Effect of dietary docosahexaenoic acid (DHA) in phospholipids or triglycerides on brain DHA uptake and accretion

The Journal of Nutritional Biochemistry - Tập 33 - Trang 91-102 - 2016
Alex P. Kitson1, Adam H. Metherel1, Chuck T. Chen1, Anthony F. Domenichiello1, Marc‐Olivier Trépanier1, Alvin Berger2,3, Richard P. Bazinet1
1Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, M5S3E2, Canada
2Arctic Nutrition AS, NO-6155, Ørsta, Norway
3Department of Food Science & Nutrition, University of Minnesota, St. Paul, MN, 55108-1038, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Igarashi, 2010, Brain lipid concentrations in bipolar disorder, J Psychiatr Res, 44, 177, 10.1016/j.jpsychires.2009.08.001

Rao, 2007, n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism, Mol Psychiatry, 12, 36, 10.1038/sj.mp.4001888

Cao, 2009, Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function, J Neurochem, 111, 510, 10.1111/j.1471-4159.2009.06335.x

Su, 2010, Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance, J Nutr Biochem, 21, 364, 10.1016/j.jnutbio.2009.11.003

Orr, 2013, Unesterified docosahexaenoic acid is protective in neuroinflammation, J Neurochem, 127, 378, 10.1111/jnc.12392

Brenna, 2011, Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life, Matern Child Nutr, 7, 59, 10.1111/j.1740-8709.2011.00301.x

Igarashi, 2011, Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex, J Alzheimers Dis, 24, 507, 10.3233/JAD-2011-101608

Soderberg, 1991, Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease, Lipids, 26, 421, 10.1007/BF02536067

Lukiw, 2005, A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease, J Clin Invest, 115, 2774, 10.1172/JCI25420

Astarita, 2010, Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease, PLoS One, 5, 10.1371/journal.pone.0012538

Cunnane, 2012, Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease, J Alzheimers Dis, 29, 691, 10.3233/JAD-2012-110629

Cunnane, 2013, Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: can we reconcile the evidence?, Prostaglandins Leukot Essent Fatty Acids, 88, 61, 10.1016/j.plefa.2012.04.006

McNamara, 2013, Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease, J Psychiatr Res, 47, 1187, 10.1016/j.jpsychires.2013.05.007

McNamara, 2007, Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder, Biol Psychiatry, 62, 17, 10.1016/j.biopsych.2006.08.026

McNamara, 2008, Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder, Psychiatry Res, 160, 285, 10.1016/j.psychres.2007.08.021

McNamara, 2007, Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications, Schizophr Res, 91, 37, 10.1016/j.schres.2006.11.027

Hamazaki, 2013, Abnormalities in the fatty acid composition of the postmortem entorhinal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder, Psychiatry Res, 210, 346, 10.1016/j.psychres.2013.05.006

Hamazaki, 2012, Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder, J Psychiatr Res, 46, 1024, 10.1016/j.jpsychires.2012.04.012

Fraser, 2010, Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease, Neurochem Res, 35, 503, 10.1007/s11064-009-0087-5

Oster, 2010, Docosahexaenoic acid and synaptic protection in Alzheimer's disease mice, Biochim Biophys Acta, 1801, 791, 10.1016/j.bbalip.2010.02.011

Cole, 2006, Docosahexaenoic acid protects from amyloid and dendritic pathology in an Alzheimer's disease mouse model, Nutr Health, 18, 249, 10.1177/026010600601800307

Zugno, 2014, Omega-3 prevents behavior response and brain oxidative damage in the ketamine model of schizophrenia, Neuroscience, 259, 223, 10.1016/j.neuroscience.2013.11.049

Park, 2012, N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test, J Nutr Biochem, 23, 924, 10.1016/j.jnutbio.2011.04.018

Igarashi, 2007, Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation, J Lipid Res, 48, 1150, 10.1194/jlr.M600549-JLR200

Moore, 1991, Astrocytes, not neurons, produce docosahexaenoic acid (22:6 omega-3) and arachidonic acid (20:4 omega-6), J Neurochem, 56, 518, 10.1111/j.1471-4159.1991.tb08180.x

Contreras, 2000, Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain, J Neurochem, 75, 2392, 10.1046/j.1471-4159.2000.0752392.x

Purdon, 1997, No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat, J Lipid Res, 38, 526, 10.1016/S0022-2275(20)37260-6

Chen, 2015, Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain, Sci Rep

Nguyen, 2014, Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid, Nature, 509, 10.1038/nature13241

Thies, 1994, Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain, Am J Physiol, 267, R1273

Ramprasath, 2013, Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil, Lipids Health Dis, 12, 178, 10.1186/1476-511X-12-178

Ulven, 2011, Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers, Lipids, 46, 37, 10.1007/s11745-010-3490-4

Maki, 2009, Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women, Nutr Res, 29, 609, 10.1016/j.nutres.2009.09.004

Schuchardt, 2011, Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations–a comparative bioavailability study of fish oil vs. krill oil, Lipids Health Dis, 10, 145, 10.1186/1476-511X-10-145

Vaisman, 2008, Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids, Am J Clin Nutr, 87, 1170, 10.1093/ajcn/87.5.1170

Carnielli, 1998, Intestinal absorption of long-chain polyunsaturated fatty acids in preterm infants fed breast milk or formula, Am J Clin Nutr, 67, 97, 10.1093/ajcn/67.1.97

Yurko-Mauro, 2015, Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study, Lipids Health Dis, 14, 99, 10.1186/s12944-015-0109-z

Salem, 2014, A reexamination of krill oil bioavailability studies, Lipids Health Dis, 13, 137, 10.1186/1476-511X-13-137

Ghasemifard, 2014, Omega-3 long chain fatty acid "bioavailability": a review of evidence and methodological considerations, Prog Lipid Res, 56, 92, 10.1016/j.plipres.2014.09.001

Nichols, 2014, Commentary on a trial comparing krill oil versus fish oil, Lipids Health Dis, 13, 2, 10.1186/1476-511X-13-2

Ramprasath, 2014, Response to commentary on a trial comparing krill oil versus fish oil, Lipids Health Dis, 13, 17, 10.1186/1476-511X-13-17

Liu, 2014, Higher efficacy of dietary DHA provided as a phospholipid than as a triglyceride for brain DHA accretion in neonatal piglets, J Lipid Res, 55, 531, 10.1194/jlr.M045930

Graf, 2010, Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters, Prostaglandins Leukot Essent Fatty Acids, 83, 89, 10.1016/j.plefa.2010.05.004

Zierenberg, 1982, Intestinal absorption of polyenephosphatidylcholine in man, J Lipid Res, 23, 1136, 10.1016/S0022-2275(20)38050-0

Amate, 2001, Feeding infant piglets formula with long-chain polyunsaturated fatty acids as triacylglycerols or phospholipids influences the distribution of these fatty acids in plasma lipoprotein fractions, J Nutr, 131, 1250, 10.1093/jn/131.4.1250

DeMar, 2004, Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15weeks of nutritional deprivation of n-3 polyunsaturated fatty acids, J Neurochem, 91, 1125, 10.1111/j.1471-4159.2004.02789.x

Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J Biol Chem, 226, 497, 10.1016/S0021-9258(18)64849-5

Domenichiello, 2013, Whole body synthesis rates of docosahexaenoic acid (DHA) from alpha-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats, J Lipid Res, 55, 62, 10.1194/jlr.M042275

Chen, 2013, The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms, J Lipid Res, 54, 2410, 10.1194/jlr.M038505

Robinson, 1992, A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis, Brain Res Brain Res Rev, 17, 187, 10.1016/0165-0173(92)90016-F

Lin, 2015, Chronic dietary n-6 PUFA deprivation leads to conservation of arachidonic acid and more rapid loss of DHA in rat brain phospholipids, J Lipid Res, 56, 390, 10.1194/jlr.M055590

Orr, 2010, The fat-1 mouse has brain docosahexaenoic acid levels achievable through fish oil feeding, Neurochem Res, 35, 811, 10.1007/s11064-010-0139-x

Wang, 1992, One-dimensional thin-layer chromatographic separation of phospholipids and lysophospholipids from tissue lipid extracts, J Chromatogr, 581, 139, 10.1016/0378-4347(92)80457-2

Morrison, 1964, Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol, J Lipid Res, 4, 600, 10.1016/S0022-2275(20)40190-7

Chen, 2011, Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study, J Neurochem, 116, 363, 10.1111/j.1471-4159.2010.07116.x

Yang, 1994, Application of the balance method to determining accumulation, metabolism, and apparent oxidation of linoleic and alpha-linolenic acids in the pregnant rat, Metabolism, 43, 940, 10.1016/0026-0495(94)90171-6

Cunnane, 1997, The majority of dietary linoleate in growing rats is beta-oxidized or stored in visceral fat, J Nutr, 127, 146, 10.1093/jn/127.1.146

Poumes-Ballihaut, 2001, Comparative bioavailability of dietary alpha-linolenic and docosahexaenoic acids in the growing rat, Lipids, 36, 793, 10.1007/s11745-001-0786-5

Belayev, 2011, Docosahexaenoic acid therapy of experimental ischemic stroke, Transl Stroke Res, 2, 33, 10.1007/s12975-010-0046-0

Hachem, 2015, Efficient Docosahexaenoic Acid Uptake by the Brain from a Structured Phospholipid, Mol Neurobiol, 10.1007/s12035-015-9228-9

Lagarde, 2001, Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain, J Mol Neurosci, 16, 201, 10.1385/JMN:16:2-3:201

Barrett, 2014, Omega-3 fatty acid supplementation as a potential therapeutic aid for the recovery from mild traumatic brain injury/concussion, Adv Nutr, 5, 268, 10.3945/an.113.005280

Di Marzo, 2010, Dietary krill oil increases docosahexaenoic acid and reduces 2-arachidonoylglycerol but not N-acylethanolamine levels in the brain of obese Zucker rats, Int Dairy J, 20, 231, 10.1016/j.idairyj.2009.11.015

Goti, 2001, Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E, J Neurochem, 76, 498, 10.1046/j.1471-4159.2001.00100.x

Vitali, 2014, HDL and cholesterol handling in the brain, Cardiovasc Res, 103, 405, 10.1093/cvr/cvu148

Panzenboeck, 2002, ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood–brain barrier constituted of porcine brain capillary endothelial cells, J Biol Chem, 277, 42781, 10.1074/jbc.M207601200

Acton, 1996, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science, 271, 518, 10.1126/science.271.5248.518

Polozova, 2007, Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers, J Mol Neurosci, 33, 56, 10.1007/s12031-007-0039-y

Polozova, 2006, Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins, Prostaglandins Leukot Essent Fatty Acids, 75, 183, 10.1016/j.plefa.2006.05.009

Rahman, 2010, The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations, Prostaglandins Leukot Essent Fatty Acids, 82, 141, 10.1016/j.plefa.2009.11.003

Chen, 2008, The low density lipoprotein receptor is not necessary for maintaining mouse brain polyunsaturated fatty acid concentrations, J Lipid Res, 49, 147, 10.1194/jlr.M700386-JLR200

Tso, 1989, The physiology and regulation of the intestinal absorption and transport of omega-3 and omega-6 fatty acids, Adv Prostaglandin Thromboxane Leukot Res, 19, 623

Schuchardt, 2013, Bioavailability of long-chain omega-3 fatty acids, Prostaglandins Leukot Essent Fatty Acids, 89, 1, 10.1016/j.plefa.2013.03.010

Arima, 2012, Surface loops of extracellular phospholipase A(1) determine both substrate specificity and preference for lysophospholipids, J Lipid Res, 53, 513, 10.1194/jlr.M022400

Aloulou, 1841, Kinetic and structural characterization of triacylglycerol lipases possessing phospholipase A1 activity, Biochim Biophys Acta, 2014, 581

Ono, 1984, Rat pancreatic phospholipase A2: purification, characterization, and N-terminal amino acid sequence, J Biochem (Tokyo), 96, 785, 10.1093/oxfordjournals.jbchem.a134896

Roussel, 1998, Structure and activity of rat pancreatic lipase-related. protein 2, J Biol Chem, 273, 32121, 10.1074/jbc.273.48.32121

Le Kim, 1976, Intestinal absorption of polyunsaturated phosphatidylcholine in the rat, Hoppe Seylers Z Physiol Chem, 357, 1321, 10.1515/bchm2.1976.357.2.1321

Tso, 1981, Role of biliary phosphatidylcholine in the absorption and transport of dietary triolein in the rat, Gastroenterology, 80, 60, 10.1016/0016-5085(81)90191-8

Mansbach, 1985, Factors influencing triacylglycerol delivery into mesenteric lymph, Am J Physiol, 249, G642

Nishimukai, 2003, Ingestion of plasmalogen markedly increased plasmalogen levels of blood plasma in rats, Lipids, 38, 1227, 10.1007/s11745-003-1183-9

Kohler, 2015, Bioavailability of fatty acids from krill oil, krill meal and fish oil in healthy subjects–a randomized, single-dose, cross-over trial, Lipids Health Dis, 14, 19, 10.1186/s12944-015-0015-4

Batetta, 2009, Endocannabinoids may mediate the ability of (n-3) fatty acids to reduce ectopic fat and inflammatory mediators in obese zucker rats, J Nutr, 139, 1495, 10.3945/jn.109.104844

Berger, 1992, Effects of various dietary fats on cardiolipin acyl composition during ontogeny of mice, Lipids, 27, 605, 10.1007/BF02536118

Malis, 1990, Incorporation of marine lipids into mitochondrial membranes increases susceptibility to damage by calcium and reactive oxygen species: evidence for enhanced activation of phospholipase A2 in mitochondria enriched with n-3 fatty acids, Proc Natl Acad Sci U S A, 87, 8845, 10.1073/pnas.87.22.8845

Plourde, 2014, Kinetics of 13C-DHA before and during fish-oil supplementation in healthy older individuals, Am J Clin Nutr, 100, 105, 10.3945/ajcn.113.074708

Ghasemifard, 2015, Metabolic fate (absorption, beta-oxidation and deposition) of long-chain n-3 fatty acids is affected by sex and by the oil source (krill oil or fish oil) in the rat, Br J Nutr, 1

Chen, 2015, Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain, Sci Rep, 5, 15791, 10.1038/srep15791

Sinclair, 1975, Incorporation of radioactive polyunsaturated fatty acids into liver and brain of developing rat, Lipids, 10, 175, 10.1007/BF02534156

Sheaff Greiner, 1996, Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys, J Lipid Res, 37, 2675, 10.1016/S0022-2275(20)37470-8

Rhee, 1997, Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins, Am J Clin Nutr, 65, 451, 10.1093/ajcn/65.2.451

Emken, 1987, Metabolism in humans of cis-12,trans-15-octadecadienoic acid relative to palmitic, stearic, oleic and linoleic acids, Lipids, 22, 495, 10.1007/BF02540365

Wijendran, 2002, Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates, Pediatr Res, 51, 265, 10.1203/00006450-200203000-00002

Igarashi, 2007, Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15week n-3 PUFA-deficient diet, J Lipid Res, 48, 152, 10.1194/jlr.M600396-JLR200

Chowdhury, 2014, Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis, Ann Intern Med, 160, 398, 10.7326/M13-1788