Precipitation of ephedrine by SEDS process using a specially designed prefilming atomizer

Labhasetwar, 1997, Nanoparticles for drug delivery, Pharm. News, 4, 28 R. Nass, Pharmaceutical suspensions, in: H.A. Lieberman, M. Rieger, G. Banker (Eds.), Pharmaceutical Dosage Forms, Marcel Dekker, New York, 1988, p. 151. Hixon, 1990, Sizing materials by crushing and grinding, Chem. Eng., 97, 99 Van Cleef, 1991, Powder technology, Am. Sci., 79, 304 Reverchon, 1998, Supercritical antisolvent precipitation of nanoparticles of superconductor precursors, Ind. Eng. Chem. Res., 37, 952, 10.1021/ie970510a Chattopadhyay, 2001, Production of griseofulvin nanoparticles using supercritical CO2 antisolvent with enhanced mass transfer, Int. J. Pharm., 228, 19, 10.1016/S0378-5173(01)00803-1 Matson, 1987, Rapid expansion of supercritical fluid solutions: solute formation of powders, thin films, and fibers, Ind. Eng. Chem. Res., 26, 2298, 10.1021/ie00071a021 Atsushi, 1995, A novel fluidized-bed coating of fine particles by rapid expansion of supercritical fluid solutions, Powder Technol., 85, 275, 10.1016/0032-5910(95)03021-X Weber, 2002, Mathematical modeling of nucleation and growth of particles formed by the rapid expansion of a supercritical solution under subsonic conditions, J. Supercrit. Fluids, 23, 65, 10.1016/S0896-8446(01)00134-6 Gosselin, 2003, Polymorphic properties of micronized carbamazepine produced by RESS, Int. J. Pharm., 252, 225, 10.1016/S0378-5173(02)00649-X Helfgen, 2003, Hydrodynamic and aerosol modelling of the rapid expansion of supercritical solutions (RESS-process), J. Supercrit. Fluids, 26, 225, 10.1016/S0896-8446(02)00159-6 Jung, 2001, Particle design using supercritical fluids: literature and patent survey, J. Supercrit. Fluids, 20, 179, 10.1016/S0896-8446(01)00064-X Gallagher, 1992, Gas anti-solvent recrystallization of RDX: formation of ultra-fine particles of a difficult-to-comminute explosive, J. Supercrit. Fluids, 5, 130, 10.1016/0896-8446(92)90030-N Cocero, 2002, Crystallization of β-carotene by a GAS process in batch effect of operating conditions, J. Supercrit. Fluids, 22, 237, 10.1016/S0896-8446(01)00125-5 Yeo, 2003, Recrystallization of sulfathiazole and chlorpropamide using the supercritical fluid antisolvent process, J. Supercrit. Fluids, 25, 143, 10.1016/S0896-8446(02)00094-3 Heater, 1998, Processing of epoxy resins using carbon dioxide as an anti-solvent, J. Supercrit. Fluids, 14, 55, 10.1016/S0896-8446(98)00106-5 Liu, 2002, Study on the phase behavior of cholesterol–acetone–CO2 system and recrystallization of cholesterol by antisolvent CO2, J. Supercrit. Fluids, 24, 1, 10.1016/S0896-8446(02)00007-4 Reverchon, 2003, Pilot scale micronization of amoxicillin by supercritical antisolvent precipitation, J. Supercrit. Fluids, 26, 1, 10.1016/S0896-8446(02)00186-9 Kerc, 1999, Micronization of drugs using supercritical carbon dioxide, Int. J. Pharm., 182, 33, 10.1016/S0378-5173(99)00063-0 Sencar-Bozic, 1997, Improvement of nifedipine dissolution characteristics using supercritical CO2, Int. J. Pharm., 148, 123, 10.1016/S0378-5173(96)04838-7 Reverchon, 2001, Supercritical fluids-assisted micronization techniques: low-impact routes for particle production, Pure Appl. Chem., 73, 1293, 10.1351/pac200173081293 R.E. Sievers, U. Karst, US Patent 5639441 (1997). R.E. Sievers, U. Karst, US Patent 6095134 (2000). Sievers, 2000, Supercritical and near-critical carbon dioxide assisted low-temperature bubble drying, Ind. Eng. Chem. Res., 39, 4831, 10.1021/ie000190m Sievers, 2001, Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO2-assisted aerosolization, J. Pharm. Sci., 90, 785, 10.1002/jps.1032 Ventosa, 2003, DELOS process: a crystallization technique using compressed fluids 1: comparison to the GAS crystallization method, J. Supercrit. Fluids, 26, 33, 10.1016/S0896-8446(02)00189-4 Ventosa, 2001, Depressurization of an expanded liquid organic solution (DELOS): a new procedure for obtaining submicron- or micron-sized crystalline particles, Cryst. Growth Des., 1, 299, 10.1021/cg0155090 N. Ventosa, J. Veciana, C. Rovira, S. Sala, S (Carburos Meta‘licos S.E.), Method for Precipitating Finely Divided Solid Particles, PCT/ES01/00327, 2000. York, 1995, A novel approach for controlled particle formation using supercritical fluids, Pharm. Res., 12, S141 Palakodaty, 1998, Supercritical fluid processing of materials from aqueous solutions: the application of SEDS to lactose as a model substance, Pharm. Res., 15, 1835, 10.1023/A:1011949805156 Moshashaee, 2000, Supercritical fluid processing of proteins. I: lysozyme precipitation from organic solution, Eur. J. Pharm. Sci., 11, 239, 10.1016/S0928-0987(00)00108-1 Ghaderi, 2000, A new method for preparing biodegradable microparticles and entrapment of hydrocortisone in DL-PLG microparticles using supercritical fluids, Eur. J. Pharm. Sci., 10, 1, 10.1016/S0928-0987(99)00079-2 Juppo, 2003, Evaluation of solid dispersion particles prepared with SEDS, Int. J. Pharm., 250, 385, 10.1016/S0378-5173(02)00577-X Reverchon, 2002, Tailoring of nano- and micro-particles of some superconductor precursors by supercritical antisolvent precipitation, J. Supercrit. Fluids, 23, 81, 10.1016/S0896-8446(01)00129-2 Sarkari, 2000, Generation of microparticles using CO2 and CO2-philic antisolvents, AIChE J., 46, 1850, 10.1002/aic.690460913 Smith, 1995, Dual-spray airblast fuel nozzle for advanced small gas turbine combustors, J. Propul. Power, 11, 244, 10.2514/3.51417 Sun, 1997, Atomization characteristics of airblast fuel injection inside a venturi tube, Atomization Sprays, 7, 245, 10.1615/AtomizSpr.v7.i3.20 Kufferath, 1999, Influence of liquid flow conditions on spray characteristics of internal-mixing twin-fluid atomizers, Int. J. Heat Fluid Flow, 20, 513, 10.1016/S0142-727X(99)00040-5 Shavit, 2001, Gas–liquid interaction in the liquid breakup region of twin-fluid atomization, Exp. Fluids, 31, 550, 10.1007/s003480100329 Pryds, 2002, An integrated numerical model of the spray forming process, Acta Mater., 50, 4075, 10.1016/S1359-6454(02)00205-7 Sattelmayer, 1986, Internal flow effects in prefilming airblast atomizers: mechanisms of atomization and droplet spectra, J. Eng. Gas Turbines Power, 108, 465, 10.1115/1.3239931 Carvalho, 1998, Liquid film break-up in a model of a prefilming airblast nozzle, Exp. Fluids, 24, 408, 10.1007/s003480050190 Liao, 2000, Instability of an annular liquid sheet surrounded by swirling airstreams, AIAA J., 38, 453, 10.2514/2.982 Liao, 2001, Advanced sub-model for airblast atomizers, J. Propul. Power, 17, 411, 10.2514/2.5757 Chin, 1999, Study on hybrid airblast atomization, AIAA J. Propul. Power, 15, 241, 10.2514/2.5418 Chin, 2000, Effect of inner and outer airflow characteristics on high liquid pressure prefilming airblast atomization, AIAA J. Propul. Power, 16, 297, 10.2514/2.5568 He, 2003, Analysis of energy efficiency of air in atomizing pseudoplastic liquid using a specially designed prefilming airblast atomizer, Ind. Eng. Chem. Res., 42, 3144, 10.1021/ie0210255 Lefebvre, 1992, Energy considerations in twin-fluid atomization, J. Eng. Gas Turbines Power, 114, 89, 10.1115/1.2906311