect, 59, 324, 10.1016/j.jhin.2004.10.012 2003, National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2003, issued August 2003, Am J Infect Control, 31, 481, 10.1016/j.ajic.2003.09.002 Edwards, 2009, National Healthcare Safety Network (NHSN) report: data summary for 2006 through 2008, issued December 2009, Am J Infect Control, 37, 783, 10.1016/j.ajic.2009.10.001 Gastmeier, 2006, Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections, J Hosp Infect, 64, 16, 10.1016/j.jhin.2006.04.017 de Gentile, 2001, Nosocomial infections in a children's hospital in Argentina: impact of a unique infection control intervention program, Infect Control Hosp Epidemiol, 22, 762, 10.1086/501859 Cavalcante, 2006, Risk factors for developing nosocomial infections among pediatric patients, Pediatr Infect Dis J, 25, 438, 10.1097/01.inf.0000217377.54597.92 Lopes, 2002, Prospective surveillance applying the national nosocomial infection surveillance methods in a Brazilian pediatric public hospital, Am J Infect Control, 30, 1, 10.1067/mic.2002.117039 Salamati, 2006, Neonatal nosocomial infections in Bahrami Children Hospital, Indian J Pediatr, 73, 197, 10.1007/BF02825479 Malik, 2001, Nosocomial infections in newborns, Indian Pediatr, 38, 68 Díaz-Ramos, 1999, Nosocomial infections: experience at a third-level pediatric hospital, Salud Publica Mex, 41, S12 Onen, 2002, Epidemiology and control of nosocomial infections in paediatric surgery, J Hosp Infect, 52, 166, 10.1053/jhin.2002.1285 Couto, 2007, A 10-year prospective surveillance of nosocomial infections in neonatal intensive care units, Am J Infect Control, 35, 183, 10.1016/j.ajic.2006.06.013 Pessoa-Silva, 2004, Healthcare-associated infections among neonates in Brazil, Infect Control Hosp Epidemiol, 25, 772, 10.1086/502475 Kawagoe, 2001, Risk factors for nosocomial infections in critically ill newborns: a 5-year prospective cohort study, Am J Infect Control, 29, 109, 10.1067/mic.2001.114162 Nagata, 2002, Nosocomial infections in a neonatal intensive care unit: incidence and risk factors, Am J Infect Control, 30, 26, 10.1067/mic.2002.119823 Abramczyk, 2003, Nosocomial infection in a pediatric intensive care unit in a developing country, Braz J Infect Dis, 7, 375, 10.1590/S1413-86702003000600004 Contreras-Cuellar, 2007, Device-associated infections in a Colombian neonatal intensive care unit, Rev Salud Publica (Bogota), 9, 439, 10.1590/S0124-00642007000300012 El-Nawawy, 2006, One year study of bacterial and fungal nosocomial infections among patients in pediatric intensive care unit (PICU) in Alexandria, J Trop Pediatr, 52, 185, 10.1093/tropej/fmi091 Deep, 2004, Clinical and microbiological profile of nosocomial infections in the pediatric intensive care unit (PICU), Indian Pediatr, 41, 1238 Martínez-Aguilar, 2001, Incidence of nosocomial bacteremia and pneumonia in pediatric unit, Salud Publica Mex, 43, 515, 10.1590/S0036-36342001000600001 Petdachai, 2000, Nosocomial pneumonia in a newborn intensive care unit, J Med Assoc Thai, 83, 392 Petdachai, 2004, Ventilator-associated pneumonia in a newborn intensive care unit. Southeast Asian, J Trop Med Public Health, 35, 724 Jaballah, 2007, Epidemiology of hospital-acquired bloodstream infections in a Tunisian pediatric intensive care unit: a 2-year prospective study, Am J Infect Control, 35, 613, 10.1016/j.ajic.2006.09.007 Jaballah, 2006, Epidemiology of nosocomial bacterial infections in a neonatal and pediatric Tunisian intensive care unit, Med Mal Infect, 36, 379 Soleto, 2003, Incidence of surgical-site infections and the validity of the National Nosocomial Infections Surveillance System risk index in a general surgical ward in Santa Cruz, Bolivia, Infect Control Hosp Epidemiol, 24, 26, 10.1086/502111 Oliveira, 2004, Postdischarge surveillance: the impact on surgical site infection incidence in a Brazilian university hospital, Am J Infect Control, 32, 358, 10.1016/j.ajic.2004.02.009 Santos, 1997, Surgical site infection: rates, etiology and resistance patterns to antimicrobials among strains isolated at Rio de Janeiro University Hospital, Infection, 25, 217, 10.1007/BF01713147 Medeiros, 2005, Surgical site infection in a university hospital in northeast Brazil, Braz J Infect Dis, 9, 310, 10.1590/S1413-86702005000400007 Santos, 1997, Incidence surveillance of wound infection in hernia surgery during hospitalization and after discharge in a university hospital, J Hosp Infect, 36, 229, 10.1016/S0195-6701(97)90198-5 Rodríguez, 2005, Prediction scales and infection on surgical sites in 15625 surgeries: 2001–2003, Rev Salud Publica (Bogota), 7, 89 Arias, 2003, Surveillance of surgical site infections: decade of experience at a Colombian tertiary care center, World J Surg, 27, 529, 10.1007/s00268-003-6786-1 Abu-Shady, 1999, Factors affecting hospital-acquired urosurgical infections, Egypt J Microbiol, 34, 629 Kotisso, 1998, Surgical wound infection in a teaching hospital in Ethiopia, East Afr Med J, 75, 402 Taye, 2005, Wound infection in Tikur Anbessa hospital, surgical department, Ethiop Med J, 43, 167 Anvikar, 1999, One year prospective study of 3280 surgical wounds, Indian J Med Microbiol, 17, 129 Bhatia, 2003, Postoperative wound infection in patients undergoing coronary artery bypass graft surgery: a prospective study with evaluation of risk factors, Indian J Med Microbiol, 21, 246, 10.1016/S0255-0857(21)03007-3 Murthy, 1998, Incidence of post operative wound infection and their antibiogram in a teaching and referral hospital, Indian J Med Sci, 52, 553 Razavi, 2005, Abdominal surgical site infections: incidence and risk factors at an Iranian teaching hospital, BMC Surg, 5, 2, 10.1186/1471-2482-5-2 Koigi-Kamau, 2005, Incidence of wound infection after caesarean delivery in a district hospital in central Kenya, East Afr Med J, 82, 357 Raka, 2007, Surgical site infections in an abdominal surgical ward at Kosovo Teaching Hospital, J Infect Dev Countries, 1, 337, 10.3855/jidc.375 Kanafani, 2006, Surgical site infections following spinal surgery at a tertiary care center in Lebanon: incidence, microbiology, and risk factors, Scand J Infect Dis, 38, 589, 10.1080/00365540600606440 Vilar-Compte, 2001, Surgical site infections in ambulatory surgery: a 5-year experience, Am J Infect Control, 29, 99, 10.1067/mic.2001.112241 Vilar-Compte, 1999, Surveillance of surgical wound infections: 18-month experience in the Instituto Nacional de Cancerología, Salud Publica Mex, 41, S44 Porras-Hernandez, 2003, A prospective study of surgical site infections in a pediatric hospital in Mexico City, Am J Infect Control, 31, 302, 10.1067/mic.2003.85 Chadli, 2005, Incidence of surgical wound infections a prospective study in the Rabat Mohamed-V military hospital, Morocco, Med Mal Infect, 35, 218, 10.1016/j.medmal.2005.03.007 Giri, 2008, Surgical site infection and antibiotics use pattern in a tertiary care hospital in Nepal, J Pak Med Assoc, 58, 148 Ameh, 2009, Surgical site infection in children: prospective analysis of the burden and risk factors in a sub-Saharan African setting, Surg Infect (Larchmt), 10, 105, 10.1089/sur.2007.082 Kesah, 2004, Aerobic bacterial nosocomial infections in paediatric surgical patients at a tertiary health institution in Lagos, Nigeria, Niger Postgrad Med J, 11, 4 Sangrasi, 2008, Surgical site infection rate and associated risk factors in elective general surgery at a public sector medical university in Pakistan, Int Wound J, 5, 74, 10.1111/j.1742-481X.2007.00365.x Hernandez, 2005, Incidence of and risk factors for surgical-site infections in a Peruvian hospital, Infect Control Hosp Epidemiol, 26, 473, 10.1086/502570 Maksimovic, 2008, Surgical site infections in orthopedic patients: prospective cohort study, Croat Med J, 49, 58, 10.3325/cmj.2008.1.58 Fehr, 2006, Risk factors for surgical site infection in a Tanzanian district hospital: a challenge for the traditional national nosocomial infections surveillance system index, Infect Control Hosp Epidemiol, 27, 1401, 10.1086/509855 Eriksen, 2003, Surgical-site infections at Kilimanjaro Christian Medical Center, J Hosp Infect, 55, 14, 10.1016/S0195-6701(03)00225-1 Luksamijarulkul, 2006, Nosocomial surgical site infection among Photharam Hospital patients with surgery: incidence, risk factors and development of risk screening form, J Med Assoc Thai, 89, 81 Kasatpibal, 2005, Extra charge and extra length of postoperative stay attributable to surgical site infection in six selected operations, J Med Assoc Thai, 88, 1083 Kehachindawat, 2007, Incidence and time trend of surgical site infection in Ramathibodi Hospital during the years 2003–2005, J Med Assoc Thai, 90, 1356 Kaya, 2006, Risk factors for and effect of a one-year surveillance program on surgical site infection at a university hospital in Turkey, Surg Infect (Larchmt), 7, 519, 10.1089/sur.2006.7.519 Hodges, 1997, Wound infection in a rural hospital: the benefit of a wound management protocol, Trop Doct, 27, 174, 10.1177/004947559702700321 Sohn, 2002, Prevalence of surgical-site infections and patterns of antimicrobial use in a large tertiary-care hospital in Ho Chi Minh City, Vietnam, Infect Control Hosp Epidemiol, 23, 382, 10.1086/502070 Nguyen, 2001, Incidence and predictors of surgical-site infections in Vietnam, Infect Control Hosp Epidemiol, 22, 485, 10.1086/501938 Le, 2006, Microbiology of surgical site infections and associated antimicrobial use among Vietnamese orthopedic and neurosurgical patients, Infect Control Hosp Epidemiol, 27, 855, 10.1086/506400 Le, 2007, Reduction in surgical site infections in neurosurgical patients associated with a bedside hand hygiene program in Vietnam, Infect Control Hosp Epidemiol, 28, 583, 10.1086/516661 Thu, 2005, Incidence of surgical site infections and accompanying risk factors in Vietnamese orthopaedic patients, J Hosp Infect, 60, 360, 10.1016/j.jhin.2005.02.006 Erman, 2005, Risk factors for surgical site infections in neurosurgery patients with antibiotic prophylaxis, Surg Neurol, 63, 107, 10.1016/j.surneu.2004.04.024 Dantas, 2006, Nosocomial infections in renal transplant patients: risk factors and treatment implications associated with urinary tract and surgical site infections, J Hosp Infect, 63, 117, 10.1016/j.jhin.2005.10.018 Sallam, 2005, Device-related nosocomial infection in intensive care units of Alexandria University Students Hospital, East Mediterr Health J, 11, 52 Inan, 2005, Daily antibiotic cost of nosocomial infections in a Turkish university hospital, BMC Infect Dis, 5, 5, 10.1186/1471-2334-5-5 Vosylius, 2003, Intensive care unit acquired infection: a prevalence and impact on morbidity and mortality, Acta Anaesthesiol Scand, 47, 1132, 10.1034/j.1399-6576.2003.00230.x Esen, 2004, Prevalence of nosocomial infections at intensive care units in Turkey: a multicentre 1-day point prevalence study, Scand J Infect Dis, 36, 144, 10.1080/00365540410019156 Oncul, 2002, The evaluation of nosocomial infection during 1-year-period in the burn unit of a training hospital in Istanbul, Turkey, Burns, 28, 738, 10.1016/S0305-4179(02)00106-7 Faria, 2008, First point prevalence survey of nosocomial infections in the intensive care units of a tertiary care hospital in Albania, J Hosp Infect, 69, 95, 10.1016/j.jhin.2008.01.029 de Leon-Rosales, 2000, Prevalence of infections in intensive care units in Mexico: a multicenter study, Crit Care Med, 28, 1316, 10.1097/00003246-200005000-00010 de Macedo, 2006, Nosocomial infections in a Brazilian burn unit, Burns, 32, 477, 10.1016/j.burns.2005.11.012 Danchaivijitr, 2005, Effect of an education program on the prevention of ventilator-associated pneumonia: a multicenter study, J Med Assoc Thai, 88, S36 Klevens, 2007, Estimating health care-associated infections and deaths in US hospitals, 2002, Public Health Rep, 122, 160, 10.1177/003335490712200205 Hajdu, 2007, A point prevalence survey of hospital-acquired infections and antimicrobial use in a paediatric hospital in north-western Russia, J Hosp Infect, 66, 378, 10.1016/j.jhin.2007.04.018 Haynes, 2009, A surgical safety checklist to reduce morbidity and mortality in a global population, N Engl J Med, 360, 491, 10.1056/NEJMsa0810119 Gaynes, 2001, Surgical site infection (SSI) rates in the United States, 1992–1998: the National Nosocomial Infections Surveillance System basic SSI risk index, Clin Infect Dis, 33, S69, 10.1086/321860 Culver, 1991, Surgical wound infection rates by wound class, operative procedure, and patient risk index, Am J Med, 91, S152, 10.1016/0002-9343(91)90361-Z Okeke, 2005, Antimicrobial resistance in developing countries: part I—recent trends and current status, Lancet Infect Dis, 5, 481, 10.1016/S1473-3099(05)70189-4 Allegranzi, 2007, Healthcare-associated infection in developing countries: simple solutions to meet complex challenges, Infect Control Hosp Epidemiol, 28, 1323, 10.1086/521656 Shears, 2007, Poverty and infection in the developing world: healthcare-related infections and infection control in the tropics, J Hosp Infect, 67, 217, 10.1016/j.jhin.2007.08.016 Allegranzi, 2010, Successful implementation of the World Health Organization hand hygiene improvement strategy in a referral hospital in Mali, Africa, Infect Control Hosp Epidemiol, 31, 133, 10.1086/649796 Asare, 2009, Hand hygiene practices in a neonatal intensive care unit in Ghana, J Infect Dev Countries, 3, 352 Picheansathian, 2008, The effectiveness of a promotion programme on hand hygiene compliance and nosocomial infections in a neonatal intensive care unit, Int J Nurs Pract, 14, 315, 10.1111/j.1440-172X.2008.00699.x Saba, 2005, Hand hygiene compliance in a hematology unit, Acta Haematol, 113, 190, 10.1159/000084449 Rosenthal, 2003, Effect of education and performance feedback on handwashing: the benefit of administrative support in Argentinean hospitals, Am J Infect Control, 31, 7, 10.1067/mic.2003.63 Hauri, 2004, The global burden of disease attributable to contaminated injections given in health care settings, Int J Std AIDS, 15, 7, 10.1258/095646204322637182 El Sayed, 2000, Epidemic transmission of human immunodeficiency virus in renal dialysis centers in Egypt, J Infect Dis, 181, 91, 10.1086/315167 Damani, 2007, Simple measures save lives: an approach to infection control in countries with limited resources, J Hosp Infect, 65, 151, 10.1016/S0195-6701(07)60034-6 Nthumba, 2010, Cluster-randomized, crossover trial of the efficacy of plain soap and water versus alcohol-based rub for surgical hand preparation in a rural hospital in Kenya, Br J Surg, 97, 1621, 10.1002/bjs.7213 Higuera, 2005, The effect of process control on the incidence of central venous catheter-associated bloodstream infections and mortality in intensive care units in Mexico, Crit Care Med, 33, 2022, 10.1097/01.CCM.0000178190.89663.E5 Rosenthal, 2003, Effect of an infection control program using education and performance feedback on rates of intravascular device-associated bloodstream infections in intensive care units in Argentina, Am J Infect Control, 31, 405, 10.1067/mic.2003.52 Haley, 1985, The efficacy of infection surveillance and control programs in preventing nosocomial infections in US hospitals, Am J Epidemiol, 121, 182, 10.1093/oxfordjournals.aje.a113990 Longtin, 2010, Patient participation: current knowledge and applicability to patient safety, Mayo Clin Proc, 85, 53, 10.4065/mcp.2009.0248 Uckay, 2008, Ventilator-associated pneumonia as a quality indicator for patient safety?, Clin Infect Dis, 46, 557, 10.1086/526534