Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects

Metabolism - Tập 52 - Trang 1579-1585 - 2003
Juris J Meier1, Michael A Nauck2, Nina Siepmann1, Michael Greulich1, Jens J Holst3, Carolyn F Deacon3, Wolfgang E Schmidt1, Baptist Gallwitz1
1Department of Medicine I, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany
2Diabeteszentrum Bad Lauterberg, Bad Lauterberg, Germany
3Department of Medical Physiology, The Panum Institute, University of Copenhagen, Copenhagen, Denmark

Tài liệu tham khảo

Creutzfeldt, 1979, The incretin concept today, Diabetologia, 16, 75, 10.1007/BF01225454 Creutzfeldt, 1992, Gut hormones and diabetes mellitus, Diabetes Metab Rev, 8, 149, 10.1002/dmr.5610080206 Jones, 1987, The effects of glucose-dependent insulinotropic polypeptide infused at physiological concentrations in normal subjects and type 2 (non-insulin-dependent) diabetic patients on glucose tolerance and B-cell secretion, Diabetologia, 30, 707, 10.1007/BF00296993 Amland, 1985, Effects of intravenously infused porcine GIP on serum insulin, plasma C-peptide, and pancreatic polypeptide in non-insulin-dependent diabetes in the fasting state, Scand J Gastroenterol, 20, 315, 10.3109/00365528509091657 Nauck, 1993, Preserved incretin activity of glucagon-like peptide 1 [7–36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus, J Clin Invest, 91, 301, 10.1172/JCI116186 Holst, 1997, The pathogenesis of NIDDM involves a defective expression of the GIP receptor, Diabetologia, 40, 984, 10.1007/s001250050779 Meier, 2002, Gastric inhibitory polypeptide (GIP), Regul Peptides, 107, 1, 10.1016/S0167-0115(02)00039-3 Meier, 2001, Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes, Diabetes, 50, 2497, 10.2337/diabetes.50.11.2497 Meier, 2002, Insulin secretion following a bolus injection of gastric inhibitory polypeptide (GIP) in first-degree relatives of type 2 diabetic patients and healthy control subjects, Diabetes, 51, A580 Deacon, 2000, Degradation of endogenous and exogenous gastric inhibitory polypeptide (GIP) in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide, J Clin Endocrinol Metab, 85, 3575, 10.1210/jc.85.10.3575 Matthews, 1985, Homeostasis model assessment, Diabetologia, 28, 412, 10.1007/BF00280883 Vilsbøll, 2001, Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients, Diabetes, 50, 609, 10.2337/diabetes.50.3.609 Vilsbøll, 2002, Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients, Diabetologia, 45, 1111, 10.1007/s00125-002-0878-6 Pederson, 1978, Interaction of gastric inhibitory polypeptide, glucose, and arginine on insulin and glucagon secreton from the perfused rat pancreas, Endocrinol, 103, 610, 10.1210/endo-103-2-610 Dupré, 1973, Stimulation of insulin secretion by gastric inhibitory polypeptide in man, J Clin Endocrinol Metab, 37, 826, 10.1210/jcem-37-5-826 Nauck, 1993, Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7–36) amide infused at near-physiological insulinotropic hormone and glucose concentrations, J Clin Endocrinol Metab, 76, 912, 10.1210/jc.76.4.912 Pratley, 2001, The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus, Diabetologia, 44, 929, 10.1007/s001250100580 Halter, 1979, Potentiation of insulin secretory responses by plasma glucose levels in man, J Clin Endocrinol Metab, 48, 946, 10.1210/jcem-48-6-946 Pfeifer, 1980, Potentiation of insulin secretion to nonglucose stimuli in normal man by tolbutamide, Diabetes, 29, 335, 10.2337/diabetes.29.5.335 Ward, 1984, Diminished B cell secretory capacity in patients with non-insulin-dependent diabetes mellitus, J Clin Invest, 74, 1318, 10.1172/JCI111542 Jorde, 1987, The insulinotropic effect of gastric inhibitory polypeptide in non-insulin dependent diabetes, Ital J Gastroenterol, 19, 76 Kubota, 1996, Identification of two missense mutations in the GIP receptor gene: A functional study and association analysis with NIDDM: No evidence of association with Japanese NIDDM subjects, Diabetes, 45, 1701, 10.2337/diabetes.45.12.1701 Amlind, 1998, Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor, Diabetologia, 41, 1194, 10.1007/s001250051051 Lynn, 2001, Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats, Diabetes, 50, 1004, 10.2337/diabetes.50.5.1004 Nauck, 2001, Quantification of the incretin effect in first-degree relatives of type 2 diabetic patients compared to healthy control subjects, Diabetologia, 44, A195