Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide

DNA Repair - Tập 7 - Trang 1202-1212 - 2008
Anne Lagerqvist1, Daniel Håkansson1, Gabriela Prochazka2, Cecilia Lundin2, Kristian Dreij3, Dan Segerbäck2, Bengt Jernström3, Margareta Törnqvist4, Albrecht Seidel5, Klaus Erixon1, Dag Jenssen1
1Department of Genetics, Microbiology and Toxicology (GMT), Arrhenius Laboratories of Natural Sciences, Stockholm University, S-106 91 Stockholm, Sweden
2Department of Biosciences and Nutrition, Novum, Karolinska Institute, S-141 57 Huddinge, Sweden
3The Institute for Environmental Medicine (IMM), Karolinska Institute, S-171 77 Stockholm, Sweden
4Department of Environmental Chemistry, Arrhenius Laboratories of Natural Sciences, Stockholm University, S-106 91 Stockholm, Sweden
5Biochemical Institute for Environmental Carcinogens, Lurup 4, D-22927 Grosshansdorf, Germany

Tài liệu tham khảo

Baird, 2005, Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action, Environ. Mol. Mutagen., 45, 106, 10.1002/em.20095 Vineis, 2005, Air pollution and cancer: biomarker studies in human populations, Carcinogenesis, 26, 1846, 10.1093/carcin/bgi216 Jankowiak, 1998, Structure, conformations, and repair of DNA adducts from dibenzo[a,l]pyrene: 32P-postlabeling and fluorescence studies, Chem. Res. Toxicol., 11, 674, 10.1021/tx970232k Braithwaite, 1999, Repair of DNA lesions: mechanisms and relative repair efficiencies, Mutat. Res., 424, 207, 10.1016/S0027-5107(99)00020-2 Geacintov, 2002, Thermodynamic and structural factors in the removal of bulky DNA adducts by the nucleotide excision repair machinery, Biopolymers, 65, 202, 10.1002/bip.10239 Buterin, 2000, Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots, Cancer Res., 60, 1849 Zhang, 2000, Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro, Nucleic Acids Res., 28, 4138, 10.1093/nar/28.21.4138 Wu, 2006, DNA helicases required for homologous recombination and repair of damaged replication forks, Annu. Rev. Genet., 40, 279, 10.1146/annurev.genet.40.110405.090636 Thompson, 2001, Homologous recombinational repair of DNA ensures mammalian chromosome stability, Mutat. Res., 477, 131, 10.1016/S0027-5107(01)00115-4 Johansson, 2006, Caffeine delays replication fork progression and enhances UV-induced homologous recombination in Chinese hamster cell lines, DNA Repair (Amst.), 5, 1449, 10.1016/j.dnarep.2006.07.005 Rechkoblit, 2002, trans-Lesion synthesis past bulky benzo[a]pyrene diol epoxide N2-dG and N6-dA lesions catalyzed by DNA bypass polymerases, J. Biol. Chem., 277, 30488, 10.1074/jbc.M201167200 Zhang, 2002, Two-step error-prone bypass of the (+)- and (−)-trans-anti-BPDE-N2-dG adducts by human DNA polymerases eta and kappa, Mutat. Res., 510, 23, 10.1016/S0027-5107(02)00249-X Avkin, 2004, Quantitative analysis of translesion DNA synthesis across a benzo[a]pyrene-guanine adduct in mammalian cells: the role of DNA polymerase kappa, J. Biol. Chem., 279, 53298, 10.1074/jbc.M409155200 Melendez-Colon, 2000, Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures, Chem. Res. Toxicol., 13, 10, 10.1021/tx9802724 Scicchitano, 2005, Transcription past DNA adducts derived from polycyclic aromatic hydrocarbons, Mutat. Res., 577, 146, 10.1016/j.mrfmmm.2005.03.015 Ruan, 2002, Synthesis and characterization of site-specific and stereoisomeric fjord dibenzo[a,l]pyrene diol epoxide-N(6)-adenine adducts: unusual thermal stabilization of modified DNA duplexes, Chem. Res. Toxicol., 15, 249, 10.1021/tx010157k Dreij, 2005, Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells, Chem Res Toxicol, 18, 655, 10.1021/tx0497090 Lloyd, 2002, p53 Controls global nucleotide excision repair of low levels of structurally diverse benzo(g)chrysene-DNA adducts in human fibroblasts, Cancer Res., 62, 5288 Suh, 1995, Formation and persistence of benzo[a]pyrene-DNA adducts in mouse epidermis in vivo: importance of adduct conformation, Carcinogenesis, 16, 2561, 10.1093/carcin/16.10.2561 Dreij, 2005, Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells, Chem. Res. Toxicol., 18, 655, 10.1021/tx0497090 Petersen, 1995, Gene-specific and strand-specific DNA repair in the G1 and G2 phases of the cell cycle, Mol. Cell Biol., 15, 3731, 10.1128/MCB.15.7.3731 Feng, 2002, Transcription-coupled DNA repair is genomic context-dependent, J. Biol. Chem., 277, 12777, 10.1074/jbc.M112297200 Hu, 2002, Transcription-coupled and transcription-independent repair of cyclobutane pyrimidine dimers in the dihydrofolate reductase gene, J. Biol. Chem., 277, 38305, 10.1074/jbc.M206375200 Ehrenberg, 1983, International Commission for Protection Against Environmental Mutagens and Carcinogens. Dosimetry of genotoxic agents and dose–response relationships of their effects, Mutat. Res., 123, 121, 10.1016/0165-1110(83)90024-6 Helleberg, 2001, Studies of dose distribution, premutagenic events and mutation frequencies for benzo[a]pyrene aiming at low dose cancer risk estimation, Mutagenesis, 16, 333, 10.1093/mutage/16.4.333 Dogra, 1990, Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing, Mol. Pharmacol., 37, 608 Helleday, 1998, Effects of carcinogenic agents upon different mechanisms for intragenic recombination in mammalian cells, Carcinogenesis, 19, 973, 10.1093/carcin/19.6.973 Chaung, 1997, The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair, Nucleic Acids Res., 25, 992, 10.1093/nar/25.5.992 Luch, 1994, Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene, Carcinogenesis, 15, 2507, 10.1093/carcin/15.11.2507 Romert, 1989, Effects of glutathione transferase activity on benzo[a]pyrene 7,8-dihydrodiol metabolism and mutagenesis studied in a mammalian cell co-cultivation assay, Carcinogenesis, 10, 1701, 10.1093/carcin/10.9.1701 Jernstrom, 1996, Glutathione S-transferase A1-1-catalysed conjugation of bay and fjord region diol epoxides or polycyclic aromatic hydrocarbons with glutathione, Carcinogenesis, 17, 1491, 10.1093/carcin/17.7.1491 Randerath, 1989, A new sensitive 32P-postlabeling assay based on the specific enzymatic conversion of bulky DNA lesions to radiolabeled dinucleotides and nucleoside 5′-monophosphates, Carcinogenesis, 10, 1231, 10.1093/carcin/10.7.1231 Plna, 1999, 32P-postlabelling of propylene oxide 1- and N(6)-substituted adenine and 3-substituted cytosine/uracil: formation and persistence in vitro and in vivo, Carcinogenesis, 20, 2025, 10.1093/carcin/20.10.2025 Phillips, 1999, Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols, Mutagenesis, 14, 301, 10.1093/mutage/14.3.301 Dreij, 2004, DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells: kinetics of adduct-removal, effects on cell cycle check points and gene expression, Polycycl. Arom. Compd., 24, 549, 10.1080/10406630490471645 Weinstein, 1976, Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo, Science, 193, 592, 10.1126/science.959820 Erixon, 1979, Mutat. Res., 59, 257, 10.1016/0027-5107(79)90164-7 Johansson, 2004, A method to monitor replication fork progression in mammalian cells: nucleotide excision repair enhances and homologous recombination delays elongation along damaged DNA, Nucleic Acids Res., 32, e157, 10.1093/nar/gnh154 Erixon, 1986, Differential regulation of base and nucleotide excision repair in mammalian cells, Basic Life Sci., 38, 159 Hjertvik, 1998, Repair of DNA damage in mammalian cells after treatment with UV and dimethyl sulphate: discrimination between nucleotide and base excision repair by their temperature dependence, Mutat. Res., 407, 87, 10.1016/S0921-8777(97)00062-1 Hoeijmakers, 2001, Genome maintenance mechanisms for preventing cancer, Nature, 411, 366, 10.1038/35077232 Jenssen, 1984, A quantitative test for mutagenicity in V79 Chinese hamster cells, 269 Helleday, 1998, A partial hprt gene duplication generated by non-homologous recombination in V79 Chinese hamster cells is eliminated by homologous recombination, J. Mol. Biol., 279, 687, 10.1006/jmbi.1998.1809 Schiltz, 1999, Characterization of the mutational profile of (+)-7R,8S-dihydroxy-9S, 10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene at the hypoxanthine (guanine) phosphoribosyltransferase gene in repair-deficient Chinese hamster V-H1 cells, Carcinogenesis, 20, 2279, 10.1093/carcin/20.12.2279 Bostrom, 2002, Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air, Environ. Health Perspect., 110, 451, 10.1289/ehp.02110s3451 Geacintov, 1997, NMR solution structures of stereoisometric covalent polycyclic aromatic carcinogen-DNA adduct: principles, patterns, and diversity, Chem. Res. Toxicol., 10, 111, 10.1021/tx9601418 Wei, 1993, Dose-dependent differences in the profile of mutations induced by (+)-7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the coding region of the hypoxanthine (guanine) phosphoribosyltransferase gene in Chinese hamster V-79 cells, Cancer Res., 53, 3294 Wei, 1994, Mutagenic selectivity at the HPRT locus in V-79 cells: comparison of mutations caused by bay-region benzo[a]pyrene 7,8-diol-9,-10-epoxide enantiomers with high and low carcinogenic activity, Carcinogenesis, 15, 1729, 10.1093/carcin/15.8.1729 Feng, 2003, Effects of genomic context and chromatin structure on transcription-coupled and global genomic repair in mammalian cells, Nucleic Acids Res., 31, 5897, 10.1093/nar/gkg808 Vreeswijk, 1994, Analysis of repair of cyclobutane pyrimidine dimers and pyrimidine 6-4 pyrimidone photoproducts in transcriptionally active and inactive genes in Chinese hamster cells, J. Biol. Chem., 269, 31858, 10.1016/S0021-9258(18)31774-5 Wei, 1995, Site-specific rates of excision repair of benzo[a]pyrene diol epoxide adducts in the hypoxanthine phosphoribosyltransferase gene of human fibroblasts: correlation with mutation spectra, Proc. Natl. Acad. Sci. U.S.A., 92, 2204, 10.1073/pnas.92.6.2204 Wei, 1996, Effect of nuclear environment on the distribution of benzo[a]pyrene diol epoxide-induced adducts in the HPRT gene of human fibroblasts, Carcinogenesis, 17, 2695, 10.1093/carcin/17.12.2695 Tornaletti, 1994, Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer, Science, 263, 1436, 10.1126/science.8128225 Mitchell, 1990, Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin, J. Biol. Chem., 265, 5353, 10.1016/S0021-9258(19)39363-9 Buterin, 2002, Trapping of DNA nucleotide excision repair factors by nonrepairable carcinogen adducts, Cancer Res., 62, 4229