Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells
Tài liệu tham khảo
Carmena, 2003, The cellular geography of aurora kinases, Nat Rev Mol Cell Biol, 4, 842, 10.1038/nrm1245
Fu, 2007, Roles of Aurora kinases in mitosis and tumorigenesis, Mol Cancer Res, 5, 1, 10.1158/1541-7786.MCR-06-0208
Marumoto, 2005, Aurora-A—a guardian of poles, Nat Rev Cancer, 5, 42, 10.1038/nrc1526
Adams, 2001, Chromosomal passengers and the (Aurora) ABCs of mitosis, Trends Cell Biol, 11, 49, 10.1016/S0962-8924(00)01880-8
Giet, 2005, Aurora kinases, aneuploidy and cancer, a coincidence or a real link?, Trends Cell Biol, 15, 241, 10.1016/j.tcb.2005.03.004
Meraldi, 2004, Aurora kinases link chromosome segregation and cell division to cancer susceptibility, Curr Opin Genet Dev, 14, 29, 10.1016/j.gde.2003.11.006
Keen, 2004, Aurora-kinase inhibitors as anticancer agents, Nat Rev Cancer, 4, 927, 10.1038/nrc1502
Ewart-Toland, 2003, Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human, Nat Genet, 34, 403, 10.1038/ng1220
Harrington, 2004, VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo, Nat Med, 10, 262, 10.1038/nm1003
Walter, 2000, The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation, Oncogene, 19, 4906, 10.1038/sj.onc.1203847
Zhou, 2002, Attachment and tension in the spindle assembly checkpoint, J Cell Sci, 115, 3547, 10.1242/jcs.00029
Musacchio, 2007, The spindle-assembly checkpoint in space and time, Nat Rev Mol Cell Biol, 8, 379, 10.1038/nrm2163
Kops, 2005, On the road to cancer: aneuploidy and the mitotic checkpoint, Nat Rev Cancer, 5, 773, 10.1038/nrc1714
Liu, 2006, Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells, J Biol Chem, 281, 18090, 10.1074/jbc.M601324200
Nowakowski, 2002, Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography, Structure, 10, 1659, 10.1016/S0969-2126(02)00907-3
Kick, 1997, Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin D, Chem Biol, 4, 297, 10.1016/S1074-5521(97)90073-9
Zhou, 2006, Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase, Cancer Res, 66, 445, 10.1158/0008-5472.CAN-05-1779
Chou, 1981, Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors, Eur J Biochem, 115, 207, 10.1111/j.1432-1033.1981.tb06218.x
Heron, 2006, SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors, Bioorg Med Chem Lett, 16, 1320, 10.1016/j.bmcl.2005.11.053
Fornari, 1996, Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin, Biochem Pharmacol, 51, 931, 10.1016/0006-2952(96)00050-0
Mansilla, 2006, Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms, Cell Cycle, 5, 53, 10.4161/cc.5.1.2267
Kasai, 2002, Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors, J Biol Chem, 277, 5187, 10.1074/jbc.M110295200
Sudo, 2004, Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint, Cancer Res, 64, 2502, 10.1158/0008-5472.CAN-03-2013
Strebhardt, 2006, Targeting polo-like kinase 1 for cancer therapy, Nat Rev Cancer, 6, 321, 10.1038/nrc1841
Weaver, 2005, Decoding the links between mitosis, cancer, and chemotherapy: the mitotic checkpoint, adaptation, and cell death, Cancer Cell, 8, 7, 10.1016/j.ccr.2005.06.011
Yamada, 2006, Spindle checkpoint function and cellular sensitivity to antimitotic drugs, Mol Cancer Ther, 5, 2963, 10.1158/1535-7163.MCT-06-0319
Wilson, 2004, New microtubule/tubulin-targeted anticancer drugs and novel chemotherapeutic strategies, J Chemother, 16, 83, 10.1179/joc.2004.16.Supplement-1.83
Jordan, 2004, Microtubules as a target for anticancer drugs, Nat Rev Cancer, 4, 253, 10.1038/nrc1317
Zhou, 2005, Targeting microtubules for cancer chemotherapy, Curr Med Chem Anticancer Agents, 5, 65, 10.2174/1568011053352569