Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations

Mechanisms of Ageing and Development - Tập 133 - Trang 556-562 - 2012
Lorna W. Harries1, Alexander D. Fellows1, Luke C. Pilling2, Dena Hernandez3, Andrew Singleton3, Stefania Bandinelli4, Jack Guralnik5, Jonathan Powell2, Luigi Ferrucci6, David Melzer2
1Institute of Biomedical and Clinical Sciences, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK
2Epidemiology and Public Health, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter EX2 5DW, UK
3Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 USA
4Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy
5University of Maryland School of Medicine, Baltimore, MD, USA
6National Institute on Aging, Baltimore, MD, USA

Tài liệu tham khảo

AbouRjaili, 2010, Current concepts in triglyceride metabolism, pathophysiology, and treatment, Metabolism: Clinical and Experimental, 59, 1210, 10.1016/j.metabol.2009.11.014 Avruch, 2006, Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase, Oncogene, 25, 6361, 10.1038/sj.onc.1209882 Bjedov, 2011, A longer and healthier life with TOR down-regulation: genetics and drugs, Biochemical Society Transactions, 39, 460, 10.1042/BST0390460 Blazejowski, 1983, Decreased rates of protein synthesis by cell-free preparations from different organs of aging mice, Mechanisms of Aging and Development, 21, 345, 10.1016/0047-6374(83)90051-9 Butler, 2008, New model of health promotion and disease prevention for the 21st century, BMJ, 337, a399, 10.1136/bmj.a399 Cao, 2011, Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson–Gilford progeria syndrome cells, Science Translational Medicine, 3, 89ra58, 10.1126/scitranslmed.3002346 Chung, 2011, Molecular inflammation as an underlying mechanism of the aging process and age-related diseases, Journal of Dental Research, 90, 830, 10.1177/0022034510387794 Colman, 2009, Caloric restriction delays disease onset and mortality in rhesus monkeys, Science (New York, N.Y.), 325, 201, 10.1126/science.1173635 Dazert, 2011, mTOR signaling in disease, Current Opinion in Cell Biology, 23, 744, 10.1016/j.ceb.2011.09.003 Debey-Pascher, 2009, RNA stabilization of peripheral blood and profiling by bead chip analysis, Methods in Molecular Biology, 496, 175, 10.1007/978-1-59745-553-4_13 Dobashi, 2011, Mammalian target of rapamycin: a central node of complex signaling cascades, International Journal of Clinical and Experimental Pathology, 4, 476 Ferrucci, 2000, Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study, Journal of the American Geriatrics Society, 48, 1618, 10.1111/j.1532-5415.2000.tb03873.x Frischmeyer, 1999, Nonsense-mediated mRNA decay in health and disease, Human Molecular Genetics, 8, 1893, 10.1093/hmg/8.10.1893 Goring, 2007, Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes, Nature Genetics, 39, 1208, 10.1038/ng2119 Hansen, 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans, Aging Cell, 6, 95, 10.1111/j.1474-9726.2006.00267.x Harries, 2011, Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing, Aging Cell, 10.1111/j.1474-9726.2011.00726.x Harrison, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice, Nature, 460, 392, 10.1038/nature08221 Howell, 2011, mTOR couples cellular nutrient sensing to organismal metabolic homeostasis, Trends in Endocrinology and Metabolism: TEM, 22, 94, 10.1016/j.tem.2010.12.003 Jia, 2010, Autophagy and longevity: lessons from C. elegans, Advances in Experimental Medicine and Biology, 694, 47, 10.1007/978-1-4419-7002-2_5 Kennedy, 2009, Hot topics in aging research: protein translation, 2009, Aging Cell, 8, 617, 10.1111/j.1474-9726.2009.00522.x Kolovou, 2011, Aging men and lipids, American Journal of Men's Health, 5, 152, 10.1177/1557988310370360 Lejeune, 2004, eIF4G is required for the pioneer round of translation in mammalian cells, Nature Structural and Molecular Biology, 11, 992, 10.1038/nsmb824 Ma, 2009, Molecular mechanisms of mTOR-mediated translational control, Nature Reviews. Molecular Cell Biology, 10, 307, 10.1038/nrm2672 Masoro, 2005, Overview of caloric restriction and aging, Mechanisms of Aging and Development, 126, 913, 10.1016/j.mad.2005.03.012 Mitchell, 1994, NIDDM in Mexican-American families. Heterogeneity by age of onset, Diabetes Care, 17, 567, 10.2337/diacare.17.6.567 Mitchell, 1996, Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study, Circulation, 94, 2159, 10.1161/01.CIR.94.9.2159 Mohamed, 2009, NFkB inhibitors: strategies from poxviruses, Cell Cycle, 8, 3125, 10.4161/cc.8.19.9683 Partridge, 2011, Aging in Drosophila: the role of the insulin/Igf and TOR signalling network, Experimental Gerontology, 46, 376, 10.1016/j.exger.2010.09.003 Proud, 2011, mTOR signalling in health and disease, Biochemical Society Transactions, 39, 431, 10.1042/BST0390431 Revelle, 2011 Strimmer, 2008, A unified approach to false discovery rate estimation, BMC Bioinformatics, 9, 303, 10.1186/1471-2105-9-303 Toda, 2012, Age-related changes in endothelial function and blood flow regulation, Pharmacology and Therapeutics, 133, 159, 10.1016/j.pharmthera.2011.10.004 Towler, 2007, AMP-activated protein kinase in metabolic control and insulin signaling, Circulation Research, 100, 328, 10.1161/01.RES.0000256090.42690.05 Wieser, 2011, Computational biology for aging. Philosophical transactions of the Royal Society of London. Series B, Biological Sciences, 366, 51, 10.1098/rstb.2010.0286 Zeller, 2010, Genetics and beyond – the transcriptome of human monocytes and disease susceptibility, PLoS One, 5, e10693, 10.1371/journal.pone.0010693