Loss of coxsackie and adenovirus receptor expression is associated with features of aggressive bladder cancer

Bergelson, 1997, Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5, Science, 275, 1320, 10.1126/science.275.5304.1320 Hemmi, 1998, The presence of human coxsackievirus and adenovirus receptor is associated with efficient adenovirus-mediated transgene expression in human melanoma cell cultures, Hum Gene Ther, 9, 2363, 10.1089/hum.1998.9.16-2363 Miller, 1998, Differential susceptibility of primary and established human glioma cells to adenovirus infection, Cancer Res, 58, 5738 Li, 1999, Loss of adenoviral receptor expression in human bladder cancer cells, Cancer Res, 59, 325 Okegawa, 2001, The mechanism of the growth-inhibitory effect of coxsackie and adenovirus receptor (CAR) on human bladder cancer, Cancer Res, 61, 6592 Wesseling, 2001, Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors, Gene Ther, 8, 969, 10.1038/sj.gt.3301473 Rauen, 2002, Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma, Cancer Res, 62, 3812 Sachs, 2002, Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer, Urology, 60, 531, 10.1016/S0090-4295(02)01748-X Qin, 2003, Coxsackievirus adenovirus receptor expression predicts the efficiency of adenoviral gene transfer into non-small cell lung cancer xenografts, Clin Cancer Res, 9, 4992 Seidman, 2001, Variation in adenovirus receptor expression and adenovirus vector-mediated transgene expression at defined stages of the cell cycle, Mol Ther, 4, 13, 10.1006/mthe.2001.0414 Wang, 1999, Coxsackievirus and adenovirus receptor cytoplasmic and transmembrane domains are not essential for coxsackievirus and adenovirus infection, J Virol, 73, 2559, 10.1128/JVI.73.3.2559-2562.1999 Cohen, 2001, The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction, Proc Natl Acad Sci USA, 98, 15191, 10.1073/pnas.261452898 Walters, 2002, Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape, Cell, 110, 789, 10.1016/S0092-8674(02)00912-1 Anders, 2003, Disruption of 3D tissue integrity facilitates adenovirus infection by deregulating the coxsackievirus and adenovirus receptor, Proc Natl Acad Sci USA, 100, 1943, 10.1073/pnas.0337599100 Bruning, 2003, CAR is a cell-cell adhesion protein in human cancer cells and is expressionally modulated by dexamethasone, TNFalpha, and TGFbeta, Gene Ther, 10, 198, 10.1038/sj.gt.3301887 Shariat, 2000, Prognostic value of P53 nuclear accumulation and histopathologic features in T1 transitional cell carcinoma of the urinary bladder, Urology, 56, 735, 10.1016/S0090-4295(00)00756-1 Shariat, 2001, E-cadherin expression predicts clinical outcome in carcinoma in situ of the urinary bladder, Urology, 57, 60, 10.1016/S0090-4295(00)00892-X Byrne, 2001, E-cadherin immunostaining of bladder transitional cell carcinoma, carcinoma in situ and lymph node metastases with long-term followup, J Urol, 165, 1473, 10.1016/S0022-5347(05)66330-6 Tokunaga, 2001, Correlation of immunohistochemical molecular staging of bladder biopsies and radical cystectomy specimens, Int J Radiat Oncol Biol Phys, 51, 16, 10.1016/S0360-3016(01)01586-3 Shariat, 2004, p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer, J Clin Oncol, 22, 1014, 10.1200/JCO.2004.03.118 Levine, 1991, The p53 tumour suppressor gene, Nature, 351, 453, 10.1038/351453a0 Esrig, 1993, p53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer, Am J Pathol, 143, 1389 Kitazono, 2001, Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228, Cancer Res, 61, 6328 Matsumoto, 2003, Effective suicide gene transfer strategy using a chimeric adenovirus vector for bladder cancer gene therapy, J Urol 169(4), 184