Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Bea, 2003, Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements, Circ. Res., 92, 386, 10.1161/01.RES.0000059561.65545.16

Bensaad, 2006, TIGAR, a p53-inducible regulator of glycolysis and apoptosis, Cell, 126, 107, 10.1016/j.cell.2006.05.036

Beyer, 2008, Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance, EMBO J., 27, 212, 10.1038/sj.emboj.7601950

Casamayor, 1999, Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo, Biochem. J., 342, 287, 10.1042/0264-6021:3420287

Cross, 1995, Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B, Nature, 378, 785, 10.1038/378785a0

Dang, 2010, Glutaminolysis: supplying carbon or nitrogen or both for cancer cells?, Cell Cycle, 9, 3884, 10.4161/cc.9.19.13302

DeBerardinis, 2007, Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis, Proc. Natl. Acad. Sci. USA, 104, 19345, 10.1073/pnas.0709747104

DeBerardinis, 2008, The biology of cancer: metabolic reprogramming fuels cell growth and proliferation, Cell Metab., 7, 11, 10.1016/j.cmet.2007.10.002

Düvel, 2010, Activation of a metabolic gene regulatory network downstream of mTOR complex 1, Mol. Cell, 39, 171, 10.1016/j.molcel.2010.06.022

Elstrom, 2004, Akt stimulates aerobic glycolysis in cancer cells, Cancer Res., 64, 3892, 10.1158/0008-5472.CAN-03-2904

Engelman, 2009, Targeting PI3K signalling in cancer: opportunities, challenges and limitations, Nat. Rev. Cancer, 9, 550, 10.1038/nrc2664

Harrison, 2006, Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells, FEBS J., 273, 2345, 10.1111/j.1742-4658.2006.05224.x

Horie, 2004, Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas, J. Clin. Invest., 113, 1774, 10.1172/JCI20513

Ishimoto, 2011, CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth, Cancer Cell, 19, 387, 10.1016/j.ccr.2011.01.038

Itoh, 1997, An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements, Biochem. Biophys. Res. Commun., 236, 313, 10.1006/bbrc.1997.6943

Kim, 2010, Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin, J. Pathol., 220, 446, 10.1002/path.2653

Kroemer, 2008, Tumor cell metabolism: cancer's Achilles' heel, Cancer Cell, 13, 472, 10.1016/j.ccr.2008.05.005

Li, 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 275, 1943, 10.1126/science.275.5308.1943

Lu, 2009, Regulation of glutathione synthesis, Mol. Aspects Med., 30, 42, 10.1016/j.mam.2008.05.005

MacLeod, 2009, Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds, Carcinogenesis, 30, 1571, 10.1093/carcin/bgp176

Malhotra, 2010, Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis, Nucleic Acids Res., 38, 5718, 10.1093/nar/gkq212

Moinova, 1999, Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element, Biochem. Biophys. Res. Commun., 261, 661, 10.1006/bbrc.1999.1109

Okawa, 2006, Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity, Biochem. Biophys. Res. Commun., 339, 79, 10.1016/j.bbrc.2005.10.185

Rada, 2011, SCF/beta-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner, Mol. Cell. Biol., 31, 1121, 10.1128/MCB.01204-10

Reddy, 2007, Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants, Am. J. Respir. Cell Mol. Biol., 37, 3, 10.1165/rcmb.2007-0004RC

Reddy, 2008, Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling, Oncogene, 27, 5821, 10.1038/onc.2008.188

Sakamoto, 2009, Role of the tumor suppressor PTEN in antioxidant responsive element-mediated transcription and associated histone modifications, Mol. Biol. Cell, 20, 1606, 10.1091/mbc.E08-07-0762

Sasaki, 2002, Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression, J. Biol. Chem., 277, 44765, 10.1074/jbc.M208704200

Sekhar, 2003, NADPH oxidase activity is essential for Keap1/Nrf2-mediated induction of GCLC in response to 2-indol-3-yl-methylenequinuclidin-3-ols, Cancer Res., 63, 5636

Shibata, 2008, Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy, Proc. Natl. Acad. Sci. USA, 105, 13568, 10.1073/pnas.0806268105

Singh, 2006, Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer, PLoS Med., 3, e420, 10.1371/journal.pmed.0030420

Singh, 2008, RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy, Cancer Res., 68, 7975, 10.1158/0008-5472.CAN-08-1401

So, 2006, Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin, Cell Death Differ., 13, 1763, 10.1038/sj.cdd.4401863

Solis, 2002, Glutamate-cysteine ligase modifier subunit: mouse Gclm gene structure and regulation by agents that cause oxidative stress, Biochem. Pharmacol., 63, 1739, 10.1016/S0006-2952(02)00897-3

Solis, 2010, Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features, Clin. Cancer Res., 16, 3743, 10.1158/1078-0432.CCR-09-3352

Taguchi, 2008, Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells, Free Radic. Biol. Med., 44, 1645, 10.1016/j.freeradbiomed.2008.01.024

Taguchi, 2010, Genetic analysis of cytoprotective functions supported by graded expression of Keap1, Mol. Cell. Biol., 30, 3016, 10.1128/MCB.01591-09

Taub, 2004, Liver regeneration: from myth to mechanism, Nat. Rev. Mol. Cell Biol., 5, 836, 10.1038/nrm1489

Thimmulappa, 2002, Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray, Cancer Res., 62, 5196

Tong, 2009, The molecular determinants of de novo nucleotide biosynthesis in cancer cells, Curr. Opin. Genet. Dev., 19, 32, 10.1016/j.gde.2009.01.002

Uruno, 2011, The Keap1-Nrf2 system as an in vivo sensor for electrophiles, Nitric Oxide, 25, 153, 10.1016/j.niox.2011.02.007

Wakabayashi, 2003, Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation, Nat. Genet., 35, 238, 10.1038/ng1248

Wang, 2008, Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues, Biochem. Biophys. Res. Commun., 373, 151, 10.1016/j.bbrc.2008.06.004

Wu, 2011, Beneficial role of Nrf2 in regulating NADPH generation and consumption, Toxicol. Sci., 123, 590, 10.1093/toxsci/kfr183

Yuan, 2008, PI3K pathway alterations in cancer: variations on a theme, Oncogene, 27, 5497, 10.1038/onc.2008.245

Zhang, 2007, Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes, Biochem. J., 404, 459, 10.1042/BJ20061611

Zhang, 2010, Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth, Mol. Cancer Ther., 9, 336, 10.1158/1535-7163.MCT-09-0589