TREM2 and the neuroimmunology of Alzheimer's disease
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Selkoe, 1991, The molecular pathology of Alzheimer's disease, Neuron, 6, 487, 10.1016/0896-6273(91)90052-2
Qiu, 2009, Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention, Dialogues Clin Neurosci, 11, 111, 10.31887/DCNS.2009.11.2/cqiu
Cruts, 2012, Locus-specific mutation databases for neurodegenerative brain diseases, Hum Mutat, 33, 1340, 10.1002/humu.22117
Hsiao, 1996, Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice, Science, 274, 99, 10.1126/science.274.5284.99
Oddo, 2003, Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction, Neuron, 39, 409, 10.1016/S0896-6273(03)00434-3
Jankowsky, 2001, Co-expression of multiple transgenes in mouse CNS: a comparison of strategies, Biomol Eng, 17, 157, 10.1016/S1389-0344(01)00067-3
Holcomb, 1998, Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes, Nat Med, 4, 97, 10.1038/nm0198-097
Bertram, 2010, The genetics of Alzheimer disease: back to the future, Neuron, 68, 270, 10.1016/j.neuron.2010.10.013
Guerreiro, 2013, TREM2 variants in Alzheimer's disease, New Engl J Med, 368, 117, 10.1056/NEJMoa1211851
Jonsson, 2013, Variant of TREM2 associated with the risk of Alzheimer's disease, New Engl J Med, 368, 107, 10.1056/NEJMoa1211103
Ozsolak, 2010, Digital transcriptome profiling from at to mole-level RNA samples, Genome Res, 20, 519, 10.1101/gr.102129.109
Ozsolak, 2010, Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation, Cell, 143, 1018, 10.1016/j.cell.2010.11.020
Ozsolak, 2010, Amplification-free digital gene expression profiling from minute cell quantities, Nat Methods, 7, 619, 10.1038/nmeth.1480
Hickman, 2013, The microglial sensome revealed by direct RNA sequencing, Nat Neurosci, 16, 1896, 10.1038/nn.3554
El Khoury, 2008, Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications, Trends Pharmacol Sci, 29, 626, 10.1016/j.tips.2008.08.004
El Khoury, 2007, Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease, Nat Med, 13, 432, 10.1038/nm1555
El Khoury, 2003, CD36 mediates the innate host response to beta-amyloid, J Exp Med, 197, 1657, 10.1084/jem.20021546
Hickman, 2008, Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice, J Neurosci, 28, 8354, 10.1523/JNEUROSCI.0616-08.2008
Hickman, 2013, The neuroimmune system in Alzheimer's disease: the glass is half full, J Alzheimer's Dis, 33, S295
El Khoury, 2010, Neurodegeneration and the neuroimmune system, Nat Med, 16, 1369, 10.1038/nm1210-1369
El Khoury, 1996, Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils, Nature, 382, 716, 10.1038/382716a0
El Khoury, 1998, Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease, Neurobiol Aging, 19, S81, 10.1016/S0197-4580(98)00036-0
Frenkel, 2013, Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression, Nat Commun, 4, 2030, 10.1038/ncomms3030
Frenkel, 2008, A nasal proteosome adjuvant activates microglia and prevents amyloid deposition, Ann Neurol, 63, 591, 10.1002/ana.21340
Stewart, 2010, CD36 ligands promote sterile inflammation through assembly of a toll-like receptor 4 and 6 heterodimer, Nat Immunol, 11, 155, 10.1038/ni.1836
Esler, 2001, A portrait of Alzheimer secretases—new features and familiar faces, Science, 293, 1449, 10.1126/science.1064638
Liao, 2004, Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway, J Biol Chem, 279, 49523, 10.1074/jbc.M402034200
Hong, 2003, Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes, Biochem Biophys Res Commun, 307, 922, 10.1016/S0006-291X(03)01270-1
Blasko, 2000, Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1–40 and Abeta1–42 by human astrocytes, Neurobiol Dis, 7, 682, 10.1006/nbdi.2000.0321
Heneka, 2005, Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice, J Neuroinflamm, 2, 22, 10.1186/1742-2094-2-22
Sastre, 2003, Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase, J Neurosci, 23, 9796, 10.1523/JNEUROSCI.23-30-09796.2003
Yan, 2003, Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease, J Neurosci, 23, 7504, 10.1523/JNEUROSCI.23-20-07504.2003
Heneka, 2005, Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice, Brain, 128, 1442, 10.1093/brain/awh452
Sastre, 2006, Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma, PNAS, 103, 443, 10.1073/pnas.0503839103
Daws, 2001, Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family, Eur J Immunol, 31, 783, 10.1002/1521-4141(200103)31:3<783::AID-IMMU783>3.0.CO;2-U
Hamerman, 2006, Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12, J Immunol, 177, 2051, 10.4049/jimmunol.177.4.2051
Turnbull, 2006, Cutting edge: TREM-2 attenuates macrophage activation, J Immunol, 177, 3520, 10.4049/jimmunol.177.6.3520
Ito, 2012, TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells, Eur J Immunol, 42, 176, 10.1002/eji.201141679
Takahashi, 2005, Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2, J Exp Med, 201, 647, 10.1084/jem.20041611
Hsieh, 2009, A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia, J Neurochem, 109, 1144, 10.1111/j.1471-4159.2009.06042.x
N‘Diaye, 2009, TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria, J Cell Biol, 184, 215, 10.1083/jcb.200808080
Stefano, 2009, The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor, J Neurochem, 110, 284, 10.1111/j.1471-4159.2009.06130.x
Paloneva, 2002, Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype, Am J Hum Genet, 71, 656, 10.1086/342259
Guerreiro, 2013, Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement, JAMA Neurol, 70, 78, 10.1001/jamaneurol.2013.579
Centonze, 2009, Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis, J Neurosci, 29, 3442, 10.1523/JNEUROSCI.5804-08.2009