Pathology of dysproteinemia: Light chain amyloidosis, non-amyloid immunoglobulin deposition disease, cryoglobulinemia syndromes, and macroglobulinemia of waldenström

Coons, 1942, The demonstration of pneumococcal antigen in tissue by the use of fluorescent antibody, J Immunol, 45, 159, 10.4049/jimmunol.45.3.159 Coons, 1950, Localization of antigen in tissue cells. II. Improvements in a method for the detection of antigen by means of fluorescent antibody, J Exp Med, 91, 1, 10.1084/jem.91.1.1 Mellors, 1956, Analytical pathology. III. New observations on the pathogenesis of glomerulonephritis, lipid nephrosis, periarteritis nodosa, and secondary amyloidosis in man, Am J Pathol, 32, 455 Vazquez, 1956, Immunohistochemical analysis of amyloid by the fluorescence technique, J Exp Med, 104, 727, 10.1084/jem.104.5.727 Vazquez, 1957, Immunohistochemical study of lesions in rheumatic fever, systemic lupus erythematosus, and rheumatoid arthritis, Lab Invest, 6, 205 Sternberger, 1979, The unlabelled antibody peroxidaseantiperoxidase (PAP) method, 109 Hsu, 1984, The use of avidin-biotin-peroxidase complex (ABC) in diagnostic and research pathology, 31 Dixon, 1968, The pathogenesis of glomerulonephritis, Am J Med, 44, 493, 10.1016/0002-9343(68)90050-8 Harist, 1979, Cutaneous immunopathology. The diagnostic use of direct and indirect immunofluorescence Techniques in dermatologic disease, Hum Pathol, 10, 625 Kyle, 1983, Amyloidosis (AL). Clinical and laboratory features in 229 cases, Mayo Clin Proc, 58, 665 Lightfoot, 1985, Cryoglobulinemias and other dysproteinemias, 1337 Gallo, 1982, The kidney in lymphoplasmacytic disorders. Part I, Pathol Annu, 17, 291 Ganeval, 1984, Light chain deposition disease: Its relation with AL type amyloidosis, Kidney Int, 26, 1, 10.1038/ki.1984.126 Brouet, 1974, Biological and clinical significance of cryoglobulins. A report of 86 cases, Am J Med, 57, 775, 10.1016/0002-9343(74)90852-3 Glenner, 1980, Amyloid deposits and amyloidosis. The beta fibrilloses, N Engl J Med, 302, 1283, 10.1056/NEJM198006053022305 Glenner, 1980, Amyloid deposits and amyloidosis. The beta fibrilloses, N Engl J Med, 302, 1333, 10.1056/NEJM198006123022403 Stone, 1975, The clinical spectrum of light chain myeloma. A study of 35 patients with special reference to the occurrence of amyloidosis, Am J Med, 58, 601, 10.1016/0002-9343(75)90496-9 Kyle, 1976, 415 Osserman, 1959, Plasma cell myeloma. II Clinical aspects, N Engl J Med, 261, 952, 10.1056/NEJM195911052611906 McAllister, 1967, Primary macroglobulinemia. Review with a report on 36 cases and notes on the value of continuous chlorambucil therapy, Am J Med, 43, 394, 10.1016/0002-9343(67)90195-7 Gallo, 1986, Characterization of tissue amyloid by immunofluorescence microscopy, Clin Immunol Immunopathol, 39, 479, 10.1016/0090-1229(86)90175-3 Verroust, 1982, Renal lesions in dysproteinemia, Springer Semin Immunopathol, 5, 333, 10.1007/BF01892092 Seligmann, 1973, Antibody activity of human myeloma globulins, Semin Hematol, 10, 163 Danon, 1983, Thirty six human monoclonal immunoglobulins with antibody activity against cytoskeletal proteins, thyroglobulin, and native DNA: Immunologic studies and clinical correlations, Blood, 62, 264, 10.1182/blood.V62.2.264.264 Wagner, 1971, M components with antibody activity: Smooth muscle antibodies, antithyroglobulin, and antistreptolysin in 5 monoclonal sera, Ann Clin Res, 3, 86 Merlini, 1986, Monoclonal immunoglobulins with antibody activity in myeloma, macroglobulinemia and related plasma cell dyscrasias, Semin Oncol, 13, 350 Schleiden, 1838, Einige Bermerkungen über den vegetabilischen Faserstoff und sein Verhältnis zum Stärkemehl. Series 2, Ann Physik, 43, 391, 10.1002/andp.18381190218 Aterman, 1976, A historical note on the iodine-sulphuric acid reaction of amyloid, Histochemistry, 49, 131, 10.1007/BF00495677 Franklin, 1979, Some unsolved problems in the amyloid diseases, Am J Med, 66, 365, 10.1016/0002-9343(79)91050-7 Gorevic, 1981, Amyloidosis, Annu Rev Med, 32, 261, 10.1146/annurev.me.32.020181.001401 Kisilevsky, 1983, Amyloidosis. A familiar problem in the light of current pathogenetic developments, Lab Invest, 49, 381 Cohen, 1987, The pathogenesis and biochemistry of amyloidosis, J Pathol, 151, 1, 10.1002/path.1711510102 Husby, 1986, Chemical and clinical classification of amyloidosis in 1985, Scand J Immunol, 23, 253, 10.1111/j.1365-3083.1986.tb01966.x Glenner, 1971, Amyloid proteins: Proof of homology with immunoglobulin light chains by sequence analysis, Science, 172, 1150, 10.1126/science.172.3988.1150 Dalakas, 1984, Nature of amyloid deposits in hypernephroma. Immunocytochemical studies in 2 cases associated with amyloid polyneuropathy, Am J Pathol, 116, 447 Pras, 1982, Amyloidosis associated with renal cell carcinoma of the AA type, Am J Med, 73, 426, 10.1016/0002-9343(82)90747-1 Ikeda, 1987, Hereditary generalized amyloidosis with polyneuropathy, Brain, 110, 315, 10.1093/brain/110.2.315 Dalakas, 1986, Characterization of amyloid deposits in biopsies of 15 patients with sporadic (non-familial or plasma cell dyscrasia) amyloid polyneuropathy, Acta Neuropathol (Berl), 69, 66, 10.1007/BF00687040 Kyle, 1978, Monoclonal gammopathy of undetermined significance. Natural history of 241 cases, Am J Med, 64, 814, 10.1016/0002-9343(78)90522-3 Williams, 1966, Light-chain disease: An abortive variant of multiple myeloma, Ann Intern Med, 65, 471, 10.7326/0003-4819-65-3-471 Frangione, 1973, Heavy chain diseases: Clinical features and molecular significance of the disordered immunoglobulin structure, Semin Hematol, 10, 53 Seligmann, 1979, Heavy chain diseases. Current findings and concepts, Immunol Rev, 48, 145, 10.1111/j.1600-065X.1979.tb00302.x Ockenhuizen, 1985, Immunoglobulin allotypes are not involved in systemic amyloidosis, J Rheumatol, 12, 742 Isobe, 1974, Patterns of amyloidosis and their association with plasma cell dyscrasia, monoclonal immunoglobulin, and Bence Jones proteins, N Eng J Med, 290, 473, 10.1056/NEJM197402282900902 Solomon, 1982, Bence Jones proteins and light chains of immunoglobulins. Preferrential association of the lambda VI subgroup of human light chains with amyloidosis AL, J Clin Invest, 70, 453, 10.1172/JCI110635 Solomon, 1986, Light chain subgroups of monoclonal immunoglobulins in amyloidosis AL, 449 Buxbaum, 1979, Amoloidosis of the AL type. Clinical, morphologic, and biochemical aspects of the response to therapy with alkylating agents and prednisone, Am J Med, 67, 867, 10.1016/0002-9343(79)90747-2 Husby, 1981, Characterization of an amyloid fibril protein from localized amyloidosis of the skin as lambda immunoglobulin light chains of variable subgroup I (A1I), Clin Exp Immunol, 45, 90 Cohen, 1983, Characterization of amyloid deposits and P component from a patient with factor X deficiency reveals protein derived from a lambda VI light chain, Am J Med, 74, 513, 10.1016/0002-9343(83)91000-8 Dwulet, 1985, Amino acid sequence of a lambda VI primary (AL) amyloid protein (WLT), Scand J Immunol, 22, 653, 10.1111/j.1365-3083.1985.tb01927.x Gertz, 1985, Isolation and characterization of a K amyloid fibril protein, Scand J Immunol, 22, 245, 10.1111/j.1365-3083.1985.tb01877.x Dwulet, 1986, Polymorphism in a kappa I primary (AL) amyloid protein (BAN), Mol Immunol, 23, 73, 10.1016/0161-5890(86)90173-2 Picken, 1986, Characterization of renal amyloid derived from the variable region of the lambda light chain subgroup II, Am J Pathol, 124, 82 Kitajima, 1986, Nodular primary cutaneous amyloidosis. Isolation and characterization of amyloid fibrils, Arch Dermatol, 122, 1425, 10.1001/archderm.122.12.1425 Samuels, 1986, Case records of the Massachusetts General Hospital, Case 26-1986, N Engl J Med, 315, 45 Doriguzzi, 1987, Early sarcolemmal dysfunction in skeletal muscle amyloidosis, J Neurol, 234, 52, 10.1007/BF00314010 Dikman, 1981, Morphologic and clinical correlates in renal amyloidosis, Hum Pathol, 12, 160, 10.1016/S0046-8177(81)80103-7 Tornroth, 1985, Renal pathology in amyloidosis, Scand J Urol Nephrol, 19, 9 daCosta, 1985, Amyloidosis localized to the lower respiratory tract; probable immunoamyloid nature of the tracheobronchial and nodular pulmonary forms, Histopathology, 9, 703, 10.1111/j.1365-2559.1985.tb02856.x Page, 1972, Immunoglobulin origin of localized nodular pulmonary amyloidosis, Res Exp Med, 159, 75, 10.1007/BF01856034 Hui, 1986, Amyloidosis presenting in the lower respiratory tract, Arch Pathol Lab Med, 110, 212 Cordier, 1986, Amyloidosis of the lower respiratory tract. Clinical and pathologic features in a series of 21 patients, Chest, 90, 827, 10.1378/chest.90.6.827 Yamada, 1985, Gastrointestinal amyloid deposition in AL (primary or myeloma-associated) and AA (secondary) amyloidosis: Diagnostic value of gastric biopsy, Hum Pathol, 16, 1206, 10.1016/S0046-8177(85)80032-0 Libbey, 1983, Use of abdominal fat tissue aspirate in the diagnosis of systemic amyloidosis, Arch Intern Med, 143, 1549, 10.1001/archinte.143.8.1549 Orfila, 1986, Abdominal fat tissue aspirate in human amyloidosis: Light, electron, and immunofluorescence microscopic studies, Hum Pathol, 17, 366, 10.1016/S0046-8177(86)80459-2 Kelly, 1981, The spectrum of peripheral neuropathy in myeloma, Neurology, 31, 24, 10.1212/WNL.31.1.24 Spechler, 1985, Case records of the Massachusetts General Hospital, Case 43-1985, N Engl J Med, 313, 1070 Besinger, 1981, Myeloma neuropathy: Passive transfer from man to mouse, Science, 213, 1027, 10.1126/science.7268405 Shirahama, 1985, Widespread occurrence of AP in amyloidotic tissues. An immunohistochemical observation, Virchows Arch, 48, 197, 10.1007/BF02890128 Snow, 1987, Sulfated glycosaminoglycans: A common constituent of all amyloids?, Lab Invest, 56, 120 Bonsib, 1986, Acellular scanning electron microscopy of spicular renal amyloidosis, Ultrastruct Pathol, 10, 497, 10.3109/01913128609007207 Romhanyi, 1972, Differences in ultrastructural organization of amyloid as revealed by sensitivity or resistance to induced proteolysis, Virchows Arch, 357, 29, 10.1007/BF00548215 Wright, 1977, Potassium permanganate reaction in amyloidosis, Lab Invest, 36, 274 Kosma, 1985, Reproducibility of morphometric measurements of amyloid after various staining methods, Anal Quant Cytol Histol, 7, 267 Tashima, 1986, Histochemical classification of systemic amyloid fibril proteins. Alkaline Guanidine method, Arch Pathol Lab Med, 110, 885 Husby, 1972, Immunological characterization of amyloid fibrils in tissue sections, Clin Exp Immunol, 11, 357 Cornwell, 1977, Identification and characterization of different amyloid fibril proteins in tissue sections, Scand J Immunol, 6, 1071, 10.1111/j.1365-3083.1977.tb00344.x Fujihara, 1980, Identification and classification of amyloid in formalin-fixed paraffin-embedded tissue sections by the unlabeled immunoperoxidase method, Lab Invest, 43, 358 Fujihara, 1981, Primary localized amyloid in the genitourinary tract, Lab Invest, 44, 55 Van der Kaa, 1986, Diagnosis of the type of amyloid in paraffin wax embedded tissue sections using antisera against human and animal amyloid proteins, Virchows Arch, 408, 649, 10.1007/BF00705343 Newland, 1986, Amyloid deposits in lymph nodes. A morphologic and immunohistochemical study, Human Pathol, 17, 1245, 10.1016/S0046-8177(86)80568-8 Shirahama, 1980, Immunocychemical identification of amyloid in formalin-fixed paraffin sections, Histochemistry, 72, 161, 10.1007/BF00517130 Shtrasburg, 1982, Demonstration of AA protein in formalin-fixed paraffin-embedded tissue, Am J Pathol, 106, 141 Looi, 1986, An investigation of the protein components of amyloid using immunoperoxidase and permanganate methods on tissue sections, Pathology, 18, 137, 10.3109/00313028609090841 Yokota, 1987, Moncolonal antibodies against synthesized short peptides corresponding to human AA amyloid protein, Acta Pathol Jpn, 37, 1135 Orfila, 1983, Immunofluorescence study of “non-idiopathic” renal amyloidosis, Hum Pathol, 14, 362, 10.1016/S0046-8177(83)80123-3 Jerath, 1980, Immunofluorescence findings in human renal amyloidosis, Am J Clin Pathol, 74, 630, 10.1093/ajcp/74.5.630 Noel, 1987, Immunohistochemical characterization of renal amyloidosis, Am J Clin Pathol, 87, 756, 10.1093/ajcp/87.6.756 Silverman, 1986, Localized primary (AL) amyloid tumor of the breast, Am J Surg Pathol, 10, 539, 10.1097/00000478-198608000-00003 Shirahama, 1967, High resolution electron microscopic analysis of the amyloid fibril, J Cell Biol, 33, 679, 10.1083/jcb.33.3.679 Glenner, 1976, Amyloid, amyloidosis, and amyloidogenesis, Int Rev Exp Pathol, 15, 2 Bourgeois, 1987, Ultrastructural appearance of amyloid, Ultrastruct Pathol, 11, 67, 10.3109/01913128709023185 Feiner, 1977, Ultrastructure of glomerulonephritis associated with cryoglobulinemia. Report of 6 cases and review of the literature, Am J Pathol, 77, 145 Silvers, 1987, Immunoglobulin light chains in nodular glomerulosclerosis: Immunoelectron microscopic quantitation, Lab Invest, 56, 73A Randall, 1976, Manifestations of systemic light chain deposition, Am J Med, 60, 293, 10.1016/0002-9343(76)90440-X Gallo, 1980, Nodular glomerulopathy associated with nonamyloidotic kappa light chain deposits and excess immunoglobulin light chain synthesis, Am J Pathol, 99, 621 Beaufils, 1978, Pathogenesis of renal disease in monoclonal gammopathies: Current concepts, Nephron, 20, 125, 10.1159/000181210 Antonovych, 1973, Light chain deposits in multiple myeloma Droz, 1984, Liver Involvement in non-amyloid light chain deposition disease, Lab Invest, 50, 683 Briefel, 1983, Renal transplantation in a patient with multiple myeloma and light chain nephropathy, Surgery, 93, 579 Gipstein, 1982, Kappa light chain nephropathy without evidence of myeloma cells, Am J Nephrol, 2, 276, 10.1159/000166661 Glassock, 1981, Nephrotic syndrome in a 52 year old woman with monoclonal gammopathy, Am J Nephrol, 1, 199, 10.1159/000166540 Tange, 1985, Glomerulosclerosis in multiple myeloma, Acta Pathol Jpn, 118, 298 Noël, 1978, Glomerulosclerose nodulaire du myeloma, L16 Seymour, 1980, Kappa light chain glomerulosclerosis in multiple myeloma, Am J Pathol, 101, 557 Tubbs, 1981, Light chain nephropathy, Am J Med, 71, 263, 10.1016/0002-9343(81)90127-3 Lindner, 1983, Systemic kappa chain deposition: An ultrastructural and immunohistochemical study, Am J Surg Pathol, 7, 85, 10.1097/00000478-198301000-00009 Morinaga, 1987, Plasmacytoma of the lung associated with nodular deposits of immunoglobulin, Am J Surg Pathol, 11, 989, 10.1097/00000478-198712000-00010 Elfenbein, 1978, Nodular mesangial lesions and nephrotic syndrome in multiple myeloma without amyloidosis, Kidney Int, 14, 710 Silva, 1980, Proliferative glomerulopathy in multiple myeloma, J Pathol, 130, 229, 10.1002/path.1711300404 Silva, 1980, Light chain glomerulonephropathy (GN) as the first manifestation of plasma cell dyscrasia (PCD), Lab Invest, 42, 151 Schwartz, 1980, The quarterly case: Nephrotic syndrome in a middle-aged man, Ultrastruct Pathol, 1, 575, 10.3109/01913128009140563 Cohen, 1981, Case records of Massachusetts General Hospital Case 1-1981, N Engl J Med, 304, 33 Lapenas, 1983, Crescentic light chain glomerulopathy. A case report, Arch Pathol Lab Med, 107, 319 Knobler, 1983, Multiple myeloma presenting as dense deposit disease. Light chain nephropathy, Nephron, 34, 58, 10.1159/000182980 King, 1978, Granular dense deposit disease, Lab Invest, 39, 591 Rao, 1978, Membranoproliferative glomerulonephritis (MPGN), an unusual manifestation of multiple myeloma (MM), Kidney Int, 14, 659 Herf, 1979, An evaluation of diabetic and pseudodiabetic glomerulosclerosis, Am J Med, 66, 1040, 10.1016/0002-9343(79)90462-5 Kobernick, 1957, Renal glomeruli in multiple myeloma, Lab Invest, 6, 478 Cauchie, 1962, Les manifestations renales des dysglobulinemies: Rapports introductifs: Les manifestations renales du myeloma. Societe du Nephrologie, J Urol Nephrol, 68, 41 Sølling, 1973, Multiple myeloma with urinary excretion of heavy chain components of IgG and nodular glomerulosclerosis, Acta Med Scand, 194, 23, 10.1111/j.0954-6820.1973.tb19409.x Olsen, 1972, Mesangial thickening and nodular glomerular sclerosis in diabetes melitus and other diseases, Acta Pathol Microbiol Scand, 80, 203 Schubert, 1974, Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma, J Clin Pathol, 27, 800, 10.1136/jcp.27.10.800 Zlotnick, 1975, Renal pathologic findings associated with monoclonal gammopathies, Arch Intern Med, 135, 40, 10.1001/archinte.135.1.40 Mallick, 1978, Detection, significance, and treatment of paraprotein in patients presenting with “idiopathic” proteinuria without myeloma, Q J Med, 47, 145 Preud'homme, 1980, Synthesis of abnormal immunoglobulins in lymphoplasmacytic disorders with visceral light chain deposition, Am J Med, 69, 703, 10.1016/0002-9343(80)90421-0 Ganeval, 1981, Systemic lambda light chain deposition in a patient with myeloma, Br J Med, 282, 681, 10.1136/bmj.282.6265.681 Gerlag, 1986, Renal transplantation in light chain nephropathy: Case report and review of the literature, Clin Nephrol, 25, 101 Preud'homme, 1980, Synthesis of abnormal heavy and light chains in multiple myeloma with visceral deposition of monoclonal immunoglobulins, Clin Exp Immunol, 42, 545 Maury, 1984, Massive cutaneous hyalinosis. Identification of the hyaline material as monoclonal kappa light chains, adhesive 90 kD glycoprotein and type I collagen, Am J Clin Pathol, 82, 543, 10.1093/ajcp/82.5.543 Sinnaih, 1985, Glomerular capillary aneurysms in light chain nephropathy. An ultrastructural proposal of pathogenesis, Am J Pathol, 118, 298 Ganeval, 1982, Light chain nephropathy. Clinical spectrum and present pathophysiological concepts, Adv Nephrol, 11, 25 Palant, 1986, Nodular glomerulosclerosis associated with myeloma. Role of light chain isoelectric point, Am J Med, 80, 98, 10.1016/0002-9343(86)90055-0 Bangerter, 1987, Kappa light chain nephropathy. A pathologic study, Virchows Arch, 410, 531 Melcion, 1984, Renal failure in myeloma: Relationship with isoelectric point of immunoglobulin light chains, Clin Nephrol, 22, 138 Bruneval, 1985, Glomerular matrix proteins in nodular glomerulosclerosis in association with light chain deposition disease and diabetes mellitus, Hum Pathol, 16, 477, 10.1016/S0046-8177(85)80086-1 Preud'homme, 1980, Human lymphoplasmacytic proliferations with production of structurally abnormal immunoglobulins, 331 Feiner, 1983, Tissue manifestations of dysglobulinemia in lymphoplasmacytic dyscrasias, Lab Invest, 48, 24a Kiprov, 1984, Polymyositis associated with monoclonal gammopathy, Lancet, 2, 1183, 10.1016/S0140-6736(84)92744-2 Hsu, 1979, Glomerular microfibrils in renal disease. A comparative electron microsopic study, Kidney Int, 16, 497, 10.1038/ki.1979.155 Sturgill, 1985, Congo Rednegative amyloidosis-like glomerulopathy, Hum Pathol, 16, 220, 10.1016/S0046-8177(85)80005-8 Alpers, 1984, Light chain glomerulopathy with amyloid-like deposits, Hum Pathol, 15, 444, 10.1016/S0046-8177(84)80078-7 Herrera, 1986, Ultrastructural immunolabeling in the diagnosis of light chain-related renal disease, Pathol Immunopathol Res, 5, 170, 10.1159/000157010 Silver, 1986, Renal and systemic kappa light chain deposits and their plasma cell origin identified by immunoelectron microscopy, Am J Pathol, 122, 17 Buxbaum, 1986, Aberrant immunoglobulin synthesis in light chain amyloidosis. Free light chain and light chain fragment production by human bone marrow cells in short term tissue culture, J Clin Immunol, 78, 798 Pasternack, 1986, Renal transplantation in 45 patients with amyloidosis, Transplantation, 42, 598, 10.1097/00007890-198612000-00005 Camoriano, 1987, Resolution of acquired factor X deficiency and amyloidosis with Melphalan and prednisone therapy, N Engl J Med, 316, 1133, 10.1056/NEJM198704303161806 Hoffmann-Guilane, 1985, Association of light chain deposition disease and amyloidosis, Pathol Res Pract, 180, 214, 10.1016/S0344-0338(85)80177-1 Jacquot, 1985, Association of systemic light chain deposition disease and amyloidosis: A report of three patients with renal involvement, Clin Nephrol, 24, 93 Smith, 1986, Simultaneous AL-type amyloid and light chain deposit disease in a liver biopsy: A case report, Histopathology, 10, 1057, 10.1111/j.1365-2559.1986.tb02542.x Kirkpatrick, 1986, Systemic kappa light chain deposition in amyloidosis and multiple myeloma: Novel morphological observations, Histopathology, 11, 1065, 10.1111/j.1365-2559.1986.tb02543.x Husby, 1986, Amyloid proteins, 23 Sletten, 1986, CArbohydrate containing AL protein, 35 Meltzer, 1966, Cryoglobulinemia: A clinical and laboratory study, Am J Med, 40, 836, 10.1016/0002-9343(66)90200-2 Meltzer, 1966, Cryoglobulinemia. A study of 29 patients. I. IgG and IgM cryoglobulins and factors affecting cryoprecipitability, Am J Med, 40, 828, 10.1016/0002-9343(66)90199-9 Grey, 1973, Cryoimmunoglobulins, Semin Hematol, 10, 87 Gorevic, 1980, Mixed cryoglobulinemia: Clinical aspects and long term followup of 40 patients, Am J Med, 69, 287, 10.1016/0002-9343(80)90390-3 McIntosh, 1970, Cryoglobulins. I. Studies on the nature, incidence, and clinical significance of serum cryoproteins in glomerulonephritis, J Lab Clin Med, 75, 566 Christian, 1963, Systemic lupus erythematosus: Cryoprecipitation of sera, J Clin Invest, 42, 823, 10.1172/JCI104774 Brandau, 1986, The temperature dependent stoichiometry of mixed cryoimmunoglobulins, J Biol Chem, 261, 16385, 10.1016/S0021-9258(18)66577-9 Cordonier, 1975, Mixed IgG-IgM cryoglobulinemia with glomerulonephritis, Am J Med, 59, 867, 10.1016/0002-9343(75)90480-5 Stoebner, 1979, Ultrastructural study of human IgG and IgG-IgM crystal cryoglobulins, Am J Clin Pathol, 71, 404, 10.1093/ajcp/71.4.404 Jacquot, 1987, Glomerulonephritis, B monoclonal small lymphocytic lymphoma, and mixed cryoglobulinemia, Clin Nephrol, 27, 263 Farragiana, 1979, Light and electron microscopic findings in five cases of cryoglobulinemia glomerulonephritis, Virchow Arch, 384, 29, 10.1007/BF00427149 Feiner, 1983, Relationship of tissue deposits of cryoglobulin to clinical features of mixed cryoglobulinemia, Hum Pathol, 14, 710, 10.1016/S0046-8177(83)80144-0 Gabrielli, 1987, Evidence of immune deposits and of basement membrane alterations in dermal vessels of normal skin of patients with essential mixed cryoglobulinemia, Arthritis Rheum, 30, 884, 10.1002/art.1780300807 Cream, 1971, Immunofluorescent studies of the skin in cryoglobulinemic vasculitis, J Dermatol, 84, 48, 10.1111/j.1365-2133.1971.tb14196.x Adam, 1973, Cryoglobulins in glomerulonephritis not related to systemic disease, Kidney Int, 3, 334, 10.1038/ki.1973.52 Ben Bassat, 1983, The clinicopathologic features of cryoglobulinemic nephropathy, Am J Clin Pathol, 79, 147, 10.1093/ajcp/79.2.147 Zimmerman, 1976, Nephropathy and mixed cryoglobulinemia. Evidence for an immune complex pathogenesis, Nephron, 16, 103, 10.1159/000180591 Weber, 1985, Rapidly progressive glomerulonephritis in IgA/G cryoglobulinemia, Nephron, 41, 248, 10.1159/000183593 Verroust, 1971, Glomerular lesions in monoclonal gammopathies and mixed essential cryoglobulinemia IgG-IgM, Adv Nephrol, 1, 161 Mazzucco, 1985, Essential mixed cryoglobulinemia associated with diabetic glomerulosclerosis, Arch Pathol Lab Med, 109, 1036 Farivar, 1976, Cryoprotein complexes and peripheral neuropathy in a patient with chronic active hepatitis, Gastrointerology, 71, 490, 10.1016/S0016-5085(76)80461-1 Vallat, 1981, Cryoglobulinemic neuropathy. Ultrastructural study of the nerve capillaries, Acta Neuropathol, 7, 252, 10.1007/978-3-642-81553-9_74 Levo, 1977, Association between hepatitis B virus and essential mixed cryoglobulinemia, N Engl J Med, 296, 1501, 10.1056/NEJM197706302962605 Utsinger, 1980, Systemic immune complex disease following intestinal bypass surgery: Bypass disease, J Am Acad Dermatol, 2, 488, 10.1016/S0190-9622(80)80149-6 Gamble, 1978, The immunopathogenesis of glomerulonephritis associated with mixed cryoglobulinemia, N Engl J Med, 299, 81, 10.1056/NEJM197807132990206 Seigneurin, 1980, Monoclonal cryoimmunoglobulin with anticytomegalovirus activity associated with T cell chronic lymphocytic leukemia, Clin Exp Immunol, 41, 317 Druet, 1969, Cryoglobulinemia in human renal disease: A study of 76 cases, clin Exp Immunol, 15, 483 Monga, 1976, Glomerular findings in mixed IgG-IgM cryoglobulinemia, Virchows Arch, 20, 185 Mazzuco, 1986, Cell interposition in glomerular capillary walls in cryoglobulinemic glomerulonephritis. Ultrastructural investigation of 23 cases, Ultrastruct Pathol, 10, 355, 10.3109/01913128609064200 Chejfec, 1981, Respiratory insufficiency in a patient with mixed cryoglobulinemia, Ultrastruct Pathol, 2, 295, 10.3109/01913128109048313 Fitzgerald, 1987, Sjogrens syndrome, vasculitis & cryoglobulinemia associated with a monoclonal IgM (kappa) paraprotein with rheumatoid factor activity, Ann Rheum Dis, 46, 485, 10.1136/ard.46.6.485 Miggiore, 1982, Glomerular localization of circulating antiglobulin activity in essential mixed cryoglobulinemia with glomerulonephritis, Kidney Int, 21, 387, 10.1038/ki.1982.34 Fornasieri, 1987, Identification of glomerular immunodeposits in essential mixed cryoglobulinemia glomerulonephritis, Kidney Int, 31, 180A Vital, 1982, Peripheral nerve damage during multiple myeloma and Waldenstrom's macroglobulinemia. An ultrastructural and immunopathologic study, Cancer, 50, 1491, 10.1002/1097-0142(19821015)50:8<1491::AID-CNCR2820500808>3.0.CO;2-Q Bengtsson, 1975, Monoclonal IgG cryoglobulinemia with secondary development of glomerulonephritis and nephrotic syndrome, Q J Med, 44, 491 Bogaars, 1973, Human IgG cryoglobulin with tubular crystal structure, Nature, 245, 117 Podell, 1987, Characterization of monoclonal igG cryoglobulins. Fine structural and morphologic analysis, Blood, 69, 677, 10.1182/blood.V69.2.677.677 Tursz, 1977, Clinical and pathologic features of Waldenstrom's macroglobulinemia in seven patients with serum monoclonal IgG or IgA, Am J Med, 67, 499, 10.1016/0002-9343(77)90193-0 Keshgegian, 1979, Waldenstrom's macroglobulinemia associated with a mixed cryoglobulinemia, Arch Pathol, 103, 270 Morel-Maroger, 1970, Pathology of the kidney in Waldenstrom's macroglobulinemia, N Engl J Med, 283, 123, 10.1056/NEJM197007162830304 Monteverde, 1988, Essential mixed cryoglobulinemia, Type II: A manifestation of a low-grade malignant lymphoma?, Acta Haemat., 79, 20, 10.1159/000205684 Forget, 1966, Waldenström's macroglobulinemia with generalized amyloidosis, Arch Intern Med, 118, 363, 10.1001/archinte.118.4.363 Lamm, 1961, Macroglobulinemia: Report of two cases, Am J Clin Pathol, 35, 53, 10.1093/ajcp/35.1.53 Martelo, 1975, Immunologically mediated renal disease in Waldenstrom's macroglobulinemia, Am J Med, 58, 567, 10.1016/0002-9343(75)90133-3 Lin, 1973, Waldenstrom's macroglobulinemia, mesangiocapillary glomerulonephritis, angitis, and myositis, Nephron, 10, 262, 10.1159/000180197 Propp, 1975, Waldenstrom's macroglobulinemia and neuropathy. Deposition of M component on myelin sheaths, Neurology, 24, 980, 10.1212/WNL.25.10.980 Julien, 1978, Polyneuropathy in Waldenstrom's macroglobulinemia, Arch Neurol, 35, 423, 10.1001/archneur.1978.00500310025005 Baird, 1983, Macroglobulinemic neuropathy. Experimental macroglobulinemic neuropathy in mice, Am J Pathol, 110, 101 Latov, 1980, Plasma cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral nerve myelin, N Engl J Med, 303, 618, 10.1056/NEJM198009113031105 Nardelli, 1981, Peripheral neuropathy associated with immunoglobulin disorders: An immunologic and ultrastructural study, Acta Neuropathol, 6, 248 Meier, 1984, Polyneuropathy in Waldenström's macroglobulinemia: Reduction of endoneurial IgM deposits after treatment with chlorambucil and plasmapheresis, Acta Neuropathol, 64, 297, 10.1007/BF00690395 Lindstrom, 1980, Renal pathology in Waldenström's macroglobulinemia with monoclonal antiglomerular antibodies and nephrotic syndrome, Clin Exp Immunol, 41, 196 Harbs, 1985, Reactivity of sera and isolated monoclonal IgM from patients with Waldenström's macroglobulinemia with peripheral nerve myelin, J Neurol, 232, 43, 10.1007/BF00314040 Vital, 1985, Waldenstrom's macroglobulinemia and peripheral neuropathy: Deposition of M component and kappa light chain in the endonerium, Neurology, 35, 603, 10.1212/WNL.35.4.603 Kahn, 1981, IgM paraproteinemia and autoimmune peripheral neuropathy, N Engl J Med, 304, 1430, 10.1056/NEJM198106043042322 Chazot, 1976, Manifestations neurologiques des gammapathies monoclonales, Rev Neurol, 132, 195 Latov, 1985, Neuropathy and anti-myelin-associated glycoprotein IgM M proteins: T cell regulation of M protein secretion in vitro, Ann Neurol, 18, 182, 10.1002/ana.410180204 Takatsu, 1985, Immunofluorescence study of patients with neuropathy and IgM M proteins, Ann Neurol, 18, 173, 10.1002/ana.410180203 Micouin, 1984, Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinemia: Secretion of identical immunoglobulin by the established lymphoid cell line, Clin Exp Immunol, 58, 677 Tousco, 1985, Antibody activity against intermediate filaments in Waldenstrom's macroglobulinemia, Hematologica, 70, 106 Naparstek, 1985, Immunochemical similarities between monoclonal antibacterial Waldenstrom's macroglobulins and monoclonal anti DNA lupus autoantibodies, J Exp Med, 161, 1523, 10.1084/jem.161.6.1525