Psychopharmacological studies in rats responding at touch-sensitive devices
Tóm tắt
A multiple choice serial reaction time task was used to investigate visual attention in rats. The intelligence panel consisted of a transparent touch-sensitive device, placed directly in front of a video monitor. Amphetamine (0.2–1.6 mg/kg IP) increased errors of omission and decreased latency to respond, but had no effect on accuracy. The 5-HT agonist quipazine (0.6–2.4 mg/kg IP) increased errors of omission, but did not affect other parameters. ICV administration of hemicholinium-3 (1–4 µg) had no effect upon performance. Thus, psychopharmacological manipulations can reliably alter performance in the touch window box, suggesting potential new avenues for rat cognitive testing.
Tài liệu tham khảo
Bussey TJ, Muir JL, Robbins TW (1994) A novel automated touchscreen procedure for assessing learning in the rat using computer graphic stimuli. Neurosci Res Commun 15: 103–110
Carli M, Samanin R (1992) Serotonin2 receptor agonists and serotonergic anorectic drugs affect rats performance differently in a five-choice serial reaction time task. Psychopharmacology 106: 228–234
Cole BJ, Robbins TW (1987) Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions. Psychopharmacology 91: 458–466
Cole BJ, Robbins TW (1992) Forebrain norepinephrine: role in controlled information processing in the rat. Neuropsychopharmacology 7: 129–142
Gaffan D, Saunders RC, Gaffan EA, Harrison S, Shields C, Owen MJ (1984) Effects of fornix transection upon associative memory in monkeys: role of the hippocampus in learned action. Q J Exp Psychol 36B: 173–221
Jäkälä P, Sirviö J, Jolkkonen J, Riekkinen P Jr, Acsady L, Riekkinen P (1992) The effects ofp-chlorophenylalanine-induced serotonin synthesis inhibition and muscarinic blockade on the performance of rats in a 5-choice serial reaction time task. Behav Brain Res 51: 29–40
Kirkby DL, Jones DNC, Higgins GA (1994) Hemicholinium-3 and cognition. J Psychopharmacol 8 [Suppl]: A13
Morris RG, Evenden JL, Sahakian, BJ, Robbins TW (1987) Computer-aided assessment of dementia: comparative studies of neuropsychological deficits in Alzheimer-type dementia and Parkinson's disease. In: Stahl SM, Iversen SD, Goodman EC (eds) Cognitive neurochemistry. Oxford University Press, Oxford, pp 21–36
Muir J, Dunnett SB, Robbins TW, Everitt BJ (1992) Attentional functions of the basal forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task. Exp Brain Res 89: 611–622
Pisacreta R, Rilling M (1987) Infrared touch technology as a response detector in animal research. Behav Res Meth Instr Comput 19: 389–396
Robbins TW, Muir JL, Killcross AS, Pretsell D (1993) Methods for assessing attention and stimulus control in the rat. In Sahgal A (ed) Behavioural neuroscience: a practical approach, vol. 1. IRL Press, Oxford, pp 13–47
Sahgal A, Steckler T (1994) Touch Windows and operant behaviour in rats. J Neurosci Methods 55: 59–64
Samanin R, Bendotti C, Miranda F, Garattini S (1977) Decrease of food intake by quipazine in the rat: relation to serotonergic receptor stimulation. J Pharm Pharmacol 29: 53–54
Steckler T, Sahgal A (1995) The role of serotonergic-cholinergic interactions in the mediation of cognitive behaviour. Behav Brain Res (in press)