Nanoemulsion: an advanced mode of drug delivery system
Tóm tắt
An advanced mode of drug delivery system has been developed to overcome the major drawbacks associated with conventional drug delivery systems. This review gives a detailed idea about a nanoemulsion system. Nanoemulsions are nano-sized emulsions, which are manufactured for improving the delivery of active pharmaceutical ingredients. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of an emulsifying agent, i.e., surfactant and co-surfactant. The droplet size of nanoemulsion falls typically in the range 20–200 nm. The main difference between emulsion and nanoemulsion lies in the size and shape of particles dispersed in the continuous phase. In this review, the attention is focused to give a basic idea about its formulation, method of preparation, characterization techniques, evaluation parameters, and various applications of nanoemulsion.
Tài liệu tham khảo
Ahuja A, Ali J, Baboota S, Faisal MS, Shakeell F, Shafiq S (2008) Stability evaluation of Celecoxib nanoemulsion containing Tween 80. Thai J Pharm Sci 32:4–9
Alka AJA, Baboota S, Shakeel F, Shafiq S (2007) Design development and evaluation of novel nanoemulsion formulations for transdermal potential of Celecoxib. Acta Pharm 57:315–332. doi:10.2478/v10007-007-0025-5
Anton N, Benoit JP, Saulnier P (2008) Design and production of nanoparticles formulated from nano-emulsion templates-a review. J Control Release 128:185–199
Asua JM (2002) Miniemulsion polymerization. Prog Polym Sci 27:1283–1346
Banker GS, Lieberman HA, Rieger MM (2002) Pharmaceutical dosage forms. Disperse Syst Marcel Dekker 2(3):339–340
Bouchemal K, Briancon S, Fessi H, Perrier E (2004a) Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization. Int J Pharm 280:242
Bouchemal K, Briancon S, Fessi H, Perrier E (2004b) Nano-emulsion formulation using spontaneous emulsification: solvent, oil and surfactant optimization. Int J Pharm 280:243
Chen H, Du D, Mao CMD, Wan J, Xu H, Yang X (2008) Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm 353:272
El-Aasser MS, Lack CD, Vanderhoff JW, Fowkes FM (1986) Miniemulsification process-different form of spontaneous emulsification. Coll Surf 29:103–118
Erol Y, Hans-Hubert B (2005) Design of a phytosphingosine-containing, positively-charged nanoemulsion as a colloidal carrier system for dermal application of ceramides. Eur J Pharm Biopharm 60:93
Farhan AJ, Mushir A, Faiyaz S, Cushman T, Roop KK, Sheikh S (2008) Investigation of nanoemulsion system for transdermal delivery of domperidone: ex-vivo and in vivo studies. Curr Nanosci 4(4):381–390
Gasco MR, Gallarate M, Pattarino F (1991) In vitro permeation of azelaic acid from viscosized microemulsions. Int J Pharm 69:193–196
Kim CK, Cho YJ, Gao ZG (2001) Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J Control Release 70:149–155
Kriwet K, Müller-Goymann C (1995) Diclofenac release from phospholipid drug systems and permeation through excised human stratum corneum. Int J Pharm 125:231–242
Perdiguer AC, Dachs FJG, Carreras N, Valdivia (1997) Nanoemulsion of the oil water type, useful as an ophthalmic vehicle and process for the preparation thereof Assignee: Laboratorios Cusi, S.A. (Barcelona, ES)
Pouton CW (1997) Formulation of selfemulsifying drug delivery systems. Adv Drug Deliv Rev 25:47–58
Sharma SN, Jain NK (1985) A text book of professional pharmacy. Vallabh Prakashan, 1st edn, p 201
Singh KK, Vingkar SK (2008) Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine. Int J Pharm 347:138
Solans C, Izquierdo P, Nolla J, Azemar N, Garcia-Celma MJ (2005) Nanoemulsions. Curr Opin Coll Interface Sci 10:102–110
Tadros T, Izquierdo P, Esquena J, Solans C (2004) Formation and stability of nano-emulsions. Adv Coll Interface Sci 108:303–318
Tiwari SB, Amiji MM (2006) Nanoemulsion formulations for tumor-targeted delivery. Nanotech Cancer Therapy. Taylor and Francis Group Editors, pp 723–739
Trotta M (1999) Influence of phase transformation on indomethacin release from microemulsions. J Control Release 60:399–405
Wagner JG, Gerrard ES, Kaiser DG (1996) The effect of the dosage form on serum levels of indoxole. Clin Pharmacol Ther 7:610–619