Hippocampal Volume and Depression: A Meta-Analysis of MRI Studies

Videbech P: MRI findings in patients with affective disorder: a meta-analysis. Acta Psychiatr Scand 1997; 96:157–168

Strakowski SM, Adler CM, DelBello MP: Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder? Bipolar Disord 2002; 4:80–88

Soares JC, Mann JJ: The anatomy of mood disorders—review of structural neuroimaging studies. Biol Psychiatry 1997; 41:86–106

Beyer JL, Krishnan KR: Volumetric brain imaging findings in mood disorders. Bipolar Disord 2002; 4:89–104

Videbech P: PET measurements of brain glucose metabolism and blood flow in major depressive disorder: a critical review. Acta Psychiatr Scand 2000; 101:11–20

Fanselow MS: Contextual fear, gestalt memories, and the hippocampus. Behav Brain Res 2000; 110:73–81

Burgess N, Maguire EA, O’Keefe J: The human hippocampus and spatial and episodic memory. Neuron 2002; 35:625–641

Veiel HO: A preliminary profile of neuropsychological deficits associated with major depression. J Clin Exp Neuropsychol 1997; 19:587–603

Ravnkilde B, Videbech P, Clemmensen K, Egander A, Rasmussen NA, Rosenberg R: Cognitive deficits in major depression. Scand J Psychol 2002; 43:239–251

Kim JJ, Diamond DM: The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci 2002; 3:453–462

Checkley S: The neuroendocrinology of depression. Int Rev Psychiatry 1996; 8:373–378

Videbech P, Ravnkilde B, Pedersen AR, Egander A, Landbo B, Rasmussen NA, Andersen F, Stødkilde-Jørgensen H, Gjedde A, Rosenberg R: The Danish PET/Depression Project: PET findings in patients with major depression. Psychol Med 2001; 31:1147–1158

Videbech P, Ravnkilde B, Pedersen TH, Hartvig H, Egander A, Clemmensen K, Rasmussen NA, Andersen F, Gjedde A, Rosenberg R: The Danish PET/Depression Project: clinical symptoms and cerebral blood flow: a regions-of-interest analysis. Acta Psychiatr Scand 2002; 106:35–44

Saxena S, Brody AL, Ho ML, Alborzian S, Ho MK, Maidment KM, Huang SC, Wu HM, Au SC, Baxter LR Jr: Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol Psychiatry 2001; 50:159–170

Sheline YI, Mittler BL, Mintun MA: The hippocampus and depression. Eur Psychiatry 2002; 17:300–305

de Asis JM, Stern E, Alexopoulos GS, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eidelberg D, Kiosses D, Silbersweig DA: Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry 2001; 158:1321–1323

Kennedy SH, Evans KR, Krüger S, Mayberg HS, Meyer JH, McCann S, Arifuzzman AI, Houle S, Vaccarino FJ: Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Am J Psychiatry 2001; 158:899–905

Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, Jerabek PA: Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 2000; 48:830–843

Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA: The functional neuroanatomy of the placebo effect. Am J Psychiatry 2002; 159:728–737

MacQueen GM, Campbell S, McEwen BS, Macdonald K, Amano S, Joffe RT, Nahmias C, Young LT: Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci USA 2003; 100:1387–1392

Sheline YI, Wang PW, Gado MH, Csernansky JG, Vannier MW: Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996; 93:3908–3913

Sheline YI, Sanghavi M, Mintun MA, Gado MH: Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999; 19:5034–5043

Bell-McGinty S, Butters MA, Meltzer CC, Greer PJ, Reynolds CF III, Becker JT: Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. Am J Psychiatry 2002; 159:1424–1427

Steffens DC, Byrum CE, McQuoid DR, Greenberg DL, Payne ME, Blitchington TF, MacFall JR, Krishnan KR: Hippocampal volume in geriatric depression. Biol Psychiatry 2000; 48:301–309

Mervaala E, Fohr J, Kononen M, Valkonen-Korhonen M, Vainio P, Partanen K, Partanen J, Tiihonen J, Viinamaki H, Karjalainen AK, Lehtonen J: Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med 2000; 30:117–125

Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS: Hippocampal volume reduction in major depression. Am J Psychiatry 2000; 157:115–117

Shah PJ, Ebmeier KP, Glabus MF, Goodwin GM: Cortical grey matter reductions associated with treatment-resistant chronic unipolar depression: controlled magnetic resonance imaging study. Br J Psychiatry 1998; 172:527–532

Posener JA, Wang L, Price JL, Gado MH, Province MA, Miller MI, Babb CM, Csernansky JG: High-dimensional mapping of the hippocampus in depression. Am J Psychiatry 2003; 160:83–89

Frodl T, Meisenzahl EM, Zetzsche T, Born C, Groll C, Jäger M, Leinsinger G, Bottlender R, Hahn K, Möller H-J: Hippocampal changes in patients with a first episode of major depression. Am J Psychiatry 2002; 159:1112–1118

Rusch BD, Abercrombie HC, Oakes TR, Schaefer SM, Davidson RJ: Hippocampal morphometry in depressed patients and control subjects: relations to anxiety symptoms. Biol Psychiatry 2001; 50:960–964

von Gunten A, Fox NC, Cipolotti L, Ron MA: A volumetric study of hippocampus and amygdala in depressed patients with subjective memory problems. J Neuropsychiatry Clin Neurosci 2000; 12:493–498

Vakili K, Pillay SS, Lafer B, Fava M, Renshaw PF, Bonello-Cintron CM, Yurgelun-Todd DA: Hippocampal volume in primary unipolar major depression: a magnetic resonance imaging study. Biol Psychiatry 2000; 47:1087–1090

Ashtari M, Greenwald BS, Kramer-Ginsberg E, Hu J, Wu H, Patel M, Aupperle P, Pollack S: Hippocampal/amygdala volumes in geriatric depression. Psychol Med 1999; 29:629–638

Pantel J, Schroder J, Essig M, Popp D, Dech H, Knopp MV, Schad LR, Eysenbach K, Backenstrass M, Friedlinger M: Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affect Disord 1997; 42:69–83

Hsieh MH, McQuoid DR, Levy RM, Payne ME, MacFall JR, Steffens DC: Hippocampal volume and antidepressant response in geriatric depression. Int J Geriatr Psychiatry 2002; 17:519–525

Swayze VW II, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC: Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biol Psychiatry 1992; 31:221–240

Pearlson GD, Barta PE, Powers RE, Menon RR, Richards SS, Aylward EH, Federman EB, Chase GA, Petty RG, Tien AY: Ziskind-Somerfeld Research Award 1996: medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biol Psychiatry 1997; 41:1–14

Altshuler LL, Bartzokis G, Grieder T, Curran J, Mintz J: Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity. Arch Gen Psychiatry 1998; 55:663–664

Hirayasu Y, Shenton ME, Salisbury DF, Dickey CC, Fischer IA, Mazzoni P, Kisler T, Arakaki H, Kwon JS, Anderson JE, Yurgelun-Todd D, Tohen M, McCarley RW: Lower left temporal lobe MRI volumes in patients with first-episode schizophrenia compared with psychotic patients with first-episode affective disorder and normal subjects. Am J Psychiatry 1998; 155:1384–1391

Brambilla P, Harenski K, Nicoletti M, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC: MRI investigation of temporal lobe structures in bipolar patients. J Psychiatr Res 2003; 37:287–295

Hauser P, Matochik J, Altshuler LL, Denicoff KD, Conrad A, Li X, Post RM: MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders. J Affect Disord 2000; 60:25–32

Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, Larson ER: Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 1999; 56:254–260

Ali SO, Denicoff KD, Altshuler LL, Hauser P, Li X, Conrad AJ, Smith-Jackson EE, Leverich GS, Post RM: Relationship between prior course of illness and neuroanatomic structures in bipolar disorder: a preliminary study. Neuropsychiatry Neuropsychol Behav Neurol 2001; 14:227–232

Ali SO, Denicoff KD, Altshuler LL, Hauser P, Li X, Conrad AJ, Mirsky AF, Smith-Jackson EE, Post RM: A preliminary study of the relation of neuropsychological performance to neuroanatomic structures in bipolar disorder. Neuropsychiatry Neuropsychol Behav Neurol 2000; 13:20–28

Pantel J, O’Leary DS, Cretsinger K, Bockholt HJ, Keefe H, Magnotta VA, Andreasen NC: A new method for the in vivo volumetric measurement of the human hippocampus with high neuroanatomical accuracy. Hippocampus 2000; 10:752–758

Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL: Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatry Res 1997; 75:31–48

Pruessner JC, Collins DL, Pruessner M, Evans AC: Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood. J Neurosci 2001; 21:194–200

Krishnan KR: Biological risk factors in late life depression. Biol Psychiatry 2002; 52:185–192

Sheline YI, Gado MH, Kraemer HV: Untreated depression and hippocampal volume loss. Am J Psychiatry 2003; 160:1516–1518

Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM: The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev 2003; 27:33–44

Tanev K: Neuroimaging and neurocircuitry in post-traumatic stress disorder: what is currently known? Curr Psychiatry Rep 2003; 5:369–383

De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS: Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 2000; 157:737–744

Kessing LV, Olsen EW, Mortensen PB, Andersen PK: Dementia in affective disorder: a case-register study. Acta Psychiatr Scand 1999; 100:176–185

Jorm AF: History of depression as a risk factor for dementia: an updated review. Aust NZ J Psychiatry 2001; 35:776–781

Jorm AF: Is depression a risk factor for dementia or cognitive decline? a review. Gerontology 2000; 46:219–227

Trichard C, Martinot JL, Alagille M, Masure MC, Hardy P, Ginestet D, Feline A: Time course of prefrontal lobe dysfunction in severely depressed in-patients: a longitudinal neuropsychological study. Psychol Med 1995; 25:79–85

Paradiso S, Lamberty GJ, Garvey MJ, Robinson RG: Cognitive impairment in the euthymic phase of chronic unipolar depression. J Nerv Ment Dis 1997; 185:748–754

Kessing LV: Cognitive impairment in the euthymic phase of affective disorder. Psychol Med 1998; 28:1027–1038

Steffens DC, Payne ME, Greenberg DL, Byrum CE, Welsh-Bohmer KA, Wagner HR, MacFall JR: Hippocampal volume and incident dementia in geriatric depression. Am J Geriatr Psychiatry 2002; 10:62–71

Eriksson PS, Perfilieva E, Bjork-Eriksson T, Alborn AM, Nordborg C, Peterson DA, Gage FH: Neurogenesis in the adult human hippocampus. Nat Med 1998; 4:1313–1317

Lee AL, Ogle WO, Sapolsky RM: Stress and depression: possible links to neuron death in the hippocampus. Bipolar Disord 2002; 4:117–128

Sapolsky RM: Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 2000; 57:925–935

Cotter DR, Pariante CM, Everall IP: Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Res Bull 2001; 55:585–595

Rajkowska G: Cell pathology in mood disorders. Semin Clin Neuropsychiatry 2002; 7:281–292

Starkman MN, Gebarski SS, Berent S, Schteingart DE: Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing’s syndrome. Biol Psychiatry 1992; 32:756–765

Arana GW, Baldessarini RJ, Ornsteen M: The dexamethasone suppression test for diagnosis and prognosis in psychiatry: commentary and review. Arch Gen Psychiatry 1985; 42:1193–1204

Arborelius L, Owens MJ, Plotsky PM, Nemeroff CB: The role of corticotropin-releasing factor in depression and anxiety disorders. J Endocrinol 1999; 160:1–12

Jacobson L, Sapolsky R: The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 1991; 12:118–134

Mitchell A: The contribution of hypercortisolaemia to the cognitive decline of geriatric depression. Int J Geriatr Psychiatry 1995; 10:401–409

Carrasco GA, Van De Kar LD: Neuroendocrine pharmacology of stress. Eur J Pharmacol 2003; 463:235–272

Kimbrell TA, Ketter TA, George MS, Little JT, Benson BE, Willis MW, Herscovitch P, Post RM: Regional cerebral glucose utilization in patients with a range of severities of unipolar depression. Biol Psychiatry 2002; 51:237–252

McEwen BS: Effects of adverse experiences for brain structure and function. Biol Psychiatry 2000; 48:721–731

Sapolsky RM: The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death. Biol Psychiatry 2000; 48:755–765

Duman RS, Heninger GR, Nestler EJ: A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54:597–606

Holsboer F: Implications of altered limbic-hypothalamic-pituitary-adrenocortical (LHPA)-function for neurobiology of depression. Acta Psychiatr Scand Suppl 1988; 341:72–111

Axelson DA, Doraiswamy PM, McDonald WM, Boyko OB, Tupler LA, Patterson LJ, Nemeroff CB, Ellinwood EH Jr, Krishnan KR: Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 1993; 47:163–173

Pariante CM, Miller AH: Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 2001; 49:391–404

Miguel-Hidalgo JJ, Rajkowska G: Morphological brain changes in depression: can antidepressants reverse them? CNS Drugs 2002; 16:361–372

Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R: Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003; 301:805–809

Manji HK, Moore GJ, Rajkowska G, Chen G: Neuroplasticity and cellular resilience in mood disorders. Mol Psychiatry 2000; 5:578–593

Scheltens P: Early diagnosis of dementia: neuroimaging. J Neurol 1999; 246:16–20