Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Kuroczycki-Saniutycz, 2017, Prevention of pancreatic cancer, Contemp Oncol (Pozn), 21, 30 Momi, 2013, Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation, Oncogene, 32, 1384, 10.1038/onc.2012.163 Xue, 2014, Mechanisms of cancer induction by tobacco-specific NNK and NNN, Cancers (Basel), 6, 1138, 10.3390/cancers6021138 Melkamu, 2013, Lipopolysaccharide enhances mouse lung tumorigenesis: a model for inflammation-driven lung cancer, Vet Pathol, 50, 895, 10.1177/0300985813476061 Pauly, 2011, Cigarette smoke, bacteria, mold, microbial toxins, and chronic lung inflammation, J Oncol, 2011, 819129 Yu, 2017, Cigarette smoke induced urocystic epithelial mesenchymal transition via MAPK pathways, Oncotarget, 8, 8791, 10.18632/oncotarget.14456 Al-Wadei, 2016, Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signaling, Eur J Cancer, 52, 188, 10.1016/j.ejca.2015.10.003 Hermann, 2014, Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice, Gastroenterology, 147, 1119, 10.1053/j.gastro.2014.08.002 Ponnusamy, 2014, Insights into the role of nicotine in pancreatic stem cell activation and acinar dedifferentiation, Gastroenterology, 147, 962, 10.1053/j.gastro.2014.09.026 Hanson, 2016, Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis, Oncotarget, 7, 39996, 10.18632/oncotarget.9557 Lau, 2016, Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Rep, 15, 1175, 10.1016/j.celrep.2016.04.019 Milde-Langosch, 2005, The Fos family of transcription factors and their role in tumourigenesis, Eur J Cancer, 41, 2449, 10.1016/j.ejca.2005.08.008 Costa, 2000, Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation, Genetics, 156, 535, 10.1093/genetics/156.2.535 Penheiter, 2005, A posttranscriptional role for the yeast Paf1-RNA polymerase II complex is revealed by identification of primary targets, Mol Cell, 20, 213, 10.1016/j.molcel.2005.08.023 Stolinski, 1997, Identification of RTF1, a novel gene important for TATA site selection by TATA box-binding protein in Saccharomyces cerevisiae, Mol Cell Biol, 17, 4490, 10.1128/MCB.17.8.4490 Chaudhary, 2007, Human RNA polymerase II-associated factor complex: dysregulation in cancer, Oncogene, 26, 7499, 10.1038/sj.onc.1210582 Ding, 2009, A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity, Cell Stem Cell, 4, 403, 10.1016/j.stem.2009.03.009 Ponnusamy, 2009, RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells, Stem Cells, 27, 3001, 10.1002/stem.237 Strikoudis, 2016, Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a, Nat Cell Biol, 18, 1127, 10.1038/ncb3424 Vaz, 2016, Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma, Oncotarget, 7, 3317, 10.18632/oncotarget.6580 Vaz, 2014, Novel role of pancreatic differentiation 2 in facilitating self-renewal and drug resistance of pancreatic cancer stem cells, Br J Cancer, 111, 486, 10.1038/bjc.2014.152 Kumar, 2015, Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages, Oncogene, 34, 2052, 10.1038/onc.2014.154 Liu, 2015, Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract, Toxicol Appl Pharmacol, 282, 9, 10.1016/j.taap.2014.10.022 Miranda-Lorenzo, 2014, Intracellular autofluorescence: a biomarker for epithelial cancer stem cells, Nat Methods, 11, 1161, 10.1038/nmeth.3112 Cao, 2014, A new tumorsphere culture condition restores potentials of self-renewal and metastasis of primary neuroblastoma in a mouse neuroblastoma model, PLoS One, 9, e86813, 10.1371/journal.pone.0086813 Wang, 2013, Sphere-forming assays for assessment of benign and malignant pancreatic stem cells, Methods Mol Biol, 980, 281, 10.1007/978-1-62703-287-2_15 Marcato, 2011, Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis, Stem Cells, 29, 32, 10.1002/stem.563 Sainz, 2015, The fuss over lipo“fuss”cin: not all autofluorescence is the same, Eur J Histochem, 59, 2512, 10.4081/ejh.2015.2512 Talotta, 2010, Heterodimerization with Fra-1 cooperates with the ERK pathway to stabilize c-Jun in response to the RAS oncoprotein, Oncogene, 29, 4732, 10.1038/onc.2010.211 Hirata, 2017, Tobacco nitrosamine NNK increases ALDH-positive cells via ROS-Wnt signaling pathway in A549 human lung cancer cells, J Toxicol Sci, 42, 193, 10.2131/jts.42.193 Liu, 2014, Transcriptional pause release is a rate-limiting step for somatic cell reprogramming, Cell Stem Cell, 15, 574, 10.1016/j.stem.2014.09.018 Moniaux, 2006, The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis, Oncogene, 25, 3247, 10.1038/sj.onc.1209353 Mueller, 2004, The Paf1 complex has functions independent of actively transcribing RNA polymerase II, Mol Cell, 14, 447, 10.1016/S1097-2765(04)00257-6 Huang, 2008, Isolation and biological analysis of tumor stem cells from pancreatic adenocarcinoma, World J Gastroenterol, 14, 3903, 10.3748/wjg.14.3903 Li, 2007, Identification of pancreatic cancer stem cells, Cancer Res, 67, 1030, 10.1158/0008-5472.CAN-06-2030 An, 2012, Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side population, PLoS One, 7, e47919, 10.1371/journal.pone.0047919 Guha, 2014, Nicotine promotes apoptosis resistance of breast cancer cells and enrichment of side population cells with cancer stem cell like properties via a signaling cascade involving galectin-3, α9 nicotinic acetylcholine receptor and STAT3, Breast Cancer Res Treat, 145, 5, 10.1007/s10549-014-2912-z Shaykhiev, 2013, Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer, Stem Cells, 31, 1992, 10.1002/stem.1459 Little, 2017, Mathematical models of tissue stem and transit target cell divisions and the risk of radiation- or smoking-associated cancer, PLoS Comput Biol, 13, e1005391, 10.1371/journal.pcbi.1005391 Karmakar, 2017, hPAF1 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells, Oncotarget, 8, 14806, 10.18632/oncotarget.14775 Momi, 2013, Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through alpha7nAChR-mediated MUC4 upregulation, Oncogene, 32, 1384, 10.1038/onc.2012.163 Liu, 2015, Epithelial-mesenchymal transition and cancer stem cells, mediated by a long non-coding RNA, HOTAIR, are involved in cell malignant transformation induced by cigarette smoke extract, Toxicol Appl Pharmacol, 282, 9, 10.1016/j.taap.2014.10.022 Kaisar, 2017, A convenient UHPLC-MS/MS method for routine monitoring of plasma and brain levels of nicotine and cotinine as a tool to validate newly developed preclinical smoking model in mouse, BMC Neurosci, 18, 71, 10.1186/s12868-017-0389-5 Earla, 2014, Drug Metab Dispos, 42, 282, 10.1124/dmd.113.055186 Miranda-Lorenzo, 2014, Intracellular autofluorescence: a biomarker for epithelial cancer stem cells, Nat Methods, 11, 1161, 10.1038/nmeth.3112 Kumar, 2015, Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages, Oncogene, 34, 2052, 10.1038/onc.2014.154 Ponnusamy, 2009, RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells, Stem Cells, 27, 3001, 10.1002/stem.237 Karmakar, 2017, hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells, Oncotarget, 14806, 10.18632/oncotarget.14775