Dexmedetomidine protects PC12 cells from ropivacaine injury through miR-381/LRRC4 /SDF-1/CXCR4 signaling pathway

Weinstein, 2018, Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children, Cochrane Database Syst Rev, 6, CD007105 Guay, 2016, Epidural local anesthetics versus opioid-based analgesic regimens for postoperative gastrointestinal paralysis, vomiting, and pain after abdominal surgery: a cochrane review, Anesth Analg, 123, 1591, 10.1213/ANE.0000000000001628 Hong, 2017, Comparison of topical ropivacaine with and without ketamine on post-surgical pain in children undergoing tonsillectomy: a randomized controlled double-blind study, J Anesth, 31, 559 Mazouz Dorval, 2016, Role of ropivacaine infiltration analgesia in bilateral reduction mammaplasty, Ann Chir Plast Esthet, 61, 91, 10.1016/j.anplas.2016.01.004 Lirk, 2008, In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity, Anesth Analg, 106, 1456, 10.1213/ane.0b013e318168514b Wang, 2017, Dexmedetomidine preconditioning plays a neuroprotective role and suppresses TLR4/NF-kappaB pathways model of cerebral ischemia reperfusion, Biomed Pharmacother, 93, 1337, 10.1016/j.biopha.2017.06.051 Peng, 2017, Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes, Exper Therap Med, 14, 689, 10.3892/etm.2017.4537 Abdallah, 2013, Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: a systematic review and meta-analysis, Br J Anaesth, 110, 915, 10.1093/bja/aet066 Trontti, 2018, Strong conservation of inbred mouse strain microRNA loci but broad variation in brain microRNAs due to RNA editing and isomiR expression, RNA, 24, 643, 10.1261/rna.064881.117 Wang, 2014, Expression of miR-15/107 family microRNAs in human tissues and cultured rat brain cells, Dev Reprod Biol, 12, 19 Ziats, 2014, Identification of differentially expressed microRNAs across the developing human brain, Mol Psychiatr, 19, 848, 10.1038/mp.2013.93 van Rooij, 2012, Introduction to the series on microRNAs in the cardiovascular system, Circ Res, 110, 481, 10.1161/CIRCRESAHA.111.257311 Hu, 2017, Microarray-based bioinformatics analysis of the combined effects of SiNPs and PbAc on cardiovascular system in zebrafish, Chemosphere, 184, 1298, 10.1016/j.chemosphere.2017.06.112 Piao, 2018, MicroRNA-381 favors repair of nerve injury through regulation of the SDF-1/CXCR4 signaling pathway via LRRC4 in acute cerebral ischemia after cerebral lymphatic blockage, Cell Physiol Biochem, 46, 890, 10.1159/000488821 Zendedel, 2012, Stromal cell-derived factor-1 alpha (SDF-1α) improves neural recovery after spinal cord contusion in rats, Brain Res, 1473, 214, 10.1016/j.brainres.2012.07.037 Marhofer, 2013, Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study, Br J Anaesth, 110, 438, 10.1093/bja/aes400 Antony, 2018, Pediatric ambulatory continuous peripheral nerve blocks, Anesthesiol Clin, 36, 455, 10.1016/j.anclin.2018.05.003 Andersen, 2017, Does dexmedetomidine have a perineural mechanism of action when used as an adjuvant to ropivacaine?: a paired, blinded, randomized trial in healthy volunteers, Anesthesiology, 126, 66, 10.1097/ALN.0000000000001429 Lu, 2018, Dexmedetomidine protects neural stem cells from ketamine-induced injury, Cell Physiol Biochem, 47, 1377, 10.1159/000490823 Sun, 2019, Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis, Cell Death Dis, 10, 167, 10.1038/s41419-019-1416-5 Wang, 2017, Dexmedetomidine protects PC12 cells from lidocaine-induced cytotoxicity through downregulation of COL3A1 mediated by miR-let-7b, DNA Cell Biol, 36, 518, 10.1089/dna.2016.3623 Zhang, 2018, Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway, J Vet Sci, 19, 512 Tang, 2011, Interaction of hsa-miR-381 and glioma suppressor LRRC4 is involved in glioma growth, Brain Res, 1390, 21, 10.1016/j.brainres.2011.03.034 Yuan, 2018, Long noncoding RNA CAT104 promotes cell viability, migration, and invasion in gastric carcinoma cells through activation of MicroRNA-381-inhibiting zinc finger E-box-binding homeobox 1 (ZEB1) expression, Oncol Res, 26, 1037, 10.3727/096504017X15144748428127 Wu, 2006, LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway, Mol Biol Cell, 17, 3534, 10.1091/mbc.e05-11-1082 Zhang, 2008, Promoter hypermethylation-mediated inactivation of LRRC4 in gliomas, BMC Mol Biol, 9, 99, 10.1186/1471-2199-9-99