Camelina sativa: An ideal platform for the metabolic engineering and field production of industrial lipids

Badami, 1980, Structure and occurrence of unusual fatty acids in minor seed oils, Prog. Lipid Res, 19, 119, 10.1016/0163-7827(80)90002-8 Li-Beisson, 2013, vol. 11, e0161 Wallis, 2010, Lipid biochemists salute the genome, Plant J., 61, 1092, 10.1111/j.1365-313X.2010.04125.x Knorzer, 1978, Evolution and Spreading of gold of pleasure (Camelina sativa sl), Ber. Deut Bot. Ges, 91, 187 Soriano, 2012, Evaluation of biodiesel derived from Camelina sativa oil, J. Am. Oil Chem. Soc, 89, 917, 10.1007/s11746-011-1970-1 Putnam, 1993, Camelina: a promising low-input oilseed, 314 Blackshaw, 2011, Alternative oilseed crops for biodiesel feedstock on the Canadian prairies, Can. J. Plant Sci, 91, 889, 10.4141/cjps2011-002 Dobre, 2011, Camelina crop-opportunities for a sustainable agriculture, Sci. Papers Series A Agron, 54, 420 Zubr, 1997, Oil-seed crop: Camelina sativa, Ind. Crops Prod, 6, 113, 10.1016/S0926-6690(96)00203-8 Urbaniak, 2008, The effect of cultivar and applied nitrogen on the performance of Camelina sativa L. in the Maritime Provinces of Canada, Can. J. Plant Sci, 88, 111, 10.4141/CJPS07115 Karcauskiene, 2014, False flax (Camelina sativa L.) as an alternative source for biodiesel production, Zemdirbyste, 101, 161, 10.13080/z-a.2014.101.021 Wysocki, 2013, Camelina: seed yield response to applied nitrogen and sulfur, Field Crops Res, 145, 60, 10.1016/j.fcr.2013.02.009 Enjalbert, 2013, Brassicaceae germplasm diversity for agronomic and seed quality traits under drought stress, Ind. Crop Prod, 47, 176, 10.1016/j.indcrop.2013.02.037 Gugel, 2006, Agronomic and seed quality evaluation of Camelina sativa in western Canada, Can. J. Plant Sci, 86, 1047, 10.4141/P04-081 Hunsaker, 2011, Water use, crop coefficients, and irrigation management criteria for Camelina production in arid regions, Irrig. Sci, 29, 27, 10.1007/s00271-010-0213-9 Conn, 1988, Resistance to Alternaria brassicae and phytoalexin-elicitation in rapeseed and other crucifers, Plant Sci, 56, 21, 10.1016/0168-9452(88)90180-X Sharma, 2002, Brassica coenospecies: a rich reservoir for genetic resistance to leaf spot caused by Alternaria brassicae, Euphytica, 125, 411, 10.1023/A:1016050631673 Li, 2005, Hazard from reliance on cruciferous hosts as sources of major gene-based resistance for managing blackleg (Leptosphaeria maculans) disease, Field Crop Res, 91, 185, 10.1016/j.fcr.2004.06.006 Séguin-Swartz, 2009, Diseases of Camelina sativa (false flax), Can. J. Plant Pathol, 31, 375, 10.1080/07060660909507612 Behera, 2010, Evaluation of plant performance of Jatropha curcas L. under different agro-practices for optimizing biomass – a case study, Biomass Bioenerg, 34, 30, 10.1016/j.biombioe.2009.09.008 Shonnard, 2010, Camelina-derived jet fuel and diesel: sustainable advanced biofuels, Environ. Prog. Sustain Energy, 29, 382, 10.1002/ep.10461 Gesch, 2013, Double-cropping with winter Camelina in the northern Corn Belt to produce fuel and food, Ind. Crop Prod, 44, 718, 10.1016/j.indcrop.2012.05.023 Gesch, 2014, Dual cropping winter Camelina with soybean in the northern Corn Belt, Agron. J., 106, 1735, 10.2134/agronj14.0215 Krohn, 2012, A life cycle assessment of biodiesel derived from the “niche filling” energy crop Camelina in the USA, Appl. Energ, 92, 92, 10.1016/j.apenergy.2011.10.025 Li, 2014, Life cycle assessment of Camelina oil derived biodiesel and jet fuel in the Canadian Prairies, Sci. Total Environ, 481, 17, 10.1016/j.scitotenv.2014.02.003 Liu, 2012, Transformation of the oilseed crop Camelina sativa by Agrobacterium-mediated floral dip and simple large-scale screening of transformants, In Vitro Cell Dev. Biol. – Plant, 48, 462, 10.1007/s11627-012-9459-7 Lu, 2008, Generation of transgenic plants of a potential oilseed crop Camelina sativa by Agrobacterium-mediated transformation, Plant Cell. Rep, 27, 273, 10.1007/s00299-007-0454-0 Nguyen, 2013, Camelina seed transcriptome: a tool for meal and oil improvement and translational research, Plant Biotechnol. J., 11, 759, 10.1111/pbi.12068 Kagale, 2014, The emerging biofuel crop Camelina sativa retains a highly undifferentiated hexaploid genome structure, Nat. Commun, 5, 3706, 10.1038/ncomms4706 Hutcheon, 2010, Polyploid genome of Camelina sativa revealed by isolation of fatty acid synthesis genes, BMC Plant Biol, 10, 233, 10.1186/1471-2229-10-233 Kang, 2011, Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa, Plant Physiol. Biochem, 49, 223, 10.1016/j.plaphy.2010.12.004 Belhaj, 2013, Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system, Plant Methods, 9, 39, 10.1186/1746-4811-9-39 Feng, 2013, Efficient genome editing in plants using a CRISPR/Cas system, Cell. Res, 23, 1229, 10.1038/cr.2013.114 Feng, 2014, Multigeneration analysis reveals the inheritance, specificity, and patterns of CRISPR/Cas-induced gene modifications in Arabidopsis, Proc. Natl. Acad. Sci. U. S. A., 111, 4632, 10.1073/pnas.1400822111 Li, 2013, Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9, Nat. Biotech, 31, 688, 10.1038/nbt.2654 Mao, 2013, Application of the CRISPR–Cas system for efficient genome engineering in plants, Mol. Plant, 6, 2008, 10.1093/mp/sst121 Bates, 2012, The significance of different diacylgycerol synthesis pathways on plant oil composition and bioengineering, Front. Plant Sci, 3, 10.3389/fpls.2012.00147 Bates, 2013, Biochemical pathways in seed oil synthesis, Curr. Opin. Plant Biol, 16, 358, 10.1016/j.pbi.2013.02.015 Ohlrogge, 1997, Regulation of Fatty Acid Synthesis, Annu. Rev. Plant Physiol. Plant Mol. Biol, 48, 109, 10.1146/annurev.arplant.48.1.109 Bates, 2011, The pathway of triacylglycerol synthesis through phosphatidylcholine in Arabidopsis produces a bottleneck for the accumulation of unusual fatty acids in transgenic seeds, Plant J., 68, 387, 10.1111/j.1365-313X.2011.04693.x Bates, 2009, Analysis of acyl fluxes through multiple pathways of triacylglycerol synthesis in developing soybean embryos, Plant Physiol, 150, 55, 10.1104/pp.109.137737 Bates, 2012, Acyl editing and headgroup Exchange are the major mechanisms that direct polyunsaturated fatty acid flux into triacylglycerols, Plant Physiol, 160, 1530, 10.1104/pp.112.204438 Lager, 2013, Plant acyl-CoA: lysophosphatidylcholine acyltransferases (LPCATs) have different specificities in their forward and reverse reactions, J. Biol. Chem, 288, 36902, 10.1074/jbc.M113.521815 Wang, 2012, Metabolic Interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds, Plant Cell, 24, 4652, 10.1105/tpc.112.104604 Kennedy, 1961, Biosynthesis of complex lipids, Fed. Proc, 20, 934 Liu, 2012, Acyl-CoA:diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology, Prog. Lipid Res, 51, 350, 10.1016/j.plipres.2012.06.001 Dahlqvist, 2000, Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants, Proc. Natl. Acad. Sci. U. S. A., 97, 6487, 10.1073/pnas.120067297 Stahl, 2004, Cloning and functional characterization of a phospholipid:diacylglycerol acyltransferase from Arabidopsis, Plant Physiol, 135, 1324, 10.1104/pp.104.044354 Zhang, 2009, DGAT1 and PDAT1 acyltransferases have Overlapping functions in Arabidopsis triacylglycerol biosynthesis and are essential for normal pollen and seed development, Plant Cell, 21, 3885, 10.1105/tpc.109.071795 Pan, 2013, Identification of a pair of phospholipid:diacylglycerol acyltransferases from developing flax (Linum usitatissimum L.) seed catalyzing the selective production of trilinolenin, J. Biol. Chem, 288, 24173, 10.1074/jbc.M113.475699 Lu, 2009, An enzyme regulating triacylglycerol composition is encoded by the ROD1 gene of Arabidopsis, Proc. Natl. Acad. Sci. U. S. A., 106, 18837, 10.1073/pnas.0908848106 Slack, 1983, Some evidence for the reversibility of the cholinephosphotransferase-catalyzed reaction in developing linseed cotyledons in vivo, Biochim. Biophys. Acta, 754, 10, 10.1016/0005-2760(83)90076-0 Broun, 1998, Catalytic Plasticity of fatty acid modification enzymes Underlying chemical diversity of plant lipids, Science, 282, 1315, 10.1126/science.282.5392.1315 Bafor, 1991, Ricinoleic acid biosynthesis and triacylglycerol assembly in microsomal preparations from developing castor-bean (Ricinus communis) endosperm, Biochem. J., 280, 507, 10.1042/bj2800507 van de Loo, 1995, An oleate 12-hydroxylase from Ricinus communis L. is a fatty acyl desaturase homolog, Proc. Natl. Acad. Sci. U. S. A., 92, 6743, 10.1073/pnas.92.15.6743 Broun, 1997, Accumulation of ricinoleic, lesquerolic, and densipolic acids in seeds of transgenic Arabidopsis plants that Express a fatty acyl hydroxylase cDNA from Castor bean, Plant Physiol, 113, 933, 10.1104/pp.113.3.933 Thelen, 2002, Metabolic engineering of fatty acid biosynthesis in plants, Metab. Eng, 4, 12, 10.1006/mben.2001.0204 Cahoon, 2006, Conjugated fatty acids accumulate to high levels in phospholipids of metabolically engineered soybean and Arabidopsis seeds, Phytochemistry, 67, 1166, 10.1016/j.phytochem.2006.04.013 van Erp, 2011, Castor phospholipid:diacylglycerol acyltransferase facilitates efficient metabolism of hydroxy fatty acids in transgenic arabidopsis, Plant Physiol, 155, 683, 10.1104/pp.110.167239 Burgal, 2008, Metabolic engineering of hydroxy fatty acid production in plants: RcDGAT2 drives dramatic increases in ricinoleate levels in seed oil, Plant Biotechnol. J., 6, 819, 10.1111/j.1467-7652.2008.00361.x Hu, 2012, The phosphatidylcholine diacylglycerol cholinephosphotransferase is required for efficient hydroxy fatty acid accumulation in transgenic Arabidopsis, Plant Physiol, 158, 1944, 10.1104/pp.111.192153 Snapp, 2014, A fatty acid condensing enzyme from Physaria fendleri increases hydroxy fatty acid accumulation in transgenic oilseeds of Camelina sativa, Planta, 240, 599, 10.1007/s00425-014-2122-2 Durrett, 2008, Plant triacylglycerols as feedstocks for the production of biofuels, Plant J., 54, 593, 10.1111/j.1365-313X.2008.03442.x Nguyen, 2010, Metabolic engineering of seeds can achieve levels of ω-7 fatty acids comparable with the highest levels found in natural plant sources, Plant Physiol, 154, 1897, 10.1104/pp.110.165340 Nguyen, 2015, Redirection of metabolic flux for high levels of omega-7 monounsaturated fatty acid accumulation in Camelina seeds, Plant Biotechnol. J., 13, 38, 10.1111/pbi.12233 Bagby, 1967, Asymmetric triglycerides from Impatiens edgeworthii seed oil, Biochim. Biophys. Acta, 137, 475, 10.1016/0005-2760(67)90128-2 Kleiman, 1967, (S)-1,2-diacyl-3-acetins: Optically active triglycerides from Euonymus verrucosus seed oil, Lipids, 2, 473, 10.1007/BF02533174 Durrett, 2010, A distinct DGAT with sn-3 acetyltransferase activity that synthesizes unusual, reduced-viscosity oils in Euonymus and transgenic seeds, Proc. Natl. Acad. Sci. U. S. A., 107, 9464, 10.1073/pnas.1001707107 Ryan, 1984, The effects of vegetable oil properties on injection and combustion in two different diesel-engines, J. Am. Oil Chem. Soc, 61, 1610, 10.1007/BF02541645 Liu, 2015, Metabolic engineering of oilseed crops top produce high levels of novel acetyl glyceride oils with reduced viscosity, freezing point and calorific value, Plant Biotechnol. J., 13, 858, 10.1111/pbi.12325 Liu, 2015, Field production, purification and analysis of high-oleic acetyl-triacylglycerols from transgenic Camelina sativa, Ind. Crop Prod, 65, 259, 10.1016/j.indcrop.2014.11.019 Li, 2012, Vernonia DGATs can complement the disrupted oil and protein metabolism in epoxygenase-expressing soybean seeds, Metab. Eng, 14, 29, 10.1016/j.ymben.2011.11.004 Singh, 2001, Transgenic expression of a Δ12-epoxygenase gene in Arabidopsis seeds inhibits accumulation of linoleic acid, Planta, 212, 872, 10.1007/s004250000456 Bates, 2014, Fatty acid synthesis is inhibited by inefficient utilization of unusual fatty acids for glycerolipid assembly, Proc. Natl. Acad. Sci. U. S. A., 111, 1204, 10.1073/pnas.1318511111 Knothe, 2003, Dependence of oil stability index of fatty compounds on their structure and concentration and presence of metals, J. Am. Oil Chem. Soc, 80, 1021, 10.1007/s11746-003-0814-x Niedzielski, 1976, Neopentyl polyol ester lubricants - bulk property optimization, Ind. Eng. Chem. Prod. Res. Dev, 15, 54 ASTM D97-12, 2012 ASTM D2500-11, 2011 ASTM D613-14, 2014 Rodríguez-Rodríguez, 2013, Characterization of the morphological changes and fatty acid profile of developing Camelina sativa seeds, Ind. Crop Prod, 50, 673, 10.1016/j.indcrop.2013.07.042 Vollmann, 2005, Genetic diversity in Camelina germplasm as revealed by seed quality characteristics and RAPD polymorphism, Plant Breed, 124, 446, 10.1111/j.1439-0523.2005.01134.x Vollmann, 2007, Agronomic evaluation of Camelina genotypes selected for seed quality characteristics, Ind. Crop Prod, 26, 270, 10.1016/j.indcrop.2007.03.017 Desta, 2014, Genomic selection: genome-wide prediction in plant improvement, Trends Plant Sci, 19, 592, 10.1016/j.tplants.2014.05.006 Heilmann, 2012, Production of wax esters in plant seed oils by oleosomal cotargeting of biosynthetic enzymes, J. Lipid Res, 53, 2153, 10.1194/jlr.M029512 Zhou, 2006, Combined transgenic expression of Δ12-desaturase and Δ12-epoxygenase in high linoleic acid seeds leads to increased accumulation of vernolic acid, Funct. Plant Biol, 33, 585, 10.1071/FP05297 Ruiz-Lopez, 2014, Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop, Plant J., 77, 198, 10.1111/tpj.12378 Ruiz-Lopez, 2015, An alternative pathway for the effective production of the omega-3 long-chain polyunsaturates EPA and ETA in transgenic oilseeds, Plant Biotechnol. J., 10.1111/pbi.12328 Malik, 2015, Production of high levels of poly-3-hydroxybutyrate in plastids of Camelina sativa seeds, Plant Biotechnol. J., 13, 675, 10.1111/pbi.12290