Effects of Exercise Training on Fitness, Mobility, Fatigue, and Health-Related Quality of Life Among Adults With Multiple Sclerosis: A Systematic Review to Inform Guideline Development

Beck, 2005, Regional variation of multiple sclerosis prevalence in Canada, Mult Scler, 11, 516, 10.1191/1352458505ms1192oa 1998, The Canadian Burden of Illness Study Group. Burden of illness of multiple sclerosis. Part II: quality of life. The Canadian Burden of Illness Study Group, Can J Neurol Sci, 25, 31 Benito-Leon, 2003, A review about the impact of multiple sclerosis on health-related quality of life, Disabil Rehabil, 25, 1291, 10.1080/09638280310001608591 Motl, 2010, Symptom cluster and quality of life: preliminary evidence in multiple sclerosis, J Neurosci Nurs, 42, 212, 10.1097/JNN.0b013e3181e26c5f Multiple Sclerosis International Federation. Global economic impact of multiple sclerosis. Availible at: http://www.msif.org/includes/documents/cm_docs/2011/g/global_economic_impact_of_ms.pdf?f=1. Accessed July 3, 2012. Motl, 2008, Worsening of symptoms is associated with lower physical activity levels in individuals with multiple sclerosis, Mult Scler, 14, 140, 10.1177/1352458507079126 Motl, 2010, Physical activity and irreversible disability in multiple sclerosis, Exerc Sport Sci Rev, 38, 186, 10.1097/JES.0b013e3181f44fab Motl, 2010, Symptom cluster and physical activity in relapsing-remitting multiple sclerosis, Res Nurs Health, 33, 398, 10.1002/nur.20396 Marrie, 2009, High frequency of adverse health behaviors in multiple sclerosis, Mult Scler, 15, 105, 10.1177/1352458508096680 Beckerman, 2010, Physical activity behavior of people with multiple sclerosis: understanding how they can become more physically active, Phys Ther, 90, 1001, 10.2522/ptj.20090345 Motl, 2005, Physical activity and multiple sclerosis: a meta-analysis, Mult Scler, 11, 459, 10.1191/1352458505ms1188oa Stuifbergen, 1997, Health promotion practices of women with multiple sclerosis, Arch Phys Med Rehabil, 78, S3, 10.1016/S0003-9993(97)90215-X Sandroff, 2012, Physical activity and multiple sclerosis: new insights regarding inactivity, Acta Neurol Scand, 126, 256, 10.1111/j.1600-0404.2011.01634.x Nortvedt, 2005, Multiple sclerosis and lifestyle factors: the Hordaland Health Study, Neurol Sci, 26, 334, 10.1007/s10072-005-0498-2 Dalgas, 2009, Physical exercise and MS recommendations, Int MS J, 16, 5 American College of Sports Medicine, 2010 Tremblay, 2012 Brouwers, 2010, Development of the AGREE II, part 1: performance, usefulness and areas for improvement, CMAJ, 182, 1045, 10.1503/cmaj.091714 Bouchard, 2012, Why study physical activity and health?, 3 Motl, 2008, Effect of exercise training on quality of life in multiple sclerosis: a meta-analysis, Mult Scler, 14, 129, 10.1177/1352458507080464 Snook, 2009, Effect of exercise training on walking mobility in multiple sclerosis: a meta-analysis, Neurorehabil Neural Repair, 23, 108, 10.1177/1545968308320641 Dalgas, 2008, Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training, Mult Scler, 14, 35, 10.1177/1352458507079445 Verhagen, 1998, The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus, J Clin Epidemiol, 51, 1235, 10.1016/S0895-4356(98)00131-0 Valent, 2007, The effects of upper body exercise on the physical capacity of people with a spinal cord injury: a systematic review, Clin Rehabil, 21, 315, 10.1177/0269215507073385 Downs, 1998, The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions, J Epidemiol Community Health, 52, 377, 10.1136/jech.52.6.377 Eng JJ, Teasell RW, Miller W, et al. The Spinal Cord Injury Rehabilitation Evidence (SCIRE) 2010. Available at: http://www.scireproject.com. Accessed May 9, 2012. McArdle, 2001 Koseoglu, 2006, Cardiopulmonary and metabolic functions, aerobic capacity, fatigue and quality of life in patients with multiple sclerosis, Acta Neurol Scand, 114, 261, 10.1111/j.1600-0404.2006.00598.x Prakash, 2010, Aerobic fitness is associated with gray matter volume and white matter integrity in multiple sclerosis, Brain Res, 1341, 41, 10.1016/j.brainres.2009.06.063 Slawta, 2002, Coronary heart disease risk between active and inactive women with multiple sclerosis, Med Sci Sports Exerc, 34, 905, 10.1097/00005768-200206000-00001 Petajan, 1996, Impact of aerobic training on fitness and quality of life in multiple sclerosis, Ann Neurol, 39, 432, 10.1002/ana.410390405 DeBolt, 2004, The effects of home-based resistance exercise on balance, power, and mobility in adults with multiple sclerosis, Arch Phys Med Rehabil, 85, 290, 10.1016/j.apmr.2003.06.003 Bjarnadottir, 2007, Multiple sclerosis and brief moderate exercise. A randomised study, Mult Scler, 13, 776, 10.1177/1352458506073780 Castellano, 2008, Cytokine responses to acute and chronic exercise in multiple sclerosis, J Appl Physiol, 104, 1697, 10.1152/japplphysiol.00954.2007 Golzari, 2010, Combined exercise training reduces IFN-gamma and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis, Int Immunopharmacol, 10, 1415, 10.1016/j.intimp.2010.08.008 Mostert, 2002, Effects of a short-term exercise training program on aerobic fitness, fatigue, health perception and activity level of subjects with multiple sclerosis, Mult Scler, 8, 161, 10.1191/1352458502ms779oa Rampello, 2007, Effect of aerobic training on walking capacity and maximal exercise tolerance in patients with multiple sclerosis: a randomized crossover controlled study, Phys Ther, 87, 545, 10.2522/ptj.20060085 Rodgers, 1999, Gait characteristics of individuals with multiple sclerosis before and after a 6-month aerobic training program, J Rehabil Res Dev, 36, 183 Schulz, 2004, Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis, J Neurol Sci, 225, 11, 10.1016/j.jns.2004.06.009 Ponichtera-Mulcare, 1997, Change in aerobic fitness of patients with multiple sclerosis during a 6-month training program, Sports Med Train Rehabil, 7, 265, 10.1080/15438629709512089 Cakt, 2010, Cycling progressive resistance training for people with multiple sclerosis: a randomized controlled study, Am J Phys Med Rehabil, 89, 446, 10.1097/PHM.0b013e3181d3e71f Konecny, 2010, Combination of aerobic and resistant training in multiple sclerosis, Scr Med (Brno), 83, 98 Kjolhede, 2012, Multiple sclerosis and progressive resistance training: a systematic review, Mult Scler, 18, 1215, 10.1177/1352458512437418 Mojtahedi, 2008, Environmental barriers to and availability of healthy foods for people with mobility disabilities living in urban and suburban neighborhoods, Arch Phys Med Rehabil, 89, 2174, 10.1016/j.apmr.2008.05.011 Steffensen, 2010, Predictors and prevalence of low bone mineral density in fully ambulatory persons with multiple sclerosis, J Neurol, 257, 410, 10.1007/s00415-009-5337-6 Broekmans, 2011, Effects of long-term resistance training and simultaneous electro-stimulation on muscle strength and functional mobility in multiple sclerosis, Mult Scler J, 17, 468, 10.1177/1352458510391339 Dalgas, 2009, Resistance training improves muscle strength and functional capacity in multiple sclerosis, Neurology, 73, 1478, 10.1212/WNL.0b013e3181bf98b4 Dalgas, 2010, Fatigue, mood and quality of life improve in MS patients after progressive resistance training, Mult Scler, 16, 480, 10.1177/1352458509360040 Harvey, 1999, The effect of weighted leg raises on quadriceps strength, EMG parameters and functional activities in people with multiple sclerosis, Physiotherapy, 85, 154, 10.1016/S0031-9406(05)65699-4 Romberg, 2004, Effects of a 6-month exercise program on patients with multiple sclerosis: a randomized study, Neurology, 63, 2034, 10.1212/01.WNL.0000145761.38400.65 de Souza-Teixeira, 2009, Effects of resistance training in multiple sclerosis, Int J Sports Med, 30, 245, 10.1055/s-0028-1105944 Fimland, 2010, Enhanced neural drive after maximal strength training in multiple sclerosis patients, Eur J Appl Physiol, 110, 435, 10.1007/s00421-010-1519-2 Perez, 2007, Effects of a resistance training program in multiple sclerosis Spanish patients: a pilot study, J Sport Rehabil, 16, 143, 10.1123/jsr.16.2.143 Taylor, 2006, Progressive resistance exercise for people with multiple sclerosis, Disabil Rehabil, 28, 1119, 10.1080/09638280500531834 White, 2006, Effect of resistance training on risk of coronary artery disease in women with multiple sclerosis, Scand J Clin Lab Invest, 66, 351, 10.1080/00365510600727686 Hayes, 2011, Effects of high-intensity resistance training on strength, mobility, balance, and fatigue in individuals with multiple sclerosis: a randomized controlled trial, J Neurol Phys Ther, 35, 2, 10.1097/NPT.0b013e31820b5a9d Beer, 2008, Robot-assisted gait training in multiple sclerosis: a pilot randomized trial, Mult Scler, 14, 231, 10.1177/1352458507082358 Gehlsen, 1984, Effects of an aquatic fitness program on the muscular strength and endurance of patients with multiple-sclerosis, Phys Ther, 64, 653, 10.1093/ptj/64.5.653 Chang, 2011, Decreased central fatigue in multiple sclerosis patients after 8 weeks of surface functional electrical stimulation, J Rehabil Res Dev, 48, 555, 10.1682/JRRD.2010.03.0038 Kent-Braun, 1996, Effects of electrically stimulated exercise training on muscle function in multiple sclerosis, J Neurol Rehabil, 10, 143 Szecsi, 2009, Functional electrical stimulation-assisted cycling of patients with multiple sclerosis: biomechanical and functional outcome—a pilot study, J Rehabil Med, 41, 674, 10.2340/16501977-0397 LaRocca, 2011, Impact of walking impairment in multiple sclerosis: perspectives of patients and care partners, Patient, 4, 189, 10.2165/11591150-000000000-00000 Goldman, 2010, Possible clinical outcome measures for clinical trials in patients with multiple sclerosis. Therapeutic advances in neurological disorders, Ther Adv Neurol Disord, 3, 229, 10.1177/1756285610374117 Motl, 2010, Walking impairment in patients with multiple sclerosis: exercise training as a treatment option, Neuropsychiatr Dis Treat, 6, 767, 10.2147/NDT.S10480 Dettmers, 2009, Endurance exercise improves walking distance in MS patients with fatigue, Acta Neurol Scand, 120, 251, 10.1111/j.1600-0404.2008.01152.x Geddes, 2009, The effects of a twelve-week home walking program on cardiovascular parameters and fatigue perception of individuals with multiple sclerosis: a pilot study, Cardiopulm Phys Ther J, 20, 5, 10.1097/01823246-200920010-00002 van den Berg, 2006, Treadmill training for individuals with multiple sclerosis: a pilot randomised trial, J Neurol Neurosurg Psychiatry, 77, 531, 10.1136/jnnp.2005.064410 Collett, 2011, Exercise for multiple sclerosis: a single-blind randomized trial comparing three exercise intensities, Mult Scler, 17, 594, 10.1177/1352458510391836 Kileff, 2005, A pilot study of the effect of aerobic exercise on people with moderate disability multiple sclerosis, Clin Rehabil, 19, 165, 10.1191/0269215505cr839oa Sabapathy, 2011, Comparing endurance- and resistance-exercise training in people with multiple sclerosis: a randomized pilot study, Clin Rehabil, 25, 14, 10.1177/0269215510375908 Freeman, 2004, Group exercise classes in people with multiple sclerosis: a pilot study, Physiother Res Int, 9, 104, 10.1002/pri.307 Lo, 2008, Improving gait in multiple sclerosis using robot-assisted, body weight supported treadmill training, Neurorehabil Neural Repair, 22, 661, 10.1177/1545968308318473 Conklyn, 2010, A home-based walking program using rhythmic auditory stimulation improves gait performance in patients with multiple sclerosis: a pilot study, Neurorehabil Neural Repair, 24, 835, 10.1177/1545968310372139 White, 2004, Resistance training improves strength and functional capacity in persons with multiple sclerosis, Mult Scler, 10, 668, 10.1191/1352458504ms1088oa Mutluay, 2008, Group exercise training approach to multiple sclerosis rehabilitation, Nobel Medicus, 4, 20 Pilutti, 2011, Effects of 12 weeks of supported treadmill training on functional ability and quality of life in progressive multiple sclerosis: a pilot study, Arch Phys Med Rehabil, 92, 31, 10.1016/j.apmr.2010.08.027 Salem, 2010, Effects of an aquatic exercise program on functional mobility in individuals with multiple sclerosis: a community-based study, J Aquat Phys Ther, 18, 22 Salem, 2011, Community-based group aquatic programme for individuals with multiple sclerosis: a pilot study, Disabil Rehabil, 33, 720, 10.3109/09638288.2010.507855 Freeman, 2010, The effect of core stability training on balance and mobility in ambulant individuals with multiple sclerosis: a multi-centre series of single case studies, Mult Scler, 16, 1377, 10.1177/1352458510378126 Krupp, 2004 Oken, 2004, Randomized controlled trial of yoga and exercise in multiple sclerosis, Neurology, 62, 2058, 10.1212/01.WNL.0000129534.88602.5C Fragoso, 2008, The positive effects of a physical activity program for multiple sclerosis patients with fatigue, NeuroRehabilitation, 23, 153, 10.3233/NRE-2008-23204 McCullagh, 2008, Long-term benefits of exercising on quality of life and fatigue in multiple sclerosis patients with mild disability: a pilot study, Clin Rehabil, 22, 206, 10.1177/0269215507082283 Sutherland, 2001, Can aerobic exercise training affect health-related quality of life for people with multiple sclerosis?, J Sport Exerc Psychol, 23, 122, 10.1123/jsep.23.2.122 Roehrs, 2004, Effects of an aquatics exercise program on quality of life measures for individuals with progressive multiple sclerosis, J Neurol Phys Ther, 28, 63, 10.1097/01.NPT.0000281186.94382.90 Velikonja, 2010, Influence of sports climbing and yoga on spasticity, cognitive function, mood and fatigue in patients with multiple sclerosis, Clin Neurol Neurosurg, 112, 597, 10.1016/j.clineuro.2010.03.006 Wier, 2011, Effect of robot-assisted versus conventional body-weight-supported treadmill training on quality of life for people with multiple sclerosis, J Rehabil Res Dev, 48, 483, 10.1682/JRRD.2010.03.0035 Mitchell, 2005, Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing, Lancet Neurol, 4, 556, 10.1016/S1474-4422(05)70166-6 Benito-Leon, 2002, Health-related quality of life and its relationship to cognitive and emotional functioning in multiple sclerosis patients, Eur J Neurol, 9, 497, 10.1046/j.1468-1331.2002.00450.x Motl, 2009, Physical activity and quality of life in multiple sclerosis: intermediary roles of disability, fatigue, mood, pain, self-efficacy and social support, Psychol Health Med, 14, 111, 10.1080/13548500802241902 McAuley, 2007, Enhancing physical activity adherence and well-being in multiple sclerosis: a randomised controlled trial, Mult Scler, 13, 652, 10.1177/1352458506072188 Romberg, 2005, Long-term exercise improves functional impairment but not quality of life in multiple sclerosis, J Neurol, 252, 839, 10.1007/s00415-005-0759-2 Latimer-Cheung AE, Martin Ginis, KA Hicks AL, et al. The development of evidence-informed physical activity guidelines for adults with multiple sclerosis. Arch Phys Med Rehabil; in press. Weikert, 2011, Most common types of physical activity self-selected by people with multiple sclerosis, Int J MS Care, 13, 16, 10.7224/1537-2073-13.1.16 Surakka, 2004, Effects of aerobic and strength exercise on motor fatigue in men and women with multiple sclerosis: a randomized controlled trial, Clin Rehabil, 18, 737, 10.1191/0269215504cr780oa Dalgas, 2010, Muscle fiber size increases following resistance training in multiple sclerosis, Mult Scler, 16, 1367, 10.1177/1352458510377222 Asano, 2008, What does a structured review of the effectiveness of exercise interventions for persons with multiple sclerosis tell us about the challenges of designing trials?, Mult Scler, 15, 412, 10.1177/1352458508101877 Cadavid, 2010, Responsiveness of the Expanded Disability Status Scale (EDSS) to disease progression and therapeutic intervention in progressive forms of multiple sclerosis, Rev Neurol, 51, 321 Hobart, 2000, Kurtzke scales revisited: the application of psychometric methods to clinical intuition, Brain, 123, 1027, 10.1093/brain/123.5.1027 Motl, 2011, Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise training, Mult Scler, 17, 1034, 10.1177/1352458511409612 Dodd, 2011, Progressive resistance training did not improve walking but can improve muscle performance, quality of life and fatigue in adults with multiple sclerosis: a randomized controlled trial, Multi Scler, 17, 1362, 10.1177/1352458511409084 Doring, 2011, Exercise in multiple sclerosis—an integral component of disease management, EPMA J, 3, 2, 10.1007/s13167-011-0136-4 Jackson, 2012, Feasibility and effects of a group kickboxing program for individuals with multiple sclerosis: a pilot report, J Bodyw Mov Ther, 16, 7, 10.1016/j.jbmt.2010.09.002 Kargarfard, 2012, Effect of aquatic exercise training on fatigue and health-related quality of life in patients with multiple sclerosis, Arch Phys Med Rehabil, 93, 1701, 10.1016/j.apmr.2012.05.006 Learmonth, 2012, The effects of a 12-week leisure centre-based, group exercise intervention for people moderately affected with multiple sclerosis: a randomized controlled pilot study, Clin Rehabil, 26, 579, 10.1177/0269215511423946 Motl, 2012, Combined training improves walking mobility in persons with significant disability from multiple sclerosis: a pilot study, J Neurol Phys Ther, 36, 32, 10.1097/NPT.0b013e3182477c92 Motl, 2012, The benefits of exercise training in multiple sclerosis, Nat Rev Neurol, 8, 487, 10.1038/nrneurol.2012.136 Motl, 2013, Physical activity, self-efficacy, and health-related quality of life in persons with multiple sclerosis: analysis of associations between individual-level changes over one year, Qual Life Res, 22, 253, 10.1007/s11136-012-0149-z Dalgas, 2012, Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis?, Ther Adv Neurol Disord, 5, 81, 10.1177/1756285611430719 Andreasen, 2011, The effect of exercise therapy on fatigue in multiple sclerosis, Mult Scler, 17, 1041, 10.1177/1352458511401120