RASSF5: An MST activator and tumor suppressor in vivo but opposite in vitro
Tóm tắt
Từ khóa
Tài liệu tham khảo
Donninger, 2016, Ras signaling through RASSF proteins, Semin Cell Dev Biol, 10.1016/j.semcdb.2016.06.007
Sun, 2016, Cellular organization and cytoskeletal regulation of the hippo signaling network, Trends Cell Biol, 10.1016/j.tcb.2016.05.003
Fallahi, 2016, The MST/hippo pathway and cell death: a non-canonical affair, Genes (Basel), 7, 10.3390/genes7060028
Kapoor, 2014, Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer, Cell, 158, 185, 10.1016/j.cell.2014.06.003
Shao, 2014, KRAS and YAP1 converge to regulate EMT and tumor survival, Cell, 158, 171, 10.1016/j.cell.2014.06.004
Lin, 2016, The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors, Mol Cell Oncol, 3, e1021441, 10.1080/23723556.2015.1021441
Nussinov, 2016, Oncogenic KRAS signaling and YAP1/beta-catenin: similar cell cycle control in tumor initiation, Semin Cell Dev Biol, 10.1016/j.semcdb.2016.04.001
Nussinov, 2016, Independent and core pathways in oncogenic KRAS signaling, Expert Rev Proteomics, 10.1080/14789450.2016.1209417
Lu, 2016, Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view, Chem Soc Rev
Lu, 2016, Ras conformational ensembles, allostery, and signaling, Chem Rev, 116, 6607, 10.1021/acs.chemrev.5b00542
Prior, 2012, A comprehensive survey of Ras mutations in cancer, Cancer Res, 72, 2457, 10.1158/0008-5472.CAN-11-2612
Sharif, 2015, Cell density regulates cancer metastasis via the Hippo pathway, Future Oncol, 11, 3253, 10.2217/fon.15.268
Nussinov, 2015, Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation, Expert Rev Proteomics, 12, 669, 10.1586/14789450.2015.1100079
Smith, 2014, Integrated RAS signaling defined by parallel NMR detection of effectors and regulators, Nat Chem Biol, 10, 223, 10.1038/nchembio.1435
Chen, 2016, Ras dimer formation as a new signaling mechanism and potential cancer therapeutic target, Mini Rev Med Chem, 16, 391, 10.2174/1389557515666151001152212
Jambrina, 2016, Phosphorylation of RAF kinase dimers drives conformational changes that facilitate transactivation, Angew Chem Int Ed Engl, 55, 983, 10.1002/anie.201509272
Peng, 2015, Inhibition of RAF isoforms and active dimers by LY3009120 leads to anti-tumor activities in RAS or BRAF mutant cancers, Cancer Cell, 28, 384, 10.1016/j.ccell.2015.08.002
Sayyed-Ahmad, 2016, Computational equilibrium thermodynamic and kinetic analysis of K-Ras dimerization through an effector binding surface suggests limited functional role, J Phys Chem B, 10.1021/acs.jpcb.6b02403
Jang, 2016, Membrane-associated Ras dimers are isoform-specific: K-Ras dimers differ from H-Ras dimers, Biochem J, 473, 1719, 10.1042/BCJ20160031
Banerjee, 2016, The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding, Curr Opin Struct Biol, 36, 10, 10.1016/j.sbi.2015.11.010
Hwang, 2014, Structural basis of the heterodimerization of the MST and RASSF SARAH domains in the Hippo signalling pathway, Acta Crystallogr D Biol Crystallogr, 70, 1944, 10.1107/S139900471400947X
Makbul, 2013, Structural and thermodynamic characterization of Nore1-SARAH: a small, helical module important in signal transduction networks, Biochemistry, 52, 1045, 10.1021/bi3014642
Stieglitz, 2008, Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II, EMBO J, 27, 1995, 10.1038/emboj.2008.125
Nan, 2015, Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway, Proc Natl Acad Sci U S A, 112, 7996, 10.1073/pnas.1509123112
Kovrigina, 2015, The Ras G domain lacks the intrinsic propensity to form dimers, Biophys J, 109, 1000, 10.1016/j.bpj.2015.07.020
Zhou, 2015, Ras nanoclusters: versatile lipid-based signaling platforms, Biochim Biophys Acta, 1853, 841, 10.1016/j.bbamcr.2014.09.008
Zhou, 2014, Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters, Mol Cell Biol, 34, 862, 10.1128/MCB.01227-13
Ni, 2013, Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5, Structure, 21, 1757, 10.1016/j.str.2013.07.008
Avruch, 2012, Protein kinases of the Hippo pathway: regulation and substrates, Semin Cell Dev Biol, 23, 770, 10.1016/j.semcdb.2012.07.002
Creasy, 1996, The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain, J Biol Chem, 271, 21049, 10.1074/jbc.271.35.21049
Hwang, 2007, Structural insight into dimeric interaction of the SARAH domains from Mst1 and RASSF family proteins in the apoptosis pathway, Proc Natl Acad Sci U S A, 104, 9236, 10.1073/pnas.0610716104
Richter, 2009, The RASSF proteins in cancer; from epigenetic silencing to functional characterization, Biochim Biophys Acta, 1796, 114
Avruch, 2009, Rassf family of tumor suppressor polypeptides, J Biol Chem, 284, 11001, 10.1074/jbc.R800073200
Aoyama, 2004, Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases, Oncogene, 23, 3426, 10.1038/sj.onc.1207486
Guo, 2007, RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network, Curr Biol, 17, 700, 10.1016/j.cub.2007.02.055
Oh, 2006, Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis, Cancer Res, 66, 2562, 10.1158/0008-5472.CAN-05-2951
Ikeda, 2009, Hippo pathway-dependent and -independent roles of RASSF6, Sci Signal, 2, ra59, 10.1126/scisignal.2000300
Khokhlatchev, 2002, Identification of a novel Ras-regulated proapoptotic pathway, Curr Biol, 12, 253, 10.1016/S0960-9822(02)00683-8
Praskova, 2004, Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras, Biochem J, 381, 453, 10.1042/BJ20040025
Cooper, 2009, RASSF2 associates with and stabilizes the proapoptotic kinase MST2, Oncogene, 28, 2988, 10.1038/onc.2009.152
Song, 2010, Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity, Biochem Biophys Res Commun, 391, 969, 10.1016/j.bbrc.2009.11.175
Vos, 2003, The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung, J Biol Chem, 278, 21938, 10.1074/jbc.M211019200
Calvisi, 2009, NORE1A tumor suppressor candidate modulates p21CIP1 via p53, Cancer Res, 69, 4629, 10.1158/0008-5472.CAN-08-3672
Park, 2010, Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis, J Biol Chem, 285, 35029, 10.1074/jbc.M110.165506
Calvisi, 2006, Ubiquitous activation of Ras and Jak/Stat pathways in human HCC, Gastroenterology, 130, 1117, 10.1053/j.gastro.2006.01.006
Calvisi, 2008, Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control, Int J Cancer, 123, 2057, 10.1002/ijc.23720
Sanchez-Sanz, 2016, MST2-RASSF protein-protein interactions through SARAH domains, Brief Bioinform, 17, 593, 10.1093/bib/bbv070
Chavan, 2015, Plasma membrane regulates Ras signaling networks, Cell Logist, 5, e1136374, 10.1080/21592799.2015.1136374
Kerkhoff, 1998, Cell cycle targets of Ras/Raf signalling, Oncogene, 17, 1457, 10.1038/sj.onc.1202185
Ewen, 2000, Relationship between Ras pathways and cell cycle control, Prog Cell Cycle Res, 4, 1, 10.1007/978-1-4615-4253-7_1
Zhang, 2002, MAPK signal pathways in the regulation of cell proliferation in mammalian cells, Cell Res, 12, 9, 10.1038/sj.cr.7290105
Donninger, 2014, Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppression, J Biol Chem, 289, 31287, 10.1074/jbc.M114.609537
Zhang, 2012, Wnt/beta-catenin signaling pathway upregulates c-Myc expression to promote cell proliferation of P19 teratocarcinoma cells, Anat Rec (Hoboken), 295, 2104, 10.1002/ar.22592
Kaveri, 2013, beta-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL, Blood, 122, 694, 10.1182/blood-2012-12-471904
Juan, 2014, Diminished WNT->beta-catenin->c-MYC signaling is a barrier for malignant progression of BRAFV600E-induced lung tumors, Genes Dev, 28, 561, 10.1101/gad.233627.113
Palomero, 2006, NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth, Proc Natl Acad Sci U S A, 103, 18261, 10.1073/pnas.0606108103
Dongre, 2014, Non-canonical notch signaling drives activation and differentiation of peripheral CD4(+) T cells, Front Immunol, 5, 54, 10.3389/fimmu.2014.00054
Sharma, 2015, PI3K/AKT/mTOR and sonic hedgehog pathways cooperate together to inhibit human pancreatic cancer stem cell characteristics and tumor growth, Oncotarget, 6, 32039, 10.18632/oncotarget.5055
Ramaswamy, 2012, Hedgehog signaling is a novel therapeutic target in tamoxifen-resistant breast cancer aberrantly activated by PI3K/AKT pathway, Cancer Res, 72, 5048, 10.1158/0008-5472.CAN-12-1248
Kern, 2015, Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia, Oncogene, 34, 5341, 10.1038/onc.2014.450
Ilic, 2011, PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis, Proc Natl Acad Sci U S A, 108, E699, 10.1073/pnas.1108237108
Cope, 2014, Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation, J Cell Sci, 127, 788, 10.1242/jcs.137588
Boussemart, 2014, eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies, Nature, 513, 105, 10.1038/nature13572
Muellner, 2011, A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer, Nat Chem Biol, 7, 787, 10.1038/nchembio.695
Nussinov, 2013, A broad view of scaffolding suggests that scaffolding proteins can actively control regulation and signaling of multienzyme complexes through allostery, Biochim Biophys Acta, 1834, 820, 10.1016/j.bbapap.2012.12.014