Enfermedad carotídea aterosclerótica extracraneal

Neurologia Argentina - Tập 3 - Trang 26-53 - 2011
Luciano A. Sposato, Francisco Klein

Tài liệu tham khảo

Barnett, 2009, Reflections on the carotid artery: 438 BC to 2009 AD. The Karolinska 2008 Award Lecture in Stroke Research, Stroke, 40, 3143, 10.1161/STROKEAHA.109.557090 Fisher, 1951, Occlusion of internal Carotid artery, Arch Neurol Psychiatr, 65, 346, 10.1001/archneurpsyc.1951.02320030083009 Fields, 1970, Joint study of extracranial arterial occlusion, V: progress report on prognosis following surgery or non-surgical treatment for transient cerebral ischemic attacks and cervical carotid stenosis, JAMA, 211, 1993, 10.1001/jama.1970.03170120039008 Fairhead, 2005, Population-based study of delays in carotid imaging and surgery and the risk of recurrent stroke, Neurology, 65, 371, 10.1212/01.WNL.0000170368.82460.b4 Foulkes, 1998, The Stroke Data Bank: design, methods, and baseline characteristics, Stroke, 19, 547, 10.1161/01.STR.19.5.547 Goldstein, 2001, Improving the reliability of stroke subgroup classification using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria, Stroke, 32, 1091, 10.1161/01.STR.32.5.1091 Chaturvedi, 2005, Carotid endarterectomy - an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology, Neurology, 65, 794, 10.1212/01.wnl.0000176036.07558.82 Coutts, 2008, Recurrent events in transient ischemic attack and minor stroke. What events are happening and to which patients?, Stroke, 39, 2461, 10.1161/STROKEAHA.107.513234 Bouthillier, 1996, Segments of the internal carotid artery: a new classification, Neurosurgery, 38, 425 Meissner, 1987, The natural history of asymptomatic carotid artery occlusive lesions, JAMA, 258, 2704, 10.1001/jama.1987.03400190086033 Hatsukami, 1997, Carotid plaque morphology and clinical events, Stroke, 28, 2201, 10.1161/01.STR.28.1.95 Badimon, 2009, Genesis and dynamics of atherosclerotic lesions: implications for early detection, Cerebrovasc Dis, 27, 38, 10.1159/000200440 Redgrave, 2008, Critical cap thickness and rupture in symptomatic carotid plaques. The oxford plaque study, Stroke, 39, 1722, 10.1161/STROKEAHA.107.507988 Rothwell, 2000, Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists’ Collaborative Group, Stroke, 31, 615, 10.1161/01.STR.31.3.615 Gao, 2007, Correlation between carotid intraplaque hemorrhage and clinical symptoms systematic review of observational studies, Stroke, 38, 2382, 10.1161/STROKEAHA.107.482760 Polak, 1998, Hypoechoic plaque at us of the carotid artery: an independent risk factor for incident stroke in adults aged 65 years or older. Cardiovascular Health Study, Radiology, 208, 649, 10.1148/radiology.208.3.9722841 Mathiesen, 2001, Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromso study, Circulation, 103, 2171, 10.1161/01.CIR.103.17.2171 Nighoghossian, 2005, The vulnerable carotid artery plaque: current imaging methods and new perspectives, Stroke, 36, 2764, 10.1161/01.STR.0000190895.51934.43 Lovett, 2004, Histological correlates of carotid plaque surface morphology on lumen contrast imaging, Circulation, 110, 2190, 10.1161/01.CIR.0000144307.82502.32 Moreno, 2006, Neovascularization in human atherosclerosis, Circulation, 113, 2245, 10.1161/CIRCULATIONAHA.105.578955 Naghavi, 2006, SHAPE Task Force: from vulnerable plaque to vulnerable patient. III Executive summary of the screening for heart attack prevention and education (SHAPE). Task Force report, Am J Cardiol, 98, 2H, 10.1016/j.amjcard.2006.03.002 Lombardo, 2004, Inflammation as a possible link between coronary and carotid plaque instability, Circulation, 109, 3158, 10.1161/01.CIR.0000130786.28008.56 Elkind, 2001, Elevated white blood cell count and carotid plaque thickness: the Northern Manhattan Stroke Study, Stroke, 32, 842, 10.1161/01.STR.32.4.842 Sapienza, 2005, Metalloproteinases and their inhibitors are markers of plaque instability, Surgery, 137, 355, 10.1016/j.surg.2004.10.011 Inzitari, 2000, The causes and risk of stroke in patients with asymptomatic internal-carotid-artery stenosis, N Eng J Med, 342, 1693, 10.1056/NEJM200006083422302 Caplan, 2000, Multiple potential risks for stroke, JAMA, 283, 1479, 10.1001/jama.283.11.1479 Momjian-Mayor, 2005, The Pathophysiology of watershed infarction in internal carotid artery disease. Review of cerebral perfusion studies, Stroke, 36, 567, 10.1161/01.STR.0000155727.82242.e1 Golledge, 2008, Identifying the carotid high risk plaque: is it still a riddle wrapped up in an enigma?, Eur J Vasc Endovasc Surg, 35, 2, 10.1016/j.ejvs.2007.09.004 Carr, 1996, Atherosclerotic plaque rupture in symptomatic carotid artery stenosis, J Vasc Surg, 23, 755, 10.1016/S0741-5214(96)70237-9 Stork, 2002, Source of microembolic signals in patients with high-grade carotid stenosis, Stroke, 33, 2014, 10.1161/01.STR.0000021002.17394.7F Cho, 2007, Is 15 mm size criterion for lacunar infarction still valid? Study on strictly subcortical middle cerebral artery territory infarction using diffusion-weighted MRI, Cerebrovasc Dis, 23, 14, 10.1159/000095753 Muci-Mendoza, 1980, Retinal fluorescein angiographic evidence for atheromatous micro-embolism, Stroke, 11, 154, 10.1161/01.STR.11.2.154 Findlay, 2002, Auditing carotid endarterectomy: a regional experience, Can J Neurol Sci, 29, 326, 10.1017/S0317167100002183 2007, Screening for Carotid Artery Stenosis: U.S. Preventive Services Task Force Recommendation Statement, Ann Intern Med, 147, 854, 10.7326/0003-4819-147-12-200712180-00005 Rothwell, 2003, Pooled analysis of individual patient data from randomized controlled trials of endarterectomy for symptomatic carotid stenosis, Lancet, 361, 107, 10.1016/S0140-6736(03)12228-3 Alexandrov, 1993, Measuring carotid stenosis: time for a reappraisal, Stroke, 24, 1292, 10.1161/01.STR.24.9.1292 Osarumwense, 2005, Carotid artery imaging in the United Kingdom: a postal questionnaire of current practice, Vascular, 13, 137, 10.1258/rsmvasc.13.3.173 Wardlaw, 2008, Carotid imaging for secondary stroke prevention in routine practice, Int J Stroke, 3, 20, 10.1111/j.1747-4949.2008.00176.x Long, 2002, Critical review of non- or minimally invasive methods (duplex ultrasonography, MR and CT-angiography) for evaluating stenosis of the proximal internal carotid artery, Eur J Vasc Endovasc Surg, 24, 43, 10.1053/ejvs.2002.1666 Blakeley, 1995, Noninvasive carotid artery testing, Ann Intern Med, 122, 360, 10.7326/0003-4819-122-5-199503010-00007 Johnston, 2001, Clinical carotid endarterectomy decision making: noninvasive vascular imaging versus cerebral angiography, Neurology, 56, 1009, 10.1212/WNL.56.8.1009 Wardlaw, 2006, Non-invasive imaging compared with intraarterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis, Lancet, 367, 1503, 10.1016/S0140-6736(06)68650-9 Hankey, 1990, Cerebral angiographic risk in mild cerebrovascular disease, Stroke, 21, 209, 10.1161/01.STR.21.2.209 1991, Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis, N Engl J Med, 325, 445, 10.1056/NEJM199108153250701 1998, Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST), Lancet, 351, 1379, 10.1016/S0140-6736(97)09292-1 Wardlaw, 2006, Accurate, practical and cost-effective assessment of carotid stenosis in the UK, Health Technol Assess, 10, 1, 10.3310/hta10300 Easton, 2009, Stroke, 40, 2276, 10.1161/STROKEAHA.108.192218 Latchaw, 2009, Recommendations for imaging of acute ischemic stroke. A scientific statement from the American Heart Association, Stroke, 40, 3646, 10.1161/STROKEAHA.108.192616 Lorenz, 2007, Prediction of clinical cardiovascular events with carotid intima-media thickness. A Systematic Review and Meta-Analysis, Circulation, 115, 459, 10.1161/CIRCULATIONAHA.106.628875 Johnsen, 2009, Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease, Curr Cardiol Rep, 11, 21, 10.1007/s11886-009-0004-1 Landry, 2004, Measurement of carotid plaque volume by 3-dimensional ultrasound, Stroke, 5, 864, 10.1161/01.STR.0000121161.61324.ab Spence, 2006, Measurement of intima-media thickness vs. carotid plaque: uses in patient care, genetic research and evaluation of new therapies, Int J Stroke, 1, 216, 10.1111/j.1747-4949.2006.00068.x Touboul, 2004, Mannheim intima-media thickness consensus, Cerebrovasc Dis, 18, 346, 10.1159/000081812 Rothwell, 1999, Prediction of benefit from carotid endarterectomy in individual patients. A risk-modelling study. European Carotid Surgery Trialists’ Collaborative Group, Lancet, 353, 2105, 10.1016/S0140-6736(98)11415-0 Carrea, 1955, Tratamiento quirúrgico de la trombosis espontánea de la carótida interna en el cuello. Anastomosis carótido-carotídea; relato de un caso, Acta Neurol Latinoamer, 1, 71 Carrea, 1955, Tratamiento quirúrgico de la trombosis espontánea de la carótida interna en el cuello. Anastomosis carótido-carotídea; relato de un caso y análisis de la literatura sobre casos operados, Medicina, 15, 20 DeBakey, 1975, Succesful carotid endarterectomy for cerebro-vascular insufficiency. Nineteen-year follow up, JAMA, 233, 1083, 10.1001/jama.1975.03260100053020 Eascott, 1954, Reconstruction of internal carotid artery in a patient with intermittent attacks of hemiplegia, Lancet, 2, 994, 10.1016/S0140-6736(54)90544-9 Muuronen, 1984, Outcome of surgical treatment of 110 patients with transient ischemic attack, Stroke, 15, 959, 10.1161/01.STR.15.6.959 Warlow, 1984, Carotid endarterectomy: does it work?, Stroke, 15, 1068, 10.1161/01.STR.15.6.1068 Winslow, 1988, The appropriateness of carotid endarterectomy, N Engl J Med, 318, 721, 10.1056/NEJM198803243181201 Tu, 1998, The fall and rise of carotid endarterectomy in the United States and Canada, N Eng J Med, 339, 1441, 10.1056/NEJM199811123392006 Liapis, 2009, ESVS Guidelines. Invasive treatment for carotid stenosis: indications, techniques, Eur J Vasc Endovasc Surg, 37, S1, 10.1016/j.ejvs.2008.11.006 Darling, 1996, Eversion endarterectomy of the internal carotid artery. Technique and results in 449 procedures, Surgery, 120, 635, 10.1016/S0039-6060(96)80010-9 Frericks, 1998, Carotid recurrent stenosis and risk of ipsilateral stroke: a systematic review of the literature, Stroke, 29, 244, 10.1161/01.STR.29.1.244 Hunter, 1987, The aetiology of symptoms in patients with recurrent carotid stenosis, Arch Surg, 122, 311, 10.1001/archsurg.1987.01400150065013 Rerkasem, 2010, Systematic review of randomized controlled trials of patch angioplasty versus primary closure during carotid endarterectomy, Stroke, 41, e55 Ferguson, 1982, Intra-operative monitoring and internal shunts: are they necessary in carotid endarterectomy?, Stroke, 13, 287, 10.1161/01.STR.13.3.287 Gumerlock, 1988, Carotid endarterectomy: to shunt or not to shunt, Stroke, 19, 1485, 10.1161/01.STR.19.12.1485 Sandmann, 1993, To shunt or not to shunt: the definitive answer with a randomized study, Vol. 5, 434 Kasprzak, 2006, General versus locoregional anesthesia in carotid surgery: a prospective randomised trial, Vasa, 35, 232, 10.1024/0301-1526.35.4.232 Rerkasem, 2008, Local versus general anaesthesia for carotid endarterectomy, Cochrane Database of Systematic Reviews, 4, 10.1002/14651858.CD000126.pub3 Rothwell, 1996, A systematic review of the risks of stroke and death due to endarterectomy for symptomatic carotid stenosis, Stroke, 27, 260, 10.1161/01.STR.27.2.260 Young, 1996, An analysis of perioperative surgical mortality and morbidity in the Asymptomatic Carotid Atherosclerosis Study, Stroke, 27, 2216, 10.1161/01.STR.27.12.2216 2004, Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial, Lancet, 363, 1491, 10.1016/S0140-6736(04)16146-1 Ferguson, 1999, The North American Symptomatic Carotid Endarterectomy Trial. Surgical results in 1,415 patients, Stroke, 30, 1751, 10.1161/01.STR.30.9.1751 Bond, 2002, Clinical and radiographic risk factors for operative stroke and death in the European Carotid Surgery Trial, Eur J Vasc Endovasc Surg, 23, 108, 10.1053/ejvs.2001.1541 Halm, 2009, Risk factors for perioperative death and stroke after carotid endarterectomy results of the New York Carotid Artery Surgery Study, Stroke, 40, 221, 10.1161/STROKEAHA.108.524785 Press, 2006, Predicting medical and surgical complications of carotid endarterectomy. Comparing the risk indexes, Arch Intern Med, 166, 914, 10.1001/archinte.166.8.914 Naylor, 2003, Seizures after carotid endarterectomy: hyperperfusion, dysautoregulation or hypertensive encephalopathy?, Eur J Vasc Endovasc Surg, 26, 39, 10.1053/ejvs.2002.1925 Ascher, 2003, Cerebral hyperperfusion syndrome after carotid endarterectomy: predictive factors and hemodynamic changes, J Vasc Surg, 37, 769, 10.1067/mva.2003.231 Nicholas, 1993, The cerebral hyperperfusion syndrome: diagnostic value of ocular pneumoplethysmography, J Vasc Surg, 17, 690, 10.1016/0741-5214(93)90112-Y Sundt, 1981, Correlation of cerebral blood flow and electroencephalographic changes during carotid endarterectomy: with results of surgery and hemodynamics of cerebral ischemia, Mayo Clin Proc, 56, 533 Ogasawara, 2003, Prediction and monitoring of cerebral hyperperfusion after carotid endarterectomy by using single-photon emission computerized tomography scanning, J Neurosurg, 99, 504, 10.3171/jns.2003.99.3.0504 van Mook, 2005, Cerebral hyperperfusion syndrome, Lancet Neurol, 4, 877, 10.1016/S1474-4422(05)70251-9 Timaran, 2009, Intracranial hemorrhage after carotid endarterectomy and carotid stenting in the United States in 2005, J Vasc Surg, 49, 623, 10.1016/j.jvs.2008.09.064 Bond, 2003, A systematic review of the risks of carotid endarterectomy in relation to the clinical indication and the timing of surgery, Stroke, 34, 2290, 10.1161/01.STR.0000087785.01407.CC Bond, 2005, A systematic review of the associations between age and sex and the operative risks of carotid endarterectomy, Cerebrovasc Dis, 20, 69, 10.1159/000086509 Rothwell, 2004, Effect of endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and to the timing of surgery, Lancet, 363, 915, 10.1016/S0140-6736(04)15785-1 Tu, 2003, Risk factors for death or stroke after carotid endarterectomy: observations from the Ontario Carotid Endarterectomy Registry, Stroke, 34, 2568, 10.1161/01.STR.0000092491.45227.0F Halm, 2005, Clinical and operative predictors of outcomes of carotid endarterectomy, J Vasc Surg, 42, 420, 10.1016/j.jvs.2005.05.029 Rothwell, 2010, External validity of results of randomized trials: disentangling a complex concept, Int J Epidemiol, 39, 94, 10.1093/ije/dyp305 1998, The final results of the NASCET trial, N Engl J Med, 339, 1415 Mayberg, 1991, Carotid endarterectomy and prevention of cerebral ischaemia in symptomatic carotid stenosis, JAMA, 266, 3289, 10.1001/jama.1991.03470230047029 1991, MRC European carotid surgery trial: interim results for symptomatic patients with severe (70–99%) or with mild (0–29%) carotid stenosis, Lancet, 337, 1235, 10.1016/0140-6736(91)92916-P Rothwell, 2005, From subgroups to individuals: general principles and the example of carotid endartectomy, Lancet, 365, 256, 10.1016/S0140-6736(05)70156-2 Rothwell, 2003, For the ECST: re-analysis of the final results of the European Carotid Surgery Trial, Stroke, 34, 514, 10.1161/01.STR.0000054671.71777.C7 Sacco, 2006, Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack. A Statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke, Stroke, 37, 577, 10.1161/01.STR.0000199147.30016.74 Usman, 2009, Metaanalysis of procedural stroke and death among octogenarians: carotid stenting versus carotid endarterectomy, J Am Coll Surg, 208, 1124, 10.1016/j.jamcollsurg.2009.02.043 Ois, 2009, High risk of early neurological recurrence in symptomatic carotid stenosis, Stroke, 40, 2727, 10.1161/STROKEAHA.109.548032 Dorigo, 2007, Carotid endarterectomy in patients with acute neurological symptoms: a case-control study, Interact Cardiovasc Thorac Surg, 6, 369, 10.1510/icvts.2006.137547 Karkos, 2007, The value of urgent carotid surgery for crescendo transient ischemic attacks, J Vasc Surg, 45, 1148, 10.1016/j.jvs.2007.02.005 Brandl, 2001, Urgent carotid endarterectomy for stroke in evolution, Vasa, 30, 115, 10.1024/0301-1526.30.2.115 Mentzer, 1981, Emergency carotid endarterectomy for fluctuating neurologic deficits, Surgery, 89, 60 Giles, 2007, Risk of stroke early after transient ischaemic attack: a systematic review and meta-analysis, Lancet Neurol, 6, 1063, 10.1016/S1474-4422(07)70274-0 Rerkasem, 2009, Systematic review of the operative risks of carotid endarterectomy for recently symptomatic stenosis in relation to the timing of surgery, Stroke, 40, e564, 10.1161/STROKEAHA.109.558528 Marquardt, 2010, Low risk of ipsilateral stroke in patients with asymptomatic carotid stenosis on best medical treatment. A prospective, population-based study, Stroke, 41, e11, 10.1161/STROKEAHA.109.561837 Nadareishvili, 2002, Long-term risk of stroke and other vascular events in patients with asymptomatic carotid artery stenosis, Arch Neurol, 59, 1162, 10.1001/archneur.59.7.1162 1995, Endarterectomy for asymptomatic carotid artery stenosis, JAMA, 273, 1421, 10.1001/jama.1995.03520420037035 Hobson, 1993, Efficacy of carotid endarterectomy for asymptomatic carotid stenosis, N Engl J Med, 328, 221, 10.1056/NEJM199301283280401 1991, Stroke, 22, 1229, 10.1161/01.STR.22.10.1229 1992, Effectiveness of carotid endarterectomy for asymptomatic carotid stenosis: design of a clinical trial, Mayo Clin Proc, 64, 897 Moore, 1996, Surgical results: a justification of the surgeon selection process for the ACAS trial, J Vasc Surg, 23, 323, 10.1016/S0741-5214(96)70277-X Rothwel, 1996, A systematic comparison of the risks of stroke and death due to carotid endarterectomy for symptomatic and asymptomatic stenosis, Stroke, 27, 266, 10.1161/01.STR.27.2.266 Halliday, 1994, Rationale and design, Eur J Vasc Surg, 8, 703 Rothwell, 2000, Low risk of ischaemic stroke in patients with collapse of the internal carotid artery distal to severe carotid stenosis: cerebral protection due to low post-stenotic flow?, Stroke, 31, 622, 10.1161/01.STR.31.3.622 Rothwell, 2004, ACST: which subgroups will benefit most from carotid endarterectomy?, Lancet, 364, 1122, 10.1016/S0140-6736(04)17090-6 Sabeti, 2007, Progression of carotid stenosis detected by duplex ultrasonography predicts adverse outcomes in cardiovascular high-risk patients, Stroke, 38, 2887, 10.1161/STROKEAHA.107.488387 Bertges, 2003, Relevance of carotid stenosis progression as a predictor of ischemic neurological outcomes, Arch Intern Med, 163, 2285, 10.1001/archinte.163.19.2285 Sabeti, 2005, Prognostic impact of fibrinogen in carotid atherosclerosis: unspecific indicator of inflammation or independent predictor of disease progression, Stroke, 36, 1400, 10.1161/01.STR.0000169931.96670.fc Kakkos, 2009, Silent embolic infarcts on computed tomography brain scans and risk of ipsilateral hemispheric events in patients with asymptomatic internal carotid artery stenosis, J Vasc Surg, 49, 902, 10.1016/j.jvs.2008.10.059 Mathias, 1977, Ein neurartiges Katheter System zur perkutanen transluminal en Angioplastie von Karotisstenossen, Fortschr Med, 95, 1007 Mathias, 1981, Perkutane transluminale Katheter-behandlung supraaortaler Arterienobstruktionen, Angio, 3, 47 Diethrich, 1997, Which carotid lesions can presently be treated with angioplasty and stents and which should not be Naylor, 1997, Carotid endarterectomy versus carotid angioplasty, Lancet, 349, 203, 10.1016/S0140-6736(96)07181-4 Bettmann, 1998, Carotid stenting and angioplasty. A statement for healthcare professionals from the Councils on Cardiovascular Radiology, Stroke, Cardio-Thoracic and Vascular Surgery, Epidemiology and Prevention, and Clinical Cardiology, American Heart Association, Circulation, 97, 121, 10.1161/01.CIR.97.1.121 Kachel, 1996, Results of balloon angioplasty in the carotid arteries, J Endovasc Surg, 3, 22, 10.1583/1074-6218(1996)003<0022:ROBAIT>2.0.CO;2 Bagley, 1997, Carotid angioplasty. Interventional Radiology and Vascular Imaging Theron, 1996, Carotid artery stenosis: treatment with protected balloon angioplasty and stent placement, Radiology, 201, 627, 10.1148/radiology.201.3.8939208 Grube, 2003, Initial multicenter experience with a novel distal protection filter during carotid artery stent implantation, Catheter Cardiovasc Interv, 58, 139, 10.1002/ccd.10348 Coppi, 2005, PRIAMUS proximal flow blockage cerebral protection during carotid stenting. Results from a multicenter Italian registry, J Cardiovasc Surg (Torino), 46, 219 Parodi, 2000, Inicial evaluation of carotid angioplasty and stenting with three different cerebral protection devices, J Vasc Surg, 32, 1127, 10.1067/mva.2000.109209 Whitlow, 2002, Carotid stenting protected with an emboli containment system, Stroke, 33, 1308, 10.1161/01.STR.0000013947.17575.B3 Ederle, 2009, Randomized controlled trials comparing endarterectomy and endovascular treatment for carotid artery stenosis: a Cochrane systematic review, Stroke, 40, 1373, 10.1161/STROKEAHA.108.531228 2001, Endovascular versus surgical treatment in patients with carotid stenosis in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): a randomised trial, Lancet, 357, 1729, 10.1016/S0140-6736(00)04893-5 Ederle, 2009, Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial, Lancet Neurol, 8, 898, 10.1016/S1474-4422(09)70228-5 Bonati, 2009, Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial, Lancet Neurol, 8, 908, 10.1016/S1474-4422(09)70227-3 2006, 30 day results from the SPACE trial of stent-protected angioplasty versus carotid endarterectomy in symptomatic patients: a randomised non-inferiority trial, Lancet, 368, 1239, 10.1016/S0140-6736(06)69122-8 Stingele, 2008, Clinical and angiographic risk factors for stroke and death within 30 days after carotid endarterectomy and stent-protected angioplasty: a subanalysis of the SPACE study, Lancet Neurol, 7, 216, 10.1016/S1474-4422(08)70024-3 Eckstein, 2008, Results of the Stent-Protected Angioplasty versus Carotid Endarterectomy (SPACE) study to treat symptomatic stenoses at 2 years: a multinational, prospective, randomised trial, Lancet Neurol, 7, 893, 10.1016/S1474-4422(08)70196-0 Mas, 2006, Endarterectomy versus stenting in patients with symptomatic severe carotid stenosis, N Engl J Med, 355, 1660, 10.1056/NEJMoa061752 Mas, 2008, Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis (EVA-3S) trial: results up to 4 years from a randomised, multicentre trial, Lancet Neurol, 7, 885, 10.1016/S1474-4422(08)70195-9 Yadav, 2004, Protected carotid-artery stenting versus endarterectomy in high-risk patients, N Engl J Med, 351, 1493, 10.1056/NEJMoa040127 Yadav, 2004, Carotid stenting in high-risk patients: design and rationale of the SAPPHIRE trial, Cleve Clin J Med, 71, S45, 10.3949/ccjm.71.Suppl_1.S45 Cambria, 2004, Stenting for carotid-artery stenosis, N Engl J Med, 351, 1565, 10.1056/NEJMe048234 Cremonesi, 2006, Carotid artery stenting: first consensus document of the ICCS-SPREAD Joint Committee, Stroke, 37, 2400, 10.1161/01.STR.0000236101.09480.b7 Roffi, 2009, Carotid artery stenting vs. endarterectomy, Eur Heart J, 30, 2693, 10.1093/eurheartj/ehp471 Rothwell, 2009, Poor outcomes after endovascular treatment of symptomatic carotid stenosis: time for a moratorium, Lancet Neurol, 8, 871, 10.1016/S1474-4422(09)70230-3 Gates, 2006, Symptomatic and asymptomatic carotid stenosis: Just when we thought we had all the answers, Intern Med J, 36, 445, 10.1111/j.1445-5994.2006.01085.x Goldstein, 2006, Stroke, 37, 1583, 10.1161/01.STR.0000223048.70103.F1 Chambless, 2000, Carotid wall thickness is predictive of incident clinical stroke: the Atherosclerosis Risk in Communities (ARIC) study, Am J Epidemiol, 151, 478, 10.1093/oxfordjournals.aje.a010233 O’Leary, 1999, Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group, N Engl J Med, 340, 14, 10.1056/NEJM199901073400103 Bots, 1997, Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study, Circulation, 96, 1432, 10.1161/01.CIR.96.5.1432 Kodama, 2000, Antiplatelet Drugs Attenuate Progression of Carotid Intima-Media Thickness in Subjects with Type 2 Diabetes, Thromb Res, 97, 239, 10.1016/S0049-3848(99)00168-1 Wang, 2006, Carotid intima-media thickness and antihypertensive treatment a meta-analysis of randomized controlled trials, Stroke, 37, 1933, 10.1161/01.STR.0000227223.90239.13 Staessen, 2003, Cardiovascular prevention and blood pressure reduction: a quantitative overview updated until 1 March 2003, J Hypertens, 21, 1055, 10.1097/00004872-200306000-00002 2001, Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack, Lancet, 358, 1033, 10.1016/S0140-6736(01)06178-5 Chobanian, 2003, The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report, JAMA, 289, 2560, 10.1001/jama.289.19.2560 1995, Cholesterol, diastolic blood pressure, and stroke: 13,000 strokes in 450,000 people in 45 prospective cohorts, Lancet, 346, 1647, 10.1016/S0140-6736(95)92836-7 Amarenco, 2007, The paradox of cholesterol and stroke, Lancet, 370, 1803, 10.1016/S0140-6736(07)61751-6 Amarenco, 2009, Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention, Lancet Neurol, 8, 453, 10.1016/S1474-4422(09)70058-4 Sillesen, 2008, Atorvastatin reduces the risk of cardiovascular events in patients with carotid atherosclerosis: a secondary analysis of the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Trial, Stroke, 39, 3297, 10.1161/STROKEAHA.108.516450 Amarenco, 2006, The dynamics of statins: from event prevention to neuroprotection, Stroke, 37, 294, 10.1161/01.STR.0000201856.90105.ab Amarenco, 2006, High-dose atorvastatin after stroke or transient ischemic attack, N Engl J Med, 355, 549, 10.1056/NEJMoa061894 Collins, 2004, Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions, Lancet, 363, 757, 10.1016/S0140-6736(04)15690-0 Amarenco, 2007, Effects of intense low-density lipoprotein cholesterol reduction in patients with stroke or transient ischemic attack: the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial, Stroke, 38, 3198, 10.1161/STROKEAHA.107.493106 Bots, 2009, Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR study, J Intern Med, 265, 698, 10.1111/j.1365-2796.2009.02073.x Youssef, 2002, The early effect of lipid-lowering treatment on carotid and femoral intima media thickness (IMT), Eur J Vasc Endovasc Surg, 23, 358, 10.1053/ejvs.2002.1611 Nakamura, 2008, Rapid stabilization of vulnerable carotid plaque within 1 month of pitavastatin treatment in patients with acute coronary syndrome, J Cardiovasc Pharmacol, 51, 365, 10.1097/FJC.0b013e318165dcad Annovazzi, 2006, (99m)Tc-interleukin-2 scintigraphy for the in vivo imaging of vulnerable atherosclerotic plaques, Eur J Nucl Med Mol Imaging, 33, 117, 10.1007/s00259-005-1899-4 Martín-Ventura, 2005, Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month, Stroke, 36, 1796, 10.1161/01.STR.0000174289.34110.b0 Durazzo, 2004, Reduction in cardiovascular events after vascular surgery with atorvastatin: a randomized trial, J Vasc Surg, 39, 967, 10.1016/j.jvs.2004.01.004 Abbott, 2007, What should we do with asymptomatic carotid stenosis?, Int J Stroke, 2, 27, 10.1111/j.1747-4949.2007.00096.x Abbott, 2009, Medical (nonsurgical) intervention alone is now best for prevention of stroke associated with asymptomatic severe carotid stenosis results of a systematic review and analysis, Stroke, 40, e573, 10.1161/STROKEAHA.109.556068 Sposato, 2008, Quality of ischemic stroke care in emerging countries. The Argentinean National Stroke Registry (ReNACer), Stroke, 39, 3036, 10.1161/STROKEAHA.108.521062 Robless, 2002, Platelet activation during carotid endarterectomy and the antiplatelet effect of dextran 40, Platelets, 13, 231, 10.1080/09537100220144849 Payne, 2004, Platelet inhibition by aspirin is diminished in patients during carotid surgery: a form of transient aspirin resistance?, Thromb Haemost, 92, 89, 10.1160/TH03-12-0758 Lennard, 1999, A policy of quality control assessment reduces the risk of intra-operative stroke during carotid endarterectomy, Eur J Vasc Endovasc Surg, 17, 234, 10.1053/ejvs.1998.0723 Gaunt, 1996, A comparison of quality control methods applied to carotid endarterectomy, Eur J Vasc Endovasc Surg, 11, 4, 10.1016/S1078-5884(96)80128-6 Levi, 1997, Transcranial doppler detected cerebral embolisation following carotid endarterectomy: high microembolic signal loads predict post-operative cerebral ischaemia, Brain, 120, 621, 10.1093/brain/120.4.621 Findlay, 1985, Effect of perioperative platelet inhibition on postcarotid endarterectomy mural thrombus formation. Results of a prospective randomized controlled trial using aspirin and dipyridamole in humans, J Neurosurg, 63, 693, 10.3171/jns.1985.63.5.0693 Lindblad, 1993, Does low-dose acetylsalicylic acid prevent stroke after carotid surgery? A double-blind, placebo-controlled randomized trial, Stroke, 24, 1125, 10.1161/01.STR.24.8.1125 Taylor, 1999, Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomized controlled trial, Lancet, 353, 2179, 10.1016/S0140-6736(99)05388-X Payne, 2004, Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients, Circulation, 109, 1476, 10.1161/01.CIR.0000121739.05643.E6 Fleming, 2009, Safety of carotid endarterectomy in patients concurrently on clopidogrel, Ann Vasc Surg, 23, 612, 10.1016/j.avsg.2009.06.004 http://products.sanofi-aventis.us/plavix/plavix.html-precautions on clopidogrel use. Adams, 2007, Stroke, 38, 1655, 10.1161/STROKEAHA.107.181486 Sobel, 2008, Antithrombotic therapy for peripheral artery occlusive disease. American College of Chest Physicians evidence-based clinical practice guidelines. 8th ed, Chest, 133, 815S, 10.1378/chest.08-0686 Naylor, 2000, Reducing the risk of carotid surgery: a 7-year audit of the role of monitoring and quality control assessment, J Vasc Surg, 32, 750, 10.1067/mva.2000.108007 Lennard, 1999, Transcranial Doppler directed dextran therapy in the prevention of carotid thrombosis: three hour monitoring is as effective as six hours, Eur J Vasc Endovasc Surg, 17, 301, 10.1053/ejvs.1998.0738 Dorman, 1995, Protamine reversal during peripheral vascular surgery: a prospective randomized trial, J Vasc Surg, 22, 248, 10.1016/S0741-5214(95)70137-0 Fearn, 1997, Should heparin be reversed after carotid endarterectomy? A randomised prospective trial, Eur J Vasc Endovasc Surg, 13, 394, 10.1016/S1078-5884(97)80082-2 Engelter, 2004, Antiplatelet therapy for preventing stroke and other vascular events after carotid endarterectomy, Stroke, 35, 1227, 10.1161/01.STR.0000125710.17337.8b Harloff, 2006, Therapeutic strategies after examination by transesophageal echocardiography in 503 patients with ischemic stroke, Stroke, 37, 859, 10.1161/01.STR.0000202592.87021.b7 Chatuverdi, 2006, The role of antiplatelet therapy in carotid stenting for ischemic stroke prevention, Stroke, 37, 1572, 10.1161/01.STR.0000221298.43117.be Chaturvedi, 2002, Carotid artery stenting for high-risk patients, Neurol Res, 24, S63, 10.1179/016164102101199927 Molloy, 1999, Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis, Stroke, 30, 1440, 10.1161/01.STR.30.7.1440 Siebler, 1994, Cerebral microembolism in symptomatic and asymptomatic high-grade internal carotid artery stenosis, Neurology, 44, 615, 10.1212/WNL.44.4.615 Markus, 2005, Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection. The Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) Trial, Circulation, 111, 2233, 10.1161/01.CIR.0000163561.90680.1C Stockx, 2006, Techniques in carotid artery stenting, Eur J Radiol, 60, 11, 10.1016/j.ejrad.2006.05.023 Bhatt, 2001, Dual antiplatelet therapy with clopidogrel and aspirin after carotid artery stenting, J Invasive Cardiol, 13, 767 McKevitt, 2005, The benefits of combined anti-platelet treatment in carotid artery stenting, Eur J Vasc Endovasc Surg, 29, 522, 10.1016/j.ejvs.2005.01.012 Gray, 2006, Protected carotid stenting in high-surgical-risk patients: the ARCHeR results, J Vasc Surg, 44, 258, 10.1016/j.jvs.2006.03.044 Diehm, 2008, Staged bilateral carotid stenting, an effective strategy in high-risk patients-insights from a prospective multicenter trial, J Vasc Surg, 47, 1227, 10.1016/j.jvs.2008.01.035 Lloyd-Jones, 2009, A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Circulation, 119, e21 Schwartz, 1995, Asymptomatic carotid artery stenosis and stroke in patients undergoing cardiopulmonary bypass, J Vasc Surg, 21, 146, 10.1016/S0741-5214(95)70253-9 Salasidis, 1995, Carotid artery duplex scanning in preoperative assessment for coronary artery revascularization: the association between peripheral vascular disease, carotid stenosis, and stroke, J Vasc Surg, 21, 154, 10.1016/S0741-5214(95)70254-7 Hines, 1998, Prophylactic carotid endarterectomy in patients with high-grade carotid stenosis undergoing coronary bypass: does it decrease the incidence of perioperative stroke?, Ann Vasc Surg, 12, 23, 10.1007/s100169900110 Safa, 1999, Management of coexisting coronary artery and asymptomatic carotid artery disease: report of a series of patients treated with coronary bypass alone, Eur J Vasc Endovasc Surg, 17, 249, 10.1053/ejvs.1998.0752 Bilfinger, 2000, Coronary and carotid operations under prospective standardized conditions: incidence and outcome, Ann Thorac Surg, 69, 1792, 10.1016/S0003-4975(00)01323-0 Turi, 2006, Carotid stenting followed by coronary bypass: is drive by coronary revascularization next?, Catheter Cardiovasc Interv, 67, 149, 10.1002/ccd.20491 Al-Mubarak, 1999, Early results of percutaneous intervention for severe coexisting carotid and coronary artery disease, Am J Cardiol, 84, 600, 10.1016/S0002-9149(99)00388-4 Randall, 2006, Is there any benefit from staged carotid and coronary revascularization using carotid stents? A single-center experience highlights the need for a randomized controlled trial, Stroke, 37, 435, 10.1161/01.STR.0000198876.32450.a7 Trachiotis, 1997, Management strategy for simultaneous carotid endarterectomy and coronary revascularization, Ann Thorac Surg, 64, 1013, 10.1016/S0003-4975(97)00795-9 Bucerius, 2003, Stroke after cardiac surgery: a risk factor analysis of 16184 consecutive adult patients, Ann Thorac Surg, 75, 472, 10.1016/S0003-4975(02)04370-9 Faggioli, 1990, The role of carotid screening before coronary artery bypass, J Vasc Surg, 12, 724, 10.1067/mva.1990.24458 Ascher, 2001, Routine preoperative carotid duplex scanning in patients undergoing open heart surgery: is it worthwhile?, Ann Vasc Surg, 15, 669, 10.1007/s10016-001-0088-6 Aboyans, 2005, A predictive model for screening cerebrovascular disease in patient undergoing coronary artery bypass grafting, Interact Cardiovasc Thorac Surg, 4, 90, 10.1510/icvts.2004.092262 Walker, 1996, Is carotid screening for coronary surgery needed?, Am Surg, 62, 308 Hill, 1999, The utility of selective screening for carotid stenosis in cardiac surgery patients, J Cardiovasc Surg (Torino), 40, 829 Eagle, 2004, ACC/AHA 2004 Guideline update for coronary artery bypass graft surgery, Circulation, 110, e340 Urbinati, 1992, Frequency and prognostic significance of silent coronary artery disease in patients with cerebral ischemia undergoing carotid endarterectomy, Am J Cardiol, 69, 1166, 10.1016/0002-9149(92)90930-W Sconocchini, 1997, Patients with carotid stenosis and clinical history negative for coronary disease: usefulness of the ergometric test for the identification of ischemic myocardial disease, Minerva Med, 88, 173 Hertzer, 1985, Coronary angiography in 506 patients with extracranial cerebrovascular disease, Arch Intern Med, 145, 849, 10.1001/archinte.1985.00360050105017 Adams, 2003, Circulation, 108, 1278, 10.1161/01.CIR.0000090444.87006.CF Mortaz Hejri, 2009, Carotid endarterectomy for carotid stenosis in patients selected for coronary artery bypass graft surgery, Cochrane Database Syst Rev, 4 Li, 2009, Strokes after cardiac surgery and relationship to carotid senosis, Arch Neurol, 66, 1091, 10.1001/archneurol.2009.114 Abu-Oma, 2004, Solid and gaseous cerebral microembolization during offpump, on-pump, and open cardiac surgery procedures, J Thorac Cardiovasc Surg, 127, 1759, 10.1016/j.jtcvs.2003.09.048 Naylor, 2009, A systematic review and meta-analysis of 30-day outcomes following staged carotid artery stenting and coronary bypass, Eur J Vasc Endovasc Surg, 37, 379, 10.1016/j.ejvs.2008.12.011 Fareed, 2009, Synchronous carotid endarterectomy and off-pump coronary bypass: an updated, systematic review of early outcomes, Eur J Vasc Endovasc Surg, 37, 375, 10.1016/j.ejvs.2008.12.008 Naylor, 2003, A systematic review of outcomes following staged and synchronous carotid endarterectomy and coronary artery bypass, Eur J Vasc Endovasc Surg, 25, 380, 10.1053/ejvs.2002.1895