Free-Choice Profiling of OR-I7 Agonists and Homologues Using GCO
Tóm tắt
Straight chain aldehydes C-7 to C-10 excite olfactory receptor I-7 (OR-I7), while aldehydes C-6, C-11, and C-12 do not. Odorants C-6 to C-12 were analyzed using free-choice profiling to determine differences in olfactory perceptions. A panel of 12 subjects, two male and ten female, analyzed a set of seven saturated straight chain aldehydes of increasing length (C-6 to C-12). Panelists were trained with pure standards and tested in two trials using a seven-odorant probe delivered via gas chromatography–olfactometry. Generalized procrustes analysis of the panelists’ scores provided information on differences of perceived odor quality. C-6 was characterized by green and grassy aromas, while C-7 to C-12 were characterized as citrus aromas with additional odor notes varying from floral, fresh, and soapy (C-7) to nutty, oily, and rancid (C-12). Differences in odor quality suggest that several different olfactory receptors including OR-I7 are involved in the processing of aldehydes C-6 to C-12.
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